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1. 发明申请

US20170281825A1 COMPOSITIONS AND METHODS FOR WOUND HEALING 审中-公开
公开(公告)号：US20170281825A1
公开(公告)日：2017-10-05
申请号：US15472330
申请日：2017-03-29
申请人： George PINS , Glenn GAUDETTE , Adam COLLETTE , William EDELMAN
发明人： George PINS , Glenn GAUDETTE , Adam COLLETTE , William EDELMAN
IPC分类号： A61L17/08 , A61L17/10 , A61L17/12
CPC分类号： A61L17/08 , A61L17/10 , A61L17/12
摘要： The present invention relates, in part, to sutures which promote wound closure and/or healing. In particular, the present invention provides fibrin microthread sutures that mimic the mechanical behavior of a target tissue thereby reducing, for example, scarring, inflammation, and cell death at the ligature site, including monofilament sutures.

2. 发明申请

US20090018559A1 Temporarily Stiffened Mesh Prostheses 审中-公开
标题翻译：临时加强网状假肢
公开(公告)号：US20090018559A1
公开(公告)日：2009-01-15
申请号：US11936049
申请日：2007-11-06
申请人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
发明人： Fatima Buevich , Frank Do , William McJames , Satish Pulapura , William Edelman , Arikha Moses , Mason Diamond , Shari Timothy
IPC分类号： A61B17/08 , A61F2/02
CPC分类号： A61F2/0063 , A61F2210/0004 , A61F2250/0067 , A61F2310/0097 , A61L27/34 , A61L27/54 , A61L27/56 , A61L27/58 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/402 , A61L2300/404 , A61L2300/406 , A61L2300/416 , A61L2300/45 , A61L2300/606 , A61L2430/02
摘要： The present invention relates to medical prostheses and methods of manufacturing those devices. In particular, the prostheses are temporarily stiffened meshes with particular coatings to provide initial stiffness and thereby permit easier surgical handling for treatment or reconstruction of soft tissue defects. Preferred embodiments include surgical meshes coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The devices of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use. By including biologically active agents and/or drugs in the coating, the devices provide prophylaxis for and can alleviate side effects or complications associated with the surgery or use of prostheses in general.
摘要翻译：本发明涉及医用假体及其制造方法。特别地，假体是具有特定涂层的临时硬化网，以提供初始刚度，从而允许更容易的手术处理以用于治疗或重建软组织缺陷。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网，所述可生物降解的聚合物可以通过涂覆网状物的细丝或纤维来临时固定那些丝或纤维的接触点和/或通过增加网状物的刚度至少是原始刚度的1.1倍。本发明的装置还可以提供与其植入，插入或手术使用相关的各种术后并发症的缓解。通过将生物活性剂和/或药物包括在涂层中，这些装置通常提供与手术或使用假体相关的副作用或并发症的预防和可以减轻。

3. 发明授权

US06375648B1 Infiltration cannula with teflon coated outer surface 有权
标题翻译：渗透套管与聚四氟乙烯涂层外表面
公开(公告)号：US06375648B1
公开(公告)日：2002-04-23
申请号：US09165940
申请日：1998-10-02
申请人： William Edelman , John C. Brumbach
发明人： William Edelman , John C. Brumbach
IPC分类号： A61M100
CPC分类号： A61M3/0279 , A61B17/3421 , A61M2202/08 , A61M2202/0014
摘要： An infiltration cannula is provided. The infiltration cannula includes an axially elongated tube having a circular cross-section, a proximal end portion adapted to receive a treatment fluid and a distal end portion with a plurality of apertures disposed in a transverse sidewall of the distal end portion of the elongated tube for dispensing the treatment fluid. The cannula also includes a teflon coating disposed over and outer surface of the elongated member.
摘要翻译：提供渗透插管。渗透套管包括具有圆形横截面的轴向细长管，适于接收处理流体的近端部分和具有设置在细长管的远端部分的横向侧壁中的多个孔的远端部分，分配治疗液。套管还包括设置在细长构件的上表面和外表面上的聚四氟乙烯涂层。

