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1. 发明授权

US08940715B2 Lipid-regulating agent and use thereof 有权
标题翻译：脂质调节剂及其用途
公开(公告)号：US08940715B2
公开(公告)日：2015-01-27
申请号：US12033654
申请日：2008-02-19
申请人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/702 , A61K31/575 , A23D9/007 , A23K1/16 , A23L1/30 , C07H3/06
CPC分类号： A23D9/007 , A23K20/163 , A23L33/10 , A61K31/702 , C07H3/06
摘要： The object of the present invention is to provide a lipid-regulating agent or a composition for regulating the amount of lipids comprising the agent. The present invention solves the above object by providing a lipid-regulating agent comprising a cyclic tetrasaccharide and/or its saccharide-derivative(s) and a composition for regulating the amount of lipids comprising the lipid-regulating agent.
摘要翻译：本发明的目的是提供一种脂质调节剂或用于调节包含该药剂的脂质的量的组合物。本发明通过提供包含环状四糖和/或其糖衍生物的脂质调节剂和用于调节包含脂质调节剂的脂质的量的组合物来解决上述目的。

2. 发明申请

US20100285562A1 ISOCYCLOMALTOOLIGOSACCHARIDE(S), ISOCYCLOMALTOOLIGOSACCHARIDE-FORMING ENZYME, THEIR PREPARATION AND USES 有权
标题翻译：异羟肟酸（SOCYCLOMALTOOLIGOSACCHARIDE）（S），异羟肟酸吡喃葡萄糖苷形成酶，其制备和用途
公开(公告)号：US20100285562A1
公开(公告)日：2010-11-11
申请号：US12764927
申请日：2010-04-21
申请人： Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12N9/00 , C12N1/20 , C07H21/04 , C12N15/70 , C12N1/21
CPC分类号： C07H3/06 , A23L29/35 , A23L33/25 , C12N9/2402 , C12N9/2405 , C12P19/04
摘要： A non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents, a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof are provided by use of an isocyclomaltooligosaccharide(s) having a structure represented by Formula 1, Cyclo{→6)-[α-D-Glcp-(1→4)]n-α-D-Glcp-(1→}, wherein “n” is 4 or 5.
摘要翻译：通过提供由葡萄糖组成的新型非还原性糖类，形成非还原性糖类的新型酶，其制备方法和方法，编码该酶的DNA，重组DNA和转化体，得到非还原性糖类，该DNA是含有非还原性糖的组合物及其用途，通过使用具有式1所示结构的环状环糊精寡糖（Cyclo（→6）） - [α-D-Glcp-（1→4））] n-α-D-Glcp-（1→}，其中“n”为4或5。

3. 发明申请

US20100059124A1 Gas Leak Detecting System for Gas Cooler 有权
标题翻译：气体冷却器气体泄漏检测系统
公开(公告)号：US20100059124A1
公开(公告)日：2010-03-11
申请号：US11922603
申请日：2007-08-30
申请人： Ryoji Ogasawara , Tsukasa Shimakawa , Michio Kubota
发明人： Ryoji Ogasawara , Tsukasa Shimakawa , Michio Kubota
IPC分类号： F16K23/00
CPC分类号： G01M3/228 , Y10T137/5835
摘要： A gas leak detecting system for a gas cooler, which can detect gas leakage continuously by a simple-structured system, and can ensure a fail-safe backup system against troubles by such a simple system, is provided. The gas leak detecting system comprises a gas cooler (1) for cooling a gas, which is supplied to and discharged from the interior of a cooler water chamber (2) via piping, with a coolant supplied to and discharged from the interior of the cooler water chamber; an automatic exhaust valve (12) for automatically discharging the gas, which has leaked into the cooler water chamber, to the outside; a gas leak detecting vessel (8) for accumulating a leakage gas discharged from the automatic exhaust valve; and a gas detecting device (13) for detecting the leakage gas within the gas leak detecting vessel.
摘要翻译：一种用于气体冷却器的气体泄漏检测系统，其可以通过简单的结构化系统连续检测气体泄漏，并且可以通过这样简单的系统来确保故障安全备用系统免受故障的影响。气体泄漏检测系统包括用于冷却气体的气体冷却器（1），其通过管道供应到冷却器水室（2）的内部并从冷却器的内部从冷却器的内部排出的冷却剂水室; 自动排气阀（12），其将已经泄漏到较冷水室中的气体自动排出到外部; 气体泄漏检测容器（8），用于累积从所述自动排气阀排出的泄漏气体; 以及用于检测气体泄漏检测容器内的泄漏气体的气体检测装置（13）。

