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1. 发明授权

US12027356B2 Method of performing IDA with CID-ECD 有权
公开(公告)号：US12027356B2
公开(公告)日：2024-07-02
申请号：US17597763
申请日：2020-07-22
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD. , University of Geneva
发明人： Gérard Hopfgartner , Anita Orsolya Ducati , Ronald F. Bonner , Yves Le Blanc
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/005 , H01J49/0054
摘要： Apparatus is provided and an IDA method is modified to detect and separately dissociate alkali-metal adducts of a compound. An ion source device ionizes one or more compounds of a sample, producing an ion beam. A mass filter selects a mass range of precursor ions from the ion beam, a mass analyzer measures intensities and m/z values of the precursor ions, and one or more of the precursor ions are selected for a peak list. For each pair of precursor ions of the peak list, if an m/z difference between the pair corresponds to an m/z difference between an alkali metal ion and another alkali metal ion or a proton, an ExD device is used to dissociate one precursor ion or both precursor ions of the pair using the processor. A CID device is used to dissociate all other precursor ions of the peak list.

2. 发明授权

US11728148B2 Method for top down proteomics using ExD and PTR 有权
公开(公告)号：US11728148B2
公开(公告)日：2023-08-15
申请号：US17650836
申请日：2022-02-11
申请人： DH TECHNOLOGIES DEVELOPMENT PTE. LTD.
发明人： Takashi Baba , Pavel Ryumin , William M. Loyd
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0059 , H01J49/0072
摘要： A dissociation device fragments a precursor ion, producing at least two different product ions with overlapping m/z values in the dissociation device. The dissociation device applies an AC voltage and a DC voltage creating a pseudopotential that traps ions below a threshold m/z including the at least two product ions. The dissociation device receives a charge reducing reagent that causes the trapped at least two product ions to be charge reduced until their m/z values increase above the threshold m/z set by the AC voltage. The increase in the m/z values of the at least two product ions decreases their overlap. The at least two product ions with increased m/z values are transmitted to another device for subsequent mass analysis by applying the DC voltage to the dissociation device relative to a DC voltage applied to the other device.

3. 发明申请

US20170025260A1 Controlling Hydrogen-Deuterium Exchange on a Spectrum by Spectrum Basis 审中-公开
标题翻译：通过光谱基础控制光谱上的氢氘交换
公开(公告)号：US20170025260A1
公开(公告)日：2017-01-26
申请号：US15286807
申请日：2016-10-06
申请人： MICROMASS UK LIMITED
发明人： Jeffery Mark BROWN , Steven Derek PRINGLE , Keith RICHARDSON
IPC分类号： H01J49/00
CPC分类号： H01J49/0077 , H01J49/00 , H01J49/0031 , H01J49/0036 , H01J49/0054 , H01J49/0072 , H01J49/06 , H01J49/065 , H01J49/26
摘要： A mass spectrometer is disclosed comprising a liquid chromatography device for separating ions. A gas phase ion-neutral reaction device is arranged downstream to perform a gas phase ion-neutral reaction such as Hydrogen-Deuterium exchange. A control system is arranged to automatically and repeatedly switch the reaction device back and forth between a first mode of operation and a second mode of operation, wherein in the first mode of operation at least some parent or precursor ions are caused to react within the reaction device and wherein in the second mode of operation substantially fewer or no parent or precursor ions are caused to react.
摘要翻译：公开了一种质谱仪，其包括用于分离离子的液相色谱装置。气相离子中性反应装置设置在下游以进行气相离子 - 中性反应如氢氘交换。控制系统被布置成在第一操作模式和第二操作模式之间来回自动重复地切换反应装置，其中在第一操作模式中，使至少一些母体或前体离子在反应中反应器件，并且其中在第二操作模式中基本上较少或没有使母体或前体离子发生反应。

