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1. 发明授权

US08524889B2 Highly-branched starch, its production and uses 有权
标题翻译：高分支淀粉，其生产和用途
公开(公告)号：US08524889B2
公开(公告)日：2013-09-03
申请号：US13443296
申请日：2012-04-10
申请人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C07H1/06 , C08B31/00
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着抗退行性的具有6-α-麦芽糖基 - 和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种生产支化淀粉而不降低分子量的方法的材料淀粉及其用途。

2. 发明申请

US20120196331A1 HIGHLY-BRANCHED STARCH, ITS PRODUCTION AND USES 有权
标题翻译：高分配淀粉，其生产和用途
公开(公告)号：US20120196331A1
公开(公告)日：2012-08-02
申请号：US13443296
申请日：2012-04-10
申请人： Tomoyuki NISHIMOTO , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki NISHIMOTO , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： C12P19/22
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着的耐退化性的具有6-α-麦芽糖基和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种不降低分子量的支链淀粉的制备方法的材料淀粉及其用途。

3. 发明授权

US4256753A 4-(2-Pyridylamino)phenylacetic acid derivatives 失效
标题翻译： 4-（2-吡啶基氨基）苯乙酸衍生物
公开(公告)号：US4256753A
公开(公告)日：1981-03-17
申请号：US95572
申请日：1979-11-19
申请人： Hitoshi Uno , Yasutaka Nagai , Katsuhiko Hino , Hideo Nakamura
发明人： Hitoshi Uno , Yasutaka Nagai , Katsuhiko Hino , Hideo Nakamura
IPC分类号： A61K31/44 , A61K31/4402 , A61K31/4418 , A61P25/04 , A61P29/00 , C07D213/74
CPC分类号： C07D213/74
摘要： Novel 4-(2'-pyridylamino)phenylacetic acid derivatives of the formula: ##STR1## wherein R.sub.1 is hydrogen, a halogen, a lower alkyl having 1 to 3 carbon atoms, or nitro, R.sub.2 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.3 is hydrogen, a halogen, or a lower alkyl having 1 to 3 carbon atoms, R.sub.4 is hydrogen or a lower alkyl having 1 to 3 carbon atoms, R.sub.5 is hydrogen or --CH.sub.2 CH.sub.2 OR.sub.6 wherein R.sub.6 is a lower alkyl having 2 or 3 carbon atoms and being substituted with 1 or 2 hydroxy groups, provided that R.sub.1 or R.sub.2 is not 4-halogen, or pharmaceutically acceptable salts thereof, and a process for the preparation thereof, pharmaceutical composition of said compounds, and a method of using said compounds as anti-inflammatory and analgesic agents. They have excellent anti-inflammatory and analgesic activities with an extremely weak ulcerogenicity in the gastrointestinal tract. Some of the compounds have superior inhibitory activity against chronic inflammation mediated by cellular immunity.
摘要翻译：下式的新型4-（2'-吡啶基氨基）苯乙酸衍生物：其中R 1是氢，卤素，具有1至3个碳原子的低级烷基或硝基，R 2是氢，卤素或低级具有1至3个碳原子的烷基，R 3是氢，卤素或具有1至3个碳原子的低级烷基，R 4是氢或具有1至3个碳原子的低级烷基，R 5是氢或-CH 2 CH 2 OR 6，其中R 6是具有2或3个碳原子并且被1或2个羟基取代的低级烷基，条件是R1或R2不是4-卤素，或其药学上可接受的盐，及其制备方法，所述化合物的药物组合物和使用所述化合物作为抗炎和止痛剂的方法。它们具有优异的抗炎和止痛活性，在胃肠道中具有非常弱的溃疡形成能力。一些化合物对由细胞免疫介导的慢性炎症具有优异的抑制活性。

