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1. 发明授权

US06953797B2 Use of phenylheteroalkylamine derivatives 失效
标题翻译：苯基杂烷基胺衍生物的用途
公开(公告)号：US06953797B2
公开(公告)日：2005-10-11
申请号：US10204808
申请日：2001-02-20
申请人： David Cheshire , Stephen Connolly , David Cox , Ian Millichip
发明人： David Cheshire , Stephen Connolly , David Cox , Ian Millichip
IPC分类号： C07D295/12 , A61K31/137 , A61K31/145 , A61K31/275 , A61K31/277 , A61K31/365 , A61K31/415 , A61K31/421 , A61K31/426 , A61K31/5375 , A61K31/695 , A61K45/00 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/06 , A61P1/18 , A61P3/10 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P17/00 , A61P17/06 , A61P19/02 , A61P19/06 , A61P25/02 , A61P25/04 , A61P25/06 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/28 , A61P25/30 , A61P27/06 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/02 , A61P43/00 , C07C211/48 , C07C211/52 , C07C253/30 , C07C255/58 , C07C315/02 , C07C317/28 , C07C319/14 , C07C323/29 , C07C323/62 , C07D263/32 , C07D277/28 , C07D295/125 , A61K31/535 , A61K31/42 , C07C255/50 , C07D263/30 , C07D295/06
CPC分类号： C07D295/125 , A61K31/137 , A61K31/277 , A61K31/421 , A61K31/426 , A61K31/5375 , A61K31/695 , C07C211/48 , C07C255/58 , C07C317/28 , C07C323/29 , C07C323/62
摘要： There is disclosed the use of a compound of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prohylaxis of inflammatory disease
摘要翻译：公开了式（I）化合物的用途，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，对映异构体或外消旋物在制备药物中的用途，用于治疗或预防一氧化氮合成酶活性抑制是有益的疾病或病症。公开了某些新的式（Ia）化合物及其药学上可接受的盐及其对映异构体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。式（I）和（Ia）的化合物是一氧化氮合酶的抑制剂，因此特别可用于炎性疾病的治疗或预防

2. 发明授权

US06887871B2 Use of phenylheteroakylamine derivatives 失效
标题翻译：苯基鸟胺衍生物的用途
公开(公告)号：US06887871B2
公开(公告)日：2005-05-03
申请号：US10204742
申请日：2001-02-20
申请人： David Cheshire , Stephen Connolly , David Cox , Peter Hamley , Antonio Mete , Austen Pimm
发明人： David Cheshire , Stephen Connolly , David Cox , Peter Hamley , Antonio Mete , Austen Pimm
IPC分类号： C07D295/08 , A61K31/137 , A61K31/138 , A61K31/275 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4412 , A61K31/445 , A61K31/4453 , A61K31/4462 , A61K31/495 , A61K31/4965 , A61K31/505 , A61K31/5375 , A61K45/00 , A61P1/00 , A61P19/02 , A61P25/04 , A61P29/00 , A61P43/00 , C07C209/68 , C07C217/48 , C07C253/30 , C07C255/54 , C07D207/12 , C07D211/22 , C07D211/46 , C07D213/38 , C07D213/50 , C07D213/61 , C07D213/64 , C07D233/24 , C07D233/64 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/092 , C07D307/14 , C07D307/52 , C07D333/20 , A61K31/535 , A01N43/50 , A01N43/76
CPC分类号： C07D213/64 , A61K31/137 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/4164 , A61K31/42 , A61K31/421 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/445 , A61K31/4453 , A61K31/4462 , A61K31/4965 , A61K31/505 , A61K31/5375 , C07C217/48 , C07C255/54 , C07C2601/02 , C07D207/12 , C07D211/22 , C07D211/46 , C07D213/38 , C07D213/61 , C07D233/24 , C07D239/26 , C07D241/12 , C07D261/08 , C07D263/32 , C07D277/28 , C07D295/088 , C07D307/14 , C07D333/20
摘要： There is disclosed the use of a compound of formula (I) wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts, enantiomers or racemates thereof, in the manufacture of a medicament, for the treatment or prophylaxis of diseases or conditions in which inhibition of nitric oxide synthase activity is beneficial. Certain novel compounds of formula (Ia) and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof are disclosed; together with processes for their preparation, compositions containing them and their use in therapy. The compounds of formulae (I) and (Ia) are inhibitors of the enzyme nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease.
摘要翻译：公开了使用式（I）的化合物，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，及其药学上可接受的盐，对映异构体或外消旋物，用于制备药物，用于治疗或预防一氧化氮合酶活性抑制有益的疾病或病症。公开了某些新的式（Ia）化合物及其药学上可接受的盐及其对映异构体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。式（I）和（Ia）的化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病。

