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1. 发明公开

US20240254086A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 审中-公开
公开(公告)号：US20240254086A1
公开(公告)日：2024-08-01
申请号：US18557191
申请日：2022-05-11
申请人： Nippon Soda Co., Ltd.
发明人： Satoshi MAKINO , Fumiya NISHIO , Hironori FURUKAWA , Masahiro KAWAGUCHI
IPC分类号： C07D213/84 , A01N37/34 , A01N43/40 , A01N43/80 , A01N43/82 , A01P7/02 , A01P7/04 , A01P17/00 , C07C317/28 , C07C323/25 , C07D413/12 , C07D417/12
CPC分类号： C07D213/84 , A01N37/34 , A01N43/40 , A01N43/80 , A01N43/82 , A01P7/02 , A01P7/04 , A01P17/00 , C07C317/28 , C07C323/25 , C07D413/12 , C07D417/12
摘要： A compound represented by Formula (I) or a salt thereof. In Formula (I), Ar represents a substituted or unsubstituted C6 to C10 aryl group or the like, L1 represents a single bond or the like, L2 represents a single bond or the like, X1 represents a cyano group or the like, X2 represents a hydrogen atom or the like, X3 represents a halogeno group or the like, A represents a nitrogen atom or the like, R1 represents a hydrogen atom or the like, R2a represents a substituted or unsubstituted C1 to C6 alkyl group and R2b represents a hydrogen atom or the like, where R2a and R2b may be combined with each other to form a substituted or unsubstituted C2 to C5 alkylene group, and Y represents a substituted or unsubstituted C1 to C6 alkyl group or the like.

2. 发明授权

US11981625B2 Sulfide-based compounds and uses thereof 有权
公开(公告)号：US11981625B2
公开(公告)日：2024-05-14
申请号：US16593212
申请日：2019-10-04
申请人： Ecolab USA Inc.
发明人： Jeremy Moloney , Ashish Dhawan , Carter Silvernail
IPC分类号： C07C323/25 , C07C319/04 , C07D213/32 , C09K8/54
CPC分类号： C07C323/25 , C07D213/32 , C09K8/54 , C07C319/04 , C09K2208/32
摘要： Disclosed are sulfide-based compounds which are a product of a Michael addition reaction between a sulfur-containing donor group and an unsaturated hydrocarbon moiety. The sulfide-based compounds may be used in compositions and methods for inhibiting corrosion.

3. 发明授权

US11701373B2 Substituted bicyclic compounds 有权
公开(公告)号：US11701373B2
公开(公告)日：2023-07-18
申请号：US17307138
申请日：2021-05-04
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Alaric J. Dyckman , T. G. Murali Dhar , Hai-Yun Xiao , John L. Gilmore , Michael G. Yang , Zili Xiao , David Marcoux
IPC分类号： A61K31/695 , C07F7/08 , A61K31/135 , C07D215/14 , C07D241/04 , C07C323/29 , C07C251/38 , C07C251/42 , C07C251/44 , C07D209/46 , C07D213/38 , C07C275/26 , C07C217/74 , C07C323/25 , C07C235/46 , C07F9/54 , C07F9/572 , C07F9/09 , C07C215/42 , C07C217/52 , C07C217/58 , C07C219/24 , C07C233/41 , C07C233/65 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07D213/32 , C07D213/69 , C07D213/70 , C07D215/12 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F9/117 , C07F9/62 , C07F9/6503 , C07F9/6509 , C07F9/655 , C07F9/6553 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661
CPC分类号： A61K31/695 , A61K31/135 , A61K31/137 , A61K31/15 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/222 , A61K31/24 , A61K31/27 , A61K31/337 , A61K31/351 , A61K31/352 , A61K31/381 , A61K31/415 , A61K31/4174 , A61K31/426 , A61K31/44 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/47 , A61K31/4965 , A61K31/505 , A61K31/661 , C07C215/42 , C07C217/52 , C07C217/58 , C07C217/74 , C07C219/24 , C07C233/41 , C07C233/65 , C07C235/46 , C07C251/38 , C07C251/42 , C07C251/44 , C07C251/50 , C07C251/52 , C07C251/54 , C07C271/34 , C07C275/26 , C07C317/28 , C07C317/32 , C07C321/16 , C07C321/22 , C07C321/28 , C07C323/25 , C07C323/29 , C07D209/46 , C07D213/32 , C07D213/38 , C07D213/69 , C07D213/70 , C07D215/12 , C07D215/14 , C07D217/24 , C07D231/12 , C07D231/20 , C07D239/26 , C07D241/04 , C07D241/12 , C07D277/24 , C07D305/08 , C07D309/06 , C07D309/12 , C07D311/58 , C07D311/76 , C07D319/20 , C07D333/16 , C07F7/08 , C07F7/081 , C07F9/091 , C07F9/117 , C07F9/5442 , C07F9/5728 , C07F9/62 , C07F9/65031 , C07F9/65522 , C07F9/650952 , C07F9/655345 , C07B2200/05 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2602/10 , C07C2603/74
摘要： Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V):

and/or a salt thereof, wherein R1 is —OH or —OP(O)(OH)2, and X1, X2, X3, R2, R2a, Ra, Rb, and Rc are defined herein. Also disclosed are methods of using such compounds as selective agonists for G protein-coupled receptor S1P1, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating, preventing, or slowing the progression of diseases or disorders in a variety of therapeutic areas, such as autoimmune diseases and vascular disease.

