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1. 发明申请

US20100278827A1 CONCATAMERIC IMMUNOADHESION MOLECULE 有权
标题翻译：综合免疫分子
公开(公告)号：US20100278827A1
公开(公告)日：2010-11-04
申请号：US12692392
申请日：2010-01-22
申请人： Yong-Hoon CHUNG , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
发明人： Yong-Hoon CHUNG , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
IPC分类号： A61K39/395 , C07K16/46 , C07H21/04 , C12N15/63 , C12N5/07 , C12P21/02 , A61P37/00
CPC分类号： C07K14/70507 , A61K2039/505 , C07K14/70521 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment pf an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
摘要翻译：公开了包含两个可溶性结构域的连续蛋白质，其中生物活性蛋白质的可溶性结构域的C末端连接到生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端。此外，本发明公开了通过在两个单体蛋白质的铰链区上形成分子间二硫键而形成的二聚体蛋白质，这两个单体蛋白质是通过将免疫应答的两个相同的可溶性细胞外区域与免疫球蛋白分子的Fc片段连接起来而形成的，糖基化蛋白质，编码单体蛋白的DNA构建体，含有DNA构建体的重组表达质粒，用重组表达质粒转化或转染的宿主细胞，以及通过培养宿主细胞制备二聚体蛋白质的方法。此外，本发明公开了包含二聚体蛋白质或其糖基化形式的药物或诊断组合物。

2. 发明授权

US07229962B2 Tetravalent etanercept 失效
标题翻译：四价依那西普
公开(公告)号：US07229962B2
公开(公告)日：2007-06-12
申请号：US10363427
申请日：2002-07-26
申请人： Yong-Hoon Chung , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
发明人： Yong-Hoon Chung , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
IPC分类号： C07K14/715 , A61K38/16
CPC分类号： C07K14/70507 , A61K2039/505 , C07K14/70521 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
摘要翻译：公开了包含两个可溶性结构域的连续蛋白质，其中生物活性蛋白质的可溶性结构域的C末端与生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端连接。此外，本发明公开了通过在两个单体蛋白的铰链区上形成分子间二硫键而形成的二聚体蛋白，该两个单体蛋白是通过将免疫应答涉及免疫应答的两个相同的可溶胞外区的连接体与免疫球蛋白分子的Fc片段糖基化蛋白质，编码单体蛋白的DNA构建体，含有DNA构建体的重组表达质粒，用重组表达质粒转化或转染的宿主细胞，以及通过培养宿主细胞制备二聚体蛋白质的方法。此外，本发明公开了包含二聚体蛋白质或其糖基化形式的药物或诊断组合物。

3. 发明申请

US20140294764A1 COMPOUNDS AND COMPOSITIONS USED TO EPIGENETICALLY TRANSFORM CELLS AND METHODS RELATED THERETO 有权
标题翻译：用于环境转化细胞的化合物和组合物及其相关方法
公开(公告)号：US20140294764A1
公开(公告)日：2014-10-02
申请号：US14356024
申请日：2012-11-08
申请人： Young-Sup Yoon , Xiaodong Cheng , Ji Woong Han , Antonello Mai
发明人： Young-Sup Yoon , Xiaodong Cheng , Ji Woong Han , Antonello Mai
IPC分类号： C07D401/12 , A61K31/551 , A61K45/06 , A61K31/541 , A61K31/55 , C07D401/14 , A61K31/517 , A61K31/5377
CPC分类号： C07D401/12 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , A61K2300/00
摘要： This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, the disclosure contemplates inducing cells, such as adult somatic cells or cells that are not naturally pluripotent, into cells with chemically induce pluripotency. In certain embodiments, the disclosure contemplates certain compounds disclosed herein, compounds disclosed herein optionally substituted with one or more substituents, derivatives, or salts thereof, for these purposes.
摘要翻译：本公开涉及表观遗传转化细胞的化合物，组合物和方法。在某些实施方案中，本公开涉及产生表观遗传改变的细胞的方法，其包括将分离的细胞与本文所公开的组合物在形成表观遗传改变的细胞的条件下混合。在某些实施方案中，本公开涉及将具有化学诱导多能性的细胞诱导细胞，例如成体体细胞或不是天然多能的细胞。在某些实施方案中，本公开涉及本文公开的某些化合物，本文公开的化合物任选被一个或多个取代基，衍生物或其盐取代，用于这些目的。

