专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08883792B2 Substituted isoquinoline derivative 有权
标题翻译：取代的异喹啉衍生物
公开(公告)号：US08883792B2
公开(公告)日：2014-11-11
申请号：US13995300
申请日：2011-12-21
申请人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
发明人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
IPC分类号： C07D401/12 , C07D217/04 , A61K31/4725 , C07D217/02 , C07D417/12 , C07D405/12 , C07D409/12 , C07D217/22
CPC分类号： C07D217/04 , C07D217/02 , C07D217/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides a novel isoquinoline-6-sulfonamide derivative that is useful as a medicine. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt, wherein R1 and R2 each independently represent a hydrogen atom, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like; R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, an optionally substituted alkanoyl group, or the like; and A represents a linear or branched alkylene group having 2 to 6 carbon atoms.
摘要翻译：本发明提供了可用作药物的新型异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或衍生物或其盐的溶剂合物，其中R1和R2各自独立地表示氢原子等; R3和R4各自独立地表示氢原子，烷基等; R5表示氢原子，任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的环烷基，任选取代的烷酰基等; A表示碳原子数2〜6的直链或支链亚烷基。

2. 发明授权

US07858615B2 (S)-(-)-1-(4-fluoroisoquinolin-5-Yl)Sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate 有权
标题翻译：（S） - （ - ） - 1-（4-氟异喹啉-5-基）磺酰基-2-甲基-1,4-高哌嗪盐酸盐二水合物
公开(公告)号：US07858615B2
公开(公告)日：2010-12-28
申请号：US11720288
申请日：2005-11-29
申请人： Takeshi Ohshima , Hiroyoshi Hidaka , Masami Shiratsuchi , Kazuhiro Onogi , Toshiaki Oda
发明人： Takeshi Ohshima , Hiroyoshi Hidaka , Masami Shiratsuchi , Kazuhiro Onogi , Toshiaki Oda
IPC分类号： A61P9/10 , A61K31/551 , C07D401/12
CPC分类号： C07D401/12
摘要： The present invention is directed to (S)-(−)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride dihydrate, to a method producing the dihydrate, and to a drug composition containing the dihydrate. The compound of the present invention has less hygroscopicity as compared with (S)-(−)-1-(4-fluoroisoquinolin-5-yl)sulfonyl-2-methyl-1,4-homopiperazine hydrochloride anhydrous crystals and thus, exhibits excellent chemical stability.
摘要翻译：本发明涉及（S） - （ - ） - 1-（4-氟异喹啉-5-基）磺酰基-2-甲基-1,4-高哌嗪盐酸盐二水合物，生产二水合物的方法和药物含有二水合物的组合物。与（S） - （ - ） - 1-（4-氟异喹啉-5-基）磺酰基-2-甲基-1,4-高哌嗪盐酸盐无水晶体相比，本发明的化合物具有较少的吸湿性，化学稳定性。

3. 发明申请

US20070088021A1 4-haloisoquinoline derivative and drug containing the same 审中-公开
标题翻译： 4-卤代异喹啉衍生物和含有它们的药物
公开(公告)号：US20070088021A1
公开(公告)日：2007-04-19
申请号：US11518141
申请日：2006-09-11
申请人： Hiroyoshi Hidaka , Masahiro Tamura , Hiroshi Nakao , Hiromichi Sigyo , Hajime Yamada , Takatoshi Ozawa , Hideo Yoshizaki
发明人： Hiroyoshi Hidaka , Masahiro Tamura , Hiroshi Nakao , Hiromichi Sigyo , Hajime Yamada , Takatoshi Ozawa , Hideo Yoshizaki
IPC分类号： A61K31/551
CPC分类号： A61K31/551 , C07D401/12
摘要： The present invention relates to compounds which have a potent Rho-kinase inhibitory action and which are useful as therapeutic agents for treating diseases, such as hypertension, pulmonary hypertension, cerebral vasospasm, angina pectoris, cardiac failure, arteriosclerosis, glaucoma, dysuria, asthma, and erectile failure, and drugs containing the compounds. The present invention provides a 4-haloisoquinoline derivative represented by formula (1): an acid-added salt thereof, or a solvate of any of the foregoing, in which X is halogen, such as fluoro, chloro, bromo and iodo.
摘要翻译：本发明涉及具有强Rho激酶抑制作用的化合物，其可用作治疗疾病的治疗剂，例如高血压，肺动脉高压，脑血管痉挛，心绞痛，心力衰竭，动脉硬化，青光眼，排尿困难，哮喘，和勃起功能障碍，以及含有化合物的药物。本发明提供由式（1）表示的4-卤代异喹啉衍生物：其酸加成盐，或上述任何一种的溶剂合物，其中X为卤素，如氟，氯，溴和碘。