3. 发明授权

US06900243B2 Phenylheteroalkylamine derivatives 失效
标题翻译：苯基杂烷基胺衍生物
公开(公告)号：US06900243B2
公开(公告)日：2005-05-31
申请号：US10204845
申请日：2001-02-20
申请人： David Cheshire , Stephen Connolly , David Cox , Antonio Mete
发明人： David Cheshire , Stephen Connolly , David Cox , Antonio Mete
IPC分类号： A61P1/00 , A61K31/04 , A61K31/135 , A61K31/138 , A61K31/277 , A61P1/02 , A61P1/04 , A61P1/18 , A61P9/02 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P15/08 , A61P17/00 , A61P17/04 , A61P17/06 , A61P17/16 , A61P19/02 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/10 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P29/00 , A61P31/04 , A61P35/00 , A61P37/04 , A61P37/08 , A61P43/00 , C07C213/02 , C07C217/20 , C07C217/44 , C07C253/30 , C07C255/54 , C07C319/20 , C07C323/25 , C07C323/62 , C07C217/18 , A61K31/237
CPC分类号： C07C323/25 , C07C217/20 , C07C217/44 , C07C255/54 , C07C323/62 , C07C2601/02 , C07C2601/08
摘要： There are provided novel compounds of formula (I), wherein R1, R2, X, Y, V, W and Z are as defined in the specification, and pharmaceutically acceptable salts thereof, and enantiomers and racemates thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of nitric oxide synthase and are thereby particularly useful in the treatment or prophylaxis of inflammatory disease and pain.
摘要翻译：提供式（I）的新化合物，其中R 1，R 2，X，Y，V，W和Z如说明书中所定义，并且药学上其可接受的盐，及其对映体和外消旋体; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是一氧化氮合酶的抑制剂，因此特别可用于治疗或预防炎性疾病和疼痛。

4. 发明授权

US11466795B2 Fastener 有权
公开(公告)号：US11466795B2
公开(公告)日：2022-10-11
申请号：US17248790
申请日：2021-02-08
申请人： David Cox
发明人： David Cox
IPC分类号： F16L3/04 , F16B15/00
摘要： A fastener for fastening pipes or electrical conduit can be installed with the optional use of nails or screws. The fastener includes sharp teeth or spikes which can be hammered into an external surface, such as wood or masonry. The teeth or spikes are positioned, oriented, and otherwise configured to best suit the intended application. Installation can be accomplished using only the fastener itself and force exceeding a minimal threshold.

5. 发明授权

US10650280B2 Systems and methods for machine learning enhanced by human measurements 有权
公开(公告)号：US10650280B2
公开(公告)日：2020-05-12
申请号：US16381291
申请日：2019-04-11
申请人： David Cox , Walter Scheirer , Samuel Anthony , Ken Nakayama
发明人： David Cox , Walter Scheirer , Samuel Anthony , Ken Nakayama
IPC分类号： G06K9/00 , G06K9/62
摘要： In various embodiments, training objects are classified by human annotators, psychometric data characterizing the annotation of the training objects is acquired, a human-weighted loss function based at least in part on the classification data and the psychometric data is computationally derived, and one or more features of a query object are computationally classified based at least its part on the human-weighted loss function.

6. 发明授权

US09194772B2 Apparatus, system, and method using immiscible-fluid-discrete-volumes 有权
标题翻译：使用不混溶流体离散体的装置，系统和方法
公开(公告)号：US09194772B2
公开(公告)日：2015-11-24
申请号：US12557488
申请日：2009-09-10
申请人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
发明人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68 , C12M1/34 , G01N1/14 , B01L3/00 , F15C5/00 , F16K99/00 , G01N35/08 , B01L3/02 , B01L7/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

7. 发明授权

US08719906B2 Reactive authorization for publications 有权
标题翻译：出版物的无效授权
公开(公告)号：US08719906B2
公开(公告)日：2014-05-06
申请号：US13321593
申请日：2009-05-28
申请人： Christer Boberg , David Cox , Mikael Klein , Sofie Lassborn , Anders Lindgren
发明人： Christer Boberg , David Cox , Mikael Klein , Sofie Lassborn , Anders Lindgren
IPC分类号： H04L29/06 , G06F21/62
CPC分类号： G06F21/6245 , G06F21/6272 , H04L63/102 , H04L67/24
摘要： Systems and methods for reactively authorizing publication of information by a third party are coordinated through the use of a presence server. The presence server communicates with other communication nodes/devices to determine and relay publication information. Publication requests that are initially unauthorized, from the perspective of the presence server, are resolved.
摘要翻译：通过使用存在服务器来协调由第三方反复授权信息发布的系统和方法。存在服务器与其他通信节点/设备通信以确定和中继发布信息。从出现服务器的角度来看，最初未经授权的发布请求已被解决。

