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    • 2. 发明申请
    • NITRIDE SEMICONDUCTOR DEVICE
    • 氮化物半导体器件
    • US20110186815A1
    • 2011-08-04
    • US13083990
    • 2011-04-11
    • Soo Min LEEHee Seok ParkJae Woong HanSeong Suk LeeCheol Soo Sone
    • Soo Min LEEHee Seok ParkJae Woong HanSeong Suk LeeCheol Soo Sone
    • H01L29/15
    • H01L33/32B82Y10/00B82Y20/00H01L33/06
    • There is provided a nitride semiconductor device including: an n-type nitride semiconductor layer; a p-type nitride semiconductor layer; and an active layer formed between the n-type and p-type nitride semiconductor layers, the active layer including a plurality of quantum well layers and at least one quantum barrier layer deposited alternately with each other, wherein the active layer includes a first quantum well layer, a second quantum well layer formed adjacent to the first quantum well layer toward the p-type nitride semiconductor layer and having a quantum level higher than a quantum level of the first quantum well layer, and a tunneling quantum barrier layer formed between the first and second quantum well layers and having a thickness enabling a carrier to be tunneled therethrough.
    • 提供了一种氮化物半导体器件,包括:n型氮化物半导体层; p型氮化物半导体层; 以及形成在所述n型和p型氮化物半导体层之间的有源层,所述有源层包括彼此交替沉积的多个量子阱层和至少一个量子势垒层,其中所述有源层包括第一量子阱 层,与第一量子阱层相邻形成朝向p型氮化物半导体层并且具有高于第一量子阱层的量子级的量子级的第二量子阱层,以及形成在第一量子阱层之间的隧穿量子势垒层 和第二量子阱层,并且具有能够使载体穿过其的厚度。
    • 6. 发明申请
    • CONCATAMERIC IMMUNOADHESION MOLECULE
    • 综合免疫分子
    • US20100278827A1
    • 2010-11-04
    • US12692392
    • 2010-01-22
    • Yong-Hoon CHUNGJi-Woong HanHye-Ja LeeEun-Yong ChoiJin-Mi Kim
    • Yong-Hoon CHUNGJi-Woong HanHye-Ja LeeEun-Yong ChoiJin-Mi Kim
    • A61K39/395C07K16/46C07H21/04C12N15/63C12N5/07C12P21/02A61P37/00
    • C07K14/70507A61K2039/505C07K14/70521C07K14/7151C07K2319/00C07K2319/30
    • Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment pf an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
    • 公开了包含两个可溶性结构域的连续蛋白质,其中生物活性蛋白质的可溶性结构域的C末端连接到生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端。 此外,本发明公开了通过在两个单体蛋白质的铰链区上形成分子间二硫键而形成的二聚体蛋白质,这两个单体蛋白质是通过将免疫应答的两个相同的可溶性细胞外区域与免疫球蛋白分子的Fc片段连接起来而形成的, 糖基化蛋白质,编码单体蛋白的DNA构建体,含有DNA构建体的重组表达质粒,用重组表达质粒转化或转染的宿主细胞,以及通过培养宿主细胞制备二聚体蛋白质的方法。 此外,本发明公开了包含二聚体蛋白质或其糖基化形式的药物或诊断组合物。
    • 7. 发明授权
    • Method and apparatus for concentrating and amplifying nucleic acid in single micro chamber
    • 在单微室中浓缩和扩增核酸的方法和装置
    • US07807360B2
    • 2010-10-05
    • US11620961
    • 2007-01-08
    • Young-rok KimJun-hong MinIn-ho LeeYoung-sun LeeChang-eun YooKi-woong Han
    • Young-rok KimJun-hong MinIn-ho LeeYoung-sun LeeChang-eun YooKi-woong Han
    • C12Q1/68
    • C12Q1/6806B01L3/5027B01L3/5088C12Q1/686C12Q2565/629C12Q2537/149C12Q2527/125
    • A method of sequentially performing concentration and amplification of nucleic acid in a single micro chamber includes: introducing a nucleic acid-containing sample and a solution including a kosmotropic salt to a micro chamber having a hydrophilic interior surface to concentrate the nucleic acid by binding the nucleic acid on the interior surface of the micro chamber; and performing a polymerase chain reaction (PCR) by adding a PCR mixture to the chamber. Since the nucleic acid is reversibly bound to the interior surface of the micro chamber, PCR yield is higher compared with a surface of aluminum oxide in which irreversible binding occurs. In addition, all processes are sequentially performed in a single micro chamber so that the number of samples, consumables, time, and labor for treatment and analysis can be reduced, detection sensitivity can be improved, and risk of sample cross contamination significantly reduced without sample loss by eliminating transporting of the sample. A complete automated system for concentration and amplification of nucleic acid is thus readily provided.
    • 在单个微室中依次进行核酸的浓缩和扩增的方法包括:将含核酸的样品和包含可染色盐的溶液引入具有亲水性内表面的微室中,以通过结合核酸来浓缩核酸 酸在微室的内表面上; 并通过向该室加入PCR混合物进行聚合酶链式反应(PCR)。 由于核酸可逆地结合到微室的内表面,与其中发生不可逆结合的氧化铝的表面相比,PCR产率更高。 此外,所有过程都在单个微室中顺序进行,以便可以减少样品数量,消耗品,时间和处理和分析的劳动力,可以提高检测灵敏度,并且样品交叉污染的风险在没有样品时显着降低 通过消除样品的运输而损失。 因此容易提供用于浓缩和扩增核酸的完整的自动化系统。