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1. 发明授权

US09012839B2 Mass spectrometer vacuum interface method and apparatus 有权
标题翻译：质谱仪真空接口方法及仪器
公开(公告)号：US09012839B2
公开(公告)日：2015-04-21
申请号：US14364616
申请日：2012-12-12
申请人： Alexander Alekseevich Makarov , Lothar Rottmann
发明人： Alexander Alekseevich Makarov , Lothar Rottmann
IPC分类号： H01J49/06 , H01J49/04 , H01J49/26
CPC分类号： H01J49/06 , H01J49/0495 , H01J49/067 , H01J49/105 , H01J49/24
摘要： A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture. Within the skimmer apparatus, a portion of the skimmed plasma adjacent the skimmer apparatus is separated from the remainder of the skimmed plasma by providing means to prevent, inhibit or impede, the separated portion from reaching the extraction optics while allowing the remainder to expand towards the extraction optics. This allows removal of ions liberated from deposition matter on the skimmer apparatus surface, thereby discriminating against such ions, and offering reduced memory effects. The remainder of the plasma can expand towards the extraction optics, so interaction and mixing between the boundary layer and the remainder of the plasma can be reduced or minimized.
摘要翻译：一种操作质谱仪真空界面的方法，其包括具有撇渣器孔径和下游离子提取光学器件的分离器装置。一个膨胀的等离子体通过撇渣器孔径被撇去。在撇渣器装置内，通过提供用于防止，抑制或妨碍分离的部分到达提取光学器件的装置将与分离器装置相邻的脱脂等离子体的一部分与剩余的等离子体分离，同时允许其余部分向着提取光学。这允许从分离器装置表面上的沉积物质释放的离子去除，从而区分这些离子，并提供减少的记忆效应。等离子体的其余部分可以朝向提取光学器件扩展，因此边界层和等离子体的其余部分之间的相互作用和混合可以被减小或最小化。

2. 发明申请

US20140027629A1 METHOD AND ANALYSER FOR ANALYSING IONS HAVING A HIGH MASS-TO-CHARGE RATIO 有权
标题翻译：用于分析具有高质量比的离子的方法和分析仪
公开(公告)号：US20140027629A1
公开(公告)日：2014-01-30
申请号：US13560303
申请日：2012-07-27
申请人： Alexander Alekseevich MAKAROV , Eduard V. DENISOV , Nicolaie Eugen DAMOC
发明人： Alexander Alekseevich MAKAROV , Eduard V. DENISOV , Nicolaie Eugen DAMOC
IPC分类号： H01J49/28
CPC分类号： H01J49/005 , H01J49/004 , H01J49/027 , H01J49/406
摘要： A method for mass analysing multiply-charged ions is provided as well as a mass analyser suitable for performing the method, the method comprising: introducing multiply-charged ions into an electrostatic mass analyser where ions undergo multiple changes of direction of motion; detecting the ions in the analyser; and determining the mass-to-charge ratio of at least some of the detected ions; wherein the absolute velocity in the analyser of at least some of the ions whose mass-to-charge ratio is determined is not greater than 8,000 m/s and the average path length over the duration of detection of such ions is longer than required for detecting such ions with a mass-to-charge ratio resolving power of 1,000. High resolution mass spectra of high m/z protein complexes, for example in a native state and with low charge, can be achieved.
摘要翻译：本发明提供了一种质量分析多电荷离子的方法以及适用于执行该方法的质量分析器，该方法包括：将多电荷离子引入静电质量分析器，其中离子经过多个运动方向的改变; 检测分析仪中的离子; 以及确定所检测的离子中的至少一些的质荷比; 其中确定质荷比的至少一些离子的分析仪中的绝对速度不大于8,000m / s，并且在这种离子的检测持续时间内的平均路径长度比检测所需的时间长这种离子的质荷比分辨能力为1,000。可以实现高m / z蛋白复合物的高分辨率质谱，例如在天然状态和低电荷下。