4. 发明申请

US20220386986A1 INSPECTION APPARATUS 有权
公开(公告)号：US20220386986A1
公开(公告)日：2022-12-08
申请号：US17774960
申请日：2019-11-07
申请人： Katsuhiko HINO
发明人： Katsuhiko HINO
IPC分类号： A61B8/06 , A61B8/08
摘要： An inspection apparatus includes a measurement apparatus that measures an inner diameter and a blood flow velocity in an artery from a fetus to a placenta of a pregnant woman, a calculation apparatus that calculates a Reynolds number based on the inner diameter and the blood flow velocity in the artery measured by the measurement apparatus, and a determination apparatus that determines, for a pregnant woman who is 20 weeks or more pregnant, that the fetus may be developing FGR in a case that the Reynolds number is less than a first threshold value.

5. 发明申请

US20090022872A1 HIGHLY-BRANCHED STARCH, ITS PRODUCTION AND USES 有权
标题翻译：高分配淀粉，其生产和用途
公开(公告)号：US20090022872A1
公开(公告)日：2009-01-22
申请号：US11911090
申请日：2006-03-14
申请人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
发明人： Tomoyuki Nishimoto , Katsuhiko Hino , Takanori Okura , Hiroto Chaen , Shigeharu Fukuda , Toshio Miyake
IPC分类号： A23L2/00 , C08B31/00 , A23L1/48 , C12P19/04
CPC分类号： C12P19/18 , A23L33/10 , A23V2002/00 , A61K9/0014 , A61K9/0056 , A61K9/06 , A61K9/2054 , A61K9/4816 , A61K9/7007 , A61K31/718 , C08B30/12 , A23V2200/302 , A23V2250/5118
摘要： An object of the present invention is to provide a novel starchy substance having a retrogradation-resistance, a process for producing the starchy substance efficiently from a material starch by enzymatic reaction, and uses thereof. The present invention attains the above object by providing branched starch having 6-α-maltosyl- and/or 6-α-maltotetraosyl-structure(s) with a marked retrogradation-resistance, a process for producing the branched starch without lowering the molecular weight of material starch, and uses thereof.
摘要翻译：本发明的目的是提供一种具有抗退行性的新型淀粉物质，通过酶促反应从材料淀粉有效地生产淀粉质物质的方法及其应用。本发明通过提供具有显着抗退行性的具有6-α-麦芽糖基 - 和/或6-α-麦芽四糖基结构的支链淀粉来实现上述目的，一种生产支化淀粉而不降低分子量的方法的材料淀粉及其用途。

6. 发明授权

US4758566A 2-(1-piperazinyl)-4-substituted phenylquinoline derivatives, processes for the preparation thereof, and pharmaceutical composition containing the same 失效
标题翻译： 2-（1-哌嗪基）-4-取代苯基喹啉衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US4758566A
公开(公告)日：1988-07-19
申请号：US893311
申请日：1986-07-28
申请人： Hitoshi Uno , Katsuhiko Hino , Toshiaki Kadokawa , Katsuyoshi Kawashima
发明人： Hitoshi Uno , Katsuhiko Hino , Toshiaki Kadokawa , Katsuyoshi Kawashima
IPC分类号： A61K31/47 , A61P1/04 , C07D215/38 , A61K31/495 , C07D401/02
CPC分类号： C07D215/38
摘要： Compounds of the formula: ##STR1## wherein R.sub.1 represents fluorine atom at the para position, chlorine atom at the para position, methyl group at the para position or trifluoromethyl group at the para or meta position; and R.sub.2 represents hydrogen atom, methyl group, ethyl group, 2-hydroxyethyl group or 3-hydroxypropyl group, provided that R.sub.2 represents ethyl group, 2-hydroxyethyl group or 3-hydroxypropyl group when R.sub.1 represents fluorine atom at the para position, methyl group at the para position or trifluoromethyl group at the para position, and a pharmaceutically acceptable salt therof, process for the preparation thereof, and pharmaceutical composition containing the same. The compounds and pharmaceutically acceptable salts thereof show excellent cytoprotective effect and useful for prophylaxis and treatment of peptic ulcer and inflammatory gastrointestinal diseases.
摘要翻译： PCT No.PCT / JP85 / 00654 Sec。 371日期1986年7月28日第 102（e）日期1986年7月28日PCT提交1985年11月27日PCT公布。公开号WO86 / 03198 日期：1986年6月5日。下式的化合物：其中R1表示对位的氟原子，对位的氯原子，对位的甲基或对位或间位的三氟甲基; R2表示氢原子，甲基，乙基，2-羟乙基或3-羟丙基，条件是当R1表示对位的氟原子时，R2表示乙基，2-羟基乙基或3-羟丙基，甲基在对位或在对位的三氟甲基，和其药学上可接受的盐，其制备方法和含有它们的药物组合物。所述化合物及其药学上可接受的盐显示出优异的细胞保护作用并且可用于预防和治疗消化性溃疡和炎性胃肠道疾病。

