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1. 发明授权

US10052203B2 Prosthetic heart valve and method 有权
公开(公告)号：US10052203B2
公开(公告)日：2018-08-21
申请号：US15467622
申请日：2017-03-23
申请人： Edwards Lifesciences PVT, Inc.
发明人： Benjamin Spenser , Netanel Benichou , Assaf Bash , Avraham Zakai
IPC分类号： A61F2/24 , A61F2/82 , A61F2/95
CPC分类号： A61F2/2418 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2421 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2463 , A61F2/82 , A61F2002/9522 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0069 , A61F2250/001 , A61F2250/0098
摘要： A prosthetic heart valve comprises a radially crimpable and radially expandable, net-like, annular support frame and a valve assembly disposed therein, the valve assembly comprising a conduit tapering from an inlet towards an outlet thereof. Some embodiments or the support frame comprise a proximal portion and a distal portion, a diameter of the proximal portion smaller than a diameter of the distal portion. The proximal portion is dimensioned for deployment in an annulus of a native aortic valve and a distal portion for deployment in an ascending aorta. Some embodiments of the conduit comprise a support construction with a three-cusp, crown-shaped cut line, the support construction sutured to the support frame around a bottom portion thereof and around the cut line. A method for using the prosthetic heart valve to replace a defective native aortic valve uses a minimally invasive procedure.

2. 发明授权

US09414909B1 Gentle artificial heart valve with improved wear characteristics 有权
标题翻译：温和人造心脏瓣膜具有改善的磨损特性
公开(公告)号：US09414909B1
公开(公告)日：2016-08-16
申请号：US14603101
申请日：2015-01-22
申请人： PATENTSPLUS LLC
发明人： Stephen K. Shu , Benton Bejach
IPC分类号： A61F2/24
CPC分类号： A61F2/2421 , A61F2/24 , A61F2/2409 , A61F2/2469 , A61F2250/0069
摘要： Disclosed herein is an artificial heart valve, comprising a valve housing comprising a distal plate and a proximal valve ring operably connected by a plurality of struts; one or more helical springs having a proximal end and a distal end; and a bellows spring having a proximal end, enclosed area, and a distal end, the distal end of the bellows spring operably attached to a first surface of a moving spring plate positioned axially in between the one or more helical springs and the bellows spring, the proximal end of the helical spring operably attached to a second surface of the moving spring plate; and a movable valve plate operably attached to the proximal end of the bellows spring, wherein the movable valve plate is configured to reversibly contact the proximal valve ring to create a seal and close the valve.
摘要翻译：本文公开了一种人造心脏瓣膜，包括阀壳体，其包括可操作地通过多个支柱连接的远端板和近端瓣环; 一个或多个具有近端和远端的螺旋弹簧; 以及具有近端，封闭区域和远端的波纹弹簧，波纹管弹簧的远端可操作地附接到轴向位于一个或多个螺旋弹簧和波纹管弹簧之间的移动弹簧板的第一表面上，螺旋弹簧的近端可操作地附接到移动弹簧板的第二表面; 以及可操作地附接到波纹管弹簧的近端的可移动阀板，其中可动阀板被构造成可逆地接触近端阀环以形成密封并关闭阀。

3. 发明申请

US20140155992A1 TRANSLUMINAL CARDIAC BALL VALVE AND METHOD FOR DEPLOYMENT THEREOF 审中-公开
标题翻译：透镜球阀及其部署方法
公开(公告)号：US20140155992A1
公开(公告)日：2014-06-05
申请号：US14087489
申请日：2013-11-22
申请人： Palmaz Scientific, Inc.
发明人： Julio C. Palmaz
IPC分类号： A61F2/24
CPC分类号： A61F2/2421 , A61F2/2418 , A61F2/2424 , A61F2/2433 , A61F2/2436 , A61F2250/0003 , A61F2250/0039
摘要： A transluminal cardiac valve includes an expandable generally tubular cage including when expanded a generally uniform central region, first and second ends each diametrically constricted relative to the central region, a blood impervious region extending from the first end of the cage to within the generally uniform central region, and an inflatable plunger freely disposed and captured within the cage when inflated.
摘要翻译：经腔心脏瓣膜包括可扩张的大致管状的保持架，其包括当膨胀时大致均匀的中心区域，相对于中心区域各自径向收缩的第一和第二端部，从保持器的第一端延伸到大致均匀的中心区域内的血液不可渗透区域区域，以及当充气时自由地设置和捕获在笼中的可充气柱塞。

