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1. 发明授权

US09265781B2 Process for producing a particulate composition comprising anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid 有权
标题翻译：制备包含无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US09265781B2
公开(公告)日：2016-02-23
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18 , A61K31/7048 , C07H17/04 , C12P19/60 , A61K9/16
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高到86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

2. 发明授权

US08765416B2 Particulate composition containing anhydrous crystalline 2-O-alpha-D-glucosyl-L-ascorbic acid, process for producing the same, and uses thereof 有权
标题翻译：含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其制备方法及其用途
公开(公告)号：US08765416B2
公开(公告)日：2014-07-01
申请号：US12875786
申请日：2010-09-03
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/44
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid; and by providing a process for producing the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶的2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上; 并提供其制造方法及其用途。

3. 发明申请

US20140178943A9 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
标题翻译：生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US20140178943A9
公开(公告)日：2014-06-26
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

4. 发明申请

US20130295618A1 PROCESS FOR PRODUCING A PARTICULATE COMPOSITION COMPRISING ANHYDROUS CRYSTALLINE 2-O-ALPHA-D-GLUCOSYL-L-ASCORBIC ACID 有权
标题翻译：生产包含无水晶体2-O-ALPHA-D-葡萄糖-L-抗坏血酸的颗粒组合物的方法
公开(公告)号：US20130295618A1
公开(公告)日：2013-11-07
申请号：US13980223
申请日：2012-03-07
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18
CPC分类号： A61K31/7048 , A61K9/16 , C07H17/04 , C12P19/18 , C12P19/60 , C12Y204/01019
摘要： The invention provides a process for enabling the production of a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside that does not significantly cake even when the production yield of ascorbic acid 2-glucoside does not reach 35% by weight. The process for producing a particulate composition containing anhydrous crystalline ascorbic acid 2-glucoside, which comprises allowing a CGTase to act on a solution containing either liquefied starch or dextrin and L-ascorbic acid and then allowing a glucoamylase to act on the resulting solution to obtain a solution with an ascorbic acid 2-glucoside production yield of at least 27%, purifying the obtained solution to increase the ascorbic acid 2-glucoside content to a level of over 86% by weight, precipitating anhydrous crystalline ascorbic acid 2-glucoside by a controlled cooling method or pseudo-controlled cooling method, collecting the precipitated anhydrous crystalline ascorbic acid 2-glucoside, and ageing and drying the collected anhydrous crystalline ascorbic acid 2-glucoside.
摘要翻译：本发明提供了一种能够生产含有抗坏血酸2-葡萄糖苷的无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，即使当抗坏血酸2-葡萄糖苷的产率不达到35重量％时也不显着。制备含有无水结晶抗坏血酸2-葡萄糖苷的颗粒组合物的方法，其包括使CGT酶作用于含有液化淀粉或糊精和L-抗坏血酸的溶液，然后使葡糖淀粉酶作用于所得溶液以获得将抗坏血酸2-葡萄糖苷产率至少为27％的溶液，纯化得到的溶液，将抗坏血酸2-葡萄糖苷含量提高至86重量％以上，将无水结晶性抗坏血酸2-葡萄糖苷通过控制冷却方式或假控制冷却方法，收集沉淀的无水结晶抗坏血酸2-葡萄糖苷，并对收集的无水结晶抗坏血酸2-葡萄糖苷进行老化和干燥。

5. 发明申请

US20110091726A1 PARTICULATE COMPOSITION CONTAINING ANHYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PROCESS FOR PRODUCING THE SAME, AND USES THEREOF 有权
标题翻译：包含无水晶体2-O-α-D-葡糖醛酸-L-抗坏血酸的颗粒组合物，其生产方法及其用途
公开(公告)号：US20110091726A1
公开(公告)日：2011-04-21
申请号：US12875786
申请日：2010-09-03
申请人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Tomoyuki Nishimoto , Shigeharu Fukuda , Toshio Miyake
IPC分类号： B32B5/00 , C07H19/01 , C12P19/60
CPC分类号： C12P19/60 , A23L33/10 , A23L33/15 , A61K8/0241 , A61K8/676 , A61K8/732 , A61K31/7048 , A61K2800/57 , A61K2800/654 , A61Q19/02 , C07H17/04 , Y10T428/2982
摘要： The present invention aims to provide a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid having a significantly, hardly solidifiable property compared to conventional ones in a grade for use in quasi-drugs; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic in an amount of over 98.0% by weight but less than 99.9% by weight, on a dry solid basis; or a degree of crystallinity of 90% or higher for anhydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, when calculated based on a profile of powder X-ray diffraction analysis of the particulate composition, and a dynamic vapor sorption level of 0.01% by weight or lower, when kept at 25° C. under a relative humidity of 35% by weight for 12 hours after removal water in the particulate composition under nitrogen gas stream; and by providing a process for producing the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物，其与用于准药物的级别相比，具有显着难以固化的性能; 其制造方法; 及其用途。本发明通过提供含有无水结晶2-O-α-D-葡糖基-L-抗坏血酸的颗粒组合物来解决上述目的，其含量超过98.0重量％但小于99.9重量％，基于干固体 ; 或无水结晶2-O-α-D-葡糖基-L-抗坏血酸的结晶度为90％以上时，基于颗粒组合物的粉末X射线衍射分析曲线和动态蒸气当在氮气流下除去颗粒组合物中的水后，在25℃相对湿度35重量％下保持12小时，吸附水平为0.01重量％以下; 并提供其制造方法及其用途。

