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1. 发明授权

US4784738A Apparatus and method for gel casting 失效
标题翻译：凝胶浇铸设备及方法
公开(公告)号：US4784738A
公开(公告)日：1988-11-15
申请号：US808307
申请日：1985-12-12
申请人： Donald D. Sleeter , George G. Fernwood , Samuel Burd
发明人： Donald D. Sleeter , George G. Fernwood , Samuel Burd
IPC分类号： C08F2/10 , G01N27/26 , G01N27/447 , G01N27/28
CPC分类号： G01N27/44704
摘要： A gel used for electrophoresis is cast in a gel enclosure in which the gel will ultimately be used during the electrophoresis, by a novel method and using novel apparatus which provide for quick assembly and avoidance of leaks. The method and apparatus involve a wettable, preferably porous, membrane such as filter paper, which is thoroughly wetted with gel forming solution, then placed over the bottom opening of the gel enclosure and held in place until the gel on the membrane sets. Sealing of any cracks, gaps or irregularities along the rim of the opening is thereby achieved by the capillary action of the gel forming solution. The enclosure itself is then filled with gel forming solution. Once the latter has set, the membrane is removed.
摘要翻译：用于电泳的凝胶被浇铸在凝胶封壳中，其中最终将在电泳期间使用凝胶，通过新颖的方法和使用提供快速组装和避免泄漏的新型装置。该方法和装置包括可湿性优选多孔的膜，例如滤纸，其用凝胶形成溶液彻底润湿，然后放置在凝胶封壳的底部开口上并保持在适当位置，直到膜组上的凝胶。因此，通过凝胶形成溶液的毛细作用可以实现沿着开口边缘的任何裂缝，间隙或不规则物的密封。然后将外壳本身用凝胶形成溶液填充。一旦后者已经设定，膜被去除。

2. 发明授权

US4612710A Method and apparatus for drying gel slabs 失效
标题翻译：干燥凝胶板的方法和装置
公开(公告)号：US4612710A
公开(公告)日：1986-09-23
申请号：US653971
申请日：1984-09-20
申请人： George G. Fernwood , Samuel Burd
发明人： George G. Fernwood , Samuel Burd
IPC分类号： G01N27/26 , F26B5/04 , F26B9/00 , G01N27/447 , F26B7/00
CPC分类号： F26B9/003 , F26B5/045 , G01N27/44704 , G01N27/44717
摘要： An apparatus for drying gel slabs supplies heat to a horizontal gel slab from a heating plate above the slab, while drawing a vacuum beneath. The heating plate is weighted and has a flat lower surface at least coextensive with the gel slab. The slab itself is placed on a porous support pad in a vacuum chamber enclosed at the top with a flexible cover which clings to the gel and seals to the perimeter of the chamber when a vacuum is applied from below. The heating plate rests on top of the cover under gravitational force, providing even heating across the entire expanse of the gel slab and for the entire duration of the drying process, resulting in a continuous and uniform vapor flow downward from the gel slab, a minimization of internal stresses, and reduced susceptibility of the gel to cracking.
摘要翻译：用于干燥凝胶板的装置在平板上方的加热板上向水平凝胶板供应热量，同时在其下方抽真空。加热板被加重，并且具有与凝胶板至少共同延伸的平坦的下表面。板坯本身被放置在密封在顶部的真空室中的多孔支撑垫上，并且当从下方施加真空时，柔性盖粘附到凝胶并且密封到室的周边。加热板在重力作用下搁置在盖的顶部，在凝胶板的整个整个平面上以及干燥过程的整个持续时间均匀加热，导致从凝胶板向下的连续均匀的蒸汽流，最小化的内应力，并降低凝胶对裂纹的敏感性。

3. 发明授权

US4493815A Supporting and filtering biochemical test plate assembly 失效
标题翻译：支持和过滤生化试板组装
公开(公告)号：US4493815A
公开(公告)日：1985-01-15
申请号：US518231
申请日：1983-07-28
申请人： George G. Fernwood , Samuel Burd
发明人： George G. Fernwood , Samuel Burd
IPC分类号： G01N33/48 , B01D61/18 , B01L3/00 , C12M1/12 , C12M1/20 , G01N33/53 , G01N33/543 , B01D25/04
CPC分类号： B01L3/50255 , B01D61/18 , G01N33/5302 , G01N33/5304 , C12M23/12 , C12M23/42 , C12M23/46 , Y10T436/25375
摘要： A biochemical test plate assembly is disclosed for use in both filter assays and fluid retention applications. The assembly comprises an upper template with a plurality of discrete apertures, a continuous microporous film underlying the upper template, a gasket underlying the microporous film with apertures matching those of the upper template, a lower template underlying the gasket with a similar array of apertures matching those of both the upper template and the gasket, each aperture terminating at its upper end in a flat boss, and a base plate having a central recess to define an enclosed chamber when the base plate and lower template are in contact, the base plate being designed to form an air-tight seal between it and the lower template.
摘要翻译：公开了用于过滤分析和流体保留应用的生化测试板组件。该组件包括具有多个离散孔的上模板，位于上模板下方的连续微孔薄膜，具有与上模板相匹配的孔的微多孔薄膜下方的垫圈，垫圈下方的模板与相似的孔匹配阵列上模板和垫片的那些，每个孔在其上端处于平坦的凸台中，并且当底板和下模板接触时，具有中心凹部以限定封闭室的底板，底板为设计成在其与下模板之间形成气密密封。