4. 发明申请

US20140135911A1 PROSTHETIC HEART VALVE AND METHOD 有权
标题翻译：先天性心脏瓣膜和方法
公开(公告)号：US20140135911A1
公开(公告)日：2014-05-15
申请号：US14159327
申请日：2014-01-20
申请人： Edwards Lifesciences PVT, Inc.
发明人： Benjamin Spenser , Netanel Benichou , Assaf Bash , Avraham Zakai
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2421 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2463 , A61F2/82 , A61F2002/9522 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0069 , A61F2250/001 , A61F2250/0098
摘要： A prosthetic heart valve comprises a radially crimpable and radially expandable, net-like, annular support frame and a valve assembly disposed therein, the valve assembly comprising a conduit tapering from an inlet towards an outlet thereof. Some embodiments or the support frame comprise a proximal portion and a distal portion, a diameter of the proximal portion smaller than a diameter of the distal portion. The proximal portion is dimensioned for deployment in an annulus of a native aortic valve and a distal portion for deployment in an ascending aorta. Some embodiments of the conduit comprise a support construction with a three-cusp, crown-shaped cut line, the support construction sutured to the support frame around a bottom portion thereof and around the cut line. A method for using the prosthetic heart valve to replace a defective native aortic valve uses a minimally invasive procedure.
摘要翻译：假体心脏瓣膜包括可径向卷曲且可径向膨胀的网状环形支撑框架和设置在其中的阀组件，所述阀组件包括从入口朝向其出口逐渐变细的导管。一些实施例或支撑框架包括近端部分和远端部分，近端部分的直径小于远端部分的直径。近端部分的尺寸设计用于展开在天然主动脉瓣的瓣环和用于部署在升主动脉中的远侧部分。导管的一些实施例包括具有三尖头冠状切割线的支撑结构，支撑结构围绕其底部围绕切割线缝合到支撑框架。使用假体心脏瓣膜替代缺陷的天然主动脉瓣的方法使用微创手术。

5. 发明授权

US07803184B2 Percutaneous aortic valve 有权
标题翻译：经皮主动脉瓣
公开(公告)号：US07803184B2
公开(公告)日：2010-09-28
申请号：US12288620
申请日：2008-10-22
申请人： James F. McGuckin, Jr. , Peter W. J. Hinchliffe
发明人： James F. McGuckin, Jr. , Peter W. J. Hinchliffe
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61B2017/00243 , A61F2/2421 , A61F2/2436 , A61F2230/0091 , Y10S623/904
摘要： The present invention provides a valve configured for insertion on the proximal and distal sides of a heart valve annulus to replace the heart valve of a patient. The valve comprises a first substantially annular portion adapted to be positioned on a proximal side of the annulus of a patient and a second substantially annular portion adapted to be positioned on a distal side of the annulus of a patient, wherein at least one of the first and second substantially annular portions is movable towards the other portion to a clamped position to clamp around the annulus. The second portion has a flow restricting portion extending therefrom and is movable between a first position to permit the flow of blood and a second position to restrict the flow of blood. In one embodiment, the valve has a suture joining the first and second portions to draw the first and second portions into closer proximity and a cinch member to secure the suture to maintain the first and second portions in the clamped position. In another embodiment, the first and second portions are connected by a first segment which biases the first and second portions toward the clamped position.
摘要翻译：本发明提供一种构造成用于插入心脏瓣膜环的近侧和远侧以更换患者的心脏瓣膜的阀。阀包括适于定位在患者的环空的近侧上的第一基本上环形的部分和适于定位在患者的环的远端侧的第二基本上环形的部分，其中，第一并且第二基本环形部分可朝向另一部分移动到夹紧位置以夹紧环形。第二部分具有从其延伸的流动限制部分，并且可在第一位置之间移动以允许血液流动，以及第二位置以限制血液流动。在一个实施例中，阀具有连接第一和第二部分以将第一和第二部分拉近更靠近的缝合线，以及紧固构件以固定缝线以将第一和第二部分保持在夹紧位置。在另一个实施例中，第一和第二部分通过将第一和第二部分朝向夹紧位置偏压的第一部分连接。