6. 发明授权

US09206215B2 Hydrous crystalline 2-O-α-D-glucosyl-L-ascorbic acid, particulate composition comprising the same, their preparation and uses 有权
标题翻译：含水结晶的2-O-α-D-葡糖基-L-抗坏血酸，包含它们的颗粒组合物，它们的制备和用途
公开(公告)号：US09206215B2
公开(公告)日：2015-12-08
申请号：US13821498
申请日：2011-09-06
申请人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
发明人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
IPC分类号： C07H17/04 , A61K31/7048 , C07H19/01 , A23L1/302 , A61K8/60 , A61Q19/00 , A61K9/14 , A61Q19/02
CPC分类号： C07H19/01 , A23L33/15 , A61K8/602 , A61K9/145 , A61K31/7048 , A61K2800/10 , A61Q19/00 , A61Q19/02 , C07H17/04
摘要： The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.
摘要翻译：本发明的目的是提供一种新的结晶2-O-α-葡萄糖基-L-抗坏血酸及其制备方法和用途，并通过提供含水结晶的2-O-α-葡糖基-L-抗坏血酸来解决上述目的包含含水结晶2-O-α-葡糖基-L-抗坏血酸的颗粒组合物及其制备方法和用途。

7. 发明申请

US20130172542A1 HYDROUS CRYSTALLINE 2-O-alpha-D-GLUCOSYL-L-ASCORBIC ACID, PARTICULATE COMPOSITION COMPRISING THE SAME, THEIR PREPARATION AND USES 有权
标题翻译：水溶性结晶2-O-α-D-葡萄糖-L-抗坏血酸，包含它们的颗粒组合物，其制备和用途
公开(公告)号：US20130172542A1
公开(公告)日：2013-07-04
申请号：US13821498
申请日：2011-09-06
申请人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
发明人： Takashi Shibuya , Seisuke Izawa , Shigeharu Fukuda
IPC分类号： C07H19/01
CPC分类号： C07H19/01 , A23L33/15 , A61K8/602 , A61K9/145 , A61K31/7048 , A61K2800/10 , A61Q19/00 , A61Q19/02 , C07H17/04
摘要： The present invention has objects to provide a novel crystalline 2-O-α-glucosyl-L-ascorbic acid and its production process and uses, and solves the above objects by providing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, a particulate composition containing hydrous crystalline 2-O-α-glucosyl-L-ascorbic acid, and their production processes and uses.
摘要翻译：本发明的目的是提供一种新的结晶2-O-α-葡糖基-L-抗坏血酸及其制备方法和用途，并通过提供含水结晶的2-O-α-葡糖基-L-抗坏血酸来解决上述目的包含含水结晶的2-O-α-葡糖基-L-抗坏血酸的颗粒组合物及其制备方法和用途。

8. 发明申请

US20130195941A1 PULLULAN-CONTAINING POWDER, METHOD FOR PRODUCING THE SAME AND USE THEREOF 审中-公开
标题翻译：含PULLULAN的粉末，其生产方法及其用途
公开(公告)号：US20130195941A1
公开(公告)日：2013-08-01
申请号：US13704814
申请日：2011-06-17
申请人： Takashi Shibuya , Seisuke Izawa , Toshio Miyake
发明人： Takashi Shibuya , Seisuke Izawa , Toshio Miyake
IPC分类号： C12P19/10 , A61K8/73 , A23L1/03 , A61K47/36
CPC分类号： C12P19/10 , A61K8/022 , A61K8/73 , A61K47/36 , A61K2800/10 , A61Q19/00 , C08B37/0018 , C08L5/00 , C12R1/645
摘要： The present invention aims to provide a particulate composition containing pullulan, which can be produced without employing any complicated purification step such as solvent precipitation and, when formed into a film, exhibits a higher rupture strength compared to conventional ones; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing pullulan which is produced from a culture obtained by culturing a mutant of a microorganism of the species Aureobasidium pullulans in a culture medium containing glucose and maltose as carbon sources, without employing a step of removing concomitant saccharides; contains a pullulan fraction and a concomitant saccharide fraction that are respectively insoluble and soluble in 75% by volume of methanol in water; has a percentage of 3% by weight or lower of the content of concomitant saccharides contained in the concomitant saccharide fraction against the content of total saccharides contained in the whole particulate composition, when determined based on the anthrone sulfuric acid method; and contains mannitol; and by providing the process of the same and uses thereof.
摘要翻译：本发明的目的在于提供一种含有支链淀粉的颗粒组合物，其可以在不使用任何复杂的纯化步骤如溶剂沉淀的情况下制备，并且当形成膜时，与常规的相比，具有更高的断裂强度; 其制造方法; 及其用途。本发明通过提供一种含有支链淀粉的颗粒组合物，其中所述组合物由通过培养含有葡萄糖和麦芽糖作为碳源的培养基中的优质链霉菌种的微生物的突变体获得的培养物而得到，而不采用以下步骤：去除伴随的糖类; 含有不溶于75％（体积）甲醇的水中的支链淀粉部分和伴随的糖类部分。当根据蒽酮硫酸法测定时，伴随糖类成分中所含的伴随糖含量相对于全部颗粒组合物中所含的总糖含量为3重量％以下的百分比; 并含有甘露醇; 并通过提供相同的方法和使用它们。