4. 发明授权

US08670518B2 Fully passive decay heat removal system for sodium-cooled fast reactors that utilizes partially immersed decay heat exchanger 有权
标题翻译：用于采用部分浸入式衰变热交换器的钠冷快堆的完全被动衰变除热系统
公开(公告)号：US08670518B2
公开(公告)日：2014-03-11
申请号：US12572851
申请日：2009-10-02
申请人： Jae-Hyuk Eoh , Tae-Ho Lee , Ji-Woong Han , Seong-O Kim
发明人： Jae-Hyuk Eoh , Tae-Ho Lee , Ji-Woong Han , Seong-O Kim
IPC分类号： G21C9/00 , G21C15/18 , G21C15/00
CPC分类号： G21C15/18 , G21C1/03 , Y02E30/34
摘要： Disclosed herein is a fully passive decay heat removal system utilizing a partially immersed heat exchanger, the system comprising: a hot pool; an intermediate heat exchanger which heat-exchanges with the sodium of the hot pool; a cold pool; a support barrel extending vertically through the boundary between the hot pool and the cold pool; a sodium-sodium decay heat exchanger received in the support barrel; a sodium-air heat exchanger provided at a position higher than the sodium-sodium decay heat exchanger; an intermediate sodium loop connecting the sodium-sodium decay heat exchanger with the sodium-air heat exchanger; and a primary pump, wherein a portion of the effective heat transfer tube of the sodium-sodium decay heat exchanger is immersed in the cold pool, particularly in a normal operating state, and the surface of the lower end of a shroud for the sodium-sodium decay heat exchanger, the lower end being immersed in the sodium of the cold pool, has perforated holes.
摘要翻译：本文公开了一种利用部分浸没的热交换器的完全被动的衰变热去除系统，该系统包括：热水池; 与热水池的钠进行热交换的中间热交换器; 一个冷水池一个垂直穿过热水池和冷水池边界的支撑桶; 接收在支撑筒中的钠钠衰变热交换器; 设置在高于钠钠衰变热交换器的位置的钠空气热交换器; 将钠钠衰变热交换器与钠空气热交换器连接的中间钠环路; 和主泵，其中钠钠衰变换热器的有效传热管的一部分浸入冷库中，特别是在正常运行状态下，并且钠 - 钠衰变换热器，下端浸入冷库钠中，具有穿孔。

5. 发明授权

US08326288B2 Method and apparatus for providing virtual mobile phone number 有权
标题翻译：提供虚拟手机号码的方法和装置
公开(公告)号：US08326288B2
公开(公告)日：2012-12-04
申请号：US11813766
申请日：2006-01-05
申请人： Yong-kyu Yoo , Ji-woong Han
发明人： Yong-kyu Yoo , Ji-woong Han
IPC分类号： G06F15/16
CPC分类号： H04M3/42008 , H04L63/0421 , H04M2207/18 , H04W4/14 , H04W8/28 , H04W12/02 , H04W88/184
摘要： The present invention relates generally to a method and apparatus for providing a virtual mobile phone number, and, more particularly, to a method and apparatus for requesting routing information, such as an actual phone number from a home location register storing the actual phone number corresponding to a virtual phone number transmitted from an originating terminal and transmitting a short message, a long message or a multimedia message to a terminating terminal corresponding to the actual phone number.
摘要翻译：本发明一般涉及一种用于提供虚拟移动电话号码的方法和装置，更具体地，涉及一种用于请求路由信息的方法和装置，例如来自存储实际电话号码对应的归属位置寄存器的实际电话号码发送到从始发终端发送的虚拟电话号码，并向对应于实际电话号码的终端发送短消息，长消息或多媒体消息。

6. 发明授权

US09458131B2 Compounds and compositions used to epigenetically transform cells and methods related thereto 有权
标题翻译：用于表观遗传转化细胞的化合物和组合物及其相关方法
公开(公告)号：US09458131B2
公开(公告)日：2016-10-04
申请号：US14356024
申请日：2012-11-08
申请人： Young-Sup Yoon , Xiaodong Cheng , Ji Woong Han , Antonello Mai
发明人： Young-Sup Yoon , Xiaodong Cheng , Ji Woong Han , Antonello Mai
IPC分类号： C07D239/72 , C07D211/08 , C07D211/56 , C07D401/12 , A61K31/517 , A61K45/06 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , C07D401/14
CPC分类号： C07D401/12 , A61K31/517 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K31/551 , A61K45/06 , C07D401/14 , A61K2300/00
摘要： This disclosure relates to compounds, compositions and methods of epigenetically transforming cells. In certain embodiments, the disclosure relates to methods of generating epigenetically altered cells comprising mixing isolated cells with compositions disclosed herein under conditions such that epigenetically altered cells are formed. In certain embodiments, the disclosure contemplates inducing cells, such as adult somatic cells or cells that are not naturally pluripotent, into cells with chemically induce pluripotency. In certain embodiments, the disclosure contemplates certain compounds disclosed herein, compounds disclosed herein optionally substituted with one or more substituents, derivatives, or salts thereof, for these purposes.
摘要翻译：本公开涉及表观遗传转化细胞的化合物，组合物和方法。在某些实施方案中，本公开涉及产生表观遗传改变的细胞的方法，其包括将分离的细胞与本文所公开的组合物在形成表观遗传改变的细胞的条件下混合。在某些实施方案中，本公开涉及将具有化学诱导多能性的细胞诱导细胞，例如成体体细胞或不是天然多能的细胞。在某些实施方案中，本公开涉及本文公开的某些化合物，本文公开的化合物任选被一个或多个取代基，衍生物或其盐取代，用于这些目的。

