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1. 发明申请

US20080132483A1 Agent for preventing or treating organ functional disorders and organ dysfunction 审中-公开
标题翻译：用于预防或治疗器官功能障碍和器官功能障碍的药剂
公开(公告)号：US20080132483A1
公开(公告)日：2008-06-05
申请号：US12009277
申请日：2008-01-17
申请人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
发明人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
IPC分类号： A61K31/553 , C07D498/00 , A61P3/04
CPC分类号： C07D413/04 , A61K31/553 , C07D267/14 , C07D281/10 , C07D413/06 , C07D413/12 , C07D417/04
摘要： The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供了用于预防或治疗器官功能障碍的药剂，用于预防或治疗器官功能障碍的药剂和用于预防或治疗肥胖症及其脱发病的药剂，其各自包括具有增加泛醌或其盐的作用的化合物或其前药; 以及含有具有角鲨烯合酶抑制作用的化合物或其前体药物的泛醌增加剂。

2. 发明申请

US20060241096A1 Agent for preventing or treating organ functional disorders and organ dysfunction 审中-公开
标题翻译：用于预防或治疗器官功能障碍和器官功能障碍的药剂
公开(公告)号：US20060241096A1
公开(公告)日：2006-10-26
申请号：US11473560
申请日：2006-06-23
申请人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
发明人： Yasuo Sugiyama , Tomoyuki Nishimoto , Yoshihiro Kiyota
IPC分类号： A61K31/553
CPC分类号： C07D413/04 , A61K31/553 , C07D267/14 , C07D281/10 , C07D413/06 , C07D413/12 , C07D417/04
摘要： The present invention provides an agent for preventing or treating organ functional disorders, an agent for preventing or treating organ dysfunction and an agent for preventing or treating obesity and deuteropathy thereof, each of which comprises a compound having an effect of increasing ubiquinone or a salt thereof or a prodrug thereof; as well as a ubiquinone increasing agent comprising a compound having a squalene synthase inhibitory effect or a salt thereof or a prodrug thereof.
摘要翻译：本发明提供了用于预防或治疗器官功能障碍的药剂，用于预防或治疗器官功能障碍的药剂和用于预防或治疗肥胖症及其脱发病的药剂，其各自包括具有增加泛醌或其盐的作用的化合物或其前药; 以及含有具有角鲨烯合酶抑制作用的化合物或其前体药物的泛醌增加剂。

3. 发明申请

US20050234116A1 Vdac regulator 失效
标题翻译： Vdac调节器
公开(公告)号：US20050234116A1
公开(公告)日：2005-10-20
申请号：US10507731
申请日：2003-03-13
申请人： Yasuo Sugiyama , Masatoshi Hazama , Norihisa Iwakami
发明人： Yasuo Sugiyama , Masatoshi Hazama , Norihisa Iwakami
IPC分类号： A61K31/422 , A61P1/00 , A61P1/16 , A61P3/04 , A61P3/06 , A61P3/10 , A61P7/06 , A61P9/00 , A61P9/10 , A61P9/12 , A61P19/02 , A61P21/00 , A61P25/00 , A61P25/04 , A61P25/08 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/02 , A61P31/18 , A61P31/20 , A61P43/00 , C07D263/34 , C07D413/04 , C07D413/14 , A61K31/4178 , A61K31/427
CPC分类号： A61K31/422 , C07D263/34 , C07D413/04 , C07D413/14 , G01N2500/04
摘要： The present invention provides a VDAC regulator comprising a compound represented by the formula (I): wherein R1 is a halogen atom, an optionally substituted heterocyclic group, an optionally substituted hydroxy group, an optionally substituted thiol group or an optionally substituted amino group; A is an optionally substituted acyl group, an optionally substituted heterocyclic group, an optionally substituted hydroxy group or an optionally esterified or amidated carboxyl group; B is an optionally substituted aromatic group; X is an oxygen atom, a sulfur atom or an optionally substituted nitrogen atom; and Y is a divalent hydrocarbon group or heterocyclic group, a salt thereof or a prodrug thereof, which is useful as an agent for the prophylaxis or treatment of Down's syndrome and the like, and the like.
摘要翻译：本发明提供一种VDAC调节剂，其包含由式（I）表示的化合物：其中R 1是卤素原子，任选取代的杂环基，任选取代的羟基，任选取代的硫醇基或任选取代的氨基; A是任选取代的酰基，任选取代的杂环基，任选取代的羟基或任选酯化或酰胺化的羧基; B是任选取代的芳基; X是氧原子，硫原子或任选取代的氮原子; Y是可用作预防或治疗唐氏综合征等的二价烃基或杂环基，其盐或前体药物等。

