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1. 发明授权

US06830914B2 RGS-containing molecules and uses thereof 失效
标题翻译：含RGS的分子及其用途
公开(公告)号：US06830914B2
公开(公告)日：2004-12-14
申请号：US09894749
申请日：2001-06-27
申请人： Martin R. Hodge , David Yowe
发明人： Martin R. Hodge , David Yowe
IPC分类号： C12N900
CPC分类号： C07K14/4702 , A61K38/00 , C07K2319/00 , Y02A50/411
摘要： Novel RGS polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length RGS proteins, the invention further provides isolated RGS fusion proteins, antigenic peptides, and anti-RGS antibodies. The invention also provides RGS nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an RGS gene has been introduced or disrupted. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：公开了新的RGS多肽，蛋白质和核酸分子。除了分离的全长RGS蛋白之外，本发明还提供了分离的RGS融合蛋白，抗原肽和抗RGS抗体。本发明还提供了RGS核酸分子，含有本发明的核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及RGS基因导入或破坏的非人类转基因动物。还提供了利用本发明组合物的诊断，筛选和治疗方法。

2. 发明授权

US06830913B1 ABCB9 transporter and uses thereof 失效
标题翻译： ABCB9转运蛋白及其用途
公开(公告)号：US06830913B1
公开(公告)日：2004-12-14
申请号：US09724653
申请日：2000-11-28
申请人： Victor Ling , Michelle L. Pollard , Bruce P. Connop , Fang Zhang
发明人： Victor Ling , Michelle L. Pollard , Bruce P. Connop , Fang Zhang
IPC分类号： C12N900
CPC分类号： C07K14/705 , A01K2217/05 , C07K2319/00
摘要： The invention provides isolated nucleic acid molecules, designated ABCB9 transporter nucleic acid molecules, which encode novel ABC transporter family members. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing ABCB9 transporter nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which an ABCB9 transporter gene has been introduced or disrupted. The invention still further provides isolated ABCB9 transporter proteins, fusion proteins, antigenic peptides, anti-ABCB9 transporter antibodies, and screening assays for ABCB9 transporter modulators. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供编码新型ABC转运蛋白家族成员的分离的核酸分子，称为ABCB9转运蛋白核酸分子。本发明还提供了反义核酸分子，含有ABCB9转运蛋白核酸分子的重组表达载体，其中引入了表达载体的宿主细胞，以及已导入或破坏了ABCB9转运蛋白基因的非人转基因动物。本发明还进一步提供分离的ABCB9转运蛋白，融合蛋白，抗原肽，抗ABCB9转运蛋白抗体以及用于ABCB9转运蛋白调节剂的筛选测定。还提供了利用本发明组合物的诊断和治疗方法。

3. 发明授权

US06808706B1 Method for keeping the quality of aqueous parenteral solution of thrombomodulin in storage and distribution 失效
标题翻译：保持血栓调节素水溶液的质量的方法
公开(公告)号：US06808706B1
公开(公告)日：2004-10-26
申请号：US09509994
申请日：2000-05-08
申请人： Masaki Yui , Akira Yokozawa , Tomoyo Murata , Kazuhisa Tsuruta , Hirotomo Shimizu
发明人： Masaki Yui , Akira Yokozawa , Tomoyo Murata , Kazuhisa Tsuruta , Hirotomo Shimizu
IPC分类号： C12N900
CPC分类号： A61K9/0019 , A61K38/00 , A61K47/02 , A61K47/12 , A61K47/26 , A61K47/44 , C07K14/7455 , Y10S514/822
摘要： A method for keeping the quality of an aqueous parenteral solution of thrombomodulin which is not in a frozen or freeze-dried state but in a liquid form in storage and distribution, characterized in that the aqueous thrombomodulin solution containing an effective amount of soluble thrombomodulin and a buffer component exhibiting a buffering activity in a pH range of 5 to 7.0 has a pH of 5 to 7.0 and that (a) the aqueous thrombomodulin solution further contains a surfactant and is in a state aseptically filled into a case or (b) the aqueous thrombomodulin solution is the form of a prefilled syringe preparation produced by aseptically filling the thrombomodulin solution into a syringe substantially without any empty space. This method provides for the storage and distribution of an aqueous parenteral solution of thrombomodulin in a liquid state for a prolonged period and makes it possible to provide an aqueous parenteral solution which is excellent in long-term stability and shaking stability and can save the trouble of dissolving in use.
摘要翻译：一种保持不是冷冻或冷冻干燥状态而是液体形式的血栓调节蛋白的水性肠胃外溶液的储存和分配的质量的方法，其特征在于含有有效量的可溶性血栓调节蛋白和在5〜7.0的pH范围内表现出缓冲活性的缓冲成分的pH为5〜7.0，（a）血栓调节素水溶液还含有表面活性剂，处于无菌填充状态的状态，或（b）血栓调节蛋白溶液是通过将基本上没有任何空白空间无菌地将血栓调节蛋白溶液注入注射器而制备的预充式注射器制剂的形式。该方法提供长时间稳定的液体状态的血栓调节蛋白的肠胃外水溶液的储存和分配，能够提供长期稳定性和摇晃稳定性优异的水性肠胃外溶液，并且可以节省溶于使用。