4. 发明授权

US4318813A Membrane plasmapheresis module 失效
标题翻译：膜血浆置换模块
公开(公告)号：US4318813A
公开(公告)日：1982-03-09
申请号：US164735
申请日：1980-06-30
申请人： William Edelman , James R. Hitchcock, Jr. , William J. Schnell
发明人： William Edelman , James R. Hitchcock, Jr. , William J. Schnell
IPC分类号： B01D63/08 , B01D63/14 , B01D31/00
CPC分类号： B01D63/14 , B01D63/084 , Y10S128/03 , Y10S261/28
摘要： A membrane plasmapheresis module (10) comprises semipermeable membrane means (11) capable of permitting blood plasma to pass therethrough while preventing the passage of blood cells, and sealed housing means (18, 19) defining a blood inlet port (43) and blood outlet port (44) positioned adjacent opposite ends of a first flow path (60) extending along one side of the membrane (11). The housing (18, 19) also defines a plasma outlet port (38) adjacent one end of separate, second flow paths (62) extending along the other side of the membrane (11). The membrane (11) may be folded together about a fold line (12) to define a pair of membrane portions (14, 16) lying against each other. The first flow path (60) extends between the membrane portions (14, 16) and the second flow path (62) may optionally extend between each membrane portion (14, 16) and a wall of the sealed housing means (18, 19), or alternatively an adjacent fold (12) of the membrane portion. A plasma outlet port (38) is defined through the housing (18, 19) at a position spaced from the membrane (11). Channels (21) are defined in the interior surface of the housing (18, 19) and positioned to face the membrane (11) to serve as a manifold to collect blood plasma from the second flow path (62). The above-described channel (21) also extends across the fold line (12) into flow communication with the plasma outlet port (38). Also, blood inlet and outlet ports (43, 44) may extend in telescopic relation with aperture ports (40, 42) in the housing for securence of the inlet and outlet ports (43, 44).
摘要翻译：膜血浆置换模块（10）包括能够允许血浆穿过其中同时防止血细胞通过的半透膜装置（11），以及限定血液入口（43）和血液出口（43）的密封的壳体装置（18,19）端口（44）位于沿着膜（11）的一侧延伸的第一流动路径（60）的相对端附近。壳体（18,19）还限定了沿隔膜（11）的另一侧延伸的分开的第二流动路径（62）的一端附近的等离子体出口（38）。膜（11）可围绕折线（12）折叠在一起，以限定彼此相对的一对膜部分（14,16）。第一流动路径（60）在膜部分（14,16）之间延伸，并且第二流动路径（62）可任选地在每个膜部分（14,16）和密封的壳体装置（18,19）的壁之间延伸，，或者替代地，膜部分的相邻折叠（12）。等离子体出口（38）通过壳体（18,19）在与膜（11）间隔开的位置处被限定。通道（21）限定在壳体（18,19）的内表面中并且定位成面对膜（11）以用作歧管以从第二流动路径（62）收集血浆。上述通道（21）也跨越折叠线（12）延伸成与等离子体出口（38）流动连通。此外，血液入口和出口端口（43,44）可以与壳体中的孔口（40,42）伸缩关系延伸，以确保入口和出口端口（43,44）。

5. 发明授权

US4073292A Control apparatus for the automatic treatment of diabetes 失效
标题翻译：用于自动治疗糖尿病的控制装置
公开(公告)号：US4073292A
公开(公告)日：1978-02-14
申请号：US736996
申请日：1976-10-29
申请人： William Edelman
发明人： William Edelman
IPC分类号： A61B5/20 , A61M5/142 , A61M5/172 , A61M5/00
CPC分类号： A61B5/201 , A61B5/14507 , A61M5/1723 , A61M5/14276 , Y10S128/13
摘要： The control apparatus of the invention comprises a feedback system to maintain the level of glucose in a diabetic within predetermined limits. Surgically implanted in the body are a means for sensing glucose levels and a means for dispensing insulin in an amount determined by the sensing mechanism. The sensing mechanism employs a chemical solution, which, like the insulin, is stored within a reservoir forming part of the surgical implant. Means are additionally provided to couple these reservoirs to the surface of the skin so as to permit their rechargings at regular time intervals. Integrated circuit technology is employed to translate an indication of an unacceptable glucose level into an automatic injection of insulin, with the electronics being of the type capable of being powered by batteries of the kind employed in pacemaker technology.
摘要翻译：本发明的控制装置包括将糖尿病患者的葡萄糖水平维持在预定限度内的反馈系统。手术植入体内是用于检测葡萄糖水平的装置和用于由感测机构确定的量分配胰岛素的装置。感测机构使用化学溶液，其像胰岛素一样储存在形成手术植入物的一部分的储液器中。另外提供了将这些储存器联接到皮肤表面的装置，以便允许它们以规则的时间间隔进行充电。采用集成电路技术将不可接受的葡萄糖水平的指示转化为胰岛素的自动注射，其中电子装置的类型能够由起搏器技术中采用的电池供电。

