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1. 发明授权

US06702705B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06702705B1
公开(公告)日：2004-03-09
申请号：US08392407
申请日：1995-02-22
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： C12N900
CPC分类号： C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C311/19 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2408 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/4075 , C07F9/5537 , C07F9/650952 , C07F9/657181 , C07H15/252 , C07H19/04 , C07K14/55 , C07K16/00 , C07K16/1063 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , C12Q1/25 , G01N33/5008 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472 , G01N2500/00
摘要： Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.
摘要翻译：公开了催化抗体。催化抗体对前药化合物是特异性的。催化抗体增强了活性药物部分与前药残留物的切割，从而激活了药物。

2. 发明授权

US06258360B1 Prodrugs activated by targeted catalytic proteins 失效
标题翻译：由靶向催化蛋白激活的前药
公开(公告)号：US06258360B1
公开(公告)日：2001-07-10
申请号：US08325554
申请日：1994-10-18
申请人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
发明人： Reid von Borstel , Jan M. Casadei , Balreddy Kamireddy , John Henry Kenten , Mark T. Martin , Richard J. Massey , Andrew D. Napper , David M. Simpson , Rodger G. Smith , Richard C. Titmas , Richard O. Williams
IPC分类号： A61K3944
CPC分类号： C07H15/252 , C07C311/19 , C07F9/2408 , C07F9/2458 , C07F9/4006 , C07F9/4075 , C07F9/650952 , C07F9/657181 , C07H19/04 , C07K14/55 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2319/00 , C12N9/0002 , G01N33/5008 , G01N2500/00
摘要： Prodrugs that are activated by and conjugated to a catalytic antibody conjugated to a moiety that binds to a tumor cell population are provided.
摘要翻译：提供由与结合肿瘤细胞群的部分缀合的催化抗体活化并与其缀合的前药。

3. 发明授权

US5593969A Lipid-A analogs: monosaccharide and dissaccharide compounds for inhibiting binding of lipid A receptors to lipid A receptors 失效
标题翻译：脂质-A类似物：用于抑制脂质A受体与脂质A受体结合的单糖和非糖化合物
公开(公告)号：US5593969A
公开(公告)日：1997-01-14
申请号：US123590
申请日：1993-09-17
申请人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
发明人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
IPC分类号： A61K38/00 , C07H13/06 , C07H15/04 , C07K16/12 , A61K31/70 , C07H3/02 , C07H3/04
CPC分类号： C07H13/06 , C07H15/04 , C07K16/1203 , A61K38/00
摘要： A compound of the formula: ##STR1## wherein: each of R.sub.1, R.sub.1 ', R.sub.2 and R.sub.2 ' independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group, R.sub.3 is OH, OCH.sub.3, CH.sub.2 COOH or ##STR2## wherein each of R.sub.2" and R.sub.2 '41 independent of each other is a substituted or unsubstituted, branched or linear C.sub.1-12 alkyl, alkene or alkyne group and:A=NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3, orA=OH, X=P(OH), X=Z=C, B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=P(OH), Y=Z=C, B=OCH.sub.3,wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=P(OH), Y=Z=C, B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, orA=OH, X=Z=C, Y=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Z=C, Y=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Z=C, Y=P(OH), B=(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-11, orA=NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, orA=OH, X=Y=C, Z=P(OH), B (if present)=OCH.sub.3, orA=OCO(CH.sub.2).sub.n NH.sub.2, X=Y=C, Z=P(OH), B=OCH.sub.3, wherein n=1-10, orA=OH, X=Y=C, Z=P(OH), B=O(CH.sub.2).sub.n CO.sub.2 H, wherein n=1-10, orA=OH, X=Y=C, Z=P (OH), B=(CH.sub.2).sub.n CO.sub.2 H and n=1-11 is disclosed. The compounds may be use to inhibit binding of Lipid A to Lipid A receptors.
摘要翻译：下式的化合物：其中：R 1，R 1'，R 2和R 2'彼此独立地为取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，R 3为 OH，OCH 3，CH 2 COOH或者其中每个R 2“和R 21'彼此独立地是取代或未取代的支链或直链C 1-12烷基，烯烃或炔基，并且：A = NH 2，X = P （OH），Y = Z = C，B = OCH 3或A = OH，X = P（OH），X = Z = C，B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = P（OH），Y = Z = C，B = OCH 3，其中n = 1-10，或A = OH，X = P（OH），Y = Z = C，B = O（CH 2）n CO 2 H，其中 n = 1-10，或A = OH，X = P（OH），Y = Z = C，B =（CH2）nCO2H，其中n = 1-10，或A = NH2，X = Z = C，Y = P（OH），B = OCH3或A = OH，X = Z = C，Y = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Z = C ，Y = P（OH），B = OCH 3，其中n = 1-10，或A = OH，X = Z = C，Y = P（OH），B = O（CH 2）n CO 2 H，其中n = 10或A = OH，X = Z = C，Y = P（OH），B =（CH2）nCO2H，其中n = 1-11或A = NH2，X = Y = C，Z = P ），B = OCH 3或A = OH，X = Y = C，Z = P（OH），B（如果存在）= OCH 3或A = OCO（CH 2）n NH 2，X = Y = C，Z = P （OH），B = OCH 3，其中n = 1-10，或A = OH，X = Y = C，Z = P（OH），B = O（CH 2）n CO 2 H，其中n = 1-10，或A = OH，X = Y = C ，Z = P（OH），B =（CH2）nCO2H和n = 1-11。该化合物可用于抑制脂质A与脂质A受体的结合。