3. 发明申请

US20110147582A1 Multiple Ion Injection in Mass Spectrometry 有权
标题翻译：质谱中的多离子注入
公开(公告)号：US20110147582A1
公开(公告)日：2011-06-23
申请号：US13008790
申请日：2011-01-18
申请人： Alexander Alekseevich MAKAROV , Oliver LANGE , Stevan Roy HORNING
发明人： Alexander Alekseevich MAKAROV , Oliver LANGE , Stevan Roy HORNING
IPC分类号： B01D59/44 , H01J49/34 , H01J49/40
CPC分类号： H01J49/0009 , H01J49/0031 , H01J49/004 , H01J49/14 , H01J49/4265
摘要： This invention relates to mass spectrometry that includes ion trapping in at least one of the stages of mass analysis. In particular, although not exclusively, this invention relates to tandem mass spectrometry where precursor ions and fragment ions are analysed. A method of mass spectrometry is provided comprising the sequential steps of: accumulating in an ion store a sample of one type of ions to be analysed; accumulating in the ion store a sample of another type of ions to be analysed; and mass analysing the combined samples of the ions; wherein the method comprises accumulating the sample of the one type of ions and/or the sample of another type of ions to achieve a target number of ions based on the results of a previous measurement of the respective type of ions.
摘要翻译：本发明涉及在质谱分析的至少一个阶段中包括离子捕获的质谱。具体地说，尽管并非排他地，本发明涉及分析前体离子和碎片离子的串联质谱法。提供了一种质谱法，其包括以下顺序步骤：在离子存储中积聚待分析的一种类型离子的样品; 在离子存储中积聚待分析的另一种类型的离子的样品; 并对离子的组合样品进行质量分析; 其中所述方法包括基于先前测量各种类型离子的结果累积一种类型离子的样品和/或另一类型离子的样品以实现目标数目的离子。

4. 发明授权

US07759638B2 Mass spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US07759638B2
公开(公告)日：2010-07-20
申请号：US11909855
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/40
CPC分类号： H01J49/004 , H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包含反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

5. 发明申请

US20090179150A1 MASS SPECTROMETER WITH LOOPED ION PATH 有权
标题翻译：带循环离子通道的质谱仪
公开(公告)号：US20090179150A1
公开(公告)日：2009-07-16
申请号：US12013352
申请日：2008-01-11
申请人： Viatcheslav V. Kovtoun , Alexander Alekseevich Makarov
发明人： Viatcheslav V. Kovtoun , Alexander Alekseevich Makarov
IPC分类号： B01D59/44
CPC分类号： H01J49/0081 , H01J49/062
摘要： A mass spectrometer includes at least one ion selector, at least one collision cell, and an ion path switching device arranged to define a looped ion path around which ions derived from a sample may be sent multiple times (without reversal of ion travel) in order to effect a desired number of isolation/fragmentation cycles for MSn analysis. When the desired number of isolation/fragmentation cycles have been completed, the ion path switching device directs the ions to a detector or a separate mass analyzer for acquisition of a mass spectrum.
摘要翻译：质谱仪包括至少一个离子选择器，至少一个碰撞池和离子路径切换装置，该离子路径切换装置被设置成限定循环的离子路径，围绕该离子路径从样品衍生的离子可以顺次多次发射（不反转离子行程）以实现MSn分析所需数量的分离/分段循环。当所需数量的隔离/破碎循环已经完成时，离子路径切换装置将离子引导到检测器或用于采集质谱的单独的质量分析器。

6. 发明申请

US20080224033A1 Mass Spectrometer 有权
标题翻译：质谱仪
公开(公告)号：US20080224033A1
公开(公告)日：2008-09-18
申请号：US11909855
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov
发明人： Alexander Alekseevich Makarov
IPC分类号： H01J49/40 , B01D59/44
CPC分类号： H01J49/004 , H01J49/04
摘要： This invention relates to mass spectrometers comprising a reaction cell and where mass spectra are collected both from unreacted ions and also from reaction product ions. In particular, although not exclusively, this invention finds use in tandem mass spectrometry where mass spectra are collected from precursor and fragment ions. The present invention provides an arrangement where ions may be sent to a reaction cell for fragmentation or other processing before onward transport to a mass analyser. Alternatively, ions may be passed directly to a mass analyser along a bypass path.
摘要翻译：本发明涉及包含反应池的质谱仪，其中质谱是从未反应的离子以及反应产物离子收集的。特别地，尽管不是排他地，本发明用于串联质谱法，其中从前体和碎片离子收集质谱。本发明提供了一种布置，其中离子可以在向前输送到质量分析器之前被送到反应池进行分段或其它处理。或者，离子可以沿着旁路路径直接传递到质量分析器。

