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1. 发明授权

US5900237A Catalytic antibodies which hydrolyze primary amides and methods for eliciting such antibodies 失效
标题翻译：水解初级酰胺的催化抗体和引发此类抗体的方法
公开(公告)号：US5900237A
公开(公告)日：1999-05-04
申请号：US362470
申请日：1996-05-04
申请人： Andrew D. Napper , Richard C. Titmas , Mark T. Martin , Wonpyo Hong
发明人： Andrew D. Napper , Richard C. Titmas , Mark T. Martin , Wonpyo Hong
IPC分类号： A61K38/00 , A61K38/43 , A61P37/02 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07D205/085 , C07D207/40 , C07D207/404 , C07F9/24 , C07F9/30 , C07F9/32 , C07F9/40 , C07F9/48 , C07F9/553 , C07F9/6509 , C07F9/6571 , C07H15/252 , C07H19/04 , C07K7/08 , C07K14/55 , C07K14/585 , C07K14/595 , C07K16/00 , C07K16/10 , C07K16/26 , C07K16/42 , C07K16/44 , C07K16/46 , C12N9/00 , C12P1/00 , C12P13/22 , C12P17/10 , C12P19/34 , C12P41/00 , C12Q1/25 , G01N33/50 , G01N33/531 , G01N33/535 , G01N33/542 , G01N33/577 , A61K39/395
CPC分类号： G01N33/5044 , B82Y5/00 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07D205/085 , C07D207/404 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/3241 , C07F9/4006 , C07F9/4075 , C07F9/4816 , C07F9/5537 , C07F9/650958 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K14/585 , C07K14/595 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/4241 , C07K16/44 , C07K16/468 , C07K7/086 , C12N9/0002 , C12P1/00 , C12P13/227 , C12P17/10 , C12P19/34 , C12P41/004 , C12Q1/25 , G01N33/5008 , G01N33/502 , G01N33/531 , G01N33/535 , G01N33/542 , G01N33/577 , C07C2101/04 , C07C2102/42 , C07K2319/00 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要： Described and claimed are compounds of formula (I) wherein Y is a polypeptide, R.sub.1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C.sub.1-21 alkyl, alkene, or alkyne group, R.sub.2 is a side chain of a naturally occurring amino acid, and X is (a), (b), (c). Such compounds are useful as haptens and immunogens for the elicitation of antibodies which catalytically enhance the rate of formation or hydrolysis of primary amide bonds. Also described and claimed are methods employing the compounds and antibodies.
摘要翻译： PCT No.PCT / US94 / 04437 371日期：1996年5月4日 102（e）日期1996年5月4日PCT 1994年4月22日PCT PCT。公开号WO94 / 25573 日期：1994年11月10日描述和要求保护的是式（I）化合物，其中Y是多肽，R 1与Y的N末端键合，并且是氢或支链或直链，取代或未取代的C 1-11烷基，烯烃或炔基，R2是天然氨基酸的侧链，X是（a），（b），（c）。这样的化合物可用作引发抗体的半抗原和免疫原，所述抗体催化增强初级酰胺键的形成或水解速率。还描述和要求保护的是使用化合物和抗体的方法。

2. 发明授权

US06258360B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06258360B1
公开(公告)日：2001-07-10
申请号：US08325554
申请日：1994-10-18
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： A61K3944
CPC分类号： C07H15/252 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H19/04 , C07K14/55 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , G01N33/5008 , G01N2500/00
摘要： Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.
摘要翻译：提供由与结合肿瘤细胞群的部分缀合的催化抗体活化并与其缀合的前药。

3. 发明授权

US06702705B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06702705B1
公开(公告)日：2004-03-09
申请号：US08392407
申请日：1995-02-22
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N900
CPC分类号： C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要： Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译：公开了催化抗体。催化抗体对前药化合物是特异性的。催化抗体增强了活性药物部分与前药残留物的切割，从而激活了药物。

4. 发明授权

US5855885A Isolation and production of catalytic antibodies using phage technology 失效
标题翻译：使用噬菌体技术分离和生产催化抗体
公开(公告)号：US5855885A
公开(公告)日：1999-01-05
申请号：US273146
申请日：1994-07-14
申请人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
发明人： Rodger Smith , John McCafferty , David Chiswell , Michael J. Darsley , Kevin Fitzgerald , John H. Kenten , Mark T. Martin , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N9/00 , A61K39/395 , A61K9/00 , A61K38/43
CPC分类号： C12N9/0002
摘要： Disclosed and claimed are methods for producing catalytic antibodies, including human catalytic antibodies, from bacteriophage. The methods require the cloning, selection, screening, and isolation of catalytic antibodies. Also disclosed and claimed are the products themselves, the catalytic antibodies, made from the phage technology. In addition, catalytic antibodies produced from the phage technology and useful in prodrug activation are disclosed and claimed. And finally, the invention also understands the production of catalytic antibodies to phosphonates.
摘要翻译：公开并要求保护的是从噬菌体产生催化抗体，包括人类催化抗体的方法。该方法需要克隆，选择，筛选和分离催化抗体。还公开和要求的是产品本身，由噬菌体技术制成的催化抗体。此外，公开并要求保护从噬菌体技术产生并可用于前药活化的催化抗体。最后，本发明还了解了产生针对膦酸盐的催化抗体。