4. 发明申请

US20060120925A1 Slide treatment apparatus and methods for use 有权
标题翻译：滑动治疗仪和使用方法
公开(公告)号：US20060120925A1
公开(公告)日：2006-06-08
申请号：US11002164
申请日：2004-12-02
申请人： Glenn Takayama , Ken Tseung , Norman Rhett , Wai Bun Wong , Samuel Burd , George Harter , Douglas Morrison
发明人： Glenn Takayama , Ken Tseung , Norman Rhett , Wai Bun Wong , Samuel Burd , George Harter , Douglas Morrison
IPC分类号： G01N9/00
CPC分类号： G01N1/312
摘要： An apparatus for treating slides has a base with a cavity, and a heater is located on a surface of the cavity. A tank, which supports a slide rack with the slides submerged in a slide treatment solution, is placed in the cavity with a tank surface immediately adjacent the heater. A temperature sensor is mounted in the base and is operable to provide a feedback signal representing a temperature of the liquid in the tank. A cover is removably hinged on the base to cover the tank. A control system is connected to the heater and the temperature sensor and has a user input/output that is operable to select a set temperature of the liquid and a cycle time.
摘要翻译：一种用于处理滑块的装置具有带空腔的基座，并且加热器位于空腔的表面上。支撑滑动架的油箱，其中滑块浸没在滑动处理溶液中，并且与紧邻加热器的罐表面放置在空腔中。温度传感器安装在基座中并且可操作以提供表示罐中的液体的温度的反馈信号。盖可拆卸地铰接在基座上以覆盖水箱。控制系统连接到加热器和温度传感器，并且具有可操作以选择液体的设定温度和循环时间的用户输入/输出。

5. 发明申请

US20120025954A1 System and method for data management in automated biological instruments 审中-公开
标题翻译：自动化生物仪器中的数据管理系统和方法
公开(公告)号：US20120025954A1
公开(公告)日：2012-02-02
申请号：US13068196
申请日：2011-05-04
申请人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter
发明人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter
IPC分类号： G06K7/01 , C12M1/00
CPC分类号： G01N1/312 , G01N35/00732 , G01N2035/00782
摘要： To simplify the process of preparing tissue specimens on slides, an advanced automated slide processing device is disclosed. The automated slide processing device comprises a robotic arm that both senses input and delivers output. The input sensing includes sensing radio frequency identifier tags (RFIDs) and the output includes writing to RFID tags. This allows the automated slide processing device to read RFID tags on chemical reagent containers, specimen slides, and slide processing modules. The information on the RFID tags can be used to program the automated slide processing device for a slide processing run, add new slide processing protocols, and determine what chemical reagents are available and where each chemical reagent containers is located.
摘要翻译：为了简化在载玻片上制备组织标本的过程，公开了一种先进的自动化载玻片处理装置。自动幻灯片处理装置包括一个既能感测输入又输出输出的机器人手臂。输入感测包括感测射频标识符标签（RFID），并且输出包括写入RFID标签。这允许自动化幻灯片处理装置读取化学试剂容器，标本片和幻灯片处理模块上的RFID标签。关于RFID标签的信息可用于编写用于幻灯片处理运行的自动幻灯片处理装置，添加新的幻灯片处理协议，以及确定哪些化学试剂可用以及每个化学试剂容器所在的位置。

6. 发明申请

US20100173394A1 Droplet-based assay system 有权
标题翻译：基于液滴的测定系统
公开(公告)号：US20100173394A1
公开(公告)日：2010-07-08
申请号：US12586626
申请日：2009-09-23
申请人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
发明人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
IPC分类号： C12M1/00 , G01N33/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.
摘要翻译：用于进行测定的系统，包括装置和方法。这些系统可以包括通过将样品组分分成液滴或其它分隔，放大或以其他方式使液滴内的组分反应，检测放大的组分或其特征，和/或分析所得数据等来分离样品组分。