4. 发明授权

US4709032A Isoquinolinesulfonamide derivatives 失效
标题翻译：异喹啉磺酰胺衍生物
公开(公告)号：US4709032A
公开(公告)日：1987-11-24
申请号：US919774
申请日：1986-10-17
申请人： Hiroyoshi Hidaka , Takanori Sone
发明人： Hiroyoshi Hidaka , Takanori Sone
IPC分类号： A61K31/47 , A61K31/472 , A61P9/08 , A61P9/12 , C07D217/02 , C07D401/12
CPC分类号： C07D401/12 , C07D217/02 , Y02P20/55
摘要： This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.

5. 发明授权

US4678783A Substituted isoquinolinesulfonyl compounds 失效
标题翻译：取代的异喹啉磺酰基化合物
公开(公告)号：US4678783A
公开(公告)日：1987-07-07
申请号：US813973
申请日：1985-12-27
申请人： Hiroyoshi Hidaka , Takanori Sone
发明人： Hiroyoshi Hidaka , Takanori Sone
IPC分类号： C07D217/02 , C07D217/22 , C07D217/24 , C07D401/12 , A61K31/495 , A61K31/47
CPC分类号： C07D401/12 , C07D217/02 , C07D217/22 , C07D217/24
摘要： An isoquinolinesulfonyl compound represented by the formula (I): ##STR1## wherein R.sup.1 : H, Cl, OHA : unsubstituted or substituted ethylene or alkyleneR.sup.2, R.sup.3 : H, alkyl, jointly forming unsubstituted or substituted ethylene or trimethyleneR.sup.4 : H, alkyl, amidinoor an acid salt thereof.They can be prepared, for example, by converting 1-R.sup.1 substituted-5-isoquinolinesulfonic acid to the corresponding sulfonyl chloride and subsequently reacting the chloride with a compound of formula ##STR2## They can be advantageously utilized as vasodilator, cerebral circulation ameliorator, antihypertensive agent and drugs for prevention and treatment of various circulatory organ diseases.
摘要翻译：由式（I）表示的异喹啉磺酰化合物：其中R1：H，Cl，OHA：未取代或取代的亚乙基或亚烷基R2，R3：H，烷基，共同形成未取代或取代的乙烯或三亚甲基R4 ：H，烷基，脒基或其酸式盐。它们可以例如通过将1-R1取代-5-异喹啉磺酸转化成相应的磺酰氯并随后使氯化物与式的化合物反应来制备。它们可以有利地用作血管扩张剂，脑循环改善剂，抗高血压药用于预防和治疗各种循环器官疾病的药剂和药物。