4. 发明申请

US20100015671A1 CYCLIC MALTOSYLMALTOSE, CYCLIC MALTOSYMALTOSE-FORMING ENZYME, THEIR PREPARATION AND USES 有权
标题翻译：环状麦芽糖醇，环状麦芽糖醇形成酶，其制备和用途
公开(公告)号：US20100015671A1
公开(公告)日：2010-01-21
申请号：US11941862
申请日：2007-11-16
申请人： Kazuhisa Mukai , Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuhisa Mukai , Hikaru Watanabe , Tomoyuki Nishimoto , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/18 , C12N9/10
CPC分类号： A61K9/2018 , A21D2/181 , A23L2/52 , A23L2/60 , A23L13/428 , A23L27/33 , A23L33/10 , A61K8/60 , A61Q11/00 , C07H3/06 , C12N9/1048 , C12P19/18
摘要： An object of the present invention is to provide an option of non-reducing saccharide by providing a novel non-reducing saccharide composed of glucose as constituents and to provide a novel enzyme forming the non-reducing saccharide, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the non-reducing saccharide, and uses thereof. The present invention solves the above object by providing a novel cyclic saccharide having a structure of cyclo{>6)-α-D-glucopyranosyl-(1>4)-α-D-glucopyranosyl-(1>6)-α-D-glucopyranosyl-(1>4)-α-D-glucopyranosyl-(1>}, cyclic maltosylmaltose, novel cyclic maltosylmaltose-forming enzyme, a method and process for producing the same, a DNA encoding the enzyme, a recombinant DNA and transformant comprising the DNA, a composition comprising the cyclic maltosylmaltose or a saccharide composition comprising the same, and uses thereof.
摘要翻译：本发明的目的是通过提供一种由葡萄糖组成的新型非还原性糖组成并提供形成非还原性糖的新型酶，提供一种非还原性糖的方法及其制备方法，编码该酶的DNA，重组DNA和包含该DNA的转化体，包含非还原性糖的组合物及其用途。本发明通过提供具有环{> 6）-α-D-吡喃葡萄糖基 - （1,4）-alpha-D-吡喃葡萄糖基 - （1,6）-alpha-D结构的新型环状糖来解决上述目的 - 吡喃葡萄糖基 - （1,4）-alpha-D-吡喃葡萄糖基 - （1>），环状麦芽糖基麦芽糖，新的环状麦芽糖基麦芽糖酶形成酶，其制备方法和方法，编码该酶的DNA，重组DNA和转化体包含该DNA，包含环状麦芽糖麦芽糖的组合物或包含其的糖组合物及其用途。

5. 发明申请

US20080113938A1 ACCELERATOR FOR MINERAL ABSORPTION AND USE THEREOF 有权
标题翻译：加速器用于矿物吸收和其使用
公开(公告)号：US20080113938A1
公开(公告)日：2008-05-15
申请号：US11961899
申请日：2007-12-20
申请人： Kazuyuki OKU , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuyuki OKU , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/715 , A61P1/00
CPC分类号： C07H3/06 , A23L33/10 , A61K31/702
摘要： The present invention has an object to provide an accelerator for mineral absorption and a composition containing the accelerator. The object is solved by providing an accelerator for mineral absorption comprising cyclic tetrasaccharide and/or saccharide derivatives thereof and a composition containing the accelerator.
摘要翻译：本发明的目的是提供一种矿物吸收促进剂和含有促进剂的组合物。该目的通过提供一种包含环状四糖和/或其糖衍生物的含矿物吸收促进剂和含有该促进剂的组合物来解决。

6. 发明申请

US20070218189A1 Reduction inhibitory agent for active oxygen eliminating-activity 审中-公开
标题翻译：活性氧消除活性的还原抑制剂
公开(公告)号：US20070218189A1
公开(公告)日：2007-09-20
申请号：US11798399
申请日：2007-05-14
申请人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23L3/3463
CPC分类号： A61Q19/00 , A23B7/08 , A23L3/3436 , A23L3/3562 , A23L29/035 , A61K8/60 , A61K31/702 , A61K2800/522 , A61Q11/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , C07H3/06
摘要： Disclosed are a reduction inhibitory agent for active oxygen eliminating activity, comprising: (a) at least 10% (w/w) of a cyclotetrasaccharide having a basic cyclic structure in Chemical Formula 1, on a dry solid basis; and (b) at least one member selected from the group consisting of saccharides and edible fibers; a method for inhibiting the reduction of active oxygen eliminating activity, comprising a step of incorporating at least one percent (w/w) of a cyclotetrasaccharide having a basic cyclic structure in Chemical Formula 1 to a plant substance, on a dry solid basis, into said plant substance with active oxygen eliminating activity in an aqueous system; and a composition obtainable by incorporating at least one percent (w/w) of a cyclotetrasaccharide having a basic cyclic structure in Chemical Formula 1 to said plant substance, on a dry solid basis, into a plant substance with active oxygen eliminating activity to inhibit the reduction of the activity of said plant substance.
摘要翻译：公开了一种活性氧消除活性的还原抑制剂，其包括：（a）化学式1中具有碱性环状结构的至少10％（w / w）的干燥固体的环状四糖; 和（b）选自由糖类和食用纤维组成的组中的至少一种; 一种抑制活性氧消除活性降低的方法，包括在化学式1中将至少1％（w / w）具有碱性环状结构的环状四糖在干固体中掺入到植物物质中的步骤，所述植物物质在含水体系中具有活性氧消除活性; 以及通过将化学式1中具有碱性环状结构的至少1％（w / w）的干燥固体的碱性环状结构的所得到的组合物，以干固体的形式掺入到具有活性氧消除活性的植物物质中，以抑制所述植物物质的活性降低。

