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1. 发明申请

US20100173394A1 Droplet-based assay system 有权
标题翻译：基于液滴的测定系统
公开(公告)号：US20100173394A1
公开(公告)日：2010-07-08
申请号：US12586626
申请日：2009-09-23
申请人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
发明人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, JR. , Phillip Belgrader
IPC分类号： C12M1/00 , G01N33/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.
摘要翻译：用于进行测定的系统，包括装置和方法。这些系统可以包括通过将样品组分分成液滴或其它分隔，放大或以其他方式使液滴内的组分反应，检测放大的组分或其特征，和/或分析所得数据等来分离样品组分。

2. 发明授权

US09156010B2 Droplet-based assay system 有权
标题翻译：基于液滴的测定系统
公开(公告)号：US09156010B2
公开(公告)日：2015-10-13
申请号：US12586626
申请日：2009-09-23
申请人： Billy Wayne Colston, Jr. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, Jr. , Phillip Belgrader
发明人： Billy Wayne Colston, Jr. , Benjamin Joseph Hindson , Kevin Dean Ness , Donald Arthur Masquelier , Fred Paul Milanovich , Douglas N. Modlin , Vincent Riot , Samuel Burd , Anthony Joseph Makarewicz, Jr. , Phillip Belgrader
IPC分类号： C12M1/34 , C12M3/00 , B01F3/08 , B01F13/00 , B01L3/02 , B01L3/00 , G01N21/3563 , B01L7/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus and methods, for performing assays. These systems may involve separating sample components by partitioning them into droplets or other partitions, amplifying or otherwise reacting the components within the droplets, detecting the amplified components, or characteristics thereof, and/or analyzing the resulting data, among others.
摘要翻译：用于进行测定的系统，包括装置和方法。这些系统可以包括通过将样品组分分成液滴或其它分隔，放大或以其他方式使液滴内的组分反应，检测放大的组分或其特征，和/或分析所得数据等来分离样品组分。

3. 发明申请

US20120028311A1 CARTRIDGE WITH LYSIS CHAMBER AND DROPLET GENERATOR 有权
标题翻译：带有LYSIS CHAMBER和DROPLET发电机的盒子
公开(公告)号：US20120028311A1
公开(公告)日：2012-02-02
申请号：US13250815
申请日：2011-09-30
申请人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Samuel Burd , Phillip Belgrader
发明人： Billy Wayne Colston, JR. , Benjamin Joseph Hindson , Kevin Dean Ness , Samuel Burd , Phillip Belgrader
IPC分类号： C12P19/34 , C12M1/40
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus, methods, compositions, kits, and software, for preparing, reacting, detecting, and/or analyzing samples in droplet-based assay systems, among others. The disclosure emphasizes, but is not limited to, a disposable cartridge with lysis chamber and droplet chamber, particularly for use in droplet-based assays.
摘要翻译：用于制备，反应，检测和/或分析基于液滴的测定系统中的样品的装置，方法，组合物，试剂盒和软件等。本公开强调但不限于具有裂解室和液滴室的一次性盒，特别用于基于液滴的测定。

4. 发明授权

US09243288B2 Cartridge with lysis chamber and droplet generator 有权
标题翻译：带裂解室和液滴发生器的筒
公开(公告)号：US09243288B2
公开(公告)日：2016-01-26
申请号：US13250815
申请日：2011-09-30
申请人： Kevin Dean Ness , Samuel Burd , Benjamin Joseph Hindson , Phillip Belgrader , Billy W. Colston, Jr.
发明人： Kevin Dean Ness , Samuel Burd , Benjamin Joseph Hindson , Phillip Belgrader , Billy W. Colston, Jr.
IPC分类号： C12Q1/68 , C12M3/00 , B01F3/08 , B01F13/00 , B01L3/02 , B01L3/00 , G01N21/3563 , G01N21/64 , B01L7/00
CPC分类号： B01L3/502784 , B01F3/0807 , B01F13/0062 , B01F15/00922 , B01F2003/0834 , B01F2003/0842 , B01F2215/0037 , B01L3/0241 , B01L3/502715 , B01L7/52 , B01L7/525 , B01L2200/0673 , B01L2200/0689 , B01L2200/10 , B01L2200/12 , B01L2300/041 , B01L2300/0654 , B01L2300/0816 , B01L2300/0819 , B01L2300/0858 , B01L2300/0867 , B01L2300/1822 , B01L2400/0478 , B01L2400/0487 , B01L2400/049 , B01L2400/0622 , B29C45/0053 , B29C45/006 , B29C2045/0079 , B29L2031/752 , C12Q1/686 , G01N21/3563 , G01N21/49 , G01N21/6428 , G01N21/6486 , G01N2021/6439 , G06F19/00 , Y02A90/26
摘要： Systems, including apparatus, methods, compositions, kits, and software, for preparing, reacting, detecting, and/or analyzing samples in droplet-based assay systems, among others. The disclosure emphasizes, but is not limited to, a disposable cartridge with lysis chamber and droplet chamber, particularly for use in droplet-based assays.
摘要翻译：用于制备，反应，检测和/或分析基于液滴的测定系统中的样品的装置，方法，组合物，试剂盒和软件等。本公开强调但不限于具有裂解室和液滴室的一次性盒，特别用于基于液滴的测定。

