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1. 发明授权

US12011692B2 Separation device 有权
公开(公告)号：US12011692B2
公开(公告)日：2024-06-18
申请号：US17861290
申请日：2022-07-11
申请人： SPF Technologies LLC
发明人： Erik O. Blomquist , Gaston De Los Reyes , Barry Gaiman
IPC分类号： B01D63/08 , B01D61/14
CPC分类号： B01D63/082 , B01D61/145 , B01D63/088 , B01D2311/08 , B01D2313/16 , B01D2313/18 , B01D2313/243
摘要： Methods and devices are disclosed for a separation device. A separation device includes a separation module having a separation membrane separating an interior of the separation module into a retentate compartment and a permeate compartment. The retentate compartment includes at least one retentate channel, a feed port fluidly coupled to the at least one retentate channel and a retentate port. The permeate compartment includes at least one permeate channel disposed within the permeate compartment and a permeate port fluidly coupled to the at least one permeate channel. a retentate collector fluidly connected to the retentate port. The device further includes a feed reservoir, a permeate reservoir, a fluidic gate located between the feed reservoir and the separation module, a vent located between the retentate channel and the permeate channel end adjacent the retentate port and a pressure differential source applied across the separation module.

2. 发明授权

US10507409B2 Hyper-productive chromatography system and process 有权
公开(公告)号：US10507409B2
公开(公告)日：2019-12-17
申请号：US15456485
申请日：2017-03-11
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： B01D15/10 , B01D15/16 , B01D15/20 , B01D15/22 , B01D15/36 , B01D15/38 , B01J20/28 , B01J20/282 , B01J20/285 , B33Y80/00 , B01J20/281 , G01N30/52 , G01N30/60 , G01N30/00 , B01J20/283 , B01D15/34
摘要： A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

3. 发明授权

US10391423B2 Stackable planar adsorptive devices 有权
公开(公告)号：US10391423B2
公开(公告)日：2019-08-27
申请号：US15456484
申请日：2017-03-11
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： B01D15/18 , B01D15/20 , B01D15/22 , B01J20/282 , B33Y10/00 , B33Y80/00 , B01J20/281 , G01N30/50 , G01N30/60 , G01N30/52 , B01J20/28
摘要： A lattice and distribution network for a stackable chromatography cassette comprising: a peripheral seal; at least one screen forming the lattice surrounded by the peripheral seal, each at least one screen comprising a plurality of struts in a latticed arrangement; a first internal distribution network fluidly coupled to the lattice and surrounded by the peripheral seal; a second internal distribution network disposed opposite the first internal distribution network, fluidly coupled to the lattice and surrounded by the peripheral seal; wherein a direction of fluid flow is established from the first internal distribution network through the lattice to the second internal distribution network; and wherein preferential streamlines are minimized.

4. 发明申请

US20170259189A1 HYPER-PRODUCTIVE CHROMATOGRAPHY SYSTEM AND PROCESS 审中-公开
公开(公告)号：US20170259189A1
公开(公告)日：2017-09-14
申请号：US15456485
申请日：2017-03-11
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： B01D15/20 , G01N30/60 , B01D15/34 , B01J20/281 , B01D15/36 , B01D15/38
CPC分类号： B01D15/206 , B01D15/10 , B01D15/163 , B01D15/22 , B01D15/34 , B01D15/362 , B01D15/363 , B01D15/3809 , B01J20/28016 , B01J20/282 , B01J20/283 , B01J20/285 , B33Y80/00 , G01N30/48 , G01N30/482 , G01N30/52 , G01N30/6047 , G01N30/6091 , G01N2030/486
摘要： A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

5. 发明申请

US20160193569A1 CYCLING ULTRA-THIN CHANNEL FILTRATION 审中-公开
标题翻译：循环超薄通道过滤
公开(公告)号：US20160193569A1
公开(公告)日：2016-07-07
申请号：US14915888
申请日：2014-09-22
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： B01D61/22 , B01D63/08 , B01D65/02 , B01D61/14
CPC分类号： B01D61/22 , B01D61/14 , B01D63/02 , B01D63/087 , B01D63/088 , B01D65/022 , B01D69/081 , B01D2313/18 , B01D2313/24 , B01D2315/16 , B01D2321/02 , B01D2321/04
摘要： A cycling ultra-thin channel filtration (cUTF) method, system and module are disclosed for concentration and purification of biomolecules. In one embodiment, a cUTF system includes a cUTF module and a cycle controller to load a feed aliquot of a feed stream into the cUTF module inducing permeation of the feed stream to build a boundary layer by pressurizing the feed stream, to stop permeation and to recover a retentate aliquot in a repeating cycle.
摘要翻译：公开了循环超薄通道过滤（cUTF）方法，系统和模块用于生物分子的浓缩和纯化。在一个实施例中，cUTF系统包括cUTF模块和循环控制器，其将进料流的进料等分试样加载到cUTF模块中，从而通过加压进料流来促进进料流的渗透以形成边界层，以阻止渗透和在重复循环中恢复滞留物等分试样。