7. 发明授权

US07241606B2 α-Isomaltosylglucosaccharide synthase, process for producing the same and use thereof 有权
标题翻译： α-异麦芽糖基糖合酶，其制备方法和用途
公开(公告)号：US07241606B2
公开(公告)日：2007-07-10
申请号：US10089549
申请日：2001-07-25
申请人： Michio Kubota , Keiji Tsusaki , Takanobu Higashiyama , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Keiji Tsusaki , Takanobu Higashiyama , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12N9/10
CPC分类号： A23G1/40 , A21D2/181 , A23C9/005 , A23C9/1307 , A23C9/1544 , A23C9/156 , A23G3/42 , A23G4/10 , A23G9/34 , A23L2/60 , A23L15/00 , A23L15/20 , A23L27/30 , A23L33/10 , A23L33/21 , A61K8/60 , A61K8/66 , A61K9/0014 , A61K47/26 , A61Q11/00 , A61Q19/00 , A61Q19/02 , A61Q19/10 , C07H3/04 , C07H3/06 , C12N9/1051 , C12N9/2425 , C12N9/2428 , C12P19/04 , C12Y302/01001 , C12Y302/01002 , C12Y302/01003 , C12Y302/0102
摘要： The object of the present invention is to provide an α-isomaltosylglucosaccharide-forming enzyme, process of the same, cyclotetrasaccharide, and saccharide composition comprising the saccharide which are obtainable by using the enzyme; and is solved by establishing an α-isomaltosylglucosaccharide-forming enzyme which forms a saccharide, having a glucose polymerization degree of at least three and having both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end, by catalyzing the α-glucosyl-transfer from a saccharide having a glucose polymerization degree of at least two and having the α-1,4 glucosidic linkage as a linkage at the non-reducing end without substantially increasing the reducing power; α-isomaltosyl-transferring method using the enzyme; method for forming α-isomaltosylglucosaccharide; process for producing a cyclotetrasaccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→} using both the α-isomaltosylglucosaccharide-forming enzyme and the α-isomaltosyl-transferring enzyme; and the uses of the saccharides obtainable therewith.
摘要翻译：本发明的目的是提供一种α-异麦芽糖基葡萄糖形成酶，其工艺，环四糖和包含可通过使用酶获得的糖的糖组合物; 并且通过建立形成葡糖聚合度至少为3并且在非还原末端具有α-1,6糖苷键作为连接的α糖异构体糖结合酶和α - 通过催化从葡萄糖聚合度至少为2并具有α-1,4糖苷键作为连接的糖的α-葡糖基转移而在非还原性末端的连接以外的1,4-葡糖苷键所述非还原端基本上不增加所述还原能力; 使用该酶的α-异麦芽糖基转移法; 形成α-异麦芽糖基糖的方法; 具有环{ - > 6）-al-D-glucopyranosyl-（1-> 3）-al-D-glucopyranosyl-（1-> 6）-al-D-glucopyranosyl-（1）的结构的环四糖的制备方法 - > 3）-al-D-吡喃葡萄糖基 - （1->}，使用α-异麦芽糖基糖形成酶和α-异麦芽糖基转移酶;以及可用其获得的糖的用途。