7. 发明申请

US20140339418A1 Mass Spectrometer Vacuum Interface Method and Apparatus 有权
标题翻译：质谱仪真空界面方法及仪器
公开(公告)号：US20140339418A1
公开(公告)日：2014-11-20
申请号：US14364616
申请日：2012-12-12
申请人： Alexander Alekseevich Makarov , Lothar Rottmann
发明人： Alexander Alekseevich Makarov , Lothar Rottmann
IPC分类号： H01J49/06 , H01J49/04
CPC分类号： H01J49/06 , H01J49/0495 , H01J49/067 , H01J49/105 , H01J49/24
摘要： A method of operating a mass spectrometer vacuum interface comprising a skimmer apparatus having a skimmer aperture and downstream ion extraction optics. An expanding plasma is skimmed through the skimmer aperture. Within the skimmer apparatus, a portion of the skimmed plasma adjacent the skimmer apparatus is separated from the remainder of the skimmed plasma by providing means to prevent, inhibit or impede, the separated portion from reaching the extraction optics while allowing the remainder to expand towards the extraction optics. This allows removal of ions liberated from deposition matter on the skimmer apparatus surface, thereby discriminating against such ions, and offering reduced memory effects. The remainder of the plasma can expand towards the extraction optics, so interaction and mixing between the boundary layer and the remainder of the plasma can be reduced or minimized.
摘要翻译：一种操作质谱仪真空界面的方法，其包括具有撇渣器孔径和下游离子提取光学器件的分离器装置。一个膨胀的等离子体通过撇渣器孔径被撇去。在撇渣器装置内，通过提供用于防止，抑制或妨碍分离的部分到达提取光学器件的装置将与分离器装置相邻的脱脂等离子体的一部分与剩余的等离子体分离，同时允许其余部分向着提取光学。这允许从分离器装置表面上的沉积物质释放的离子去除，从而区分这些离子，并提供减少的记忆效应。等离子体的其余部分可以朝向提取光学器件扩展，因此边界层和等离子体的其余部分之间的相互作用和混合可以被减小或最小化。

8. 发明申请

US20120109537A1 METHOD OF GENERATING A MASS SPECTRUM HAVING IMPROVED RESOLVING POWER 有权
标题翻译：生成具有改进的分辨率的质谱的方法
公开(公告)号：US20120109537A1
公开(公告)日：2012-05-03
申请号：US13278015
申请日：2011-10-20
申请人： Alexander Alekseevich MAKAROV
发明人： Alexander Alekseevich MAKAROV
IPC分类号： G06F19/00
CPC分类号： H01J49/0036 , G06F19/70 , H01J49/027 , H01J49/38
摘要： A method is disclosed for generating a mass spectrum, e.g. for Fourier transform mass spectrometry, having improved resolving power. The method includes steps of acquiring a plurality of mass spectra from a mass spectrometer using image current detection determining the centroids of at least some of the peaks which have a sufficient signal-to-noise (S/N) ratio so that the variation of the centroid of each such peak from the plurality of mass spectra is significantly lower than the full-width at half-maximum, dM, of the peak in the m/z domain; and generating a histogram of the centroids determined from the plurality of acquired mass spectra thereby forming a composite mass spectrum. The resultant composite mass spectrum comprises peaks having full-width at half-maximum, dMC, significantly narrower than the peak width, dM, of the corresponding peaks in the plurality of acquired mass spectra.
摘要翻译：公开了用于产生质谱的方法，例如用于傅立叶变换质谱，具有改进的分辨能力。该方法包括以下步骤：使用图像电流检测从质谱仪获取多个质谱，确定具有足够的信噪比（S / N）比的至少一些峰的质心，使得来自多个质谱的每个这样的峰的质心显着低于m / z域中的峰的半峰最大值dM的全宽; 以及生成由所述多个获取的质谱确定的质心的直方图，从而形成复合质谱。所得到的复合质谱包括半峰全宽，dMC，比多个获取质谱中相应峰的峰宽dM明显窄的峰。

