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    • 5. 发明授权
    • Shaping of microparticles in electric-field cages
    • 电场笼中微粒的形成
    • US5948328A
    • 1999-09-07
    • US700395
    • 1996-08-23
    • Stefan FiedlerAndreas VoigtThomas SchnelleGuenter FuhrTorsten MuellerRolf HagedornJan HornungHenning GlasserBernd Wagner
    • Stefan FiedlerAndreas VoigtThomas SchnelleGuenter FuhrTorsten MuellerRolf HagedornJan HornungHenning GlasserBernd Wagner
    • B01J2/00B01J13/02B01J19/08
    • B01J13/02B01J19/087B01J2/00
    • In the method proposed, microparticles suspended in a liquid or droplets suspended in a liquid with which they are immiscible are shaped by high-frequency electric fields in a three-dimensional electrode array of a size in the micrometer or submicrometer range and subsequently consolidated by prior art chemical bonding procedures or by physical methods. The disposition, geometry and control of the electrodes determine the shape of the particles. The particles themselves must have a conductivity and/or relative dielectric constant lower than the solution surrounding them. For some, this can be achieved only at certain frequencies in the kHz and MHz band which are determined by the passive electrical properties of the particles and the surrounding solution. The particles or droplets are repelled by the electrodes so that they are shaped in the free solution without making contact with any surface and can then be consolidated. This makes it possible to shape micrometer and submicrometer size particles of the kind required in chromatography, affinity biochemistry and medicine, as well as for filter systems.
    • PCT No.PCT / DE95 / 00237 Sec。 371日期:1996年8月23日 102(e)日期1996年8月23日PCT提交1995年2月23日PCT公布。 WO95 / 23020 PCT公开号 日期1995年8月31日在所提出的方法中,悬浮在液体中的微粒悬浮在与其不混溶的液体中的微滴通过在微米或亚微米范围内的尺寸的三维电极阵列中的高频电场 并随后通过现有技术的化学键合方法或通过物理方法进行固结。 电极的布置,几何形状和控制决定了颗粒的形状。 颗粒本身必须具有低于围绕它们的溶液的导电性和/或相对介电常数。 对于一些,这只能在通过颗粒和周围溶液的被动电特性确定的kHz和MHz频带的某些频率下实现。 颗粒或液滴被电极排斥,使得它们在游离溶液中成形,而不与任何表面接触,然后可以被固结。 这使得可以形成色谱,亲和力生物化学和药物所需类型的微米和亚微米尺寸的颗粒,以及过滤系统。