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1. 发明授权

US08765416B2 Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof 有权
标题翻译：含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其制备方法及其用途
公开(公告)号：US08765416B2
公开(公告)日：2014-07-01
申请号：US12875786
申请日：2010-09-03
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/44
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上; 并提供其制造方法及其用途。

2. 发明申请

US20140178943A9 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
标题翻译：生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US20140178943A9
公开(公告)日：2014-06-26
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

3. 发明申请

US20120329098A1 CELLOBIOSE 2-EPIMERASE, ITS PREPARATION AND USES 有权
标题翻译： CELLOBIOSE 2-EPIMERASE，其制备和用途
公开(公告)号：US20120329098A1
公开(公告)日：2012-12-27
申请号：US13590460
申请日：2012-08-21
申请人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
发明人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/24
CPC分类号： C12N9/90 , C12P19/02 , C12P19/12
摘要： The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.
摘要翻译：本发明的目的是提供一种耐热纤维二糖2-差向异构酶，其制备和用途。本发明通过提供热稳定性纤维二糖2-差向异构酶，编码该酶的DNA，重组DNA和包含该DNA的转化体，该酶的制备方法和使用该酶生产异构化糖的方法来实现上述目的。

4. 发明授权

US08324375B2 Branched α-glucan, α-glucosyltransferase which forms the glucan, their preparation and uses 有权
标题翻译：形成葡聚糖的分支α-葡聚糖，α-葡萄糖基转移酶，其制备和应用
公开(公告)号：US08324375B2
公开(公告)日：2012-12-04
申请号：US12597660
申请日：2008-04-23
申请人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
发明人： Hikaru Watanabe , Takuo Yamamoto , Tomoyuki Nishimoto , Keiji Tsusaki , Kazuyuki Oku , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C07H1/00 , C07H3/00 , C08B37/00 , A01N43/04 , A61K31/715 , C12P19/18 , C12P19/14 , C12N9/00 , C12N9/10
CPC分类号： A23L33/21 , A21D2/18 , A23C9/1307 , A23C9/1544 , A23L2/39 , A23L9/20 , A23L11/05 , A23L29/35 , A23L33/10 , A23L33/18 , A23V2002/00 , A61K8/73 , A61K8/732 , A61K9/06 , A61K9/20 , A61K31/716 , A61K31/718 , A61Q11/00 , A61Q17/04 , A61Q19/00 , A61Q19/02 , C08B37/0009 , C12N9/1051 , C12P19/04 , C12P19/18 , C12R1/06 , C12R1/09 , Y02P20/52 , A23V2250/5118 , A23V2200/3262 , A23V2200/328
摘要： The present invention has objects to provide a glucan useful as water-soluble dietary fiber, its preparation and uses. The present invention solves the above objects by providing a branched α-glucan, which is constructed by glucose molecules and characterized by methylation analysis as follows: (1) Ratio of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol to 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is in the range of 1:0.6 to 1:4; (2) Total content of 2,3,6-trimethyl-1,4,5-triacetyl-glucitol and 2,3,4-trimethyl-1,5,6-triacetyl-glucitol is 60% or higher in the partially methylated glucitol acetates; (3) Content of 2,4,6-trimethyl-1,3,5-triacetyl-glucitol is 0.5% or higher but less than 10% in the partially methylated glucitol acetates; and (4) Content of 2,4-dimethyl-1,3,5,6-tetraacetyl-glucitol is 0.5% or higher in the partially methylated glucitol acetates; a novel α-glucosyltransferase which forms the branched α-glucan, processes for producing them, and their uses.
摘要翻译：本发明的目的是提供可用作水溶性膳食纤维的葡聚糖及其制备和用途。本发明通过提供由葡萄糖分子构成并以甲基化分析为特征的支链α-葡聚糖来解决上述目的：（1）2,3,6-三甲基-1,4,5-三乙酰基 - 葡萄糖醇至2,3,4-三甲基-1,5,6-三乙酰基 - 葡萄糖醇的比例范围为1:0.6至1:4; （2）部分甲基化的2,3,6-三甲基-1,4,5-三乙酰 - 葡萄糖醇和2,3,4-三甲基-1,5,6-三乙酰 - 葡糖醇的总含量为60％以上葡萄糖醇乙酸酯; （3）部分甲基化葡萄糖醇乙酸酯中2,4,6-三甲基-1,3,5-三乙酰 - 葡萄糖醇的含量为0.5％以上且小于10％和（4）部分甲基化葡萄糖醇乙酸酯中2,4-二甲基-1,3,5,6-四乙酰 - 葡萄糖醇的含量为0.5％以上; 形成支链α-葡聚糖的新型α-葡糖基转移酶，其制备方法及其用途。

