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1. 发明授权

US08288714B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US08288714B2
公开(公告)日：2012-10-16
申请号：US12944357
申请日：2010-11-11
申请人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander A. Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕获离子捕获组件的靶离子阱中的离子的方法，该方法包括一系列体积排列使得离子可以从一个体积向下一个体积横越，该体积包括目标离子阱，从而使离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

2. 发明授权

US07847243B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US07847243B2
公开(公告)日：2010-12-07
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

3. 发明申请

US20110057099A1 ION TRAPPING 有权
标题翻译：离子捕捉
公开(公告)号：US20110057099A1
公开(公告)日：2011-03-10
申请号：US12944357
申请日：2010-11-11
申请人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/04
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

4. 发明申请

US20080156984A1 Ion Trapping 有权
标题翻译：离子捕获
公开(公告)号：US20080156984A1
公开(公告)日：2008-07-03
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积排列使得离子可以从一个体积向下一个体积移动，所述体积包括目标离子阱，由此离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

5. 发明申请

US20100193680A1 Mass Spectrometry 有权
标题翻译：质谱
公开(公告)号：US20100193680A1
公开(公告)日：2010-08-05
申请号：US12762140
申请日：2010-04-16
申请人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich MAKAROV , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： H01J49/26
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

6. 发明授权

US08278619B2 Mass spectrometry 有权
标题翻译：质谱
公开(公告)号：US08278619B2
公开(公告)日：2012-10-02
申请号：US12762140
申请日：2010-04-16
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

7. 发明授权

US07728288B2 Mass spectrometry 有权
标题翻译：质谱
公开(公告)号：US07728288B2
公开(公告)日：2010-06-01
申请号：US11909857
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

8. 发明申请

US20080191129A1 Mass Spectrometry 有权
标题翻译：质谱
公开(公告)号：US20080191129A1
公开(公告)日：2008-08-14
申请号：US11909857
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Alexander Kholomeev , Oliver Lange
IPC分类号： B01D59/44
CPC分类号： H01J49/04
摘要： This invention relates to a mass spectrometer including a reaction cell and to a method of using such a mass spectrometer. In particular, although not exclusively, this invention relates to a tandem mass spectrometer and to tandem mass spectrometry. The invention provides a method of mass spectrometry using a mass spectrometer having a longitudinal axis, comprising guiding ions to travel along the longitudinal axis of the mass spectrometer in a forwards direction to pass through an intermediate ion store and then to enter a reaction cell, to process the ions within the reaction cell, to eject the processed ions to travel back along the longitudinal axis to enter the intermediate ion store once more, and to eject one or more pulses of the processed ions in an off-axis direction to a mass analyser.
摘要翻译：本发明涉及包括反应池的质谱仪和使用这种质谱仪的方法。具体地说，尽管不是排他地，本发明涉及串联质谱仪和串联质谱法。本发明提供了使用具有纵向轴线的质谱仪的质谱法，其包括引导离子沿着向前方向沿着质谱仪的纵向轴线行进以通过中间离子储存器然后进入反应池，至处理反应池内的离子，以便使经处理的离子沿着纵轴排出回来，再次进入中间离子储存区，并将处理离子的一个或多个脉冲沿离轴方向排出到质量分析器。

9. 发明授权

US08686350B2 Multiple ion injection in mass spectrometry 有权
标题翻译：多重离子注入质谱法
公开(公告)号：US08686350B2
公开(公告)日：2014-04-01
申请号：US13853603
申请日：2013-03-29
申请人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
发明人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
IPC分类号： H01J49/00
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analyzed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analyzed; accumulating in the ion store a sample of another type of ions to be analyzed; and mass analyzing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

10. 发明授权

US08410424B2 Multiple ion injection in mass spectrometry 有权
标题翻译：多重离子注入质谱法
公开(公告)号：US08410424B2
公开(公告)日：2013-04-02
申请号：US13008790
申请日：2011-01-18
申请人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
发明人： Alexander A. Makarov , Oliver Lange , Stevan R. Horning
IPC分类号： B01D59/44
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

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