8. 发明申请

US20070099869A1 Association product of α-glycosyl α,α-trehalose with ionic metal compound 审中-公开
标题翻译： α-糖基α，α-海藻糖与离子金属化合物的结合产物
公开(公告)号：US20070099869A1
公开(公告)日：2007-05-03
申请号：US10559812
申请日：2004-06-06
申请人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
发明人： Kazuyuki Oku , Michio Kubota , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/715
CPC分类号： C07H3/06 , A23L5/00 , A23L9/00 , A23L21/00 , A23L27/33 , A23L27/50 , A23L29/30 , A23L33/165 , A23V2002/00 , C07H1/00 , A23V2250/636 , A23V2250/156
摘要： The present invention has an object to provide a composition of metal ion compound whose inherent and unsatisfactory properties for its industrial application such as deliquescence, reducing power, oxidizing power, low solubility in water, etc., have been improved; and their preparations and uses. The present invention solves the above object by providing an associated complex of α-glycosyl α,α-trehalose and a metal ion compound, and its preparations and uses.
摘要翻译：本发明的目的是提供一种金属离子化合物的组合物，其具有其潮溶性，降低功率，氧化能力，在水中的低溶解性等工业应用的固有和不令人满意的性能得到改善; 及其准备和使用。本发明通过提供α-糖基α，α-海藻糖和金属离子化合物的相关复合物及其制备和用途来解决上述目的。

9. 发明授权

US07211422B2 Polypeptide having α-isomaltosylglucosaccharide synthase activity 有权
标题翻译：具有α-异麦芽糖糖合酶活性的多肽
公开(公告)号：US07211422B2
公开(公告)日：2007-05-01
申请号：US10466085
申请日：2002-01-09
申请人： Michio Kubota , Kazuhiko Maruta , Takuo Yamamoto , Shigeharu Fukuda
发明人： Michio Kubota , Kazuhiko Maruta , Takuo Yamamoto , Shigeharu Fukuda
IPC分类号： C12N9/10 , C12N1/12 , C12N1/15
CPC分类号： C12P19/18 , C12N9/1051 , C12N9/2402 , C12N9/2428
摘要： The object of the present invention is to provide a polypeptide which can be used to produce a saccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, a DNA encoding the polypeptide, and uses thereof. The present invention solves the above object by establishing a polypeptide which has an enzymatic activity of forming a saccharide with a glucose polymerization degree of 3 or higher and bearing both the α-1,6 glucosidic linkage as a linkage at the non-reducing end and the α-1,4 glucosidic linkage other than the linkage at the non-reducing end from a saccharide with a glucose polymerization degree of 2 or higher and bearing the α-1,4 glucosidic linkage as a linkage at the non-reducing end by α-glucosyl transferring reaction without substantially increasing the reducing power, a DNA encoding the polypeptide, a replicable recombinant DNA comprising the DNA encoding the polypeptide and an autonomously replicable vector, a transformant constructed by introducing the recombinant DNA into an appropriate host, and uses thereof.
摘要翻译：本发明的目的是提供一种可用于制备具有环{ - > 6）-al-D-glucopyranosyl-（1-> 3）-al-D-glucopyranosyl-（ 1-> 6）-α-D-吡喃葡萄糖基 - （1-> 3）-al-D-glucopyranosyl-（1->}，编码多肽的DNA及其用途本发明通过建立上述目的来解决上述目的具有形成葡萄糖聚合度为3以上的糖的酶活性的多肽，并且在非还原末端具有作为连接的α-1,6糖苷键和α-1,4糖苷键的其他比非葡萄糖聚合度为2或更高的糖类在非还原性末端的连接，并且通过α-葡糖基转移反应在非还原末端具有α-1,4糖苷键作为键，而基本上不增加降低能力，编码多肽的DNA，包含编码DNA的可复制重组DNA 多肽和可自主复制的载体，通过将重组DNA引入合适的宿主而构建的转化体及其用途。

10. 发明授权

US07186701B2 Dehydrating agent and method for dehydrating moist article using the agent and dehydrated article obtained by the method 有权
标题翻译：使用该方法获得的试剂和脱水制品脱水剂和脱水湿物品的方法
公开(公告)号：US07186701B2
公开(公告)日：2007-03-06
申请号：US10466438
申请日：2002-01-17
申请人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
发明人： Michio Kubota , Tomoyuki Nishimoto , Hajime Aga , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A61K31/702 , C08B37/00
CPC分类号： B01J20/262 , A21D2/181 , A23C13/125 , A23L3/42 , A61K9/0014 , A61K47/26 , A61K47/40 , B01J20/22 , C07H3/06
摘要： The present invention has the object to dehydrate hydrous matters without denaturing or deteriorating them by using a dehydrating agent comprising an anhydrous cyclotetrasaccharide, and provides a dehydrating agent comprising the cyclotetrasaccharide; a method for dehydrating hydrous matters through a step of incorporating, contacting or coexisting the cyclotetrasaccharide into, with, or in the hydrous matters; and dehydrated products obtainable thereby.
摘要翻译：本发明的目的是通过使用包含无水环四糖的脱水剂使含水物脱水而不使其变性或变质，并提供包含环四糖的脱水剂; 通过将环四糖与含水物质结合，接触或共存的步骤脱水含水物质的方法; 和可得到的脱水产品。

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