6. 发明申请

US20170296295A1 ADJUSTABLE HEADPIECE WITH ANATOMICAL MARKERS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20170296295A1
公开(公告)日：2017-10-19
申请号：US15507994
申请日：2015-09-30
申请人： Timothy Andrew WAGNER , William EDELMAN , Laura DIPIETRO , Paul James MULHAUSER , Kyungmin Andy LEE , Highland Instruments
发明人： Timothy Andrew Wagner , William Edelman , Laura Dipietro , Paul James Mulhauser , Kyungmin Andy Lee
IPC分类号： A61B90/00 , A61N7/00 , A61N1/04 , F16M13/04
CPC分类号： A61B90/39 , A61B2090/3937 , A61B2090/502 , A61N1/0456 , A61N1/0472 , A61N1/0484 , A61N7/00 , A61N2007/0021 , A61N2007/0026 , F16M13/04
摘要： The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.

7. 发明申请

US20160157708A1 ENDOBRONCHIAL TUBE WITH INTEGRATED IMAGE SENSOR 审中-公开
公开(公告)号：US20160157708A1
公开(公告)日：2016-06-09
申请号：US15042160
申请日：2016-02-12
申请人： Elias DAHER , Matthias BENEDIKT SCHUH , William EDELMAN
发明人： Elias DAHER , Matthias BENEDIKT SCHUH , William EDELMAN
IPC分类号： A61B1/267 , A61B1/015 , A61B1/05 , A61B1/00 , A61M16/04 , A61B1/06
CPC分类号： A61M16/0463 , A61B1/00018 , A61B1/00082 , A61B1/00091 , A61B1/00094 , A61B1/00124 , A61B1/012 , A61B1/015 , A61B1/05 , A61B1/051 , A61B1/0676 , A61B1/0684 , A61B1/07 , A61B1/12 , A61B1/126 , A61B1/2676 , A61B1/313 , A61M15/00 , A61M16/0057 , A61M16/04 , A61M16/0404 , A61M16/0434 , A61M16/0459 , A61M16/0461 , A61M16/0465 , A61M16/0486 , A61M16/0488 , A61M16/0833 , A61M16/104
摘要： An endobronchial tube comprising at least two lumens of different lengths for selectively associating with a patient about at least two locations relative to the Tracheal Carina. said tube comprising: a first lumen having an open distal end that associates proximally to the Carina within the Trachea, with a first inflatable cuff; a second lumen having an open distal end that extends distally, past the Carina and associates within one of the Left Bronchial branch and Right Bronchial branch with a second inflatable cuff; a dedicated image sensor lumen spanning the length of said first lumen, the dedicated image sensor lumen comprising an image sensor and illumination source disposed adjacent to the distal end of said first lumen, and configured to provide an image of the Tracheal bifurcation of the Tracheal Carina, the openings of the Left Bronchial branch, and the opening Right Bronchial branch; and at least one dedicated cleaning lumen disposed parallel with said dedicated image sensor lumen along the length of said endobronchial tube and wherein said cleaning lumen is configured to forms a cleaning nozzle at the distal end, wherein said cleaning nozzle is directed toward said image sensor lumen at its distal end.

8. 发明授权

US08591531B2 Mesh pouches for implantable medical devices 有权
标题翻译：用于可植入医疗器械的网袋
公开(公告)号：US08591531B2
公开(公告)日：2013-11-26
申请号：US11936054
申请日：2007-11-06
申请人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
发明人： Fatima Buevich , Arikha Moses , Frank Do , William McJames , William Edelman , Mason Diamond , Satish Pulapura
IPC分类号： A61B17/08 , B65D69/00
CPC分类号： A61L31/10 , A61B2017/00889 , A61B2017/00893 , A61B2090/0815 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/00 , A61N1/375
摘要： Biodegradable polymer-coated surgical meshes formed into pouches are described for use with cardiac rhythm management devices (CRMs) and other implantable medical devices. Such meshes are formed into a receptacle, e.g., a pouch or other covering, capable of encasing, surrounding and/or holding the cardiac rhythm management device or other implantable medical device for the purpose of securing it in position, inhibiting or reducing bacterial growth, providing pain relief and/or inhibiting scarring or fibrosis on or around the CRM or other implantable medical device. Preferred embodiments include surgical mesh pouches coated with one or more biodegradable polymers that can act as a stiffening agent by coating the filaments or fibers of the mesh to temporarily immobilize the contact points of those filaments or fibers and/or by increasing the stiffness of the mesh by at least 1.1 times its original stiffness. The pouches of the invention can also provide relief from various post-operative complications associated with their implantation, insertion or surgical use, and, optionally, include one or more drugs in the polymer matrix of the coating to provide prophylactic effects and/or alleviate side effects or complications associated with the surgery or implantation of the CRM or other implantable medical device.
摘要翻译：描述形成袋的可生物降解的聚合物涂覆的手术网与心律管理装置（CRM）和其他可植入医疗装置一起使用。这样的网状物形成为能够包围，围绕和/或保持心律管理装置或其它可植入医疗装置的容器，例如袋或其它覆盖物，以确保其在适当位置，抑制或减少细菌生长，在CRM或其他可植入医疗设备上或周围提供疼痛缓解和/或抑制瘢痕形成或纤维化。优选的实施方案包括涂覆有一种或多种可生物降解的聚合物的手术网袋，其可以通过涂覆网的细丝或纤维来暂时固定那些丝或纤维的接触点和/或通过增加网的刚度而充当硬化剂至少是其原始刚度的1.1倍。本发明的小袋还可以缓解与其植入，插入或手术使用相关的各种术后并发症，并且任选地在包衣的聚合物基质中包括一种或多种药物以提供预防效果和/或缓解侧与手术或植入CRM或其他可植入医疗器械相关的影响或并发症。