6. 发明申请

US20130274269A1 NOVEL SUBSTITUTED ISOQUINOLINE DERIVATIVE 有权
标题翻译：新型取代的异喹啉衍生物
公开(公告)号：US20130274269A1
公开(公告)日：2013-10-17
申请号：US13995300
申请日：2011-12-21
申请人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
发明人： Hiroyoshi Hidaka , Kengo Sumi , Kouichi Takahashi , Yoshihiro Inoue
IPC分类号： C07D217/04 , C07D405/12 , C07D417/12 , C07D401/12
CPC分类号： C07D217/04 , C07D217/02 , C07D217/22 , C07D401/12 , C07D405/12 , C07D409/12 , C07D417/12
摘要： The present invention provides a novel isoquinoline-6-sulfonamide derivative that is useful as a medicine. The present invention provides an isoquinoline-6-sulfonamide derivative represented by Formula (1), a salt thereof, or a solvate of the derivative or the salt, wherein R1 and R2 each independently represent a hydrogen atom, or the like; R3 and R4 each independently represent a hydrogen atom, an alkyl group, or the like; R5 represents a hydrogen atom, an optionally substituted alkyl group, an optionally substituted alkenyl group, an optionally substituted alkynyl group, an optionally substituted cycloalkyl group, an optionally substituted alkanoyl group, or the like; and A represents a linear or branched alkylene group having 2 to 6 carbon atoms.
摘要翻译：本发明提供了可用作药物的新型异喹啉-6-磺酰胺衍生物。本发明提供由式（1）表示的异喹啉-6-磺酰胺衍生物，其盐或衍生物或其盐的溶剂合物，其中R1和R2各自独立地表示氢原子等; R3和R4各自独立地表示氢原子，烷基等; R5表示氢原子，任选取代的烷基，任选取代的烯基，任选取代的炔基，任选取代的环烷基，任选取代的烷酰基等; A表示碳原子数2〜6的直链或支链亚烷基。

7. 发明申请

US20080064681A1 Therapeutic agent for treating glaucoma 审中-公开
标题翻译：用于治疗青光眼的治疗剂
公开(公告)号：US20080064681A1
公开(公告)日：2008-03-13
申请号：US11518131
申请日：2006-09-11
申请人： Hiroyoshi Hidaka , Masahiro Nishio , Kengo Sumi
发明人： Hiroyoshi Hidaka , Masahiro Nishio , Kengo Sumi
IPC分类号： A61K31/551 , A61K31/496 , A61K31/4709
CPC分类号： A61K31/4709 , A61K31/496 , A61K31/551
摘要： The present invention provides compounds useful as therapeutic agent for treating glaucoma and methods for treating glaucoma. That is, a therapeutic agent for treating glaucoma containing, as an active ingredient, a compound represented by formula (1) below is synthesized, and the therapeutic agent is administered in the form of eye drops to a glaucoma patient. Thus, the intraocular pressure is reduced. In the above formula, ring A represents a 5- to 11-membered cyclic amino group, which may have a substituted group, and X represents a halogen.
摘要翻译：本发明提供可用作治疗青光眼的治疗剂的化合物和治疗青光眼的方法。也就是说，合成用于治疗青光眼的治疗剂，其含有作为活性成分的下述式（1）表示的化合物，并且所述治疗剂以眼药水的形式给予青光眼患者。因此，眼压降低。在上式中，环A表示可以具有取代基的5至11元环氨基，X表示卤素。

8. 发明申请

US20060128762A1 Medicinal composition and method for treating malignant tumor and utilization thereof 审中-公开
标题翻译：用于治疗恶性肿瘤的药物组合物和方法及其应用
公开(公告)号：US20060128762A1
公开(公告)日：2006-06-15
申请号：US10526858
申请日：2003-09-05
申请人： Hiroyoshi Hidaka , Masato Matsuda , Fumitake Katoh
发明人： Hiroyoshi Hidaka , Masato Matsuda , Fumitake Katoh
IPC分类号： A61K31/44
CPC分类号： C07D213/42 , A61K31/4409 , A61K33/24 , A61K45/06 , C07D213/72 , A61K2300/00
摘要： The present invention provides an excellent method and a pharmaceutical composition for treating a malignant tumor, and use thereof. Specifically, the present invention is related to a pharmaceutical composition for treating malignant tumor comprising a specific aminostilbazole derivative or a pharmaceutically acceptable salt thereof, which is administered in combination with chemotherapy and/or radiotherapy, a method of treatment and use of said compound.
摘要翻译：本发明提供治疗恶性肿瘤的优异方法和药物组合物及其用途。具体地说，本发明涉及一种治疗恶性肿瘤的药物组合物，其包含与化学疗法和/或放射治疗组合施用的特定氨基芪衍生物或其药学上可接受的盐，所述化合物的治疗和使用方法。