7. 发明授权

US4677107A Anti-peptic ulcer agent 失效
标题翻译：抗消化性溃疡剂
公开(公告)号：US4677107A
公开(公告)日：1987-06-30
申请号：US784215
申请日：1985-10-04
申请人： Toshiaki Kadokawa , Katsuyoshi Kawashima , Hitoshi Uno , Katsuhiko Hino
发明人： Toshiaki Kadokawa , Katsuyoshi Kawashima , Hitoshi Uno , Katsuhiko Hino
IPC分类号： A61K31/47 , C07D215/38 , A61K31/495
CPC分类号： C07D215/38 , A61K31/47 , Y10S514/926 , Y10S514/927
摘要： Use of a compound of the formula: ##STR1## wherein R is hydrogen atom or ethyl group, or a pharmaceutically acceptable salt thereof for prophylaxis and/or treatment of peptic ulcer, and a method for prophylaxis and/or treatment of peptic ulcer disease which comprises administering an effective amount of the above-mentioned compound to warm blooded aninal, especially human. Said active compounds have excellent pharmacological activities such as inhibition of ulceration and inhibition of gastric secretion, and hence, are useful as an anti-peptic ulcer agent.
摘要翻译：下式化合物：其中R是氢原子或乙基的化合物或其药学上可接受的盐用于消化性溃疡的预防和/或治疗，以及预防和/或治疗消化性溃疡疾病的方法，其中包括将有效量的上述化合物给予温血的阴性，特别是人。所述活性化合物具有优异的药理活性，例如抑制溃疡和抑制胃分泌，因此可用作抗消化性溃疡剂。

