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    • 6. 发明授权
    • Sliding roof device
    • 滑动屋顶装置
    • US06588834B2
    • 2003-07-08
    • US09989190
    • 2001-11-21
    • Kenji MaetaMasaji IshikawaAkira MatsuuraReiki KawamuraYasuo Oyama
    • Kenji MaetaMasaji IshikawaAkira MatsuuraReiki KawamuraYasuo Oyama
    • B60J7053
    • B60J7/0573
    • A sliding roof device includes a housing disposed along at least front edge of an opening formed on a roof of a vehicle, a casing disposed along the housing, a driving force transmitting member slidably mounted and guided in the housing and driven by a driving mechanism and a sliding panel connected to the driving force transmitting member and being movable so as to open and close the opening by the sliding movement of the driving force transmitting member, wherein the casing is formed by a flexible raw material and a plural engaging portions which are displaced at least one of upper and lower and front and rear are formed on the housing, and wherein the casing is securely engaged with the engaging portions so as to be arranged zigzag.
    • 滑动屋顶装置包括沿着车辆顶部形成的开口的至少前边缘设置的壳体,沿着壳体设置的壳体,可滑动地安装和引导在壳体中并由驱动机构驱动的驱动力传递构件, 连接到驱动力传递构件的滑动面板,并且可移动以便通过驱动力传递构件的滑动运动来打开和关闭开口,其中壳体由柔性原料和多个啮合部分形成, 在壳体上形成有上,下和前后两者中的至少一个,并且其中壳体与接合部分牢固地接合以便被锯齿形地布置。
    • 10. 发明授权
    • Thrombolytic agent
    • 溶血剂
    • US4568545A
    • 1986-02-04
    • US508163
    • 1983-06-27
    • Hisashi MiharaHiroyuki SumiAkira MatsuuraTadahiko Inukai
    • Hisashi MiharaHiroyuki SumiAkira MatsuuraTadahiko Inukai
    • A61K38/00C12N9/64A61K37/54C12N9/48
    • C12N9/6402A61K38/00Y10S514/822
    • The invention discloses that the tissues of earthworms contain fibrinolytically or thrombolytically active ingredients which can be extracted and purified by a suitable sequence of extraction and purification procedures into the individual active ingredients including six novel proteases named F-O-HM-45, F-I-1-HM-54, F-I-2-HM-15, F-II-HM-64, F-III-1-HM-27 and F-III-2-HM-89. The chromatographic fractionation of the earthworm extract with an aqueous extractant gives five active fractions, the first four of which contain each one of the first mentioned four proteases and the last of which contains the last mentioned two proteases. The disclosure includes description of the suitable purification methods for the proteases as well as the physico-chemical identification data thereof. Various thrombolytic medicament forms prepared with the novel proteases as the effective ingredient are described together with the results of the clinical tests carried out by the oral administration of the novel proteases.
    • 本发明公开了蚯蚓的组织含有纤维蛋白溶解或血栓溶解活性成分,其可以通过适当的提取和纯化程序提取和纯化到各个活性成分中,包括六种新的命名为FO-HM-45,FI-1-HM -54,FI-2-HM-15,F-II-HM-64,F-III-1-HM-27和F-III-2-HM-89。 用含水萃取剂的蚯蚓提取物的色谱分离提供了五种活性级分,其中前四种含有前述四种蛋白酶中的每一种,最后含有最后提到的两种蛋白酶。 本公开包括对蛋白酶的合适的纯化方法的描述以及其物理化学鉴定数据。 用新型蛋白酶作为有效成分制备的各种血栓溶解药物形式与通过口服施用新型蛋白酶进行的临床试验的结果一并描述。