5. 发明授权

US09505619B2 Graphitic nanotubes in luminescence assays 有权
标题翻译：石墨纳米管在发光测定中
公开(公告)号：US09505619B2
公开(公告)日：2016-11-29
申请号：US11385277
申请日：2006-03-20
申请人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
发明人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
IPC分类号： G01N33/573 , C12Q1/32 , C01B31/02 , B82Y30/00 , B82Y40/00 , C07K17/06 , D01F9/12 , D01F11/14 , G01N33/543 , G01N33/58 , H01M4/60 , G01N21/69 , G01N21/76 , G01N30/88 , G11C13/02
CPC分类号： C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
摘要翻译：石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“buckytubes”）和原纤维，被用作电致化学发光测定中的固体支持物。石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。

6. 发明授权

US09448235B2 Methods and apparatus for improved luminescence assays using microparticles 有权
标题翻译：用于使用微粒改进发光测定的方法和装置
公开(公告)号：US09448235B2
公开(公告)日：2016-09-20
申请号：US12591528
申请日：2009-11-23
申请人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
发明人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
IPC分类号： G01N27/26 , G01N33/543 , B82Y30/00 , C07H21/00 , C12Q1/68 , G01N33/532 , G01N33/533 , G01N33/58
CPC分类号： G01N33/54346 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/54366 , G01N33/5438 , G01N33/552 , G01N33/553 , G01N33/582 , G01N33/587 , G01N2458/30 , C12Q2563/149 , C12Q2563/113 , C12Q2537/125
摘要： A method and apparatus for performing electrochemiluminescence assays are presented. In exemplary embodiments of the present invention an apparatus comprises an ECL-inactive electrode surface having a first assay-ligand immobilized thereon and an ECL-active microparticle having a second assay ligand immobilized thereon. In exemplary embodiments of the present invention a method comprises (a) forming a mixture comprising an electrochemiluminescent label and a microparticle having a first assay-ligand immobilized thereon, (b) applying electrochemical energy to an electrode surface in the presence of said mixture, and (c) measuring emitted electrochemiluminescence, where the microparticle is ECL-active and where the electrode surface is ECL-inactive when electrochemical energy is applied to it in the presence of said mixture.
摘要翻译：提出了一种用于进行电化学发光测定的方法和装置。在本发明的示例性实施方案中，一种装置包括其上固定有第一测定配体的ECL非活性电极表面和其上固定有第二测定配体的ECL活性微粒。在本发明的示例性实施方案中，方法包括（a）形成包含电化学发光标记和其上固定有第一测定配体的微粒的混合物，（b）在所述混合物存在下将电化学能施加到电极表面，以及（c）测量发射的电化学发光，其中微粒是ECL-活性的，并且当在所述混合物的存在下施加电化学能时，电极表面是ECL-无活性的。

7. 发明授权

US06846629B2 Methods and apparatus for improved luminescence assays using microparticles 有权
标题翻译：用于使用微粒改进发光测定的方法和装置
公开(公告)号：US06846629B2
公开(公告)日：2005-01-25
申请号：US09896962
申请日：2001-06-29
申请人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
发明人： George B. Sigal , Jacob N. Wohlstadter , Satyanarayana Gudibande , Mark T. Martin , James L. Wilbur
IPC分类号： C07H21/00 , C12Q1/68 , G01N33/533 , G01N33/543 , G01N33/58 , C07H19/00 , C07H21/04 , C12P19/34 , C07H21/07
CPC分类号： G01N33/54346 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , G01N33/532 , G01N33/533 , G01N33/54306 , G01N33/54366 , G01N33/5438 , G01N33/552 , G01N33/553 , G01N33/582 , G01N33/587 , G01N2458/30 , C12Q2563/149 , C12Q2563/113 , C12Q2537/125
摘要： Microparticles comprising a core and electrochemiluminescent moieties within the core and methods of using the same in assays.
摘要翻译：核心内的核心和核心内的电化学发光部分以及在分析中使用该微粒子的方法。