6. 发明申请

US20100174361A1 PROSTHETIC VALVE WITH SEMI-RIGID AND FLEXIBLE LEAFLETS 审中-公开
标题翻译：具有半刚性和柔性叶片的前置阀
公开(公告)号：US20100174361A1
公开(公告)日：2010-07-08
申请号：US12723840
申请日：2010-03-15
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul, JR.
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

7. 发明申请

US20080183279A1 Prosthetic Valve with Slanted Leaflet Design 有权
标题翻译：假体瓣与倾斜小叶设计
公开(公告)号：US20080183279A1
公开(公告)日：2008-07-31
申请号：US12019987
申请日：2008-01-25
申请人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul
发明人： Frances Kristen Bailey , Brian C. Case , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2412 , A61F2/2421 , A61F2/2475
摘要： The invention relates to a prosthetic valve for regulating fluid flow through a body lumen. The valve includes a frame and a valve member comprising at least one semi-rigid leaflet and at least one flexible leaflet.
摘要翻译：本发明涉及一种用于调节通过体腔的流体流动的人造瓣膜。阀包括框架和阀构件，阀构件包括至少一个半刚性小叶和至少一个柔性小叶。

8. 发明申请

US20070225802A1 Artificial valve for implantation and related methods 有权
标题翻译：人工瓣植入及相关方法
公开(公告)号：US20070225802A1
公开(公告)日：2007-09-27
申请号：US11591290
申请日：2006-11-01
申请人： Peter Forsell
发明人： Peter Forsell
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2421 , A61F2/2475 , A61F2250/0001
摘要： An artificial valve (100) and related methods are provided for implantation in a patient's blood vessel (200), in particular an artificial heart valve, including a first (10) and a second (20) valve member each having a first smooth surface (11, 21) facing each other so as to form a sealing contact between the first and second valve members and further having at least one blood flow passage (13, 23a) extending from the first surface to a second surface (12, 22) located on an opposite side of the respective valve member, wherein at least one (10) of the valve members is arranged so as to be displaceable relative to the other (20) valve member in a slidable manner such that the passage (23a) of the second valve (20) member can be brought into at least partial alignment with the passage (13) of the first valve member (10) while maintaining the sealing contact between the first and second valve members, and a displacing mechanism (M; 50-56) for the relative displacement of the valve members (10, 20). The valve members can be made from ceramics. A valve system comprises the artificial valve (100) and additional components such as a motor (M), an energy source (E), a control unit (C), a pressure sensor (P), a feed back system and/or an alarm system.
摘要翻译：提供人工瓣膜（100）和相关方法用于植入患者的血管（200），特别是人造心脏瓣膜，其包括第一（10）和第二（20）个阀构件，每个具有第一平滑表面 11,21）彼此面对以形成第一和第二阀构件之间的密封接触，并且还具有从第一表面延伸到第二表面（12,22）的至少一个血流通道（13,23a）位于相应阀构件的相对侧上，其中至少一个（10）的阀构件被布置成可滑动地相对于另一个（20）阀构件移位，使得通道（23a）能够保持第一和第二阀构件之间的密封接触以及位移机构（M; M）的至少部分地与第一阀构件（10）的通道（13）对准。 50 - 56）阀构件（10,20）的放置。阀构件可以由陶瓷制成。阀系统包括人造阀（100）和附加部件，例如马达（M），能量源（E），控制单元（C），压力传感器（P），反馈系统和/或警报系统。