7. 发明授权

US06838051B2 Integrated sample-processing system 失效
公开(公告)号：US06838051B2
公开(公告)日：2005-01-04
申请号：US09778224
申请日：2001-02-06
申请人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Ley J. Leytes , Samuel Burd
发明人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Ley J. Leytes , Samuel Burd
IPC分类号： B01L3/00 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N21/00
CPC分类号： B01L3/50853 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/112499 , Y10T436/114165
摘要： The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

8. 发明授权

US09156010B2 Droplet-based assay system 有权
标题翻译：基于液滴的测定系统
公开(公告)号：US09156010B2
公开(公告)日：2015-10-13
申请号：US12586626
申请日：2009-09-23
申请人： Billy Wayne Colston, Jr. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, Jr. , Phillip Belgrader
发明人： Billy Wayne Colston, Jr. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, Jr. , Phillip Belgrader
IPC分类号： C12M1/34 , C12M3/00 , B01F3/08 , B01F13/00 , B01L3/02 , B01L3/00 , G01N21/3563 , B01L7/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.
摘要翻译：用于进行测定的系统，包括装置和方法。这些系统可以包括通过将样品组分分成液滴或其它分隔，放大或以其他方式使液滴内的组分反应，检测放大的组分或其特征，和/或分析所得数据等来分离样品组分。

9. 发明授权

US4493896A Dual chamber microplate washer 失效
标题翻译：双室微板清洗机
公开(公告)号：US4493896A
公开(公告)日：1985-01-15
申请号：US434309
申请日：1982-10-14
申请人： George B. La Motte, III , Samuel Burd
发明人： George B. La Motte, III , Samuel Burd
IPC分类号： B01L99/00 , G01N35/10 , C12M1/00 , C12M1/32 , B01L3/00
CPC分类号： B01L99/00 , G01N35/1065
摘要： A novel apparatus is disclosed for the alternate filling and evacuation of all wells simultaneously of a multi-well microplate. The apparatus consists of a flat, horizontally disposed distribution head comprised of an upper and a lower chamber formed by these parallel plates, with a rectangular array of tubes passing through the lower of the three plates such that two tubes are aligned with each well of a microplate, one for filling and the other for evacuation. The filling tubes and evacuation tubes extend below the lower plate for unequal distances, the evacuation tubes being the more extended. All filling tubes communicate with one of the two chambers in the distribution head, while all evacuation tubes communicate with the other. The microplate is supported below the distribution head with the tubes in proper alignment, and means are provided for bringing the microplate and the tubes in close proximity, for applying a vacuum to the chamber communicating with the evacuation tubes, and for supplying pressurized wash fluid to the chamber communicating with the filling tubes. The apparatus provides a faster washing process for microplates, and is more reliable and efficient than devices already known for the same or similar purposes.
摘要翻译：公开了一种用于多孔微孔板同时填充和排空所有孔的新型装置。该装置由平坦的水平布置的分配头组成，该分配头包括由这些平行板形成的上部和下部腔，其中矩形阵列的管穿过三个板的下部，使得两个管与一个微板，一个填充，另一个用于疏散。填充管和排气管在下板下方延伸不等距离，排气管更加延伸。所有填充管与分配头中的两个室中的一个连通，而所有排气管与另一个连通。微孔板支撑在分配头下方，管正确对准，并且提供用于使微板和管紧密接近的装置，用于向与排气管连通的室施加真空，并将加压洗涤流体供应到该室与填充管连通。该装置为微孔板提供更快的洗涤过程，并且比相同或相似目的已知的装置更可靠和高效。

10. 发明授权

US4133312A Connector for attachment of blood tubing to external arteriovenous shunts and fistulas 失效
标题翻译：用于将血管连接到外部动静脉分流器和瘘管的连接器
公开(公告)号：US4133312A
公开(公告)日：1979-01-09
申请号：US731865
申请日：1976-10-13
申请人： Samuel Burd
发明人： Samuel Burd
IPC分类号： A61M39/02 , A61M1/14 , A61M25/00 , A61M25/18 , A61M5/00 , F16L47/00
CPC分类号： A61M25/0014
摘要： A universal connector for a blood tubing set having a blood tube attached to one end portion and alternative means on the other end portion of said connector for selectively connecting and locking to the blood tube an external arteriovenous shunt, or a fistula.
摘要翻译：一种用于血管组件的通用连接器，其具有附接到一个端部的血管，并且在所述连接器的另一端部上的可选装置用于选择性地将血管连接和锁定到外部动静脉分流器或瘘管。

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