5. 发明申请

US20120040407A1 CELLOBIOSE 2-EPIMERASE, ITS PREPARATION AND USES 审中-公开
公开(公告)号：US20120040407A1
公开(公告)日：2012-02-16
申请号：US13147965
申请日：2010-01-25
申请人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
发明人： Hikaru Watanabe , Masahiro Yagi , Tomoyuki Nishimoto , Hiroto Chaen , Shigeharu Fukuda
IPC分类号： C12P19/24 , C12N15/61 , C12N1/00 , C12N1/21 , C12N1/19 , C12N9/90 , C12N15/63
CPC分类号： C12N9/90 , C12P19/02 , C12P19/12
摘要： The present invention has objects to provide a thermostable cellobiose 2-epimerase, its preparation and uses. The present invention attains the above objects by providing a thermostable cellobiose 2-epimerase, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a process for producing the enzyme, and a process for producing isomerized saccharides using the enzyme.

6. 发明授权

US07732426B2 Isocyclomaltooligosaccharide (S) , isocyclomaltooligosaccharide-forming enzyme, their preparation and uses 有权
标题翻译：异环寡糖（S），异环寡糖寡糖形成酶，其制备和用途
公开(公告)号：US07732426B2
公开(公告)日：2010-06-08
申请号：US11663919
申请日：2005-09-26
申请人： Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/715 , A61K31/702 , C07H1/00
CPC分类号： C07H3/06 , A23L29/35 , A23L33/25 , C12N9/2402 , C12N9/2405 , C12P19/04
摘要： The present invention have objects to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above objects by providing an isocyclomaltooligosaccharide(s) having a structure represented by General Formula 1, a novel isocyclomaltooligosaccharide-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the isocyclomaltooligosaccharide(s) or a saccharide composition comprising the same, and uses thereof. Cyclo{→6)-[α-D-Glcp-(1→4)]n-α-D-Glcp-(1→} General Formula 1 (In General Formula 1, “n” means a number of 4 or 5).
摘要翻译：本发明的目的是提供一种由葡萄糖组成的新型非还原性糖组成的非还原性糖类，提供形成非还原性糖类的新型酶，其制造方法及其制造方法，编码酶的DNA，重组DNA和包含DNA的转化体，包含非还原性糖的组合物及其用途。本发明通过提供具有由通式1表示的结构的异环型低聚半乳糖，新型的异环型低聚葡萄糖形成酶，其制备方法和方法，编码该酶的DNA，重组DNA和转化体来解决上述目的包含DNA，包含异环寡脱醇糖的组合物或包含该组合物的糖组合物及其用途。环状{→6） - [α-D-Glcp-（1→4）] n-α-D-Glcp-（1→}通式1（在通式1中，“n”表示4或5 ）。