9. 发明授权

US07186824B2 Reduction inhibitory agent for active-oxygen eliminating activity 有权
标题翻译：活性氧消除活性的还原抑制剂
公开(公告)号：US07186824B2
公开(公告)日：2007-03-06
申请号：US10670525
申请日：2003-09-26
申请人： Hajime Aga , Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
发明人： Hajime Aga , Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C07H1/00
CPC分类号： A61K31/7016 , A61K36/03 , A61K36/07 , A61K36/11 , A61K36/15 , A61K36/16 , A61K36/185 , A61K36/21 , A61K36/23 , A61K36/232 , A61K36/27 , A61K36/28 , A61K36/282 , A61K36/287 , A61K36/31 , A61K36/315 , A61K36/42 , A61K36/45 , A61K36/46 , A61K36/48 , A61K36/482 , A61K36/484 , A61K36/515 , A61K36/52 , A61K36/53 , A61K36/534 , A61K36/535 , A61K36/67 , A61K36/68 , A61K36/70 , A61K36/73 , A61K36/734 , A61K36/736 , A61K36/75 , A61K36/752 , A61K36/77 , A61K36/81 , A61K36/82 , A61K36/87 , A61K36/88 , A61K36/886 , A61K36/888 , A61K36/8945 , A61K36/8962 , A61K36/899 , A61K36/8994 , A61K36/8998 , A61K36/9066 , A61K36/9068 , A61K2300/00
摘要： A reduction inhibitory agent for active-oxygen eliminating activity comprises trehalose as an effective ingredient. A method for inhibiting the reduction of active-oxygen eliminating activity comprises incorporating either trehalose or the reduction inhibitory agent into plant edible products and/or plant antioxidants. A composition is provided that reduces the active-oxygen eliminating activity of plant edible products and/or plant antioxidants.
摘要翻译：活性氧消除活性的还原抑制剂包括海藻糖作为有效成分。抑制活性氧消除活性降低的方法包括将海藻糖或还原抑制剂掺入植物性食品和/或植物抗氧化剂中。提供了降低植物可食用产品和/或植物抗氧化剂的活性氧消除活性的组合物。

10. 发明申请

US20060159834A1 Refined royal jelly 审中-公开
标题翻译：精制皇家果冻
公开(公告)号：US20060159834A1
公开(公告)日：2006-07-20
申请号：US10525157
申请日：2003-09-04
申请人： Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
发明人： Takashi Shibuya , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23K1/00
CPC分类号： A61K8/64 , A23G9/38 , A23K20/10 , A23K50/40 , A23L21/20 , A23L33/11 , A23L33/15 , A23V2002/00 , A61K8/988 , A61Q19/00 , A23V2200/304
摘要： The object of the present invention is to provide an allergen-reduced royal jelly, having less fear of causing allergic symptoms, obtained by reducing allergens and keeping the useful pharmacological actions of royal jelly, a process for producing the same, and its uses. The present invention solves the above object by providing an allergen-reduced royal jelly where the amount of water-soluble proteins is reduced to less than 50% (w/w) to the amount of total proteins; a process for producing the allergen-reduced royal jelly comprising the steps of separating a royal jelly into a precipitate and a supernatant comprising water-soluble proteins by adding water and centrifuging, collecting low molecular substances by eliminating high molecular substances comprising water-soluble proteins from the resulting supernatant using ultra-filtration or gel filtration chromatography, and mixing the resulting low molecular substances with the aforesaid precipitate; a composition comprising the allergen-reduced royal jelly; and the uses of the composition for foods, feeds, baits, pet foods, and cosmetics.
摘要翻译：本发明的目的是提供一种通过减少过敏原并保持蜂王浆的有用药理作用而获得的对过敏症状的恐惧较少的过敏原降低的蜂王浆，其制备方法及其用途。本发明通过提供一种致敏剂降低的蜂王浆来解决上述目的，其中水溶性蛋白质的量降低到总蛋白质量的少于50％（w / w）; 一种生产降解过敏原的蜂王浆的方法，包括以下步骤：将蜂王浆分离成沉淀物，通过加入水分和离心分离含有水溶性蛋白质的上清液，通过除去含有水溶性蛋白质的高分子物质来收集低分子物质所得上清液使用超滤或凝胶过滤层析，并将得到的低分子物质与上述沉淀物混合; 包含变应原降低的蜂王浆的组合物; 以及食品，饲料，饵料，宠物食品和化妆品组合物的用途。

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