5. 发明授权

US06838051B2 Integrated sample-processing system 失效
公开(公告)号：US06838051B2
公开(公告)日：2005-01-04
申请号：US09778224
申请日：2001-02-06
申请人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Ley J. Leytes , Samuel Burd
发明人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Ley J. Leytes , Samuel Burd
IPC分类号： B01L3/00 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , G01N21/00
CPC分类号： B01L3/50853 , G01N35/028 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/112499 , Y10T436/114165
摘要： The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.

6. 发明授权

US06902703B2 Integrated sample-processing system 失效
标题翻译：综合样本处理系统
公开(公告)号：US06902703B2
公开(公告)日：2005-06-07
申请号：US09777343
申请日：2001-02-05
申请人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
发明人： Samuel A. Marquiss , Christopher G. Cesar , Jon F. Petersen , David P. Stumbo , Amer El-Hage , Glenn R. Edwards , Douglas N. Modlin , Lev J. Leytes , Samuel Burd
IPC分类号： B01L3/00 , C07F15/00 , C12Q1/68 , G01N21/25 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10 , B01L3/02
CPC分类号： G01N35/028 , B01L3/50853 , C07F15/0053 , C12Q1/6816 , C12Q1/6827 , G01N21/253 , G01N21/645 , G01N35/1011 , G01N35/1074 , G01N2035/00237 , G01N2035/0405 , G01N2035/0425 , G01N2035/0462 , Y10T436/11 , Y10T436/119163 , Y10T436/25 , Y10T436/2575 , C12Q2565/107
摘要： The invention provides an integrated sample-processing system and components thereof for preparing and/or analyzing samples. The components may include a transport module, a fluidics module, and an analysis module, among others.
摘要翻译：本发明提供了用于制备和/或分析样品的综合样品处理系统及其组件。组件可以包括传输模块，流体模块和分析模块等。

7. 发明申请

US20060120925A1 Slide treatment apparatus and methods for use 有权
标题翻译：滑动治疗仪和使用方法
公开(公告)号：US20060120925A1
公开(公告)日：2006-06-08
申请号：US11002164
申请日：2004-12-02
申请人： Glenn Takayama , Ken Tseung , Norman Rhett , Wai Bun Wong , Samuel Burd , George Harter , Douglas Morrison
发明人： Glenn Takayama , Ken Tseung , Norman Rhett , Wai Bun Wong , Samuel Burd , George Harter , Douglas Morrison
IPC分类号： G01N9/00
CPC分类号： G01N1/312
摘要： An apparatus for treating slides has a base with a cavity, and a heater is located on a surface of the cavity. A tank, which supports a slide rack with the slides submerged in a slide treatment solution, is placed in the cavity with a tank surface immediately adjacent the heater. A temperature sensor is mounted in the base and is operable to provide a feedback signal representing a temperature of the liquid in the tank. A cover is removably hinged on the base to cover the tank. A control system is connected to the heater and the temperature sensor and has a user input/output that is operable to select a set temperature of the liquid and a cycle time.
摘要翻译：一种用于处理滑块的装置具有带空腔的基座，并且加热器位于空腔的表面上。支撑滑动架的油箱，其中滑块浸没在滑动处理溶液中，并且与紧邻加热器的罐表面放置在空腔中。温度传感器安装在基座中并且可操作以提供表示罐中的液体的温度的反馈信号。盖可拆卸地铰接在基座上以覆盖水箱。控制系统连接到加热器和温度传感器，并且具有可操作以选择液体的设定温度和循环时间的用户输入/输出。