4. 发明申请

US20160254130A1 MS/MS Analysis Using ECD or ETD Fragmentation 有权
标题翻译：使用ECD或ETD分段的MS / MS分析
公开(公告)号：US20160254130A1
公开(公告)日：2016-09-01
申请号：US15028202
申请日：2014-10-09
申请人： MICROMASS UK LIMITED
发明人： Jeffery Mark Brown
IPC分类号： H01J49/00 , H01J49/16
CPC分类号： H01J49/0072 , H01J49/0054 , H01J49/164
摘要： A method of mass spectrometry is disclosed comprising: providing supercharged analyte ions; and supplying electrons or reagent ions to said analyte ions so as to transfer charge from said reagent ions or electrons to said analyte ions, said transfer of charge causing at least some of said analyte ions to dissociate. The charge transfer step is performed at a relatively high pressure and preferably substantially at atmospheric pressure.
摘要翻译：公开了一种质谱法，其包括：提供超荷电分析物离子; 以及将电子或试剂离子供应到所述分析物离子，以便将电荷从所述试剂离子或电子转移到所述分析物离子，所述电荷转移导致所述分析物离子的至少一部分离解。电荷转移步骤在相当高的压力下进行，优选基本上在大气压下进行。

5. 发明授权

US09129788B2 Lens for electron capture dissociation, Fourier transform ion cyclotron resonance mass spectrometer comprising the same and method for improving signal of Fourier transform ion cyclotron resonance mass spectrometer 有权
标题翻译：用于电子捕获离解的透镜，包含相同的傅里叶变换离子回旋共振质谱仪和用于改进傅里叶变换离子回旋共振质谱仪的信号的方法
公开(公告)号：US09129788B2
公开(公告)日：2015-09-08
申请号：US14351524
申请日：2012-10-10
申请人： KOREA BASIC SCIENCE INSTITUTE
发明人： Myoung Choul Choi , Sang Hwan Choi , Se Gyu Lee , Jeong Min Lee
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/067 , H01J49/0027 , H01J49/0054 , H01J49/062 , H01J49/38
摘要： A lens for electron capture dissociation may include: a first electrode and a second electrode spaced apart from each other and arranged along a first direction; and a third electrode and a fourth electrode spaced apart from each other and arranged along a second direction perpendicular to the first direction. The first electrode and the second electrode may be disposed in a space in which a magnetic field is formed in the first direction and trap electrons. The third electrode and the fourth electrode may be in the form of a flat plate and may apply an electric field to the trapped electrons in the second direction.
摘要翻译：用于电子捕获解离的透镜可以包括：第一电极和彼此间隔开并沿着第一方向布置的第二电极; 以及与第一方向垂直的第二方向配置的第三电极和第四电极。第一电极和第二电极可以设置在其中在第一方向上形成磁场并捕获电子的空间中。第三电极和第四电极可以是平板的形式，并且可以在第二方向上对捕获的电子施加电场。

6. 发明申请

US20150187557A1 ELECTRON SOURCE FOR AN RF-FREE ELECTRONMAGNETOSTATIC ELECTRON-INDUCED DISSOCIATION CELL AND USE IN A TANDEM MASS SPECTROMETER 有权
标题翻译：用于无RF电子电子感应电解诱导电解质的电子源和在TANDEM MASS SPECTROMETER中使用
公开(公告)号：US20150187557A1
公开(公告)日：2015-07-02
申请号：US14420545
申请日：2013-08-15
申请人： State of Oregon acting by and through the State board of higher education on behalf of OSU
发明人： Douglas F. Barofsky , Valery G. Voinov
IPC分类号： H01J49/14 , H01J49/26 , H01J49/08
CPC分类号： H01J49/147 , H01J49/0054 , H01J49/062 , H01J49/08 , H01J49/26
摘要： An electron source for electron-induced dissociation in an RF-free electromagnetostatic cell for use installation in a tandem mass spectrometer is provided. An electromagnetostatic electron-induced dissociation cell may include at least one magnet having an opening disposed therein and having a longitudinal axis extending through the opening, the magnet having magnetic flux lines associated therewith, and an electron emitter having an electron emissive surface comprising a sheet, the emitter disposed about the axis at a location relative to the magnet where the electron emissive surface is substantially perpendicular to the magnetic flux lines at the electron emissive surface.
摘要翻译：提供了一种用于无串联电磁静电电池中电子诱导解离的电子源，用于串联质谱仪中的安装。电磁静电电子诱导解离单元可以包括至少一个具有设置在其中的开口的磁体，并且具有延伸穿过该开口的纵向轴线，该磁体具有与之相关联的磁通线，以及具有包括片材的电子发射表面的电子发射体，所述发射极围绕所述轴设置在相对于所述磁体的位置处，其中所述电子发射表面基本上垂直于所述电子发射表面处的磁通线。