4. 发明公开

US20230218549A1 ALKOXY COMPOUNDS FOR DISEASE TREATMENT 审中-公开
公开(公告)号：US20230218549A1
公开(公告)日：2023-07-13
申请号：US17817927
申请日：2022-08-05
申请人： Acucela Inc.
发明人： Ian L. SCOTT , Vladimir A. KUKSA , Mark W. ORME , Thomas L. LITTLE, JR. , Anna GALL , Feng HONG
IPC分类号： A61K31/137 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C317/28 , C07C323/25 , C07D277/24 , C07D309/06 , C07C217/20 , C07C215/20 , C07C309/06 , C07C217/84 , C07C323/33 , A61K31/165 , A61K31/222
CPC分类号： A61K31/137 , A61K31/165 , A61K31/222 , C07C215/20 , C07C217/20 , C07C217/60 , C07C217/62 , C07C217/64 , C07C217/72 , C07C217/84 , C07C225/16 , C07C229/38 , C07C233/18 , C07C235/08 , C07C251/86 , C07C279/08 , C07C309/06 , C07C317/28 , C07C323/25 , C07C323/33 , C07D277/24 , C07D309/06 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/42
摘要： The present invention relates generally to compositions and methods for treating neurodegenerative diseases and disorders, particularly ophthalmic diseases and disorders. Provided herein are alkoxyl derivative compounds and pharmaceutical compositions comprising these compounds. The subject compositions are useful for treating and preventing ophthalmic diseases and disorders, including age-related macular degeneration (AMD) and Stargardt’s Disease.

5. 发明授权

US11690922B2 Lipid compound as well as lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing same 有权
公开(公告)号：US11690922B2
公开(公告)日：2023-07-04
申请号：US17870313
申请日：2022-07-21
申请人： Purecodon (Hong Kong) Biopharma Ltd.
发明人： Ke Huang , Binxi Ge , Yingwen Li , Yuping Liu , Yinjia Gao , Zhenhua Sun
IPC分类号： A61K48/00 , A61K47/10 , A61K31/713 , A61K9/127 , A61K9/14 , C07C217/08 , C07C219/06 , C07C229/16 , C07C233/18 , C07C233/36 , C07C237/12 , C07C323/25 , C07C323/52 , A61K47/18
CPC分类号： A61K48/005 , A61K9/127 , A61K9/145 , A61K31/713 , A61K47/10 , A61K47/18 , A61K48/0033 , C07C217/08 , C07C219/06 , C07C229/16 , C07C233/18 , C07C233/36 , C07C237/12 , C07C323/25 , C07C323/52
摘要： The present invention belongs to the technical field of gene therapy, and particularly relates to a series of lipid compounds as well as a lipid carrier, nucleic acid lipid nanoparticle composition and pharmaceutical preparation containing the same. A compound having a structure of a formula (I) provided by the present invention can be used for preparing a lipid carrier together with other lipid compounds, and exhibits pH response, and the entrapment efficiency to a nucleic acid drug is high, which greatly improves in-vivo delivery efficiency of the nucleic acid drug; and furthermore, a lipid compound with a specific structure can be chosen as a lipid carrier based on an organ in which the nucleic acid drug needs to be enriched, having a good market application prospect.

6. 发明公开

US20230202975A1 PROCESS FOR THE PREPARATION OF CYSTEAMINE BITARTRATE AND PRODUCT SO OBTAINED 审中-公开
公开(公告)号：US20230202975A1
公开(公告)日：2023-06-29
申请号：US18087969
申请日：2022-12-23
申请人： Recordati Industria Chimica e Farmaceutica S.p.A.
发明人： Antonella MIGLIORINI , Francesco YAFTEH MIHAN , Franca SEGNALINI , Angela TUOZZI
IPC分类号： C07C319/06 , C07C323/25 , C07C59/255
CPC分类号： C07C319/06 , C07C323/25 , C07C59/255 , C07B2200/13
摘要： The present invention relates to a new, enhanced process for the manufacture of Cysteamine Bitartrate (I) and of its key intermediate thiazolidine (II).
Furthermore, it relates to a new processes for the manufacture of crystalline anhydrous Cysteamine Bitartrate (polymorph L2) and monohydrate Cysteamine Bitartrate (polymorph L1). The crystalline anhydrous Cysteamine Bitartrate (polymorph L2) so obtained is characterized by particularly fine particle size and good appearance.