9. 发明授权

US4729621A Integral optical fiber coupler 失效
标题翻译：一体式光纤耦合器
公开(公告)号：US4729621A
公开(公告)日：1988-03-08
申请号：US710196
申请日：1985-03-11
申请人： William Edelman
发明人： William Edelman
IPC分类号： A61B18/20 , A61N5/06 , G02B6/42 , G02B6/32
CPC分类号： G02B6/4203
摘要： A device for transferring high energy electromagnetic radiation from a laser to an optical fiber, which comprises a cone-shaped coupler having a wide proximal end and a narrow distal end, wherein the proximal end is in the form of a convex surface which acts as a focussing lens adapted to receive radiation from a laser and to transmit said radiation into and through said optical fiber and the distal end is attached to the input end of the optical fiber to form an integral assembly therewith, said cone-shaped coupler having a taper angle .theta. defined by the equation ##EQU1## wherein N.A. is the numerical aperture of the fiber material and .mu. is the refractive index of the material of the coupler at the wavelength of the incident radiation. A process for removing an obstruction by laser surgery using said device is also disclosed.
摘要翻译：一种用于将高能电磁辐射从激光传输到光纤的装置，其包括具有宽近端和窄远端的锥形耦合器，其中所述近端呈凸形表面的形式，其作为聚焦透镜，其适于接收来自激光器的辐射并且将所述辐射传输到所述光纤中并且穿过所述光纤并且所述远端附接到所述光纤的输入端以与其形成一体的组件，所述锥形耦合器具有锥角 θ，其中NA是纤维材料的数值孔径，μ是耦合器在入射辐射波长处的材料的折射率。还公开了通过使用所述装置的激光手术去除梗阻的过程。

10. 发明授权

US4657014A Liquid interface fiberoptic coupler 失效
标题翻译：液体界面光纤耦合器
公开(公告)号：US4657014A
公开(公告)日：1987-04-14
申请号：US710184
申请日：1985-03-11
申请人： William Edelman , Hamid R. Naghieh , Dennis Constantinou
发明人： William Edelman , Hamid R. Naghieh , Dennis Constantinou
IPC分类号： A61B18/20 , A61B18/24 , A61N5/06 , B23K26/08 , G02B6/04 , G02B6/26 , G02B6/32 , G02B6/36 , G02B6/42 , A61B17/36
CPC分类号： G02B6/4296 , A61B18/245 , G02B6/262 , G02B6/32 , G02B6/4204 , G02B6/424
摘要： A device for conveying high energy electromagnetic radiation from a laser source to an optical fiber which comprises a sleeve having a proximal end and a distal end and being adapted to enclose a liquid which is transparent to said radiation, the distal end of said sleeve being adapted to be attached to the input end of the optical fiber; and a focussing lens attached to the proximal end of said sleeve said liquid having a refractive index which substantially matches the refractive index of the lens and of the optical fiber. A process for removing an obstruction by laser surgery using said device is also disclosed.
摘要翻译：一种用于将高能电磁辐射从激光源传送到光纤的装置，该装置包括具有近端和远端的套筒，并且适于封闭对所述辐射是透明的液体，所述套筒的远端适于要连接到光纤的输入端; 以及聚焦透镜，其附接到所述套筒的近端，所述液体具有与透镜和光纤的折射率基本一致的折射率。还公开了通过使用所述装置的激光手术去除梗阻的过程。

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