7. 发明申请

US20150122985A1 PLASMA-BASED ELECTRON CAPTURE DISSOCIATION (ECD) APPARATUS AND RELATED SYSTEMS AND METHODS 有权
标题翻译：基于等离子体的电子捕获解决（ECD）设备及相关系统和方法
公开(公告)号：US20150122985A1
公开(公告)日：2015-05-07
申请号：US14483462
申请日：2014-09-11
申请人： Agilent Technologies, Inc.
发明人： Trygve Ristroph , Mark Denning , Kenneth R. Newton , Guthrie Partridge
IPC分类号： H01J49/00 , H01J49/26 , H01J49/10
CPC分类号： H01J49/0054 , H05H1/24 , H05H1/2406 , H05H2001/4645 , H05H2001/481
摘要： An electron capture dissociation (ECD) apparatus includes a plasma source for generating plasma. Analyte ions are exposed to the plasma in an ECD interaction region, either inside or outside the plasma source. The apparatus may include one or more devices for refining the plasma in preparation for interaction with the analyte ions. Refining may entail removing unwanted species from the plasma, such as photons, metastable particles, neutral particles, and/or high-energy electrons unsuitable for ECD, and/or controlling a density of low-energy electrons in the plasma.
摘要翻译：电子捕获离解（ECD）装置包括用于产生等离子体的等离子体源。分析物离子在等离子体源的内部或外部的ECD相互作用区域中暴露于等离子体。该装置可以包括用于精制等离子体以准备与分析物离子相互作用的一个或多个装置。精炼可能需要从等离子体中除去不需要的物质，例如不适合于ECD的光子，亚稳颗粒，中性粒子和/或高能电子，和/或控制等离子体中低能电子的密度。

8. 发明申请

US20150060659A1 VITAMIN B2 DETECTION BY MASS SPECTROMETRY 审中-公开
标题翻译：维生素B2通过质谱检测
公开(公告)号：US20150060659A1
公开(公告)日：2015-03-05
申请号：US14534661
申请日：2014-11-06
申请人： Quest Diagnostics Investments Inc.
发明人： Changming Yang , Sum Chan
IPC分类号： G01N33/487 , G01N30/72 , H01J49/00
CPC分类号： G01N33/487 , G01N30/72 , G01N30/7233 , G01N33/6848 , G01N33/82 , G01N2030/027 , H01J49/0027 , H01J49/0031 , H01J49/0054 , Y10T436/147777
摘要： Methods are described for measuring the amount of a vitamin B2 in a sample. More specifically, mass spectrometric methods are described for detecting and quantifying vitamin B2 in a sample utilizing on-line extraction methods coupled with tandem mass spectrometric techniques.
摘要翻译：描述了用于测量样品中维生素B2的量的方法。更具体地，描述了利用在线提取方法与串联质谱技术相结合来检测和定量样品中维生素B2的质谱方法。