9. 发明授权

US06403607B1 Sulfonamide derivatives and drugs containing the same as the active ingredient 失效
标题翻译：磺酰胺衍生物和含有与活性成分相同的药物
公开(公告)号：US06403607B1
公开(公告)日：2002-06-11
申请号：US09647533
申请日：2000-10-02
申请人： Hiroyoshi Hidaka , Tsutomu Inoue , Isao Umezawa , Hiroyuki Nakano , Hiroshi Nakamura , Naofumi Watanabe , Shizumasa Yokota , Tomomitsu Sasaki , Yumi Yajima
发明人： Hiroyoshi Hidaka , Tsutomu Inoue , Isao Umezawa , Hiroyuki Nakano , Hiroshi Nakamura , Naofumi Watanabe , Shizumasa Yokota , Tomomitsu Sasaki , Yumi Yajima
IPC分类号： A61K3147
CPC分类号： C07D213/76 , C07C311/08 , C07C311/21 , C07C311/29 , C07C323/49 , C07D213/74 , C07D213/75 , C07D213/81 , C07D215/40 , C07D217/02 , C07D243/08 , C07D401/04 , C07D401/12
摘要： The present invention discloses a sulfonamide derivative represented by the following formula (1): [wherein A represents a nitrogen atom, —CH═, etc.; Z represents an oxygen atom, etc.; Ar1 represents an aryl group, etc.; Ar2 represents an alkyl group, etc.; Ra represents a hydrogen atom, etc.; Rb represents a hydrogen atom, etc.; and Rc represents an alkyl group, etc.], or a salt thereof; and drugs containing the derivative or a salt thereof as an active ingredient. This compound exhibits radical scavenging action, gastric mucous secretion augmenting action, and anti-HP action, and thus is effective as a peptic ulcer therapeutic agent.
摘要翻译：本发明公开了由下式（1）表示的磺酰胺衍生物：[其中A表示氮原子，-CH =等; Z表示氧原子等; Ar1表示芳基等。 Ar2表示烷基等。 Ra表示氢原子等; Rb表示氢原子等; Rc表示烷基等]或其盐; 和含有衍生物或其盐的药物作为活性成分。该化合物显示自由基清除作用，胃粘液分泌增加作用和抗HP作用，因此作为消化性溃疡治疗剂是有效的。

10. 发明授权

US4634770A Isoquinolinesulfonamide derivatives 失效
标题翻译：异喹啉磺酰胺衍生物
公开(公告)号：US4634770A
公开(公告)日：1987-01-06
申请号：US548722
申请日：1983-11-04
申请人： Hiroyoshi Hidaka , Takanori Sone
发明人： Hiroyoshi Hidaka , Takanori Sone
IPC分类号： A61K31/47 , A61K31/472 , A61P9/08 , A61P9/12 , C07D217/02 , C07D401/12
CPC分类号： C07D401/12 , C07D217/02 , Y02P20/55
摘要： This invention relates to novel isoquinolinesulfonamide derivatives of Formula (I): ##STR1## wherein A is a C.sub.0-10 alkylene group or a C.sub.0-10 alkylene group having a C.sub.1-10 alkyl group, a phenyl group, a substituted phenyl group or a phenylalkyl group; R.sub.1 and R.sub.2 each is a hydrogen atom; or R.sub.1 and R.sub.2 are linked directly to form an ethylene group unsubstituted or substituted with a C.sub.1-4 alkyl group;R.sub.3 and R.sub.4 each is a hydrogen atom, a C.sub.1-6 alkyl group or linked directly to form a C.sub.2-6 alkylene group; and the pharmaceutically acceptable acid addition salt thereof, and to a process for preparing them. The isoquinoline derivatives possess a relaxatory action for vascular smooth muscle and action for increasing blood flow and are useful as a vasodilator and a hypotensor.
摘要翻译：本发明涉及式（I）的新型异喹啉磺酰胺衍生物：其中A是C0-10亚烷基或具有C1-10烷基的C0-10亚烷基，苯基，取代苯基基团或苯基烷基; R1和R2各自为氢原子; 或R 1和R 2直接连接形成未被取代或被C 1-4烷基取代的亚乙基; R 3和R 4各自为氢原子，C 1-6烷基或直接连接以形成C 2-6亚烷基; 及其药学上可接受的酸加成盐及其制备方法。异喹啉衍生物具有血管平滑肌的松弛作用和增加血流量的作用，可用作血管扩张剂和低血压。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式