9. 发明授权

US07159592B1 Methods and apparatus for transmyocardial direct coronary revascularization 有权
标题翻译：经心肌直接冠状动脉血运重建的方法和装置
公开(公告)号：US07159592B1
公开(公告)日：2007-01-09
申请号：US09710332
申请日：2000-11-09
申请人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Margaret W. Tumas , Theodore C. Lamson , Marc Jensen
发明人： Joshua Makower , J. Christopher Flaherty , Timothy R. Machold , Jason Brian Whitt , Margaret W. Tumas , Theodore C. Lamson , Marc Jensen
IPC分类号： A61B19/00
CPC分类号： A61B17/00234 , A61B17/00491 , A61B17/0643 , A61B17/11 , A61B17/12022 , A61B17/12045 , A61B17/12131 , A61B17/12136 , A61B17/12172 , A61B17/3417 , A61B18/00 , A61B18/1477 , A61B18/1492 , A61B90/40 , A61B2017/00243 , A61B2017/00247 , A61B2017/00252 , A61B2017/00504 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139 , A61B2017/12127 , A61B2017/306 , A61B2017/347 , A61B2018/00392 , A61B2018/1425 , A61F2/07 , A61F2/2412 , A61F2/2418 , A61F2/2421 , A61F2/2475 , A61F2/2493 , A61F2/90 , A61F2/94 , A61F2002/30079 , A61F2210/009 , A61F2220/0008 , A61M39/24 , A61M2025/0076 , A61M2025/1052
摘要： Methods and apparatus for direct coronary revascularization wherein a transmyocardial passageway is formed between a chamber of the heart and a coronary blood vessel to permit blood to flow therebetween. In some embodiments, the transmyocardial passageway is formed between a chamber of the heart and a coronary vein. The invention includes unstented transmyocardial passageways, as well as transmyocardial passageways wherein protrusive stent devices extend from the transmyocardial passageway into an adjacent coronary vessel or chamber of the heart. The apparatus of the present invention include protrusive stent devices for stenting of transmyocardial passageways, intraluminal valving devices for valving of transmyocardial passageways, intracardiac valving devices for valving of transmyocardial passageways, endogenous tissue valves for valving of transmyocardial passageways, and ancillary apparatus for use in conjunction therewith.
摘要翻译：用于直接冠状动脉血运重建的方法和装置，其中在心脏室与冠状血管之间形成经心肌通道以允许血液在其间流动。在一些实施例中，在心脏室和冠状静脉之间形成经心肌通路。本发明包括不连续的经心肌通道以及经心肌通道，其中突出的支架装置从心肌通道延伸到相邻的心脏的冠状血管或腔室。本发明的装置包括用于跨心肌通道支架的突出支架装置，用于跨心肌通道的阀门的腔内瓣膜装置，用于跨心肌通道的阀门的心脏内瓣膜装置，用于跨心肌通道的阀门的内源性组织瓣膜以及用于联合的辅助装置随之而来。

10. 发明申请

US20050192665A1 Implantable prosthetic valve 有权
标题翻译：可植入人工瓣膜
公开(公告)号：US20050192665A1
公开(公告)日：2005-09-01
申请号：US11045773
申请日：2005-01-28
申请人： Benjamin Spenser , Netanel Benichu , Assaf Bash , Avraham Zakai
发明人： Benjamin Spenser , Netanel Benichu , Assaf Bash , Avraham Zakai
IPC分类号： A61F2/24 , A61F2/82 , A61F2/04 , B21F1/00
CPC分类号： A61F2/2418 , A61F2/2403 , A61F2/2409 , A61F2/2412 , A61F2/2415 , A61F2/2421 , A61F2/2427 , A61F2/2433 , A61F2/2436 , A61F2/2463 , A61F2/82 , A61F2002/9522 , A61F2210/0014 , A61F2220/0008 , A61F2220/0016 , A61F2220/0075 , A61F2220/0083 , A61F2230/0054 , A61F2230/0069 , A61F2250/001 , A61F2250/0098
摘要： A valve prosthesis device is disclosed suitable for implantation in body ducts. The device comprises support stent, comprised of a deployable construction adapted to be initially crimped in a narrow configuration suitable for catheterization through the body duct to a target location and adapted to be deployed by exerting substantially radial forces from within by means of a deployment device to a deployed state in the target location, the support stent provided with a plurality of longitudinally rigid support beams of fixed length; valve assembly comprising a flexible conduit having an inlet end and an outlet, made of pliant material attached to the support beams providing collapsible slack portions of the conduit at the outlet. When flow is allowed to pass through the valve prosthesis device from the inlet to the outlet the valve assembly is kept in an open position, whereas a reverse flow is prevented as the collapsible slack portions of the valve assembly collapse inwardly providing blockage to the reverse flow.
摘要翻译：公开了适于植入体内管道的瓣膜假体装置。该装置包括支撑支架，其包括可展开结构，其适于首先被压接成适于通过身体导管进行导管插入到目标位置的窄构造，并且适于通过借助于展开装置从内部施加基本上径向的力而部署到在目标位置处的展开状态，支撑支架设置有多个具有固定长度的纵向刚性支撑梁; 阀组件包括具有入口端和出口的柔性导管，该入口端和出口由连接到支撑梁的柔性材料制成，从而在出口处提供导管的可收缩松弛部分。当允许流体从入口到出口通过瓣膜假体装置时，阀组件保持在打开位置，而当阀组件的可折叠松弛部分向内折叠时，防止反向流动，从而阻止逆流。

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