9. 发明申请

US20110303839A1 AP-ECD METHODS AND APPARATUS FOR MASS SPECTROMETRIC ANALYSIS OF PEPTIDES AND PROTEINS 失效
标题翻译： AP-ECD方法和装置用于肽和蛋白质的质谱分析
公开(公告)号：US20110303839A1
公开(公告)日：2011-12-15
申请号：US13203142
申请日：2010-02-23
申请人： Damon B. Robb
发明人： Damon B. Robb
IPC分类号： H01J49/26
CPC分类号： H01J49/0054 , H01J49/0072 , H01J49/165
摘要： An in-source atmospheric pressure electron capture dissociation (AP-ECD) method and apparatus for mass spectrometric analysis of peptides and proteins. An electrified sprayer generates a multiply-charged peptide/protein ions from a sample solution, a source of electrons for negative reagents, and a flow of gas for guiding positively charged ions from the electrified sprayer to a downstream reaction region within the guide. The reaction region being at or near atmospheric pressure and substantially free of the electric field from the electrified sprayer. In another embodiment, the method uses electron transfer dissociation (ETD), in the event that anions are substituted for electrons as the negative reagents. Fragment ions exiting the reaction region are subsequently passed into a mass analyzer of a mass spectrometer for mass analysis of the ions.
摘要翻译：用于肽和蛋白质质谱分析的源内大气压电子捕获解离（AP-ECD）方法和装置。带电的喷雾器从样品溶液中产生多重充电的肽/蛋白质离子，用于阴性试剂的电子源和用于将带正电荷的离子从电化喷雾器引导到引导件内的下游反应区域的气体流。反应区域处于或接近大气压并且基本上没有来自带电喷雾器的电场。在另一个实施方案中，在阴离子被取代电子作为阴性试剂的情况下，该方法使用电子转移离解（ETD）。离开反应区域的片段离子随后进入质谱仪的质谱仪，用于质量分析离子。

10. 发明申请

US20110204221A1 MASS SPECTROMETER AND METHOD OF MASS SPECTROMETRY 审中-公开
标题翻译：质谱仪和质谱法
公开(公告)号：US20110204221A1
公开(公告)日：2011-08-25
申请号：US13122418
申请日：2009-10-08
申请人： Hiroyuki Satake , Masuyoshi Yamada
发明人： Hiroyuki Satake , Masuyoshi Yamada
IPC分类号： H01J49/26 , H01J49/40
CPC分类号： H01J49/063 , H01J49/0031 , H01J49/004 , H01J49/0054 , H01J49/0072
摘要： When a high-speed analyzer such as a quadrupole mass filter is united with an analyzer which requires a reaction time of 10 msec, such as an ion dissociation chamber of the ion trap type, a problem arises that an ion loss occurs due to a difference in analysis speed between the analyzers. A high-throughput analysis is intended to be achieved by eliminating this loss. A pre ion trap (4) is provided between a quadrupole filter (3) and an ion dissociation chamber (5), and ions are accumulated in the pre ion trap (4) while operations such as dissociation, isolation and ejection are being performed in the ion dissociation chamber (5). This configuration solves a problem with the ion dissociation chamber (5), which is a decrease in transmittance of the dissociation chamber (5), i.e., a decrease in throughput, and accordingly enables a high-throughput structural analysis on a measurement sample.
摘要翻译：当将诸如四极质量过滤器的高速分析仪与需要10毫秒的反应时间的分析仪（例如离子阱型离子解离室）结合在一起时，会产生由于差异而产生离子损失的问题在分析仪之间的分析速度。旨在通过消除这种损失来实现高通量分析。在四极过滤器（3）和离子解离室（5）之间提供预离子阱（4），并且离子聚集在预离子阱（4）中，同时在诸如解离，分离和喷射之类的操作中进行离子解离室（5）。这种结构解决了离子解离室（5）的问题，离子解离室（5）是解离室（5）的透射率降低，即通过量的降低，因此能够对测量样品进行高通量结构分析。

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