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1. 发明授权

US07717952B2 Artificial prostheses with preferred geometries 有权
标题翻译：具有优选几何形状的人造假体
公开(公告)号：US07717952B2
公开(公告)日：2010-05-18
申请号：US11586285
申请日：2006-10-25
申请人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
发明人： Brian C. Case , Ram H. Paul, Jr. , Grant T. Hoffman
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0054 , A61F2230/0078 , A61F2230/008 , A61F2250/0039
摘要： Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
摘要翻译：提供可植入的医疗装置，例如可植入后的支架和瓣膜，其具有某些优选的形状。优选地，可植入医疗装置的一部分可以限定具有优选几何形状的窦区。窦区可以具有本文所述的一种或多种优选的几何构型，例如减轻或预防体内血栓形成。医疗装置可以包括阀装置，例如位于窦区内的一个或多个瓣叶。可植入的医疗装置可以从身体容器内的导管输送，并且优选地可以从压缩构型扩展到径向扩张的构型。可植入的框架可以是自膨胀的或球囊的可膨胀的。医疗装置的一部分，例如可植入框架或瓣膜小叶，任选地涂覆有一种或多种生物活性材料。

2. 发明授权

US08128682B2 Medical device with tensionably attached remodelable material 有权
标题翻译：具有可张力连接的可重塑材料的医疗装置
公开(公告)号：US08128682B2
公开(公告)日：2012-03-06
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, Jr. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodelable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当变弱的框架部分处于第一构型时，可重塑材料将框架从径向压缩构型扩展到径向扩张构型。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

3. 发明授权

US08403977B2 Self-orienting delivery system 有权
标题翻译：自动送货系统
公开(公告)号：US08403977B2
公开(公告)日：2013-03-26
申请号：US11800292
申请日：2007-05-04
申请人： Brian C. Case , Ram H. Paul, Jr.
发明人： Brian C. Case , Ram H. Paul, Jr.
IPC分类号： A61F2/06 , A61F2/84 , A61M29/02
CPC分类号： A61M25/01 , A61F2/95 , A61F2002/30125 , A61F2002/30538 , A61F2230/0008 , A61F2250/0006 , A61M25/0074 , A61M25/0082
摘要： Delivery systems for delivering and deploying expandable intraluminal medical devices within a body vessel are provided. A portion of the delivery system that includes the expandable intraluminal medical device orients itself about an axis based on characteristics of the body vessel, such as the relative orientation of major and minor axes of the vessel. This allows the intraluminal medical device to be deployed in the vessel in a desired orientation relative to the vessel. Embodiments can be used with any suitable intraluminal medical device, including valve devices, stents, drug-coated stents, filters, and other suitable devices. Methods of delivering and deploying intraluminal medical devices are also described.
摘要翻译：提供了用于在身体容器内递送和部署可膨胀的管腔内医疗装置的输送系统。包括可扩展的管腔内医疗装置的输送系统的一部分基于身体血管的特征（例如血管的主轴和短轴的相对取向）绕轴线定向。这允许管腔内医疗装置相对于容器以期望的方向部署在容器中。实施例可以与任何合适的管腔内医疗装置一起使用，包括瓣膜装置，支架，药物涂层的支架，过滤器和其它合适的装置。还描述了递送和部署管腔内医疗装置的方法。

4. 发明授权

US08398663B2 Valvulotome device and method 有权
标题翻译：瓣膜切除装置及方法
公开(公告)号：US08398663B2
公开(公告)日：2013-03-19
申请号：US12781300
申请日：2010-05-17
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices and methods are provided. Valvulotome devices include one or more valvulotome arms that have a u-shaped curved body with opposing arms and a base portion that extends between the arms. The valvulotome arm defines a notch open at one end on one of the arms and extending into the base portion of the u-shaped curved body. The notch defines an angled surface that provides a cutting edge. Methods of making valvulotome devices are also described.
摘要翻译：提供瓣膜切除装置和方法。瓣膜切开装置包括一个或多个瓣膜切开臂，其具有带相对臂的u形弯曲体和在臂之间延伸的基部。瓣膜切开臂限定了在一个臂上的一端处开口并且延伸到U形弯曲体的基部中的凹口。切口限定了提供切削刃的成角度的表面。还描述了制造瓣膜切开术装置的方法。

