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1. 发明申请

US20080171924A9 NONINVASIVE DETERMINATION OF ALCOHOL IN TISSUE 有权
标题翻译：非酒精组织中酒精的测定
公开(公告)号：US20080171924A9
公开(公告)日：2008-07-17
申请号：US10852415
申请日：2004-05-24
申请人： Trent Ridder , John Maynard , Russell Abbink , Robert Johnson , Edward Hull , Andrew Meigs , Alan Ross , Dashiell Birnkrant
发明人： Trent Ridder , John Maynard , Russell Abbink , Robert Johnson , Edward Hull , Andrew Meigs , Alan Ross , Dashiell Birnkrant
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0075 , A61B5/14546
摘要： An apparatus and method for non-invasive determination of attributes of human tissue by quantitative infrared spectroscopy. The system includes subsystems optimized to contend with the complexities of the tissue spectrum, high signal-to-noise ratio and photometric accuracy requirements, tissue sampling errors, calibration maintenance problems, and calibration transfer problems. The subsystems include an illumination subsystem, a tissue sampling subsystem, a spectrometer subsystem, a data acquisition subsystem, and a processing subsystem. The invention is applicable, as examples, to determining the concentration or change of concentration of alcohol in human tissue.
摘要翻译：一种用于通过定量红外光谱非侵入式确定人体组织属性的装置和方法。该系统包括优化的子系统，以应对组织光谱的复杂性，高信噪比和光度精度要求，组织采样误差，校准维护问题和校准转移问题。子系统包括照明子系统，组织采样子系统，光谱仪子系统，数据采集子系统和处理子系统。作为实例，本发明可用于确定人体组织中酒精浓度或浓度的变化。

2. 发明申请

US20070088205A1 Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 有权
标题翻译：使用组织荧光测定糖化终产物或疾病状态的测量
公开(公告)号：US20070088205A1
公开(公告)日：2007-04-19
申请号：US11561380
申请日：2006-11-17
申请人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
发明人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/412 , A61B5/441
摘要： A method of detefnnining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of waveliengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
摘要翻译：确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。例如，如果不采用适当的校正，组织的反射率可能导致错误。本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。其他生物信息可与荧光性质结合使用，有助于测定组织状态。本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

3. 发明申请

US20060211928A1 Determination of a measure of a glycation end-product or disease state using tissue fluorescence preferentially from the dermis 有权
标题翻译：使用优先来自真皮的组织荧光测定糖基化终产物或疾病状态的量度
公开(公告)号：US20060211928A1
公开(公告)日：2006-09-21
申请号：US11417463
申请日：2006-05-03
申请人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
发明人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/412 , A61B5/441
摘要： A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
摘要翻译：确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。例如，如果不采用适当的校正，组织的反射率可能导致错误。本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。其他生物信息可与荧光性质结合使用，有助于测定组织状态。本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

4. 发明申请

US20050148834A1 Determination of a measure of a glycation end-product or disease state using tissue fluorescence 有权
标题翻译：使用组织荧光测定糖基化终产物或疾病状态的量度
公开(公告)号：US20050148834A1
公开(公告)日：2005-07-07
申请号：US10972173
申请日：2004-10-22
申请人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
发明人： Edward Hull , Marwood Ediger , Christopher Brown , John Maynard , Robert Johnson
IPC分类号： A61B5/00 , G01N20060101
CPC分类号： A61B5/1455 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/0068 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/412 , A61B5/441
摘要： A method of determining a measure of a tissue state (e.g., glycation end-product or disease state) in an individual. A portion of the tissue of the individual is illuminated with excitation light, then light emitted by the tissue due to fluorescence of a chemical with the tissue responsive to the excitation light is detected. The detected light can be combined with a model relating fluorescence with a measure of tissue state to determine a tissue state. The invention can comprise single wavelength excitation light, scanning of excitation light (illuminating the tissue at a plurality of wavelengths), detection at a single wavelength, scanning of detection wavelengths (detecting emitted light at a plurality of wavelengths), and combinations thereof. The invention also can comprise correction techniques that reduce determination errors due to detection of light other than that from fluorescence of a chemical in the tissue. For example, the reflectance of the tissue can lead to errors if appropriate correction is not employed. The invention can also comprise a variety of models relating fluorescence to a measure of tissue state, including a variety of methods for generating such models. Other biologic information can be used in combination with the fluorescence properties to aid in the determination of a measure of tissue state. The invention also comprises apparatuses suitable for carrying out the method, including appropriate light sources, detectors, and models (for example, implemented on computers) used to relate detected fluorescence and a measure of tissue state.
摘要翻译：确定个体中组织状态（例如，糖基化终产物或疾病状态）的量度的方法。用激发光照射个体组织的一部分，然后检测由组织响应于激发光的化学物质的荧光而由组织发出的光。检测到的光可以与将荧光与组织状态的测量相关联的模型组合以确定组织状态。本发明可以包括单波长激发光，激发光的扫描（以多个波长照射组织），单个波长的检测，检测波长的扫描（检测多个波长的发射光）及其组合。本发明还可以包括校正技术，其减少由于检测到除了组织中的化学物质的荧光以外的光的测定误差。例如，如果不采用适当的校正，组织的反射率可能导致错误。本发明还可以包括将荧光与组织状态的测量相关联的各种模型，包括用于产生这种模型的各种方法。其他生物信息可与荧光性质结合使用，有助于测定组织状态。本发明还包括适于执行该方法的装置，包括用于检测荧光和组织状态测量的适当的光源，检测器和模型（例如，在计算机上实现）。