7. 发明授权

US11555051B2 Dithioamine reducing agents 有权
公开(公告)号：US11555051B2
公开(公告)日：2023-01-17
申请号：US16256941
申请日：2019-01-24
申请人： Wisconsin Alumni Research Foundation
发明人： Ronald T. Raines , John Lukesh
IPC分类号： C07K1/113 , C12N9/96 , C07D339/08 , C07C329/16 , C07C323/25 , C07C327/06
摘要： Dithioamine reducing agents useful for the reduction of disulfide bonds. The reducing agents of this invention are useful, for example, to reduce disulfide bonds, particularly in proteins, or to prevent the formation of disulfide bonds, particularly in proteins and other biological molecules. Reducing agents of this invention can be employed to regulate protein function in proteins in which a sulfhydryl group is associated with biological activity. Reducing agents of this invention can prevent inactivation of a given protein or enhance activation of a given protein or other biological molecule in vitro and/or in vivo. Reducing agents of this invention can prevent or reduce oxidation of cysteine residues in proteins and prevent the formation of reduced activity protein dimers (or other oligomers). Reducing agents of this invention are useful and suitable for application in a variety of biological applications, particularly as research and synthetic reagents. The invention provides S-acylated dithioamines which can be selectively activated reducing agents by removal of the S-acyl groups enzymatically or chemically. The invention further provides dithiane precursors of thioamino reducing agents. The invention provides dithioamine reducing agents, S-acylated dithioamines and dithianes which are immobilized on surfaces, including among others, glass, quartz, microparticles, nanoparticles and resins.

8. 再颁专利

USRE49233E1 Ionizable cationic lipid for RNA delivery 有权
公开(公告)号：USRE49233E1
公开(公告)日：2022-10-04
申请号：US16351301
申请日：2019-03-12
申请人： Arcturus Therapeutics, Inc.
发明人： Joseph E. Payne , Padmanabh Chivukula
IPC分类号： C07C323/52 , A61K47/18 , A61K47/20 , C07C235/12 , C07C237/12 , C07C271/22 , C07C323/25 , C07C323/60 , C07C333/04 , C07J41/00 , C11C3/04 , C12N15/11 , C12N15/113
摘要： What is described is a compound of formula (1) wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N; X1 is a bond, or is —CO—O— whereby L2-CO—O—R2 is formed; X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof.

9. 发明申请

US20210363461A1 COMPOUNDS FOR PROVIDING A LONG-LASTING STRAWBERRY ODOR 有权
公开(公告)号：US20210363461A1
公开(公告)日：2021-11-25
申请号：US16981332
申请日：2019-06-18
申请人： FlRMENICH SA
发明人： Andreas Herrmann , Sylvain Etter , Johannes Feser , Alain Trachsel
IPC分类号： C11B9/00 , C07C323/22 , C11D3/00 , C11D3/50 , A61K8/46 , A61Q5/12 , A61Q5/02 , A61Q19/10 , C07C323/52 , C07C323/43 , C07C317/24 , C07C323/25 , C11D11/00 , A61K8/41
摘要： Described herein are compounds that are able to generate oct-2-en-4-one and thus to provide a long-lasting or substantive strawberry odor to an environment. Also described herein is a method of imparting a long-lasting strawberry odor to surfaces, such as hard surfaces, fabric, skin or hair. Also described herein is a method of using said compounds in perfumery. Also described herein are perfuming compositions or perfumed articles including the compounds.

10. 发明授权

US11155668B2 Contact-killing, QAC functionalized thermoplastic polyurethane for catheter applications 有权
公开(公告)号：US11155668B2
公开(公告)日：2021-10-26
申请号：US16154074
申请日：2018-10-08
申请人： THE UNIVERSITY OF AKRON , COOK MEDICAL TECHNOLOGIES, LLC
发明人： Matthew L. Becker , Zachary K. Zander , Sean Chambers , Alec Cerchiari , Willie C. McRoy, Jr.
IPC分类号： C08G18/08 , A61L15/26 , A61L29/06 , A61L15/46 , C08G18/66 , C08G18/83 , C08G18/32 , C08G18/67 , C08G18/48 , A61L31/16 , A61L17/04 , C08G18/75 , A61L29/16 , A61L17/00 , C08G18/24 , A61L31/06 , C09D175/04 , A61L27/18 , A61L27/34 , A61L29/04 , C07C319/20 , C08L75/04 , C07C323/25 , C07C323/52
摘要： In various embodiments, the present invention provides a functionalized thermoplastic polyurethane (TPU) containing bulk incorporated or surface-grafted quaternary ammonium compounds (QAC)s for contact-killing of a variety of microbes, where the QACs are on the surface of TPU to provide a sterile surface material that prevents bacteria commonly involved in device-associated infections (DAIs) from proliferating. The functionalized TPUs of the present invention can be formed into a wide variety of 3-dimensional shapes, such as catheters, medical tubing, laryngeal or tracheal stents, sutures, prosthetics, wound dressings, and/or a coating for medical devices and contains the residue of either a QAC containing diol monomer or an alkene functional diol monomer, which then allows the TPU to be functionalized with a QAC containing disulfide or free thiol compound, to form a quaternary ammonium functionalized thermoplastic polyurethane compound having antimicrobial properties for use in medical devices.

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