4. 发明授权

US5597573A Lipid-A analogs: new monosaccharide and disaccharide intermediates for eliciting therapeutic antibodies and for antitumor and antiviral activities 失效
标题翻译：脂类-A类似物：用于引发治疗性抗体和抗肿瘤和抗病毒活性的新单糖和二糖中间体
公开(公告)号：US5597573A
公开(公告)日：1997-01-28
申请号：US405438
申请日：1995-03-14
申请人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
发明人： Balreddy Kamireddy , Michael J. Darsley , David M. Simpson , Richard J. Massey
IPC分类号： A61K38/00 , C07H13/06 , C07H15/04 , C07K16/12 , A61K39/02 , A61K31/70 , C07H17/02
CPC分类号： C07H13/06 , C07H15/04 , C07K16/1203 , A61K38/00
摘要： The present invention relates to novel amidine components of formula (II): ##STR1## A method for eliciting antibodies in an animal which bind to Lipid A or LPS comprising administering to the animal as an immunogen a composition comprising such a compound is also disclosed.
摘要翻译：本发明涉及式（II）的新型脒组分：（II）在结合脂质A或LPS的动物中引发抗体的方法，包括向动物作为免疫原施用包含这种化合物的组合物也披露。

5. 发明授权

US5952462A Transition state analogs 失效
标题翻译：过渡状态类比
公开(公告)号：US5952462A
公开(公告)日：1999-09-14
申请号：US333237
申请日：1994-11-02
申请人： Michael J. Powell , Richard C. Titmas , Richard J. Massey
发明人： Michael J. Powell , Richard C. Titmas , Richard J. Massey
IPC分类号： C07C237/22 , C07K16/10 , C12N9/00 , C12Q1/25 , C07K5/12 , A61K38/12
CPC分类号： B82Y5/00 , C07C237/22 , C07K16/1063 , C12N9/0002 , C12Q1/25 , G01N2333/16 , G01N2333/96472
摘要： Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon and boron containing compounds. Antibodies which are catalytically active for chemical reactions, in particular, the cleavage or formation of a selected peptide linkage or an ester bond, and which are elicited by such antigens are disclosed as well as methods for producing the antibodies and methods for catalyzing the cleavage or formation of a peptide linkage or in ester bond in a molecule.
摘要翻译：公开了能够引发抗体的抗原，其可以催化化学反应，特别是包含半抗原或半抗原和合适的载体分子的肽键的切割或形成。除了其他之外，半抗原包括含有硅和硼的化合物。公开了对于化学反应具有催化活性的抗体，特别是选择的肽键或酯键的切割或形成，并且由这些抗原引发的抗体以及用于产生抗体的方法和用于催化切割的方法在分子中形成肽键或酯键。

