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1. 发明授权

US08382822B2 Implantable vascular device 有权
标题翻译：植入式血管装置
公开(公告)号：US08382822B2
公开(公告)日：2013-02-26
申请号：US12574870
申请日：2009-10-07
申请人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
发明人： Dusan Pavcnik , Brian C. Case , Jacob A. Flagle , Michael Garrison , Andrew K. Hoffa , Raymond B. Leonard, II , Thomas A. Osborne , Ram H. Paul, Jr. , Darin G. Schaeffer , Richard B Sisken
IPC分类号： A61F2/06 , A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2002/825 , A61F2002/8483 , A61F2220/0016 , A61F2230/0008 , A61F2230/001 , A61F2230/0017 , A61F2230/0021 , A61F2230/0026 , A61F2230/0054 , A61F2230/0058 , A61F2230/0095
摘要： A valve prosthesis, such as an artificial venous valve, having a support frame and leaf structure comprising one or more leaflets in which the outer edge of each leaflet engages the inner circumference of the bodily passageway along a serpentine path urged against the passageway by an expandable frame, while the inner edges move in response to fluid to restrict retrograde flow. Optionally, one or more elements can extend from the support frame/leaf structure to provide centering support and/or protection from the leaflet adhering to the vessel wall. In one embodiment, the centering support structure comprises a second or third expandable frames attached to and extending from the proximal and/or distal ends of main valve structure and support frame. In another embodiment, one or more support elements extend outward from the valve support frame to engage the vessel wall to provide greater longitudinal stability.
摘要翻译：一种阀门假体，例如人造静脉瓣，其具有支撑框架和叶片结构，其包括一个或多个小叶，每个小叶的外边缘沿着沿着通过可扩张的第二通道推动抵靠通道的蛇形路径接合身体通道的内周框架，而内边缘响应流体移动以限制逆行流。任选地，一个或多个元件可以从支撑框架/叶结构延伸，以提供定位支撑和/或防止附着在血管壁上的小叶的保护。在一个实施例中，定心支撑结构包括附接到主阀结构和支撑框架的近端和/或远端的第二或第三可膨胀框架。在另一个实施例中，一个或多个支撑元件从阀支撑框架向外延伸以接合血管壁以提供更大的纵向稳定性。

2. 发明申请

US20060212111A1 Vascular valves having implanted and target configurations and methods of preparing the same 有权
标题翻译：具有植入和靶构造的血管瓣及其制备方法
公开(公告)号：US20060212111A1
公开(公告)日：2006-09-21
申请号：US11260770
申请日：2005-10-27
申请人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
发明人： Brian Case , Jacob Flagle , Michael Garrison , F. Obermiller , Dusan Pavcnik
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2436 , A61F2/2475 , A61F2210/0004 , A61F2220/0016 , A61F2250/0067
摘要： Described are vascular valve devices for implantation in a patient. The vascular valve devices are designed to compensate for the retraction characteristics of a remodelable material used to form one or more leaflets. Alternatively, or in addition, the devices are designed to reduce retraction of the remodelable leaflet-forming material. Further described are methods for preparing and using these vascular valve devices.
摘要翻译：描述了用于植入患者体内的血管瓣膜装置。血管瓣膜装置被设计成补偿用于形成一个或多个传单的可重塑材料的回缩特性。或者或另外，设备被设计成减少可重塑的小叶形成材料的缩回。进一步描述了制备和使用这些血管瓣膜装置的方法。