4. 发明授权

US5677298A Benzoxazepine-2-one compounds and their use 失效
标题翻译：苯并西泮-2-酮化合物及其用途
公开(公告)号：US5677298A
公开(公告)日：1997-10-14
申请号：US696118
申请日：1996-08-13
申请人： Hidefumi Yukimasa , Masakuni Kori , Ryuichi Tozawa , Yasuo Sugiyama
发明人： Hidefumi Yukimasa , Masakuni Kori , Ryuichi Tozawa , Yasuo Sugiyama
IPC分类号： C12N9/99 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P3/06 , A61P43/00 , C07D223/16 , C07D243/04 , C07D243/10 , C07D243/12 , C07D243/14 , C07D243/16 , C07D243/24 , C07D245/06 , C07D255/04 , C07D257/04 , C07D267/14 , C07D267/22 , C07D281/10 , C07D285/00 , C07D417/06 , C07D417/12 , C07D498/04 , A01N43/72 , C07D303/48
CPC分类号： C07D223/16 , C07D243/04 , C07D243/12 , C07D243/24 , C07D255/04 , C07D267/14 , C07D281/10 , C07D417/06 , C07D417/12
摘要： Disclosed is a squalene synthetase inhibitor which comprises the compound represented by the formula (I) ##STR1## wherein R.sub.1 stands for H or an optionally substituted hydrocarbon group; R.sub.2 and R.sub.3 independently stand for H, an optionally substituted alkyl group, an optionally substituted phenyl group or an optionally substituted aromatic heterocyclic group; Z stands for a carbon chain containing a double bond or --Z'--C(OH)-- (Z' stands for a bond or a straight-chain or branched alkylene chain); the symbol ......... stands for a double bond or a single bond; Y stands for an optionally esterified carboxyl group, an optionally substituted carbamoyl group, an optionally substituted hydroxyl group, an optionally substituted amino group or an optionally substituted heterocyclic radical having a protonizable hydrogen; X stands for O or S; G stands for O or S; and the ring A is optionally substituted, or a pharmaceutically acceptable salt thereof, and which is useful for the prophylaxis or therapy of hypercholesteremia or coronary sclerosis of mammals.
摘要翻译：公开了一种角鲨烯合成酶抑制剂，其包含由式（I）表示的化合物，其中R1代表H或任选取代的烃基; R2和R3独立地代表H，任选取代的烷基，任选取代的苯基或任选取代的芳族杂环基; Z表示含有双键或-Z'-C（OH） - （Z'表示键或直链或支链亚烷基链）的碳链; 符号+ E，ovs ......... + EE代表双键或单键; Y表示任选酯化的羧基，任选取代的氨基甲酰基，任选取代的羟基，任选取代的氨基或具有可质子化氢的任选取代的杂环基; X代表O或S; G代表O或S; 并且环A任选被取代，或其药学上可接受的盐，其可用于预防或治疗哺乳动物的高胆固醇血症或冠状动脉硬化症。

5. 发明授权

US5492929A Condensed heterocyclic compounds useful for inhibiting acyl-CoA 失效
标题翻译：用于抑制酰基辅酶A的缩合杂环化合物
公开(公告)号：US5492929A
公开(公告)日：1996-02-20
申请号：US165925
申请日：1993-12-14
申请人： Hideaki Natsugari , Yasuo Sugiyama , Yoshinori Ikeura
发明人： Hideaki Natsugari , Yasuo Sugiyama , Yoshinori Ikeura
IPC分类号： C07D209/14 , C07D209/18 , C07D209/40 , C07D307/79 , C07D307/81 , C07D307/82 , C07D333/58 , C07D333/60 , C07D333/66 , A61K31/34
CPC分类号： C07D307/79 , C07D209/14 , C07D209/18 , C07D209/40 , C07D307/81 , C07D307/82 , C07D333/58 , C07D333/60 , C07D333/66
摘要： Novel compound represented by the formula: ##STR1## wherein ring A, ring B and ring C each stands for an optionally substituted benzene ring; X stands for --NR-- wherein R stands for hydrogen atom or an optionally substituted hydrocarbon group, --O-- or --S--; Y stands for --(CH.sub.2)n-- wherein n denotes 1 or 2 or --NH--; and R.sup.a stands for a hydrogen atom or an optionally substituted hydrocarbon group, provided that when ring C is unsubstituted or substituted only at para-position, ring B is substituted at least at ortho-position or a salt thereof which have an excellent acyl-CoA: cholesterol acyltransferase inhibiting action and cholesterol-lowering activity, their production and medicinal use.
摘要翻译：由下式表示的新型化合物：其中环A，环B和环C各自代表任选取代的苯环; X代表-NR-，其中R代表氢原子或任选取代的烃基，-O-或-S-; Y代表 - （CH2）n-，其中n表示1或2或-NH-; 并且Ra表示氢原子或任选取代的烃基，条件是当环C未被取代或仅在对位取代时，环B至少在邻位被取代，或其盐具有优异的酰基辅酶A 胆固醇酰基转移酶抑制作用和胆固醇降低活性，其生产和药用。