5. 发明申请

US20060178570A1 Methods and apparatuses for noninvasive determinations of analytes 审中-公开
标题翻译：非侵入性测定分析物的方法和装置
公开(公告)号：US20060178570A1
公开(公告)日：2006-08-10
申请号：US11350916
申请日：2006-02-09
申请人： M. Robinson , Russell Abbink , Robert Johnson
发明人： M. Robinson , Russell Abbink , Robert Johnson
IPC分类号： A61B5/00 , G01J4/00
CPC分类号： G01N21/21 , A61B5/14558 , G01N21/49 , G01N2021/4792
摘要： The present invention provides methods and apparatuses for accurate noninvasive determination of tissue properties. Some embodiments of the present invention comprise an optical sampler having an illumination subsystem, adapted to communicate light having a first polarization to a tissue surface; a collection subsystem, adapted to collect light having a second polarization communicated from the tissue after interaction with the tissue; wherein the first polarization is different from the second polarization. The difference in the polarizations can discourage collection of light specularly reflected from the tissue surface, and can encourage preferential collection of light that has interacted with a desired depth of penetration or path length distribution in the tissue. The different polarizations can, as examples, be linear polarizations with an angle between, or elliptical polarizations of different handedness.
摘要翻译：本发明提供用于精确无创确定组织性质的方法和装置。本发明的一些实施例包括具有照明子系统的光学采样器，适于将具有第一偏振光的光传送到组织表面; 收集子系统，适于在与所述组织相互作用之后收集从所述组织传递的具有第二极化的光; 其中所述第一极化不同于所述第二极化。极化的差异可以阻止从组织表面反射的光的收集，并且可以鼓励优先收集与组织中所需的穿透深度或路径长度分布相互作用的光。作为示例，不同的极化可以是具有不同手性的角度或椭圆偏振之间的线性偏振。

6. 发明申请

US20080103396A1 Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 审中-公开
标题翻译：用于使用组织荧光测定糖化终产物或疾病状态的方法和装置
公开(公告)号：US20080103396A1
公开(公告)日：2008-05-01
申请号：US11964675
申请日：2007-12-26
申请人： Robert Johnson , Marwood Ediger , John Maynard
发明人： Robert Johnson , Marwood Ediger , John Maynard
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/443
摘要： Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.
摘要翻译：本发明的实施方案提供了适合于从组织收集的光谱信息确定体内组织的性质的装置。照明系统提供多个宽带范围的光，其传送到光学探针。光学探头接收来自照明系统的光，并将其透射到体内组织，并响应于宽带光或其组合，接收通过其体内组织发射的宽带光而漫射反射的光。光学探针将光传送到产生表示光的光谱性质的信号的光谱仪。分析系统根据光谱性质确定体内组织的性质。校准装置安装成使其周期性地与光学探针光通信。

7. 发明申请

US20070197880A1 Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence of Various Sites 失效
标题翻译：使用各种部位的组织荧光测定糖化终产物或疾病状态的测量
公开(公告)号：US20070197880A1
公开(公告)日：2007-08-23
申请号：US11675524
申请日：2007-02-15
申请人： John Maynard , Marwood Ediger , Robert Johnson , M. Robinson
发明人： John Maynard , Marwood Ediger , Robert Johnson , M. Robinson
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/0071 , A61B5/1455
摘要： Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe can be a flexible probe in some embodiments, allowing ease of application. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.
摘要翻译：本发明的实施方案提供一种适合于从各种组织部位收集的光谱信息确定体内组织的性质的装置。照明系统提供多个宽带范围的光，其传送到光学探针。在一些实施例中，光学探针可以是柔性探针，允许易于应用。在一些实施例中，可使用光均质器和模式加扰器来提高性能。在一些实施例中，光学探针物理接触组织，并且在一些实施例中，物理接触组织。光学探针从照明系统接收光并将其传输到组织，并且响应于宽带光或其组合而接收从体内组织发出的响应于通过其荧光发射的宽带光而漫反射的光。光学探针可以将光传送到产生表示光的光谱特性的信号的光谱仪。分析系统根据光谱性质确定体内组织的性质。