7. 发明授权

US08213969B2 Mobile terminal for chatting by using SMS and method thereof 有权
标题翻译：使用SMS进行聊天的移动终端及其方法
公开(公告)号：US08213969B2
公开(公告)日：2012-07-03
申请号：US12159383
申请日：2007-02-01
申请人： Seung-Hwa Paik , Kwang-Soo Seo , Youn-Pil Jeung , Ji-Woong Han
发明人： Seung-Hwa Paik , Kwang-Soo Seo , Youn-Pil Jeung , Ji-Woong Han
IPC分类号： H04W4/00
CPC分类号： H04M1/72552 , H04L51/04 , H04L51/38 , H04W4/14
摘要： The present invention relates to a mobile communication terminal that supports a text chatting function by using a short message service, and a text chatting service method. For this purpose, the present invention provides a mobile communication terminal including a program memory, a data storage unit, a key input unit, a display, and a microprocessor. The program memory stores a text chatting program for the text chatting service and a program that performs additional functions executed in the text chatting service. The data storage unit stores a text chatting message transmitted/received through the text chatting service. The key input unit includes a key button for generating the text chatting message. The display displays the transmitted/received text chatting message on a chatting window. The microprocessor executes the text chatting program and performs a control function to display text chatting messages communicated with a mobile communication terminal of a chatting contact on the chatting window. Herein, the text chatting message is transmitted/received by using a short message service. According to the present invention, a text chatting service using a short message service can be realized by simply changing a user interface of the mobile communication terminal so that a user can check a transmitted/received short message through one screen window, and provide a cost reduction by using a less expensive short message service than a data charge.
摘要翻译：本发明涉及通过使用短消息服务来支持文本聊天功能的移动通信终端和文本聊天服务方法。为此，本发明提供了包括程序存储器，数据存储单元，键输入单元，显示器和微处理器的移动通信终端。程序存储器存储用于文本聊天服务的文本聊天程序和执行在文本聊天服务中执行的附加功能的程序。数据存储单元存储通过文本聊天服务发送/接收的文本聊天消息。键输入单元包括用于产生文本聊天消息的按键。显示器在聊天窗口上显示发送/接收的文本聊天消息。微处理器执行文本聊天程序并执行控制功能，以在聊天窗口上显示与聊天联系人的移动通信终端通信的文本聊天消息。这里，通过使用短消息服务来发送/接收文本聊天消息。根据本发明，可以通过简单地改变移动通信终端的用户接口来实现使用短消息服务的文本聊天服务，使得用户可以通过一个屏幕窗口检查发送/接收的短消息，并提供成本通过使用比数据费用更便宜的短消息服务来减少。

8. 发明申请

US20100177860A1 FULLY PASSIVE DECAY HEAT REMOVAL SYSTEM FOR SODIUM-COOLED FAST REACTORS THAT UTILIZES PARTIALLY IMMERSED DECAY HEAT EXCHANGER 有权
标题翻译：用于冷却的快速反应器的完全被动衰减的热去除系统，其使用部分强制衰减热交换器
公开(公告)号：US20100177860A1
公开(公告)日：2010-07-15
申请号：US12572851
申请日：2009-10-02
申请人： Jae-Hyuk Eoh , Tae-Ho Lee , Ji-Woong Han , Seong-O Kim
发明人： Jae-Hyuk Eoh , Tae-Ho Lee , Ji-Woong Han , Seong-O Kim
IPC分类号： G21C9/00
CPC分类号： G21C15/18 , G21C1/03 , Y02E30/34
摘要： Disclosed herein is a fully passive decay heat removal system utilizing a partially immersed heat exchanger, the system comprising: a hot pool; an intermediate heat exchanger which heat-exchanges with the sodium of the hot pool; a cold pool; a support barrel extending vertically through the boundary between the hot pool and the cold pool; a sodium-sodium decay heat exchanger received in the support barrel; a sodium-air heat exchanger provided at a position higher than the sodium-sodium decay heat exchanger; an intermediate sodium loop connecting the sodium-sodium decay heat exchanger with the sodium-air heat exchanger; and a primary pump, wherein a portion of the effective heat transfer tube of the sodium-sodium decay heat exchanger is immersed in the cold pool, particularly in a normal operating state, and the surface of the lower end of a shroud for the sodium-sodium decay heat exchanger, the lower end being immersed in the sodium of the cold pool, has perforated holes.
摘要翻译：本文公开了一种利用部分浸没的热交换器的完全被动的衰变热去除系统，该系统包括：热水池; 与热水池的钠进行热交换的中间热交换器; 一个冷水池一个垂直穿过热水池和冷水池边界的支撑桶; 接收在支撑筒中的钠钠衰变热交换器; 设置在高于钠钠衰变热交换器的位置的钠空气热交换器; 将钠钠衰变热交换器与钠空气热交换器连接的中间钠环路; 和主泵，其中钠钠衰变换热器的有效传热管的一部分浸入冷库中，特别是在正常运行状态下，并且钠 - 钠衰变换热器，下端浸入冷库钠中，具有穿孔。