8. 发明授权

US5847159A 1-�.omega.-(3,4-dihydro-2-naphthalenyl)alkyl!-cyclic amine derivatives, process for preparing the same, and pharmaceutical composition containing the same 失效
标题翻译： 1- [ω-（3,4-二氢-2-萘基）烷基] - 环胺衍生物，其制备方法和含有该衍生物的药物组合物
公开(公告)号：US5847159A
公开(公告)日：1998-12-08
申请号：US930603
申请日：1997-10-14
申请人： Naoki Kai , Aki Kanehira , Toshiya Morie , Katsuhiko Hino , Katsuyoshi Kawashima , Isao Shimizu , Kazuhisa Akiyama
发明人： Naoki Kai , Aki Kanehira , Toshiya Morie , Katsuhiko Hino , Katsuyoshi Kawashima , Isao Shimizu , Kazuhisa Akiyama
IPC分类号： C07D207/06 , A61K31/40 , A61K31/445 , A61K31/4453 , A61K31/452 , A61K31/55 , A61P7/12 , A61P13/10 , A61P25/00 , C07D207/08 , C07D207/10 , C07D207/12 , C07D207/20 , C07D207/22 , C07D207/24 , C07D295/02 , C07D295/03 , C07D295/073 , C07D295/096 , C07D295/155 , C07D317/70 , C07D405/06
CPC分类号： C07D295/03 , C07D207/10 , C07D207/12 , C07D207/20 , C07D207/22 , C07D207/24 , C07D295/073 , C07D295/096 , C07D295/155 , C07D317/70 , C07C2102/10 , C07C2103/24
摘要： 1-�.omega.-(3,4-Dihydro-2-naphthalenyl)alkyl!cyclic amine derivative of the formula (I): ##STR1## wherein R.sup.1 and R.sup.2 are H, halogen, OH, alkyl, alkoxy, hydroxymethyl, etc., or R.sup.1 and R.sup.2 combine to form methylenedioxy, trimethylene, etc., R.sup.3 is H, etc., R.sup.4 is H, OH, alkyl, etc., R.sup.5 is H, alkyl, etc., p is integer of from 2 to 6, and q is integer of from 3 to 7, provided that when p is 2, and q is 5, R.sup.1, R.sup.2, R.sup.3, R.sup.4 and R.sup.5 are not simultaneously H, or salts thereof, or N-oxide derivatives thereof, or a process for preparing the same, or pharmaceutical composition containing the same. The compounds of the present invention show potent inhibitory effect on the micturition reflex, and are useful as agents for treatment of frequent urination and urinary incontinence.
摘要翻译： PCT No.PCT / JP96 / 01009 Sec。 371日期1997年10月14日第 102（e）日期1997年10月14日PCT 1996年4月12日PCT PCT。出版物WO96 / 33169 日本1996年10月24日，式（I）的ω-（3,4-二氢-2-萘基）烷基]环胺衍生物：其中R 1和R 2是H，卤素，OH，烷基，烷氧基，羟甲基等，或R 1和R 2结合形成亚甲二氧基，三亚甲基等，R 3为H等，R 4为H，OH，烷基等，R 5为H，烷基等， p为2〜6的整数，q为3〜7的整数，条件是当p为2，q为5时，R1，R2，R3，R4和R5不同时为H，或其盐，或 N-氧化物衍生物或其制备方法，或含有它们的药物组合物。本发明的化合物对排尿反射显示出有效的抑制作用，并且可用作治疗尿频和尿失禁的药剂。

9. 发明授权

US5185338A Medicament for treating cerebral insufficiency diseases, novel 2-(1-piperazinyl)-4-phenylcycloalkanopyrimidine derivatives, and process for the production thereof 失效
标题翻译：治疗脑功能不全疾病的药物，新型2-（1-哌嗪基）-4-苯基环烷基嘧啶衍生物及其制备方法
公开(公告)号：US5185338A
公开(公告)日：1993-02-09
申请号：US711894
申请日：1991-06-07
申请人： Katsuhiko Hino , Naoki Kai , Masato Sakamoto , Tatsuya Kon , Makoto Oka , Kiyoshi Furukawa , Yoshiaki Ochi
发明人： Katsuhiko Hino , Naoki Kai , Masato Sakamoto , Tatsuya Kon , Makoto Oka , Kiyoshi Furukawa , Yoshiaki Ochi
IPC分类号： A61K31/505 , C07D239/70
CPC分类号： C07D239/70 , A61K31/505
摘要： Medicament for the treatment of cerebral insufficiency diseases comprising as an active ingredient a compound of the formula: ##STR1## wherein n is 3, 4, 5 or 6; R.sup.1 is hydrogen atom, C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.8 cycloalkyl, hydroxy-C.sub.2 -C.sub.6) alkyl, unsubstituted or substituted aryl, heteroaryl, unsubstituted or substituted aryl-(C.sub.1 -C.sub.6) alkyl, unsubstituted or substituted aryl-carbonyl-(C.sub.1 -C.sub.6) alkyl, or acyl; R.sup.2 is hydrogen atom, halogen atom, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, or trifluoromethyl; and R.sup.3 is hydrogen atom or C.sub.1 -C.sub.6 alkyl, or an acid addition salt thereof, novel 2-(1-piperazinyl)-4-phenyl-cycloalkanopyrimidine derivatives having excellent cerebral function improving activity, processes for the preparation thereof.
摘要翻译：用于治疗脑功能不全疾病的药物，其包含下式的化合物作为活性成分：其中n为3,4,5或6;其中n为3,4,5或6; R 1是氢原子，C 1 -C 6烷基，C 3 -C 8环烷基，羟基-C 2 -C 6）烷基，未取代或取代的芳基，杂芳基，未取代或取代的芳基 - （C 1 -C 6）烷基，未取代或取代的芳基 - 羰基 - （ C 1 -C 6）烷基或酰基; R2是氢原子，卤素原子，C1-C6烷基，C1-C6烷氧基或三氟甲基; 和R3是氢原子或C1-C6烷基或其酸加成盐，具有优异的脑功能改善活性的新型2-（1-哌嗪基）-4-苯基 - 环烷基嘧啶衍生物，其制备方法。