3. 发明申请

US20050228479A1 Medical device delivery system 审中-公开
标题翻译：医疗器械输送系统
公开(公告)号：US20050228479A1
公开(公告)日：2005-10-13
申请号：US11149721
申请日：2005-06-09
申请人： Dusan Pavcnik , Brian Case , Christopher Dixon , Jacob Flagle , Michael Garrison , Andrew Hoffa , Ray Leonard
发明人： Dusan Pavcnik , Brian Case , Christopher Dixon , Jacob Flagle , Michael Garrison , Andrew Hoffa , Ray Leonard
IPC分类号： A61F2/01 , A61F2/06 , A61F2/24 , A61F2/84
CPC分类号： A61F2/95 , A61F2/2436 , A61F2002/011 , A61F2002/9517
摘要： A delivery system (10) for implanting a medical device (30) such as a venous valve into the vasculature of a patient. The delivery system includes a delivery catheter (11) having a device-containing portion (15) adjacent to the distal end (14) thereof, and an inner member (16) extending through the catheter and beyond the distal end thereof, to an atraumatic distal tip portion (17) forward of the catheter distal end. Delivery catheter (11) includes inner tube (122), flat wire coil (123) compression fitted therearound, and outer tube (112) mechanically connected to roughened outer surface (126) of the inner tube through the spacing of the coil. Delivery catheter (11) can be provided with a window (184) to allow fluoroscopic visualization of a stent valve within the delivery system.
摘要翻译：一种用于将诸如静脉瓣的医疗装置（30）植入患者脉管系统的输送系统（10）。递送系统包括具有与其远端（14）相邻的装置容纳部分（15）的输送导管（11）和延伸穿过导管并超出其远端的内部构件（16）到无创伤远端尖端部分（17）在导管远端的前方。输送导管（11）包括内管（122），压缩在其周围的扁平线圈（123）和通过线圈的间隔机械地连接到内管的粗糙化的外表面（126）的外管（112）。输送导管（11）可以设置有窗口（184），以允许支架瓣膜在输送系统内的荧光透视可视化。

4. 发明申请

US20070142721A1 Monitoring of physiological analytes 有权
标题翻译：生理分析物的监测
公开(公告)号：US20070142721A1
公开(公告)日：2007-06-21
申请号：US11699850
申请日：2007-01-30
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.
摘要翻译：提供了用于测量生物系统中存在的目标化学分析物浓度的方法和装置。采用器件配置和/或测量技术来降低干扰物质对传感器灵敏度的影响。本发明的一个重要应用涉及用于监测血糖值的方法和装置。

5. 发明申请

US20050283178A1 Delivery system that facilitates visual inspection of an intraluminal medical device 有权
标题翻译：输送系统，便于目视检查管腔内医疗器械
公开(公告)号：US20050283178A1
公开(公告)日：2005-12-22
申请号：US11123312
申请日：2005-05-06
申请人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
发明人： Jacob Flagle , Brian Case , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/00 , A61F2/06 , A61F2/84 , A61M25/00 , A61M25/01 , A61M25/10 , A61M29/00
CPC分类号： A61M25/0043 , A61F2/95 , A61F2250/0091 , A61M25/10 , A61M2025/1079
摘要： Delivery systems, methods of making delivery systems, and methods of treatment are provided. A delivery system according to the invention facilitates a visual inspection of an intraluminal medical device included in the delivery system.
摘要翻译：提供交付系统，交付系统的方法和处理方法。根据本发明的递送系统便于对包括在递送系统中的管腔内医疗装置的目视检查。

6. 发明申请

US20070106372A1 IMPLANTABLE MEDICAL DEVICE WITH CONSTRAINED EXPANSION 有权
标题翻译：具有约束扩张的可植入医疗装置
公开(公告)号：US20070106372A1
公开(公告)日：2007-05-10
申请号：US11539925
申请日：2006-10-10
申请人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
发明人： Thomas Osborne , Brian Case , Jacob Flagle , Andrew Hoffa , Michael Garrison
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2230/0026 , A61F2230/0095
摘要： Medical devices for implantation in a body vessel are provided. A medical device according to the invention comprises a support structure and one or more graft members comprising a valve portion and a constraining portion. The support structure has a first, unexpanded configuration and a second, expanded configuration. The constraining portion is adapted to substantially prevent the support structure from achieving the second, expanded configuration. The valve portion is adapted to permit fluid flow through a body vessel in a first direction and substantially prevent fluid flow through the vessel in a second, opposite direction.
摘要翻译：提供用于植入体内的医疗装置。根据本发明的医疗装置包括支撑结构和包括阀部分和约束部分的一个或多个移植部件。支撑结构具有第一，未膨胀的构造和第二扩展构型。约束部分适于基本上防止支撑结构实现第二扩张构型。阀部分适于允许流体沿第一方向流过身体容器，并且基本上防止流体沿第二相反方向流过血管。