9. 发明授权

US07670602B2 Concatameric immunoadhesion molecule 有权
标题翻译：共聚蛋白免疫粘附分子
公开(公告)号：US07670602B2
公开(公告)日：2010-03-02
申请号：US11739288
申请日：2007-04-24
申请人： Yong-Hoon Chung , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
发明人： Yong-Hoon Chung , Ji-Woong Han , Hye-Ja Lee , Eun-Yong Choi , Jin-Mi Kim
IPC分类号： A61K39/395
CPC分类号： C07K14/70507 , A61K2039/505 , C07K14/70521 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
摘要翻译：公开了包含两个可溶性结构域的连续蛋白质，其中生物活性蛋白质的可溶性结构域的C末端与生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端连接。此外，本发明公开了通过在两个单体蛋白的铰链区上形成分子间二硫键而形成的二聚体蛋白，该两个单体蛋白是通过将免疫应答涉及免疫应答的两个相同的可溶胞外区的连接体与免疫球蛋白分子的Fc片段糖基化蛋白质，编码单体蛋白的DNA构建体，含有DNA构建体的重组表达质粒，用重组表达质粒转化或转染的宿主细胞，以及通过培养宿主细胞制备二聚体蛋白质的方法。此外，本发明公开了包含二聚体蛋白质或其糖基化形式的药物或诊断组合物。

10. 发明申请

US20090011466A1 CONCATAMERIC IMMUNOADHESION MOLECULE 有权
标题翻译：综合免疫分子
公开(公告)号：US20090011466A1
公开(公告)日：2009-01-08
申请号：US11739288
申请日：2007-04-24
申请人： Yong-Hoon CHUNG , Ji-Woong HAN , Hye-Ja LEE , Eun-Yong CHOI , Jin-Mi KIM
发明人： Yong-Hoon CHUNG , Ji-Woong HAN , Hye-Ja LEE , Eun-Yong CHOI , Jin-Mi KIM
IPC分类号： C12P21/02 , C07K14/54 , C12N15/62 , C12N15/85 , C12N5/10
CPC分类号： C07K14/70507 , A61K2039/505 , C07K14/70521 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： Disclosed are concatameric proteins comprising two soluble domains, in which the C-terminus of a soluble domain of a biologically active protein is linked to the N-terminus of an identical soluble domain or a distinct soluble domain of a biologically active protein. Also, the present invention discloses dimeric proteins formed by formation of intermolecular disulfide bonds at the hinge region of two monomeric proteins formed by linkage of a concatamer of two identical soluble extracellular regions of proteins involving immune response to an Fc fragment of an immunoglobulin molecule, their glycosylated proteins, DNA constructs encoding the monomeric proteins, recombinant expression plasmids containing the DNA construct, host cells transformed or transfected with the recombinant expression plasmids, and a method of preparing the dimeric proteins by culturing the host cells. Further, the present invention discloses pharmaceutical or diagnostic compositions comprising the dimeric protein or its glycosylated form.
摘要翻译：公开了包含两个可溶性结构域的连续蛋白质，其中生物活性蛋白质的可溶性结构域的C末端与生物活性蛋白质的相同可溶性结构域或不同可溶性结构域的N末端连接。此外，本发明公开了通过在两个单体蛋白的铰链区上形成分子间二硫键而形成的二聚体蛋白，该两个单体蛋白是通过将免疫应答涉及免疫应答的两个相同的可溶胞外区的连接体与免疫球蛋白分子的Fc片段糖基化蛋白质，编码单体蛋白的DNA构建体，含有DNA构建体的重组表达质粒，用重组表达质粒转化或转染的宿主细胞，以及通过培养宿主细胞制备二聚体蛋白质的方法。此外，本发明公开了包含二聚体蛋白质或其糖基化形式的药物或诊断组合物。

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