7. 发明申请

US20090118255A1 Crp Lowering Agent 审中-公开
标题翻译： Crp降剂
公开(公告)号：US20090118255A1
公开(公告)日：2009-05-07
申请号：US11659941
申请日：2005-08-08
申请人： Yoshimi Imura , Ryuichi Tozawa , Tomoyuki Nishimoto
发明人： Yoshimi Imura , Ryuichi Tozawa , Tomoyuki Nishimoto
IPC分类号： A61K31/553 , C07D413/02
CPC分类号： A61K31/553 , A61K31/00
摘要： The present invention provides a novel drug which is useful as a preventive and/or therapeutic agent for various diseases involved in elevation of CRP level, in particular, inflammatory disease and cancer comprising a compound having inhibitory activity against squalene synthase or a salt thereof, or a prodrug thereof.
摘要翻译：本发明提供一种新的药物，其可用作涉及CRP水平升高，特别是炎性疾病和癌症的各种疾病的预防和/或治疗剂，其包含对角鲨烯合酶或其盐具有抑制活性的化合物或其前药。

8. 发明申请

US20090022872A1 HIGHLY-BRANCHED STARCH, ITS PRODUCTION AND USES 有权
标题翻译：高分配淀粉，其生产和用途
公开(公告)号：US20090022872A1
公开(公告)日：2009-01-22
申请号：US11911090
申请日：2006-03-14
申请人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23L2/00 , C08B31/00 , A23L1/48 , C12P19/04
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶促反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着抗退行性的具有6-α-麦芽糖基 - 和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种生产支化淀粉而不降低分子量的方法的材料淀粉及其用途。

9. 发明申请

US20080132483A1 Agent for preventing or treating organ functional disorders and organ dysfunction 审中-公开
标题翻译：用于预防或治疗器官功能障碍和器官功能障碍的药剂
公开(公告)号：US20080132483A1
公开(公告)日：2008-06-05
申请号：US12009277
申请日：2008-01-17
申请人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
发明人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
IPC分类号： A61K31/553 , C07D498/00 , A61P3/04
CPC分类号： C07D413/04 , A61K31/553 , C07D267/14 , C07D281/10 , C07D413/06 , C07D413/12 , C07D417/04
摘要： The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供了用于预防或治疗器官功能障碍的药剂，用于预防或治疗器官功能障碍的药剂和用于预防或治疗肥胖症及其脱发病的药剂，其各自包括具有增加泛醌或其盐的作用的化合物或其前药; 以及含有具有角鲨烯合酶抑制作用的化合物或其前体药物的泛醌增加剂。

10. 发明授权

US07309697B2 Cyclic maltosylmatose 有权
标题翻译：循环麦芽糖
公开(公告)号：US07309697B2
公开(公告)日：2007-12-18
申请号：US10569959
申请日：2004-08-26
申请人： Kazuhisa Mukai , Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuhisa Mukai , Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/715 , C07H1/00
CPC分类号： A61K9/2018 , A21D2/181 , A23L2/52 , A23L2/60 , A23L13/428 , A23L27/33 , A23L33/10 , A61K8/60 , A61Q11/00 , C07H3/06 , C12N9/1048 , C12P19/18
摘要： An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{→6)-α-D-glucopyranosyl-(1→4)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→4)-α-D-glucopyranosyl-(1→6}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.
摘要翻译：本发明的目的是通过提供一种由葡萄糖组成的新型非还原性糖组成并提供形成非还原性糖的新型酶，提供一种非还原性糖的方法及其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，包含非还原性糖的组合物及其用途。本发明通过提供具有环{ - > 6）-α-D-吡喃葡萄糖基 - （1-> 4）-α-D-吡喃葡萄糖基 - （1-> 6） - 结构的新型环状糖来解决上述目的。 α-D-吡喃葡萄糖基 - （1-> 4）-α-D-吡喃葡萄糖基 - （1-> 6），环状麦芽糖基麦芽糖，新型环状麦芽糖基麦芽糖酶形成酶，其制备方法和方法，编码酶，重组DNA和包含该DNA的转化体，包含环状麦芽糖基麦芽糖的组合物或包含其的糖组合物及其用途。

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