4. 发明授权

US06780624B2 Glycosyltransferases for biosynthesis of oligosaccharides, and genes encoding them 失效
标题翻译：用于寡糖生物合成的糖基转移酶和编码它们的基因
公开(公告)号：US06780624B2
公开(公告)日：2004-08-24
申请号：US10007267
申请日：2001-12-03
申请人： Emil C. Gotschlich
发明人： Emil C. Gotschlich
IPC分类号： C12N900
CPC分类号： C07K14/22 , C12N9/1048 , C12N9/1051 , C12P19/18
摘要： The present invention is directed to nucleic acids encoding glycosyltransferases, the proteins encoded thereby, and to methods for synthesizing oligosaccharides using the glycosyltransferases of the invention. In particular, the present application is directed to identification a glycosyltransferase locus of Neisseria gonorrhoeae containing five open reading frames for five different glycosyltransferases. The functionally active glycosyltransferases of the invention are characterized by catalyzing reactions such as adding Gal &bgr;1→4 to GlcNAc or Glc; adding GalNAc or GlcNAc &bgr;1→3 to Gal; and adding Gal &agr;1→4 to Gal. The glycosyltransferases of the invention are particularly suited to the synthesis of the oligosaccharides Gal&bgr;1→4GlcNAc&bgr;1→3Gal&bgr;1→4Glc (a mimic of lacto-N-neotetraose), GalNAc&bgr;1→3Gal&bgr;1→4GlcNAc&bgr;1→3Gal&bgr;1→4Glc&bgr;1→4 (a mimic ganglioside), and Gal&agr;1→4Gal&bgr;1→4Glc&bgr;1→4Hep→R (a mimic of the saccharide portion of globo-glycolipids).
摘要翻译：本发明涉及编码糖基转移酶的核酸，由此编码的蛋白质，以及使用本发明的糖基转移酶合成寡糖的方法。特别地，本申请涉及鉴定含有五个不同糖基转移酶的五个开放阅读框的淋病奈瑟氏球菌的糖基转移酶基因座。本发明的功能活性糖基转移酶的特征在于催化反应，例如向GlcNAc或Glc加入Galβ1-4; 将GalNAc或GlcNAcβ1-> 3加入Gal; 并将Galα1-> 4加入Gal。本发明的糖基转移酶特别适用于寡糖Galbeta1→4GlcNAcβ1→3Galβ1→4Glc（乳-N-新四糖的模拟），GalNAcβ1→3Galβ1→4GlcNAcβ1→3Galβ1→4Glcbeta1→ 4（模拟神经节苷脂）和Galalpha1->4Galβ1→4Glcbeta1-> 4Hep-> R（模拟糖尿糖的糖部分）。

5. 发明授权

US06743616B2 Highly productive alpha-amylases 失效
标题翻译：高生产力的α-淀粉酶
公开(公告)号：US06743616B2
公开(公告)日：2004-06-01
申请号：US09971611
申请日：2001-10-09
申请人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
发明人： Hiroyuki Araki , Keiji Endo , Hiroshi Hagihara , Kazuaki Igarashi , Yasuhiro Hayashi , Katsuya Ozaki
IPC分类号： C12N900
CPC分类号： C12N9/2417 , C11D3/386
摘要： The invention relates to mutant &agr;-amylases that may be produced at high yield from recombinant microorganisms.
摘要翻译：本发明涉及可以从重组微生物以高产率产生的突变型α-淀粉酶。