8. 发明授权

US06177270B1 Reaction-based selection for expression of and concentration of catalytic moieties 失效
标题翻译：用于催化部分的表达和浓缩的基于反应的选择
公开(公告)号：US06177270B1
公开(公告)日：2001-01-23
申请号：US09235353
申请日：1999-01-21
申请人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
发明人： Mark T. Martin , Rodger G. Smith , Michael J. Darsley , David M. Simpson , Gary F. Blackburn
IPC分类号： C12N700
CPC分类号： C40B40/02 , C12N15/1037 , C12Q1/02 , C12Q1/6811 , C12Q1/70 , G01N33/56983
摘要： Disclosed and claimed are methods for selecting a recombinant virus, phage or cell expressing a catalytic antibody or catalytic portion thereof, or for selecting catalytic activity by a moiety. The method employs reaction-based selection for catalytic activity. The method can also be used to concentrate (increase the proportion of catalytic to non-catalytic moieties) a sample containing a catalytic moiety or viruses, phages or cells expressing a catalytic moiety. The selection or concentrating can be by employing a mechanism-based inhibitor, catalysis-accelerated movement, surface binding, changes in enthalpic component of binding as a function of temperature, or changes in binding by competition, or combinations thereof. The invention also comprehends a method for producing a recombinant virus or a cell-line expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof; and, this method can include infecting a suitable host with viruses which are screened for the expression. In addition, recombinant viruses and cell-lines so expressing a catalytic moiety such as a catalytic antibody or catalytic portion thereof are also disclosed and claimed.
摘要翻译：公开并要求的是选择重组病毒，表达催化抗体或其催化部分的噬菌体或细胞，或用于通过部分选择催化活性的方法。该方法采用基于反应的催化活性选择。该方法还可用于浓缩（增加非催化部分的催化剂比例）含有催化部分或表达催化部分的病毒，噬菌体或细胞的样品。选择或浓缩可以通过采用基于机理的抑制剂，催化加速运动，表面结合，作为温度的函数的结合焓分量的变化，或通过竞争的结合变化，或其组合。本发明还包括生产重组病毒或表达催化部分如催化抗体或其催化部分的细胞系的方法; 并且该方法可以包括用筛选表达的病毒感染合适的宿主。此外，还公开和要求保护了重组病毒和表达催化部分如催化抗体或其催化部分的细胞系。

9. 发明授权

US07348182B2 Directed microwave chemistry 失效
标题翻译：定向微波化学
公开(公告)号：US07348182B2
公开(公告)日：2008-03-25
申请号：US10234092
申请日：2002-09-05
申请人： Mark T. Martin , Richard Saul
发明人： Mark T. Martin , Richard Saul
IPC分类号： G01N33/543 , C12M1/00
CPC分类号： C12N13/00 , B01J19/126 , C12N11/00 , G01N1/44 , G01N33/5436 , G01N33/54393 , Y10S436/806 , Y10T436/115831 , Y10T436/116664 , Y10T436/24
摘要： The present invention concerns a novel means by which chemical preparations can be made. Reactions can be accelerated on special chips using microwave energy. The chips contain materials that efficiently absorb microwave energy causing chemical reaction rate increases. The invention is important in many small scale chemical transformations including those used in protein chemistry and in combinatorial chemistry.
摘要翻译：本发明涉及可以制备化学制剂的新型方法。使用微波能量的特殊芯片可以加速反应。这些芯片含有有效吸收微波能量的材料，导致化学反应速率增加。本发明在许多小规模的化学转化中是重要的，包括用于蛋白质化学和组合化学的化学转化。

10. 发明授权

US6165708A Electrochemiluminescent monitoring of compounds 失效
标题翻译：电化学发光监测化合物
公开(公告)号：US6165708A
公开(公告)日：2000-12-26
申请号：US880209
申请日：1997-06-23
申请人： Pam Liang , Mark T. Martin , Liwen Dong
发明人： Pam Liang , Mark T. Martin , Liwen Dong
IPC分类号： C07D499/26 , C12Q1/34 , G01N21/78 , G01N27/327 , G01N27/42 , C12Q1/00
CPC分类号： C12Q1/34 , G01N2333/986 , G01N2415/00 , G01N2458/30 , G01N2458/40
摘要： Detectable compounds comprising a chemically-transformable first compound covalently linked to an electrochemiluminescent compound are provided. Such compounds are useful in processes and kits that monitor the status of the first compound and derive information from such monitoring.
摘要翻译：提供了包含与电化学发光化合物共价连接的可化学转化的第一化合物的可检测化合物。这些化合物可用于监测第一化合物的状态并从这种监测中导出信息的方法和试剂盒。

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