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1. 发明授权

US09194772B2 Apparatus, system, and method using immiscible-fluid-discrete-volumes 有权
标题翻译：使用不混溶流体离散体的装置，系统和方法
公开(公告)号：US09194772B2
公开(公告)日：2015-11-24
申请号：US12557488
申请日：2009-09-10
申请人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
发明人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68 , C12M1/34 , G01N1/14 , B01L3/00 , F15C5/00 , F16K99/00 , G01N35/08 , B01L3/02 , B01L7/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

2. 发明授权

US08102529B2 Refractive index matching in capillary illumination 有权
$Refractive index matching in capillary illumination$
标题翻译：毛细管照射中的折射率匹配
公开(公告)号：US08102529B2
公开(公告)日：2012-01-24
申请号：US12637717
申请日：2009-12-14
申请人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
发明人： Richard Reel , Eric Nordman , Tomoyuki Sakai , Satoshi Takahashi , Ryoji Inaba
IPC分类号： G01J4/00
CPC分类号： G01N21/64 , F21V5/00 , G01N21/645 , G01N27/44721 , G01N2021/6463 , G01N2201/068 , Y10T436/143333
摘要： System and method for fluorescent light excitation and detection from samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于荧光灯激发和检测样品的系统和方法，以提高数值孔径和/或减少荧光灯的串扰。

3. 发明申请

US20070141593A1 Apparatus, system, and method using immiscible-fluid-discrete-volumes 审中-公开
标题翻译：使用不混溶流体离散体的装置，系统和方法
公开(公告)号：US20070141593A1
公开(公告)日：2007-06-21
申请号：US11507735
申请日：2006-08-22
申请人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
发明人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , C12Q2535/101 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

4. 发明申请

US20070086026A1 Method of selecting inks for use in imaging with an imaging apparatus 失效
标题翻译：用成像装置选择用于成像的油墨的方法
公开(公告)号：US20070086026A1
公开(公告)日：2007-04-19
申请号：US11250002
申请日：2005-10-13
申请人： Jincheng Huang , Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Jincheng Huang , Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： G06F15/00
CPC分类号： H04N1/6022
摘要： A method of selecting inks for use in imaging with an imaging apparatus includes establishing a high fidelity colorant cube having a plurality of vertex lines pertaining to a corresponding plurality of basic inks, and at least one other vertex line pertaining to at least one high fidelity ink; determining first mixing coordinates of the at least one high fidelity ink and the plurality of basic inks for face grids of the high fidelity colorant cube based on a maximum permitted ink amount; determining second mixing coordinates of the at least one high fidelity ink and the plurality of basic inks for interior grids of the high fidelity colorant cube based on the maximum permitted ink amount; and generating a color conversion lookup table based on the first mixing coordinates and the second mixing coordinates for printing with the imaging apparatus.
摘要翻译：选择用于成像设备成像的墨水的方法包括：建立具有多个与相应的多种基本油墨相关的多个顶点线的高保真着色剂立方体，以及至少一个与至少一个高保真墨水 ; 基于最大允许墨量确定所述至少一个高保真墨水和所述多个高保真着色剂立方体的面格栅的基础油墨的第一混合坐标; 基于所述最大允许墨量，确定所述至少一个高保真墨水和所述多个高保真着色剂立方体的内部网格的基础油墨的第二混合坐标; 以及基于所述第一混合坐标和所述第二混合坐标生成用于与所述成像设备一起打印的颜色转换查找表。

5. 发明申请

US20070039866A1 Device, system, and method for depositing processed immiscible-fluid-discrete-volumes 有权
标题翻译：用于存放经处理的不混溶流体离散体的装置，系统和方法
公开(公告)号：US20070039866A1
公开(公告)日：2007-02-22
申请号：US11507733
申请日：2006-08-22
申请人： Benjamin Schroeder , David Cox , Mark Oldham , Richard Reel , Willy Wiyatno
发明人： Benjamin Schroeder , David Cox , Mark Oldham , Richard Reel , Willy Wiyatno
IPC分类号： B01D24/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments relate to systems and/or methods for sample preparation that can be used for biochemical and/or molecular biology procedures involving small volumes, for example, micro volumes or smaller. Methods and systems that can reduce sample size requirements and increase the number of samples on a substrate are provided. Samples can be applied to a plate or other appropriate substrate and can be used for, inter alia, sequencing reactions. In some embodiments, apparatuses, systems, and/or methods for charged analyte collection are provided. Charged analytes in a sample can be electrokinetically collected or extracted from a conduit through a hole formed in a sidewall of the conduit, by application of an electric field that causes the charged analytes to migrate in a direction that is transverse to the conduit.
摘要翻译：各种实施方案涉及用于样品制备的系统和/或方法，其可用于涉及小体积例如微量或更小的生物化学和/或分子生物学过程。提供了可以减少样品尺寸要求并增加基材上样品数量的方法和系统。样品可以施用于板或其它合适的底物，并且可以用于尤其是测序反应。在一些实施例中，提供了用于带电分析物收集的装置，系统和/或方法。通过施加导致带电分析物沿横向于导管的方向迁移的电场，样品中的带电分析物可以通过形成在导管侧壁中的孔从导管电动收集或提取。