7. 发明申请

US20070038291A1 Intralumenally-implantable frames 有权
标题翻译：腔内可植入框架
公开(公告)号：US20070038291A1
公开(公告)日：2007-02-15
申请号：US11545746
申请日：2006-10-10
申请人： Brian Case , Jacob Flagle , Michael Garrison
发明人： Brian Case , Jacob Flagle , Michael Garrison
IPC分类号： A61F2/90
CPC分类号： A61F2/86 , A61F2/06 , A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2/915 , A61F2002/068 , A61F2002/91508 , A61F2002/91516 , A61F2002/91533 , A61F2002/91575 , A61F2220/0016 , A61F2220/0058 , A61F2230/0054 , A61F2250/0037 , A61F2250/0039
摘要： Implantable frames for use in body passages are provided herein. The implantable frames can include a plurality of hoop members joined by a plurality of longitudinal connecting members to form a tubular frame defining a cylindrical lumen. The plurality of longitudinal connecting members may include one or more pairs of closely-spaced longitudinal connecting members aligned substantially parallel to the longitudinal axis of the implantable frame. The circumferential distance between the closely-spaced longitudinal connecting members preferably subtends an angle less than (2π/n) radians, where (n) is an integer equal to the total number of longitudinal connecting members connecting two longitudinally adjacent hoop members.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架可以包括由多个纵向连接构件连接以形成限定圆柱形管腔的管状框架的多个环形构件。多个纵向连接构件可以包括一对或多对紧密间隔的纵向连接构件，其基本上平行于可植入框架的纵向轴线对准。紧密间隔的纵向连接构件之间的圆周距离优选地对角度小于（2pi / n）弧度的角度，其中（n）是等于连接两个纵向相邻的箍构件的纵向连接构件的总数的整数。

8. 发明申请

US20070021826A1 Intralumenally implantable frames 有权
标题翻译：心内植入式框架
公开(公告)号：US20070021826A1
公开(公告)日：2007-01-25
申请号：US11487629
申请日：2006-07-17
申请人： Brian Case , Jacob Flagle , Michael Garrison
发明人： Brian Case , Jacob Flagle , Michael Garrison
IPC分类号： A61F2/06 , A61F2/86
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2/91 , A61F2002/91575 , A61F2220/0016 , A61F2230/0054
摘要： Implantable frames for use in body passages are provided herein. The implantable frames comprise one or more of certain preferred structural features that are generally applicable to frames comprising a plurality of curved and straight member portions that together define an interior lumen extending along a longitudinal axis between a proximal end and a distal end. The implantable frames have an exterior surface comprising a plurality of openings between the interior lumen and the exterior surface, and preferably include one or more undulating hoop members attached to one or more longitudinal connecting members. The implantable frames can be formed from any suitable material, but preferably comprise material permitting the frame to radially self-expand from a radially compressed configuration to a radially expanded configuration. The implantable frames are useful for endolumenal implantation within a body vessel, for example as a stent or as a support frame of an implantable valve.
摘要翻译：本文提供了用于身体通道的植入框架。可植入框架包括一些优选结构特征中的一个或多个，其通常可应用于包括多个弯曲和直的构件部分的框架，所述多个弯曲和直的构件部分一起限定沿近端和远端之间的纵向轴线延伸的内腔。可植入框架具有包括在内腔和外表面之间的多个开口的外表面，并且优选地包括附接到一个或多个纵向连接构件的一个或多个起伏环箍构件。可植入框架可以由任何合适的材料形成，但优选地包括允许框架从径向压缩构型向径向扩张构型的径向自扩展的材料。可植入框架可用于体内容器内腔内植入，例如作为支架或可植入瓣膜的支撑框架。

9. 发明申请

US20050215872A1 Monitoring of physiological analytes 有权
公开(公告)号：US20050215872A1
公开(公告)日：2005-09-29
申请号：US10982166
申请日：2004-11-05
申请人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
发明人： Bret Berner , Chia-Ming Chiang , Michael Garrison , Janan Jona , Russell Potts , Janet Tamada , Michael Tierney
IPC分类号： G01N27/28 , A61B5/00 , A61B5/145 , A61B5/1477 , A61N1/30 , G01N27/327 , A61B5/05
CPC分类号： A61B5/1486 , A61B5/14532 , A61B5/150022 , A61B5/150091 , A61B5/157 , A61N1/30 , C12Q1/006
摘要： Methods and devices are provided for measuring the concentration of target chemical analytes present in a biological system. Device configuration and/or measurement techniques are employed in order to reduce the effect of interfering species on sensor sensitivity. One important application of the invention involves a method and device for monitoring blood glucose values.

10. 外观设计

USD409150S Cable for connecting a portable phone with headset 失效
公开(公告)号：USD409150S
公开(公告)日：1999-05-04
申请号：US83958
申请日：1998-02-20
申请人： Bradley D. Davis , Michael Garrison
设计人： Bradley D. Davis , Michael Garrison

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