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1. 发明申请

US20100193680A1 Mass Spectrometry 有权
标题翻译：质谱
公开(公告)号：US20100193680A1
公开(公告)日：2010-08-05
申请号：US12762140
申请日：2010-04-16
申请人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： H01J49/26
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

2. 发明授权

US08278619B2 Mass spectrometry 有权
标题翻译：质谱
公开(公告)号：US08278619B2
公开(公告)日：2012-10-02
申请号：US12762140
申请日：2010-04-16
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

3. 发明授权

US07728288B2 Mass spectrometry 有权
标题翻译：质谱
公开(公告)号：US07728288B2
公开(公告)日：2010-06-01
申请号：US11909857
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

4. 发明申请

US20080191129A1 Mass Spectrometry 有权
标题翻译：质谱
公开(公告)号：US20080191129A1
公开(公告)日：2008-08-14
申请号：US11909857
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

5. 发明授权

US07847243B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US07847243B2
公开(公告)日：2010-12-07
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

6. 发明申请

US20110057099A1 ION TRAPPING 有权
标题翻译：离子捕捉
公开(公告)号：US20110057099A1
公开(公告)日：2011-03-10
申请号：US12944357
申请日：2010-11-11
申请人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/04
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

7. 发明申请

US20080156984A1 Ion Trapping 有权
标题翻译：离子捕获
公开(公告)号：US20080156984A1
公开(公告)日：2008-07-03
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

8. 发明授权

US07612335B2 Method and apparatus for ion fragmentation by electron capture 有权
标题翻译：通过电子捕获离子碎裂的方法和装置
公开(公告)号：US07612335B2
公开(公告)日：2009-11-03
申请号：US10592744
申请日：2005-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung
IPC分类号： H01J49/26
CPC分类号： H01J49/0054
摘要： The present invention relates to a method and apparatus for ion fragmentation by electron capture. The present invention provides a method of generating fragment ions by electron capture, comprising; directing ions to be fragmented into a fragmentation chamber of a mass spectrometer into a fragmentation chamber of a mass spectrometer arrangement; trapping at least some of the ions to be fragmented in at least one direction of the fragmentation chamber by using a magnetic field, the ions being trapped within a volume V; generating an electron beam using an electron source located away from the volume V; irradiating the trapped ions in the volume V with the electrons generated by the electron source in the presence of the said magnetic field, so as to cause dissociation; and ejecting the resultant fragment ions from the fragmentation chamber for subsequent analysis at a different location away from the fragmentation chamber.
摘要翻译：本发明涉及一种通过电子捕获离子破碎的方法和装置。本发明提供了一种通过电子捕获产生碎片离子的方法，包括：将离子分散成质谱仪的碎裂室进入质谱仪布置的碎裂室; 通过使用磁场捕获在碎裂室的至少一个方向上被分段的至少一些离子，离子被捕获在体积V内; 使用远离体积V的电子源产生电子束; 在存在所述磁场的情况下用电子源产生的电子照射体积V中的被俘获的离子，从而导致解离; 并将所得的碎片离子从碎裂室排出，以便在远离碎裂室的不同位置进行后续分析。

9. 发明授权

US08288714B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US08288714B2
公开(公告)日：2012-10-16
申请号：US12944357
申请日：2010-11-11
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

10. 发明申请

US20080315080A1 Electrostatic Trap 有权
标题翻译：静电捕集阱
公开(公告)号：US20080315080A1
公开(公告)日：2008-12-25
申请号：US10587478
申请日：2006-06-05
申请人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
发明人： Alexander Makarov , Eduard V. Denisov , Gerhard Jung , Wilko Balschun , Stevan Roy Horning
IPC分类号： B01D59/46
CPC分类号： H01J49/4245 , H01J49/0027 , H01J49/02 , H01J49/282 , H01J49/406 , H01J49/425
摘要： An electrostatic trap such as an orbitrap is disclosed, with an electrode structure. An electrostatic trapping field of the form U′(r,φ,z) is generated to trap ions within the trap so that they undergo isochronous oscillations. The trapping field U′(r, φ,z) is the result of a perturbation W to an ideal field U(r, φ,z) which, for example, is hyperlogarithmic in the case of an orbitrap. The perturbation W may be introduced in various ways, such as by distorting the geometry of the trap so that it no longer follows an equipotential of the ideal field U(r, φ,z), or by adding a distortion field (either electric or magnetic). The magnitude of the perturbation is such that at least some of the trapped ions have an absolute phase spread of more than zero but less than about 2π radians over an ion detection period Tm.
摘要翻译：公开了诸如轨道捕获器的静电捕获器，具有电极结构。产生U'（r，phi，z）形式的静电捕获场，以捕获陷阱内的离子，使它们经历同步振荡。捕获场U'（r，phi，z）是对于理想场U（r，phi，z）的扰动W的结果，其在例如轨道捕获的情况下例如是超对数的。扰动W可以以各种方式引入，例如通过使陷波器的几何形状变形，使得其不再遵循理想场U（r，phi，z）的等电位，或者通过添加失真场（电或磁性）。扰动的幅度使得至少一些捕获的离子在离子检测周期Tm之后具有大于零但小于约2pi弧度的绝对相位扩展。

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