10. 发明授权

US5021421A 2-(1-Piperazinyl)-4-phenylcycloalkanopyridine derivatives, processes for the production thereof, and pharmaceutical composition containing the same 失效
标题翻译： 2-（1-哌嗪基）-4-苯基环烷基吡啶衍生物，其制备方法和含有它们的药物组合物
公开(公告)号：US5021421A
公开(公告)日：1991-06-04
申请号：US481183
申请日：1990-02-20
申请人： Katsuhiko Hino , Naoki Kai , Masato Sakamoto , Tatsuya Kon , Makoto Oka , Kiyoshi Furukawa , Yoshiaki Ochi
发明人： Katsuhiko Hino , Naoki Kai , Masato Sakamoto , Tatsuya Kon , Makoto Oka , Kiyoshi Furukawa , Yoshiaki Ochi
IPC分类号： C07D215/38 , C07D221/04 , C07D221/22 , C07D401/04 , C07D401/12
CPC分类号： C07D215/38 , C07D221/04 , C07D221/22 , C07D401/04 , C07D401/12
摘要： Novel 2-(1-piperazinyl)-4-phenyl-cycloalkanopyridine derivatives of the formula (I): ##STR1## wherein n is 3, 4, 5, 6 or 7; R.sup.1 is a hydrogen atom, C.sub.1 -C.sub.10 alkyl, C.sub.2 -C.sub.6 alkenyl, C.sub.2 -C.sub.6 alkynyl, C.sub.3 -C.sub.8 cycloalkyl, C.sub.3 -C.sub.6 cycloalkyl-(C.sub.1 -C.sub.4) alkyl, hydroxy-(C.sub.2 -C.sub.6) alkyl, C.sub.1 -C.sub.3 alkoxy-(C.sub.2 -C.sub.6) alkyl, acyloxy-(C.sub.2 -C.sub.6), alkyl, unsubstituted or substituted aroyl-(C.sub.1 -C.sub.6) alkyl, unsubstituted or substituted aryl, heteroaryl, or acyl; R.sup.2 and R.sup.3 are the same or different and are each a hydrogen atom, a halogen atom, C.sub.1 -C.sub.6 alkyl, C.sub.1 -C.sub.6 alkoxy, trifluoromethyl, or hydroxy; R.sup.4, R.sup.5 and R.sup.6 are the same or different and are each a hydrogen atom, C.sub.1 -C.sub.6 alkyl, or phenyl, or two of R.sup.4, R.sup.5 and R.sup.6 combine to form a single bond or C.sub.1 -C.sub.3 alkylene; R.sup.7 and R.sup.8 are the same or different and are each a hydrogen atom or C.sub.1 -C.sub.3 alkyl; m is 2 or 3, or an acid addition salt thereof, which is useful as a psychotropic drug, and processes for the preparation thereof.

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