5. 发明申请

US20100280586A1 MEDICAL DEVICE WITH TENSIONABLY ATTACHED REMODELABLE MATERIAL 有权
标题翻译：具有可张紧连接的可重复材料的医疗装置
公开(公告)号：US20100280586A1
公开(公告)日：2010-11-04
申请号：US12777947
申请日：2010-05-11
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul, JR. , Sean D. Chambers
IPC分类号： A61F2/82
CPC分类号： A61F2/2418 , A61F2/07 , A61F2/2475 , A61F2/86 , A61F2/90 , A61F2002/075 , A61F2210/0004 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0071 , A61F2250/0018 , A61F2250/0031 , A61F2250/0071
摘要： Medical devices for implantation in a body vessel, and methods of using and making the same, are provided. A medical device includes a support frame having struts and a weakened frame portion, and a remodelable material tensionably attached to the support frame. The weakened frame portion has a first configuration in which the support frame has a first outward radial force and a second configuration in which the support frame has a second, lesser outward radial force. The remodellable material restricts expansion of the frame from a radially compressed configuration to a radially expanded configuration when the weakened frame portion is in the first configuration. The remodelable material can form one or more valve leaflets adapted to regulate fluid flow in a body vessel, such as a vein.
摘要翻译：提供了用于植入体内的医疗装置及其使用和制造方法。医疗装置包括具有支柱和弱化框架部分的支撑框架和可张紧地附接到支撑框架的可重塑材料。弱化的框架部分具有第一构造，其中支撑框架具有第一向外径向力和第二构造，其中支撑框架具有第二较小的向外径向力。当减弱的框架部分处于第一构造时，可重构材料限制框架从径向压缩构型到径向膨胀构型的膨胀。可重塑材料可以形成适于调节诸如静脉的体内血管中的流体流动的一个或多个瓣膜小叶。

6. 发明授权

US07717930B2 Valvulotome with a cutting edge 有权
标题翻译：瓣切开术带有切削刃
公开(公告)号：US07717930B2
公开(公告)日：2010-05-18
申请号：US11070130
申请日：2005-02-28
申请人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
发明人： Ram H. Paul, Jr. , Brian C. Case , Jacob A. Flagle
IPC分类号： A61B17/22
CPC分类号： A61B17/3207 , A61B17/320725 , A61B2017/22097
摘要： Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
摘要翻译：提供包括切削刃的瓣膜切开装置。一些瓣膜切开装置可切割地与身体血管内的静脉瓣膜接合，同时切割边缘的至少一部分基本上平行于瓣膜切开装置的纵向轴线定向。瓣膜切开装置优选地构造成在沿着身体血管的纵向轴线平移瓣膜切开装置时可滑动地接合静脉瓣膜瓣。瓣膜切开装置还可以包括一个或多个可变长度和尺寸的瓣膜切开臂。在一些实施例中，瓣膜切开装置可以是自膨胀的。本发明的实施例还提供包括瓣膜切开装置的输送系统。本发明还提供了使用瓣膜切开装置的方法。还提供了包括瓣膜切开装置的套件。

7. 发明授权

US08382822B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

8. 发明授权

US08216299B2 Method to retract a body vessel wall with remodelable material 有权
标题翻译：用可重塑材料收回体管壁的方法
公开(公告)号：US08216299B2
公开(公告)日：2012-07-10
申请号：US11095209
申请日：2005-03-31
申请人： Ram H. Paul, Jr. , Brian C. Case
发明人： Ram H. Paul, Jr. , Brian C. Case
IPC分类号： A61F2/06
CPC分类号： A61L27/367 , A61F2/2475 , A61F2/82 , A61F2/958 , A61F2210/0004 , A61L27/227 , A61L27/3633 , A61L27/3641 , A61L27/3645
摘要： The present invention provides remodelable materials for retracting the interior walls of a body vessel via remodeling processes. Also provided are methods, kits and devices for the same.
摘要翻译：本发明提供了用于通过重塑过程回缩身体血管的内壁的可重塑材料。还提供了相同的方法，套件和设备。

9. 发明申请

US20100174361A1 PROSTHETIC VALVE WITH SEMI-RIGID AND FLEXIBLE LEAFLETS 审中-公开
标题翻译：具有半刚性和柔性叶片的前置阀
公开(公告)号：US20100174361A1
公开(公告)日：2010-07-08
申请号：US12723840
申请日：2010-03-15
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

10. 发明授权

US07604661B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US07604661B2
公开(公告)日：2009-10-20
申请号：US11931182
申请日：2007-10-31
申请人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
发明人： Dusan Pavcnik , Thomas A. Osborne , Brian C. Case , Jacob A. Flagle , Michael L. Garrison , Ram H. Paul, Jr. , Andrew K. Hoffa , Raymond B. Leonard, II , Darin G. Schaeffer , Richard B. Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/24 , A61F2/01 , A61F2/2418 , A61F2/2475 , A61F2002/018 , A61F2002/8483 , A61F2230/0008 , A61F2230/001 , A61F2230/0023 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0069 , A61F2230/0095
摘要： An valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶结构，其包括一个或多个小叶，其中每个小叶的外边缘沿着沿着通过可扩展框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

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