6. 发明授权

US06946272B1 Transition state analogs 失效
标题翻译：过渡状态类比
公开(公告)号：US06946272B1
公开(公告)日：2005-09-20
申请号：US09303716
申请日：1999-04-30
申请人： Michael J. Powell , Richard C. Titmas , Richard J. Massey
发明人： Michael J. Powell , Richard C. Titmas , Richard J. Massey
IPC分类号： C12P1/00 , C07B61/00 , C07K16/10 , C07K16/42 , C07K16/44 , C12N5/10 , C12N9/00 , C12N15/02 , C12P13/22 , C12P17/10 , C12P19/02 , C12P19/04 , C12P19/34 , C12P21/00 , C12P21/06 , C12P21/08 , C12P41/00 , C12Q1/25 , C12R1/91 , G01N33/535 , G01N33/542
CPC分类号： C07K16/1063 , B82Y5/00 , C07K16/4241 , C07K16/44 , C12N9/0002 , C12P1/00 , C12P13/227 , C12P17/10 , C12P19/34 , C12P41/004 , C12Q1/25 , G01N33/535 , G01N33/542 , G01N2333/16 , G01N2333/96472
摘要： Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon and boron containing compounds. Antibodies which are catalytically active for chemical reactions, in particular, the cleavage or formation of a selected peptide linkage or an ester bond, and which are elicited by such antigens are disclosed as well as methods for producing the antibodies and methods for catalyzing the cleavage or formation of a peptide linkage or in ester bond in a molecule.
摘要翻译：公开了能够引发抗体的抗原，其可以催化化学反应，特别是包含半抗原或半抗原和合适的载体分子的肽键的切割或形成。除了其他之外，半抗原包括含有硅和硼的化合物。公开了对于化学反应具有催化活性的抗体，特别是选择的肽键或酯键的切割或形成，并且由这些抗原引发的抗体以及用于产生抗体的方法和用于催化切割的方法在分子中形成肽键或酯键。

7. 发明授权

US06521432B1 Methods for enhancing the rate of modification of metastable bonds 失效
标题翻译：提高亚稳态修饰速率的方法
公开(公告)号：US06521432B1
公开(公告)日：2003-02-18
申请号：US08479849
申请日：1995-06-07
申请人： Michael J. Powell , Anthony R. Rees , Paul M. Booth , Wonpyo Hong , Richard C. Titmas , Richard J. Massey
发明人： Michael J. Powell , Anthony R. Rees , Paul M. Booth , Wonpyo Hong , Richard C. Titmas , Richard J. Massey
IPC分类号： C12N900
CPC分类号： C07D207/404 , C07C229/46 , C07C229/48 , C07C235/74 , C07C271/24 , C07C311/06 , C07C317/44 , C07C2601/04 , C07C2602/42 , C07D205/085 , C07F9/2458 , C07F9/301 , C07F9/3211 , C07F9/4006 , C07F9/5537 , C07K7/02 , C07K14/005 , C07K16/00 , C07K16/1063 , C07K16/241 , C07K16/4291 , C12N9/0002 , C12N2740/16122 , C12Q1/25 , G01N33/531 , G01N33/577 , G01N2333/16 , G01N2333/96472
摘要： Antigens capable of eliciting antibodies which can enhance the rate of chemical reactions at peptide bonds are disclosed. In particular, the rate of cleavage or formation of metastable peptide bonds, such as ASN-X, ASP-X, GLN-X, GLU-X, LYS-X, and HIS-Y-X, where X and Y are any amino acid, is enhanced by antibodies elicited by said antigen.
摘要翻译：公开了能够引发可增加肽键化学反应速率的抗体的抗原。特别地，其中X和Y是任何氨基酸的亚稳态肽键的切割或形成速率，例如ASN-X，ASP-X，GLN-X，GLU-X，LYS-X和HIS-YX，由所述抗原引起的抗体增强。