9. 发明申请

US20120104245A1 Multi-Channel Detection 有权
标题翻译：多通道检测
公开(公告)号：US20120104245A1
公开(公告)日：2012-05-03
申请号：US13345329
申请日：2012-01-06
申请人： Alexander Alekseevich MAKAROV
发明人： Alexander Alekseevich MAKAROV
IPC分类号： H01J49/26
CPC分类号： H01J49/406 , H01J49/004 , H01J49/025 , H01J49/061 , H01J49/408
摘要： A mass spectrometer and method of mass spectrometry wherein charged particles in a beam undergo multiple changes of direction. A detection arrangement detects a first portion of the charged particle beam, and provides a first output based upon the intensity of the detected first portion of the charged particle beam. The detection arrangement detects a second portion of the charged particle beam that has traveled a greater path length through the mass spectrometer than the first portion of the charged particle beam, and provides a second output based upon the detected second portion of the charged particle beam. A controller adjusts the parameters of the charged particle beam and/or the detection arrangement, based upon the first output of the detection arrangement, so as to adjust the second output of the detection arrangement.
摘要翻译：质谱仪和质谱法，其中光束中的带电粒子经历多个方向改变。检测装置检测带电粒子束的第一部分，并且基于所检测到的带电粒子束的第一部分的强度提供第一输出。检测装置检测带电粒子束的第二部分，该第二部分已经比通过质谱仪行进了比带电粒子束的第一部分更大的路径长度，并且基于检测到的带电粒子束的第二部分提供第二输出。控制器基于检测装置的第一输出调整带电粒子束和/或检测装置的参数，以便调整检测装置的第二输出。

10. 发明授权

US07847243B2 Ion trapping 有权
标题翻译：离子捕获
公开(公告)号：US07847243B2
公开(公告)日：2010-12-07
申请号：US11909850
申请日：2006-03-29
申请人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
发明人： Alexander Alekseevich Makarov , Eduard V. Denisov , Gerhard Jung , Robert Malek , Oliver Lange
IPC分类号： H01J49/00
CPC分类号： H01J49/423 , H01J49/004 , H01J49/425 , H01J49/4295
摘要： This invention relates to a method of trapping ions and to an ion trapping assembly. In particular, the present invention has application in gas-assisted trapping of ions in an ion trap prior to a mass analysis of the ions in a mass spectrometer. The invention provides a method of trapping ions in a target ion trap of an ion trapping assembly that comprises a series of volumes arranged such that ions can traverse from one volume to the next, the volumes including the target ion trap, whereby ions are allowed to pass repeatedly through the volumes such that they also pass into and out from the target ion trap without being trapped. Potentials may be used to reflect the ions from respective ends of the ion trapping assembly. Optionally, a potential well and/or gas-assisted cooling may be used to cause the ions to settle in the target ion trap.
摘要翻译：本发明涉及一种捕获离子和离子捕获组件的方法。特别地，本发明在质谱仪中对离子的质量分析之前，已经将其应用于离子阱中的气体辅助捕获。本发明提供了一种捕集离子捕获组件的靶离子阱中的离子的方法，该离子捕获组件包括一系列体积，这些体积被布置成使得离子可以从一个体积向下一个体积穿过，包括靶离子阱，其中离子被允许反复通过体积，使得它们也被进入和离开目标离子阱而不被捕获。电位可用于从离子捕获组件的相应末端反射离子。任选地，潜在的井和/或气体辅助冷却可用于使离子沉淀在目标离子阱中。

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