8. 发明申请

US20130207791A1 HAPTIC DIRECTIONAL FEEDBACK HANDLES FOR LOCATION DEVICES 有权
标题翻译：用于位置设备的HAPTIC DIRECTIONAL FEEDBACK HANDLES
公开(公告)号：US20130207791A1
公开(公告)日：2013-08-15
申请号：US13570084
申请日：2012-08-08
申请人： Mark S. Olsson , Garrett A. Newby , Alexander Logan Warren , David Cox
发明人： Mark S. Olsson , Garrett A. Newby , Alexander Logan Warren , David Cox
IPC分类号： G08B6/00
CPC分类号： G08B6/00 , G01V3/081 , G01V3/12 , G01V3/165
摘要： Locating devices and systems providing haptic tactile feedback are disclosed. In one embodiment, a locator includes a haptic handle configured to provide directional signals through an operator's sense of touch to aid in locating and tracing a buried conductor or other object such as a pipe or cable.
摘要翻译：公开了提供触觉触觉反馈的定位装置和系统。在一个实施例中，定位器包括触觉手柄，其被配置为通过操作者的触感来提供定向信号，以帮助定位和跟踪掩埋的导体或其它物体，例如管道或电缆。

9. 发明授权

US08499726B2 Internal combustion engines 有权
标题翻译：内燃机
公开(公告)号：US08499726B2
公开(公告)日：2013-08-06
申请号：US12663519
申请日：2008-05-28
申请人： David Cox
发明人： David Cox
IPC分类号： F01B7/12 , F02B25/08 , F02B75/28
CPC分类号： F01B9/023 , F01B1/08 , F01B7/04 , F01B7/10 , F02B25/08 , F02B75/24 , F02B75/28 , F02B2075/025 , F02B2075/1808 , F02B2275/40 , F02F1/22 , F02F3/0015 , Y02T10/125
摘要： The invention provides a 2-stroke internal combustion engine comprising two opposed cylinders, each cylinder housing two opposed pistons and having at least one exhaust port and at least one intake port, and a crankshaft having asymmetrically arranged journals and scotch-yoke mechanisms for driving the journals from the pistons. The pistons in each cylinder operate to open its exhaust port or ports before its intake port or ports and to close its exhaust port or ports before its intake port or ports.
摘要翻译：本发明提供一种二冲程内燃机，其包括两个相对的气缸，每个气缸容纳两个相对的活塞并且具有至少一个排气口和至少一个进气口，以及具有不对称排列的轴颈和用于驱动来自活塞的期刊。每个气缸中的活塞在其进气口或端口之前操作以打开其排气端口，并在其进气口或端口之前关闭其排气口或端口。

10. 发明申请

US20120304252A1 METHOD AND SYSTEM FOR AUTHORIZATION OF PRESENCE INFORMATION 有权
标题翻译：用于授权存在信息的方法和系统
公开(公告)号：US20120304252A1
公开(公告)日：2012-11-29
申请号：US13574696
申请日：2010-01-27
申请人： Christer Boberg , Mikael Klein , Anders Lindgren , Sofie Lassborn , David Cox
发明人： Christer Boberg , Mikael Klein , Anders Lindgren , Sofie Lassborn , David Cox
IPC分类号： G06F21/00
CPC分类号： H04L67/24 , H04L63/105
摘要： Embodiments of the present invention include a system and method for implementing a presence system. According to an embodiment of the present invention, responsive to receiving a request for presence information associated with a presentity from a watcher, the presence system receives instructions indicating that an authorization instance other than the presentity shall be given an opportunity to change or verify an authorization rule associated with the request for presence information. As a consequence, the presence system notifies the authorization instance of the request for presence information, thereby enabling the authorization instance to change or verify the authorization rule. The presence system also makes a final decision on the authorization rule on the basis of the instructions and a notification indicating a change or verification of the authorization rule.
摘要翻译：本发明的实施例包括用于实现存在系统的系统和方法。根据本发明的实施例，响应于从观察者接收到与呈现体相关联的存在信息的请求，存在系统接收指示，指示除了呈现体之外的授权实例有机会改变或验证授权与存在信息请求相关联的规则。因此，存在系统通知授权实例对存在信息的请求，从而使授权实例能够改变或验证授权规则。存在系统还根据指令和指示更改或验证授权规则的通知对授权规则作出最终决定。

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