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    • 2. 发明授权
    • Artificial prostheses with preferred geometries
    • 具有优选几何形状的人造假体
    • US07717952B2
    • 2010-05-18
    • US11586285
    • 2006-10-25
    • Brian C. CaseRam H. Paul, Jr.Grant T. Hoffman
    • Brian C. CaseRam H. Paul, Jr.Grant T. Hoffman
    • A61F2/06
    • A61F2/2418A61F2/2475A61F2220/0016A61F2220/005A61F2220/0058A61F2230/0054A61F2230/0078A61F2230/008A61F2250/0039
    • Implantable medical devices, such as intraluminally implantable stents and valves, are provided having certain preferred shapes. Preferably, a portion of the implantable medical device can define a sinus region having a preferred geometry. The sinus region can have one or more preferred geometric configurations described herein, for example to mitigate or prevent thrombosis within a body vessel. The medical device can include a valve means, such as one or more valve leaflets positioned within the sinus region. The implantable medical devices can be delivered from a catheter within a body vessel, and are preferably expandable from a compressed configuration to a radially expanded configuration. The implantable frames can be self-expanding or balloon expandable. Portions of the medical device, such as the implantable frame or a valve leaflet, are optionally coated with one or more bioactive materials.
    • 提供可植入的医疗装置,例如可植入后的支架和瓣膜,其具有某些优选的形状。 优选地,可植入医疗装置的一部分可以限定具有优选几何形状的窦区。 窦区可以具有本文所述的一种或多种优选的几何构型,例如减轻或预防体内血栓形成。 医疗装置可以包括阀装置,例如位于窦区内的一个或多个瓣叶。 可植入的医疗装置可以从身体容器内的导管输送,并且优选地可以从压缩构型扩展到径向扩张的构型。 可植入的框架可以是自膨胀的或球囊的可膨胀的。 医疗装置的一部分,例如可植入框架或瓣膜小叶,任选地涂覆有一种或多种生物活性材料。
    • 6. 发明授权
    • Valvulotome with a cutting edge
    • 瓣切开术带有切削刃
    • US07717930B2
    • 2010-05-18
    • US11070130
    • 2005-02-28
    • Ram H. Paul, Jr.Brian C. CaseJacob A. Flagle
    • Ram H. Paul, Jr.Brian C. CaseJacob A. Flagle
    • A61B17/22
    • A61B17/3207A61B17/320725A61B2017/22097
    • Valvulotome devices comprising a cutting edge are provided. Some valvulotome devices incisably engage a venous valve leaflet within a body vessel while at least a portion of the cutting edge is oriented substantially parallel to the longitudinal axis of the valvulotome device. Valvulotome devices are preferably configured to slidably engage a venous valve leaflet upon translation of the valvulotome device along the longitudinal axis of a body vessel. A valvulotome device can further comprise one or more valvulotome arms of variable lengths and dimensions. In some embodiments, the valvulotome device can be self expanding. Embodiments of the invention also provide delivery systems comprising a valvulotome device. The present invention also provides for methods of using a valvulotome device. Kits comprising a valvulotome device are also provided.
    • 提供包括切削刃的瓣膜切开装置。 一些瓣膜切开装置可切割地与身体血管内的静脉瓣膜接合,同时切割边缘的至少一部分基本上平行于瓣膜切开装置的纵向轴线定向。 瓣膜切开装置优选地构造成在沿着身体血管的纵向轴线平移瓣膜切开装置时可滑动地接合静脉瓣膜瓣。 瓣膜切开装置还可以包括一个或多个可变长度和尺寸的瓣膜切开臂。 在一些实施例中,瓣膜切开装置可以是自膨胀的。 本发明的实施例还提供包括瓣膜切开装置的输送系统。 本发明还提供了使用瓣膜切开装置的方法。 还提供了包括瓣膜切开装置的套件。
    • 9. 发明授权
    • Prosthetic valve with slanted leaflet design
    • 假体瓣带有倾斜小叶设计
    • US07678144B2
    • 2010-03-16
    • US12019987
    • 2008-01-25
    • Frances Kristen BaileyBrian C. CaseRam H. Paul, Jr.
    • Frances Kristen BaileyBrian C. CaseRam H. Paul, Jr.
    • A61F2/24
    • A61F2/2412A61F2/2421A61F2/2475
    • The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet. The at least one semi-rigid leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one semi-rigid leaflet is slanted in a retrograde direction from the second portion to the first portion. The at least one flexible leaflet comprises a first portion and a second portion, the first portion attached to the frame and the second portion free of the frame. The at least one flexible leaflet is slanted in a retrograde direction from the first portion to the second portion when at rest.
    • 本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。 阀包括框架和阀构件,阀构件包括至少一个半刚性小叶和至少一个柔性小叶。 至少一个半刚性小叶包括第一部分和第二部分,第一部分附接到框架,第二部分没有框架。 至少一个半刚性小叶从第二部分向第一部分沿逆行方向倾斜。 所述至少一个柔性小叶包括第一部分和第二部分,所述第一部分附接到所述框架并且所述第二部分没有所述框架。 当静止时,至少一个柔性小叶在从第一部分到第二部分的逆行方向上倾斜。