6. 发明申请

US20060124463A1 Method of cell capture 有权
公开(公告)号：US20060124463A1
公开(公告)日：2006-06-15
申请号：US11338255
申请日：2006-01-24
申请人： Richard Reel , Eric Nordman , Zbigniew Bryning
发明人： Richard Reel , Eric Nordman , Zbigniew Bryning
IPC分类号： B03C5/02
CPC分类号： G01N27/44704 , B01L3/502 , B01L2200/0631 , B01L2200/0647 , B01L2300/0645 , B01L2400/0415 , B03C5/026 , G01N1/40 , G01N27/44756 , G01N2001/4038
摘要： Embodiments of methods and devices are disclosed for the manipulation (e.g., concentration, purification, capture, trapping, location, transfer) of analytes, e.g., biomolecules, with respect to analyte-containing solutions, using one or more electric fields.

7. 发明申请

US20050285891A1 Method of correcting neutral color shifts caused by cartridge variations 有权
标题翻译：校正墨盒变化引起的中性色彩偏移的方法
公开(公告)号：US20050285891A1
公开(公告)日：2005-12-29
申请号：US10877577
申请日：2004-06-25
申请人： Anna Deer , Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Anna Deer , Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： B41J29/393 , H04N1/56 , H04N1/60
CPC分类号： H04N1/603 , H04N1/56
摘要： A method for correcting neutral color shift in a production cartridge for use in an imaging system includes determining a colorant increment data based on a standard cartridge neutral variation signature color data and a standard cartridge neutral sensitivity signature color data associated with a standard cartridge, and based on a production cartridge neutral variation signature color data and a production cartridge neutral sensitivity signature color data associated with the production cartridge, and using the colorant increment data to correct the neutral color shift.
摘要翻译：一种用于校正用于成像系统的生产筒中的中性色移的方法包括：基于标准盒式中心变化标记颜色数据和与标准盒相关联的标准盒式中性敏感性签名颜色数据来确定着色剂增量数据，并且基于在与生产墨盒相关联的生产墨盒中性变化签名颜色数据和生产墨盒中性敏感度签名颜色数据上，并使用着色剂增量数据来校正中性色彩偏移。

8. 发明申请

US20050206900A1 Fluorescent light detection 有权
标题翻译：荧光灯检测
公开(公告)号：US20050206900A1
公开(公告)日：2005-09-22
申请号：US10805096
申请日：2004-03-19
申请人： Richard Reel , Eric Nordman
发明人： Richard Reel , Eric Nordman
IPC分类号： G01N15/14 , G01N21/03 , G01N21/64 , G01N27/447
CPC分类号： G01N21/645 , G01N21/0303 , G01N2021/0346 , G01N2021/6417 , G01N2021/6478
摘要： System and method for fluorescent light detection from biological samples to enhance the numerical aperture and/or reduce the cross-talk of the fluorescent light.
摘要翻译：用于生物样品的荧光检测的系统和方法，以增强数值孔径和/或减少荧光灯的串扰。

9. 发明申请

US20050200646A1 Method for calibrating production printing cartridges for use in an imaging system 失效
标题翻译：用于校准用于成像系统的生产打印盒的方法
公开(公告)号：US20050200646A1
公开(公告)日：2005-09-15
申请号：US10800571
申请日：2004-03-15
申请人： Anna Deer , Xuan-Chao Huang , Brant Nystrom , Richard Reel
发明人： Anna Deer , Xuan-Chao Huang , Brant Nystrom , Richard Reel
IPC分类号： B41J2/205
CPC分类号： B41J2/17503 , G03G15/5062 , G03G15/5066 , G03G21/1889
摘要： A method for calibrating a production printing cartridge for use in an imaging system includes the steps of obtaining first standard cartridge signature color data associated with a standard printing cartridge and a first substrate, obtaining second standard cartridge signature color data associated with the standard printing cartridge and a second substrate, obtaining first production cartridge signature color data associated with the production printing cartridge and the first substrate, and estimating second production cartridge signature color data associated with the production printing cartridge and the second substrate based on the first standard cartridge signature color data, the second standard cartridge signature color data, and the first production cartridge signature color data.
摘要翻译：用于校准用于成像系统的生产打印盒的方法包括以下步骤：获得与标准打印盒和第一基板相关联的第一标准墨盒签名颜色数据，获得与标准打印盒相关联的第二标准墨盒签名颜色数据，以及第二基板，获得与所述生产打印盒和所述第一基板相关联的第一生产墨盒签名颜色数据，以及基于所述第一标准墨盒签名颜色数据估计与所述生产打印盒和所述第二基板相关联的第二生产墨盒签名颜色数据，第二标准墨盒签名颜色数据和第一生产墨盒签名颜色数据。

10. 发明授权

US08384898B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US08384898B2
公开(公告)日：2013-02-26
申请号：US13442107
申请日：2012-04-09
申请人： Mark Oldham , Eric Nordman , Richard Reel , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

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