8. 发明申请

US20070276199A1 Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 审中-公开
标题翻译：使用组织荧光测定糖化终产物或疾病状态的测量
公开(公告)号：US20070276199A1
公开(公告)日：2007-11-29
申请号：US11624214
申请日：2007-01-17
申请人： Marwood Ediger , John Maynard , Robert Johnson , Maurizio Di Mauro
发明人： Marwood Ediger , John Maynard , Robert Johnson , Maurizio Di Mauro
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/0071 , A61B5/14532 , A61B5/1455 , A61B5/443 , A61B5/445
摘要： Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.
摘要翻译：本发明的实施方案提供了适合于从组织收集的光谱信息确定体内组织的性质的装置。照明系统提供多个宽带范围的光，其传送到光学探针。光学探头接收来自照明系统的光，并将其透射到体内组织，并且响应于宽带光或其组合而接收从体内组织发射的荧光通过其荧光而发射的光的漫射反射光。光学探针将光传送到产生表示光的光谱性质的信号的光谱仪。分析系统根据光谱性质确定体内组织的性质。校准装置安装成使其周期性地与光学探针光通信。

9. 发明申请

US20070265532A1 Determination of a Measure of a Glycation End-Product or Disease State Using a Flexible Probe to Determine Tissue Fluorescence of Various Sites 失效
标题翻译：使用灵活的探针测定各种位点的组织荧光测定糖化终产物或疾病状态
公开(公告)号：US20070265532A1
公开(公告)日：2007-11-15
申请号：US11677498
申请日：2007-02-21
申请人： John Maynard , Marwood Ediger , Robert Johnson , M. Robinson
发明人： John Maynard , Marwood Ediger , Robert Johnson , M. Robinson
IPC分类号： A61B6/00
CPC分类号： A61B5/1455 , A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/14546 , G01N21/255 , G01N21/49 , G01N21/645 , G01N21/6486
摘要： Embodiments of the present invention provide an apparatus with a flexible probe suitable for determining properties of in vivo tissue from spectral information collected from various tissue sites. An illumination system provides light at a plurality of broadband ranges, which are communicated to a flexible optical probe. Light homogenizers and mode scramblers can be employed to improve the performance in some embodiments. The optical probe in some embodiments physically contacts the tissue, and in some embodiments does not physically contact the tissue. The optical probe receives light from the illumination system and transmits it to tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe can communicate the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties.
摘要翻译：本发明的实施方案提供一种具有柔性探针的装置，其适合于从各种组织部位收集的光谱信息来确定体内组织的性质。照明系统在多个宽带范围内提供光，其传送到柔性光学探针。在一些实施例中，可使用光均质器和模式加扰器来提高性能。在一些实施例中，光学探针物理接触组织，并且在一些实施例中，物理接触组织。光学探针从照明系统接收光并将其传输到组织，并且响应于宽带光或其组合而接收从体内组织发出的响应于通过其荧光发射的宽带光而漫反射的光。光学探针可以将光传送到产生表示光的光谱特性的信号的光谱仪。分析系统根据光谱性质确定体内组织的性质。

10. 发明申请

US20110313296A9 Method and Apparatus for Determination of a Measure of a Glycation End-Product or Disease State Using Tissue Fluorescence 审中-公开
标题翻译：用于使用组织荧光测定糖化终产物或疾病状态的方法和装置
公开(公告)号：US20110313296A9
公开(公告)日：2011-12-22
申请号：US11964675
申请日：2007-12-26
申请人： Robert Johnson , Marwood Ediger , John Maynard
发明人： Robert Johnson , Marwood Ediger , John Maynard
IPC分类号： A61B6/00
CPC分类号： A61B5/0071 , A61B5/0075 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/443
摘要： Embodiments of the present invention provide an apparatus suitable for determining properties of in vivo tissue from spectral information collected from the tissue. An illumination system provides light at a plurality of broadband ranges, which are communicated to an optical probe. The optical probe receives light from the illumination system and transmits it to in vivo tissue, and receives light diffusely reflected in response to the broadband light, emitted from the in vivo tissue by fluorescence thereof in response to the broadband light, or a combination thereof. The optical probe communicates the light to a spectrograph which produces a signal representative of the spectral properties of the light. An analysis system determines a property of the in vivo tissue from the spectral properties. A calibration device mounts such that it is periodically in optical communication with the optical probe.
摘要翻译：本发明的实施方案提供了适合于从组织收集的光谱信息确定体内组织的性质的装置。照明系统提供多个宽带范围的光，其传送到光学探针。光学探头接收来自照明系统的光，并将其透射到体内组织，并响应于宽带光或其组合，接收通过其体内组织发射的宽带光而漫射反射的光。光学探针将光传送到产生表示光的光谱性质的信号的光谱仪。分析系统根据光谱性质确定体内组织的性质。校准装置安装成使其周期性地与光学探针光通信。

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