6. 发明授权

US06720170B2 Pesticide microemulsions and dispersant/penetrant formulations 失效
标题翻译：农药微乳液和分散剂/渗透剂配方
公开(公告)号：US06720170B2
公开(公告)日：2004-04-13
申请号：US09826559
申请日：2001-04-04
申请人： Bryan Hiromoto
发明人： Bryan Hiromoto
IPC分类号： C12N900
CPC分类号： A01N63/00 , A01N25/04 , A01N25/30 , A01N43/16 , A01N61/00 , A01N63/02 , A01N63/04 , A01N2300/00 , A01N37/06
摘要： A clear aqueous emulsion of a complex comprising a moiety having a hydrophilic core to which is covalently bound the backbone of at least one monounsaturated C16-C20 fatty acid and appropriate surfactants is effective in controlling agricultural pests, including nematodes.
摘要翻译：包含具有亲水核心部分的共价键的共价结合至少一种单不饱和C 16 -C 20脂肪酸的主链和适当的表面活性剂的透明水性乳液可有效地控制包括线虫在内的农业害虫。

7. 发明授权

US06645745B1 Identification of a new member of the cytochrome P450 3A (CYP3A) gene family: CYP3AX 有权
标题翻译：鉴定细胞色素P450 3A（CYP3A）基因家族的新成员：CYP3AX
公开(公告)号：US06645745B1
公开(公告)日：2003-11-11
申请号：US09583447
申请日：2000-05-30
申请人： Leszek Wojnowski , Klaus Gellner , Regina Eiselt
发明人： Leszek Wojnowski , Klaus Gellner , Regina Eiselt
IPC分类号： C12N900
CPC分类号： C12N9/0077 , A01K2217/05 , C40B40/00
摘要： The present invention relates to polynucleotides encoding the CYP3AX protein and variants thereof. Further, the present invention also provides vectors comprising said polynucleotides, in particular vectors, wherein polynucleotides of the present invention are operatively linked to regulatory elements allowing expression in prokaryotic and/or eukaryotic host cells. In addition, the present invention relates to proteins encoded by said polynucleotides and antibodies specifically recognizing such proteins. The present invention also concerns transgenic non-human animals comprising the above-described polynucleotide or vectors. Moreover, the present invention relates to methods for identifying and obtaining drug candidates and inhibitors for therapy of disorders related to the malfunction of the CYP3AX genes as well as to methods of diagnosing the status of such disorders. The present invention also relates to methods for the identification of molecular variants of the CYP3AX polynucleotide or protein. The present invention furthermore provides pharmaceutical and diagnostic compositions comprising the above-described polynucleotides, vectors, proteins, antibodies, drugs and inhibitors obtainable by the above-described method. Said compositions are particularly useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of CYP3AX genes or their product.
摘要翻译：本发明涉及编码CYP3AX蛋白的多核苷酸及其变体。此外，本发明还提供了包含所述多核苷酸，特别是载体的载体，其中本发明的多核苷酸可操作地连接到允许在原核和/或真核宿主细胞中表达的调节元件。此外，本发明涉及由所述多核苷酸编码的蛋白质和特异性识别这些蛋白质的抗体。本发明还涉及包含上述多核苷酸或载体的转基因非人动物。此外，本发明涉及用于鉴定和获得药物候选物的方法和用于治疗与CYP3AX基因故障相关的疾病的抑制剂以及诊断这些病症状态的方法。本发明还涉及用于鉴定CYP3AX多核苷酸或蛋白质的分子变体的方法。本发明还提供包含上述多核苷酸，载体，蛋白质，抗体，药物和可通过上述方法获得的抑制剂的药物和诊断组合物。所述组合物特别可用于利用作为CYP3AX基因的底物，抑制剂或调节剂或其产物的药物来诊断和治疗各种疾病。

8. 发明授权

US06607901B1 Alkaline alpha-galactosidase 失效
标题翻译：碱性α-半乳糖苷酶
公开(公告)号：US06607901B1
公开(公告)日：2003-08-19
申请号：US09744086
申请日：2001-04-25
申请人： Arthur Schaffer , Gao Zhifang
发明人： Arthur Schaffer , Gao Zhifang
IPC分类号： C12N900
CPC分类号： C12N9/2465 , A23C11/106 , A23L11/33 , A23L29/06 , C12Y302/01022
摘要： An enzyme isolated from an organism that metabolizes alpha-galactosyl containing saccharides, comprising an alpha-galactosidase (E.C. 3.2.1.22, alpha-D-galactoside galatohydrolase) with optimal activity in the neutral to alkaline pH range, and which hydrolyzes a variety of alpha-galactose containing saccharides, in particular raffinose. The enzyme is preferably a protein monomer and an ex-alpha-galactosidase.
摘要翻译：从生物体中分离的酶代谢含有α-半乳糖基的糖类的酶，其包含在中性至碱性pH范围内具有最佳活性的α-半乳糖苷酶（EC 3.2.1.22，α-D-半乳糖苷加氢水解酶），并且其水解各种α 含半乳糖的糖类，特别是棉子糖。酶优选为蛋白质单体和ex-α-半乳糖苷酶。