6. 发明授权

US4643939A Oil absorbing cosmetic tissue 失效
标题翻译：吸油化妆品组织
公开(公告)号：US4643939A
公开(公告)日：1987-02-17
申请号：US835928
申请日：1986-03-04
申请人： Yasuo Sugiyama , Osamu Hiraoka , Tamotsu Nakazawa , Kenji Nakamura
发明人： Yasuo Sugiyama , Osamu Hiraoka , Tamotsu Nakazawa , Kenji Nakamura
IPC分类号： A45D40/00 , A61K8/02 , A61Q17/00 , A61Q19/00 , B32B5/16
CPC分类号： A61Q17/005 , A45D40/00 , A61K8/0208 , A61Q19/008 , Y10S428/913 , Y10T428/2982 , Y10T442/2525
摘要： An oil absorbing cosmetic tissue consisting of an oil absorbant sheet impregnated with a bactericide, the tissue thus able to remove excess skin oil and at the same time suppress the proliferation of bacteria so as to reduce the adverse effects of bacteria on the skin.
摘要翻译：由浸渍有杀菌剂的吸油片组成的吸油化妆品组织，能够除去过量的皮肤油，同时抑制细菌的增殖，从而减少细菌对皮肤的不利影响。

7. 发明授权

US06545009B1 Retinoid-related receptor function regulating agent 失效
标题翻译：类视黄醇相关受体功能调节剂
公开(公告)号：US06545009B1
公开(公告)日：2003-04-08
申请号：US09720644
申请日：2000-12-28
申请人： Yasuo Sugiyama , Yu Momose , Hiroyuki Kimura , Junichi Sakamoto , Hiroyuki Odaka
发明人： Yasuo Sugiyama , Yu Momose , Hiroyuki Kimura , Junichi Sakamoto , Hiroyuki Odaka
IPC分类号： A61K31435
CPC分类号： C07D413/04 , C07D263/32 , C07D277/30 , C07D417/04
摘要： 1,3-Azole derivatives, pharmaceutical compositions thereof and methods for regulating the function of retinoid-related receptors with 1,3-azole derivatives are disclosed. Such regulation may be useful for preventing or treating diabetes, preventing or treating hyperlipidemia, preventing or treating impaired glucose tolerance (IGT) or for preventing transition from impaired glucose tolerance to diabetes.
摘要翻译：公开了1,3-唑衍生物，其药物组合物和调节具有1,3-唑衍生物的类视黄醇相关受体功能的方法。这种调节可用于预防或治疗糖尿病，预防或治疗高脂血症，预防或治疗葡萄糖耐量异常（IGT）或预防糖耐量受损转变为糖尿病。

8. 发明授权

US6110909A Benzoxazepine compounds, their production and use as lipid lowering agents 失效
标题翻译：苯并西泮化合物，其生产和用作降脂剂
公开(公告)号：US6110909A
公开(公告)日：2000-08-29
申请号：US43265
申请日：1998-03-12
申请人： Hidefumi Yukimasa , Yasuo Sugiyama , Ryuichi Tozawa
发明人： Hidefumi Yukimasa , Yasuo Sugiyama , Ryuichi Tozawa
IPC分类号： A61P9/10 , C07D267/14 , C07D413/06 , C07D413/12 , C07D413/14 , C07D491/10 , C07D521/00 , C07F9/6527 , C07F9/6558 , A61K31/553
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D267/14 , C07D281/10 , C07D413/06 , C07D413/12 , C07D413/14 , C07D491/10 , C07F9/6527 , C07F9/65583
摘要： This invention provides new benzoxazepine compounds represented by the formula: ##STR1## [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R.sub.1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.
摘要翻译： PCT No.PCT / JP96 / 02596 Sec。 371日期1998年3月12日 102（e）1998年3月12日PCT PCT 1996年9月12日PCT公布。出版物WO97 / 10224 日本公开1997年3月20日本发明提供由下式表示的新的苯并恶氮化合物：其中R代表任选被羟基取代的低级烷基，X代表任选取代的氨基甲酰基或任选取代的具有脱质子氢原子，R1表示低级烷基，W表示卤原子]，其具有降低胆固醇水平和降低三倍体水平的活性，并且可用于预防和治疗高脂血症。