8. 发明授权

US6057121A Method of catalyzing stereochemical reactions 失效
标题翻译：催化立体化学反应的方法
公开(公告)号：US6057121A
公开(公告)日：2000-05-02
申请号：US478954
申请日：1995-06-07
申请人： Richard J. Massey , Michael J. Powell , Richard C. Titmas
发明人： Richard J. Massey , Michael J. Powell , Richard C. Titmas
IPC分类号： C07K16/10 , C12N9/00 , C12P1/00 , C12P13/22 , C12P17/10 , C12P19/34 , C12P21/08 , C12P41/00 , C12Q1/25
CPC分类号： B82Y5/00 , C07K16/1063 , C12N9/0002 , C12P1/00 , C12P13/227 , C12P17/10 , C12P19/34 , C12P41/004 , C12Q1/25 , G01N2333/16 , G01N2333/96472
摘要： A method for increasing the rate of a chemical reaction involving conversion of at least one reactant to at least one product which comprises contacting the reactant with at least one appropriate monoclonal antibody to the reactant under suitable conditions permitting formation of a complex between the monoclonal antibody and the reactant, conversion of the reactant to the product and release of the product from the complex, the monoclonal antibody being characterized by a K>1, where K=k.sub.r /k.sub.p, k.sub.r is the affinity constant of the monoclonal antibody for the reactant and k.sub.p is the affinity constant of the monoclonal antibody for the product, by an r.sub.1 >r.sub.0, where r.sub.1 is the rate of formation of the complex between the antibody and the reactant and where r.sub.0 is the rate of the chemical reaction in the absence of monclonal antibody, by an r.sub.2 >r.sub.0, where r.sub.2 is the rate of the conversion of the complexed reactant to the complexed product and by an r.sub.3 >r.sub.0, where r.sub.3 is the rate of release of the product from the complex.
摘要翻译：一种用于增加涉及将至少一种反应物转化为至少一种产物的化学反应速率的方法，该方法包括使反应物与至少一种合适的单克隆抗体在合适的条件下接触，从而允许单克隆抗体和反应物，反应物向产物的转化和产物从复合物的释放，单克隆抗体的特征在于K> 1，其中K = kr / kp，kr是单克隆抗体对于反应物的亲和常数， kp是单克隆抗体对产物的亲和常数，通过r1> r0，其中r1是抗体和反应物之间复合物的形成速率，其中r0是在没有单克隆的情况下化学反应的速率抗体，r2> r0，其中r2是复合反应物转化为络合产物的速率和r3> r0，其中r3是产物释放速率从复杂。

9. 发明授权

US09505619B2 Graphitic nanotubes in luminescence assays 有权
标题翻译：石墨纳米管在发光测定中
公开(公告)号：US09505619B2
公开(公告)日：2016-11-29
申请号：US11385277
申请日：2006-03-20
申请人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
发明人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
IPC分类号： G01N33/573 , C12Q1/32 , C01B31/02 , B82Y30/00 , B82Y40/00 , C07K17/06 , D01F9/12 , D01F11/14 , G01N33/543 , G01N33/58 , H01M4/60 , G01N21/69 , G01N21/76 , G01N30/88 , G11C13/02
CPC分类号： C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
摘要翻译：石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“buckytubes”）和原纤维，被用作电致化学发光测定中的固体支持物。石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。

10. 发明授权

US06362011B1 Graphitic nanotubes in luminescence assays 有权
标题翻译：石墨纳米管在发光测定中
公开(公告)号：US06362011B1
公开(公告)日：2002-03-26
申请号：US09243215
申请日：1999-02-02
申请人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
发明人： Richard J. Massey , Mark T. Martin , Liwen Dong , Ming Lu , Alan Fischer , Fabian Jameison , Pam Liang , Robert Hoch , Jonathan K. Leland
IPC分类号： G01N33551
CPC分类号： C01B31/0213 , B82Y30/00 , B82Y40/00 , C01B32/152 , C01B32/174 , C01B2202/34 , C01B2202/36 , C07K17/06 , D01F9/12 , D01F11/14 , G01N21/69 , G01N21/76 , G01N33/54373 , G01N33/5438 , G01N33/582 , G01N2030/8863 , G11C13/025 , H01M4/60 , Y10S435/968 , Y10S436/805 , Y10S436/806 , Y10S977/737 , Y10S977/742
摘要： Graphitic nanotubes, which include tubular fullerenes (commonly called “buckytubes”) and fibrils, which are functionalized by chemical substitution, are used as solid supports in electrogenerated chemiluminescence assays. The graphitic nanotubes are chemically modified with functional group biomolecules prior to use in an assay. Association of electrochemiluminescent ruthenium complexes with the functional group biomolecule-modified nanotubes permits detection of molecules including nucleic acids, antigens, enzymes, and enzyme substrates by multiple formats.
摘要翻译：石墨纳米管，其包括通过化学取代官能化的管状富勒烯（通常称为“巴氏管”）和原纤维，被用作电致化学发光测定中的固体支持物。石墨纳米管在用于测定之前用官能团生物分子进行化学修饰。电化学发光钌络合物与官能团生物分子修饰的纳米管的关联允许通过多种形式检测包括核酸，抗原，酶和酶底物的分子。

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