9. 发明授权

US06582945B1 Immunological control of &bgr;-amyloid levels in vivo 有权
标题翻译：体内β-淀粉样蛋白水平的免疫控制
公开(公告)号：US06582945B1
公开(公告)日：2003-06-24
申请号：US09594366
申请日：2000-06-15
申请人： Victor Raso
发明人： Victor Raso
IPC分类号： C12N900
CPC分类号： C07K16/18 , A61K38/00 , A61K39/0007 , A61K39/3955 , C07K2317/34 , C12N9/0002 , Y10S977/729 , Y10S977/896 , Y10S977/915 , Y10S977/918
摘要： Disclosed are antibodies which catalyze hydrolysis of &bgr;-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using &bgr;-amyloid peptides which incorporate transition state analogs are also provided. Also disclosed is a vectorized antibody which is characterized by the ability to cross the blood brain barrier, and is further characterized by the ability to catalyze the hydrolysis of &bgr;-amyloid. The vectorized antibody can take the form of a bispecific antibody, which has a first specificity for the transferrin receptor and a second specificity for a transition state adopted by &bgr;-amyloid during hydrolysis.
摘要翻译：公开了催化β-淀粉样蛋白水解的抗体。产生的抗体的特征在于它们水解的酰胺键。还提供了通过使用结合过渡态类似物的β-淀粉样肽产生抗体的方法。还公开了一种载体化抗体，其特征在于穿过血脑屏障的能力，其特征还在于催化β-淀粉样蛋白的水解的能力。载体化抗体可以采用双特异性抗体的形式，其具有转铁蛋白受体的第一特异性，并且在水解期间由β-淀粉样蛋白所采用的过渡态的第二特异性。

10. 发明授权

US06562606B1 Methods and compositions for disrupting the epithelial barrier function 失效
标题翻译：破坏上皮屏障功能的方法和组合物
公开(公告)号：US06562606B1
公开(公告)日：2003-05-13
申请号：US09608568
申请日：2000-06-30
申请人： Peter M. Elias , Kenneth R. Feingold , Walter M. Holleran
发明人： Peter M. Elias , Kenneth R. Feingold , Walter M. Holleran
IPC分类号： C12N900
CPC分类号： A61K31/70 , A61K9/0014 , A61K31/01 , A61K31/13 , A61K31/20 , A61K31/365 , A61K31/495 , A61K31/575 , A61K31/66 , A61K38/09 , A61K45/06 , A61K47/12 , A61K47/18 , A61K47/183 , A61K47/22 , A61K47/26 , A61K47/28 , Y10S514/946 , Y10S514/947
摘要： A method for disrupting epithelial barrier function in a host in need of the topical administration of a physiologically active substance which comprises applying to the epithelium of the host, barrier-disrupting amount of at least one agent selected from the group consisting of an inhibitor of ceramide synthesis, inhibitor of acylceramide synthesis, inhibitor of glucosylceramide synthesis, and inhibitor of sphingomyelin synthesis, an inhibitor of fatty acid synthesis, an inhibitor of cholesterol synthesis, a degradation enzyme of ceramides, acylceramide, glucosylceramides, sphingomyelin, an inhibitor of phospholipid, glycosphingolipid, including glucosylceramide, acylceramide or sphingomyelin degradation, and both inhibitors and stimulators of metabolic enzymes of free fatty acids, ceramide, and cholesterol, as well as a topical composition useful therefor are disclosed.
摘要翻译：一种用于破坏需要局部施用生理活性物质的宿主中的上皮屏障功能的方法，其包括向所述宿主的上皮施用屏障破坏量的至少一种选自神经酰胺抑制剂的药剂合成抑制剂，糖基神经酰胺合成抑制剂，鞘磷脂合成抑制剂，脂肪酸合成抑制剂，胆固醇合成抑制剂，神经酰胺降解酶，酰基神经酰胺，葡糖基神经酰胺，鞘磷脂，磷脂抑制剂，鞘糖脂，包括葡萄糖神经酰胺，酰基神经酰胺或鞘磷脂降解，以及游离脂肪酸，神经酰胺和胆固醇的代谢酶的抑制剂和刺激剂以及其有用的局部组合物。

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