9. 发明授权

US5847368A Electric heating unit and method of producing same 失效
标题翻译：电加热单元及其制造方法
公开(公告)号：US5847368A
公开(公告)日：1998-12-08
申请号：US667148
申请日：1996-06-20
申请人： Yasuo Sugiyama
发明人： Yasuo Sugiyama
IPC分类号： F27D1/00 , F27D99/00 , H05B3/60 , H05B1/00 , H01C1/034 , H05B3/00 , H05B3/44
CPC分类号： F27D99/0006 , F27D1/0036 , H05B3/60 , Y10T29/49083
摘要： An electric heating unit comprises a heat-insulating main body consisting primarily of a heat-insulating material and formed with a groove in a surface thereof, and a heating element provided in the groove and shaped in the form of waves with an amplitude greater than the width of the groove, the heating element having at widthwise opposite sides thereof bent portions extending into the main body from groove-defining opposite side walls thereof and thereby integrally supported by the main body. A bottom-forming member of refractory material made separately from the main body covers the bottom of the groove and is supported by the main body integrally therewith so that the surface of the member toward the opening of the groove is exposed from the main body. The heating element is disposed closer to the groove opening than the bottom-forming member and integrally supported by the main body so as to be in contact with portions of the surface of the member. The heating element is positioned within the groove and exposed outside the main body.
摘要翻译：电加热单元包括主要由绝热材料构成并在其表面上形成有凹槽的绝热主体，以及设置在凹槽中的加热元件，其形状波形大于槽的宽度，加热元件在其宽度方向的相对侧上具有从其与槽相对的侧壁延伸到主体中的弯曲部分，从而由主体一体地支撑。与主体分开形成的耐火材料的底部形成构件覆盖槽的底部，并且与主体一体地支撑，使得朝向槽的开口的构件的表面从主体露出。加热元件设置成比底部形成部件更靠近槽开口，并且由主体一体地支撑，以便与部件的表面的部分接触。加热元件位于槽内并暴露在主体外部。

10. 发明授权

US4590712A Vertical spindle duplex head for a grinder 失效
标题翻译：用于研磨机的垂直主轴双面打印头
公开(公告)号：US4590712A
公开(公告)日：1986-05-27
申请号：US785082
申请日：1985-10-04
申请人： Yasuo Sugiyama , Masaomi So , Ichiro Hamaguchi , Kenichi Maeda
发明人： Yasuo Sugiyama , Masaomi So , Ichiro Hamaguchi , Kenichi Maeda
IPC分类号： B24B7/17 , B24B7/16 , B24B47/10 , B24B5/00
CPC分类号： B24B7/162
摘要： A vertical spindle duplex head for a grinder includes an annular pressure wheel and a receiver wheel arranged to rotate and revolve workpieces between the annular surfaces of the pressure wheel and the receiver wheel and a grindstone for one end portion of the workpieces driven in the opposite directions of rotation of the pressure wheel and receiver wheel and at their different rotational ratios. The workpieces rotate and revolve between these wheels, thereby grinding their end face by means of a grindstone arranged around the external periphery of a rotary carrier.The pressure wheel and receiver wheel are rotatably driven in opposite directions and at their different rotational speeds by distributing driving force from one source to each of them and a variable driving means is provided on one of the transmittance routes of the driving force extending from the place of distributing the driving force to both of the pressure wheel and the receiver wheel, whereby the rotational ratio of each of them can be optionally changed.
摘要翻译：用于研磨机的垂直主轴双面打印头包括环形压力轮和接收轮，其被布置成在压力轮和接收轮的环形表面之间旋转和旋转工件，以及用于沿相反方向驱动的工件的一个端部的磨石的压力轮和接收轮的旋转并且以其不同的旋转比。工件在这些车轮之间旋转并旋转，从而通过绕旋转载体的外周布置的磨石研磨它们的端面。压力轮和接收轮通过将驱动力从一个源分配到它们中的每一个而以相反方向和不同的转速旋转地驱动，并且可变驱动装置设置在从该位置延伸的驱动力的透射路径之一将驱动力分配到压力轮和接收轮两者，由此可以任意地改变它们中的每一个的旋转比。

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