8. 发明授权

US4784738A Apparatus and method for gel casting 失效
标题翻译：凝胶浇铸设备及方法
公开(公告)号：US4784738A
公开(公告)日：1988-11-15
申请号：US808307
申请日：1985-12-12
申请人： Donald D. Sleeter , George G. Fernwood , Samuel Burd
发明人： Donald D. Sleeter , George G. Fernwood , Samuel Burd
IPC分类号： C08F2/10 , G01N27/26 , G01N27/447 , G01N27/28
CPC分类号： G01N27/44704
摘要： A gel used for electrophoresis is cast in a gel enclosure in which the gel will ultimately be used during the electrophoresis, by a novel method and using novel apparatus which provide for quick assembly and avoidance of leaks. The method and apparatus involve a wettable, preferably porous, membrane such as filter paper, which is thoroughly wetted with gel forming solution, then placed over the bottom opening of the gel enclosure and held in place until the gel on the membrane sets. Sealing of any cracks, gaps or irregularities along the rim of the opening is thereby achieved by the capillary action of the gel forming solution. The enclosure itself is then filled with gel forming solution. Once the latter has set, the membrane is removed.
摘要翻译：用于电泳的凝胶被浇铸在凝胶封壳中，其中最终将在电泳期间使用凝胶，通过新颖的方法和使用提供快速组装和避免泄漏的新型装置。该方法和装置包括可湿性优选多孔的膜，例如滤纸，其用凝胶形成溶液彻底润湿，然后放置在凝胶封壳的底部开口上并保持在适当位置，直到膜组上的凝胶。因此，通过凝胶形成溶液的毛细作用可以实现沿着开口边缘的任何裂缝，间隙或不规则物的密封。然后将外壳本身用凝胶形成溶液填充。一旦后者已经设定，膜被去除。

9. 发明授权

US4612710A Method and apparatus for drying gel slabs 失效
标题翻译：干燥凝胶板的方法和装置
公开(公告)号：US4612710A
公开(公告)日：1986-09-23
申请号：US653971
申请日：1984-09-20
申请人： George G. Fernwood , Samuel Burd
发明人： George G. Fernwood , Samuel Burd
IPC分类号： G01N27/26 , F26B5/04 , F26B9/00 , G01N27/447 , F26B7/00
CPC分类号： F26B9/003 , F26B5/045 , G01N27/44704 , G01N27/44717
摘要： An apparatus for drying gel slabs supplies heat to a horizontal gel slab from a heating plate above the slab, while drawing a vacuum beneath. The heating plate is weighted and has a flat lower surface at least coextensive with the gel slab. The slab itself is placed on a porous support pad in a vacuum chamber enclosed at the top with a flexible cover which clings to the gel and seals to the perimeter of the chamber when a vacuum is applied from below. The heating plate rests on top of the cover under gravitational force, providing even heating across the entire expanse of the gel slab and for the entire duration of the drying process, resulting in a continuous and uniform vapor flow downward from the gel slab, a minimization of internal stresses, and reduced susceptibility of the gel to cracking.
摘要翻译：用于干燥凝胶板的装置在平板上方的加热板上向水平凝胶板供应热量，同时在其下方抽真空。加热板被加重，并且具有与凝胶板至少共同延伸的平坦的下表面。板坯本身被放置在密封在顶部的真空室中的多孔支撑垫上，并且当从下方施加真空时，柔性盖粘附到凝胶并且密封到室的周边。加热板在重力作用下搁置在盖的顶部，在凝胶板的整个整个平面上以及干燥过程的整个持续时间均匀加热，导致从凝胶板向下的连续均匀的蒸汽流，最小化的内应力，并降低凝胶对裂纹的敏感性。

10. 发明申请

US20120025954A1 System and method for data management in automated biological instruments 审中-公开
标题翻译：自动化生物仪器中的数据管理系统和方法
公开(公告)号：US20120025954A1
公开(公告)日：2012-02-02
申请号：US13068196
申请日：2011-05-04
申请人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter
发明人： Glenn Takayama , Xiangchun Ye , Samuel Burd , George Harter
IPC分类号： G06K7/01 , C12M1/00
CPC分类号： G01N1/312 , G01N35/00732 , G01N2035/00782
摘要： To simplify the process of preparing tissue specimens on slides, an advanced automated slide processing device is disclosed. The automated slide processing device comprises a robotic arm that both senses input and delivers output. The input sensing includes sensing radio frequency identifier tags (RFIDs) and the output includes writing to RFID tags. This allows the automated slide processing device to read RFID tags on chemical reagent containers, specimen slides, and slide processing modules. The information on the RFID tags can be used to program the automated slide processing device for a slide processing run, add new slide processing protocols, and determine what chemical reagents are available and where each chemical reagent containers is located.
摘要翻译：为了简化在载玻片上制备组织标本的过程，公开了一种先进的自动化载玻片处理装置。自动幻灯片处理装置包括一个既能感测输入又输出输出的机器人手臂。输入感测包括感测射频标识符标签（RFID），并且输出包括写入RFID标签。这允许自动化幻灯片处理装置读取化学试剂容器，标本片和幻灯片处理模块上的RFID标签。关于RFID标签的信息可用于编写用于幻灯片处理运行的自动幻灯片处理装置，添加新的幻灯片处理协议，以及确定哪些化学试剂可用以及每个化学试剂容器所在的位置。

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