6. 发明授权

US12017212B2 High pressure fluidic devices having volume integrity and homogenous flow 有权
公开(公告)号：US12017212B2
公开(公告)日：2024-06-25
申请号：US17013718
申请日：2020-09-07
申请人： SPF Technologies LLC
发明人： Theodore McCabe, Jr. , Gaston De Los Reyes , Amanda Lemire , Danielle Marquis
IPC分类号： B01L3/00 , B29C64/118 , B33Y10/00 , B33Y40/20 , B33Y80/00 , B29L31/14
CPC分类号： B01L3/502707 , B29C64/118 , B33Y10/00 , B33Y40/20 , B33Y80/00 , B01L2200/06 , B01L2200/12 , B29L2031/14
摘要： A fluidic device includes an impermeable base, single-strand walls coupled to the impermeable plate. The single-strand walls include a plurality of loops, each loop has a lower part of a double wedge and an upper part of a double wedge aligned with the lower part of the double wedge. The device also includes a lattice connected to the single-strand wall with a loop-as-wipe connection and a gabbled roof disposed opposite the impermeable base and coupled to the tops of the single-strand walls.

7. 发明申请

US20220362685A1 CHROMATOGRAPHIC CASSETTE 有权
公开(公告)号：US20220362685A1
公开(公告)日：2022-11-17
申请号：US17871086
申请日：2022-07-22
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： B01D15/22 , G01N30/60 , B01D15/18 , B33Y10/00 , B33Y80/00 , B01D15/20 , G01N30/52 , B01J20/281
摘要： A chromatographic cassette includes a cassette including a chamber, chromatographic media disposed within the cassette chamber, a distribution network fluidly coupled to the chromatographic media and an inlet port and an outlet port coupled to the distribution network. A hyper-productive chromatography technique includes providing a scalable and stackable chromatographic cassette, loading a sample to be processed, operating the scalable chromatographic cassette having an adsorptive chromatographic bed having a volume greater than 0.5 liter by establishing a flow at a linear velocity greater than 500 cm/hr with a residence time of the loading step of less than one minute.

8. 发明申请

US20160161453A1 STACKABLE PLANAR ADSORPTIVE DEVICES 审中-公开
标题翻译：可堆叠式平面设备
公开(公告)号：US20160161453A1
公开(公告)日：2016-06-09
申请号：US14907804
申请日：2014-08-12
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： G01N30/52 , B01D15/22 , G01N30/60 , B01D15/20
CPC分类号： G01N30/52 , B01D15/1842 , B01D15/206 , B01D15/22 , B01J20/28016 , B01J20/28042 , B01J20/282 , B33Y80/00 , G01N30/6047 , G01N2030/527 , G01N2030/528
摘要： Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed is packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block. In another embodiment, the adsorptive bed device includes an adsorptive block, first and second planar distributors and peripheral seal. The adsorptive media includes multiple layers of planarly cohesive media and when operated in a shallow bed configuration possesses significant tensile strength along its planar dimensions enabling it to support the hydraulic pressures that will be generated by the fluids being processed through the adsorptive devices.
摘要翻译：吸附床装置包括具有应力吸收刚性结构的壳体中的支架和填充有吸附珠的开放细胞。支架限制多个吸附珠的运动，吸收沿着液体流动方向由液压梯度引起的应力，并将一部分感应的压缩应力传递到壳体。在一个实施方案中，将吸附床填充到色谱柱中，在另一个实施方案中，将吸附床密封在整体块中。在另一个实施方案中，吸附床装置包括吸附块，第一和第二平面分布器和周边密封件。吸附介质包括多层平面内聚介质，当在浅床结构中操作时，沿着其平面尺寸具有显着的拉伸强度，使其能够支持将被通过吸附装置加工的流体产生的液压。

9. 发明授权

US09599594B2 Stackable planar adsorptive devices 有权
公开(公告)号：US09599594B2
公开(公告)日：2017-03-21
申请号：US14907804
申请日：2014-08-12
申请人： SPF Technologies LLC
发明人： Gaston de los Reyes
IPC分类号： G01N30/52 , B01D15/20 , B01D15/18 , B01D15/22 , B01J20/28 , B33Y80/00 , G01N30/60 , B01J20/282
CPC分类号： G01N30/52 , B01D15/1842 , B01D15/206 , B01D15/22 , B01J20/28016 , B01J20/28042 , B01J20/282 , B33Y80/00 , G01N30/6047 , G01N2030/527 , G01N2030/528
摘要： Adsorptive bed devices include a scaffold in housing having a stress absorbing rigid structure and open cells filled with adsorptive beads. The scaffold restricts movement of the plurality of adsorptive beads, absorbs stress induced by a hydraulic pressure gradient along a direction of liquid flow and transfers a portion of the induced compressive stress to the housing. In one embodiment the adsorptive bed is packed into a chromatography column, and in another embodiment the adsorptive bed is sealed in a monolithic block. In another embodiment, the adsorptive bed device includes an adsorptive block, first and second planar distributors and peripheral seal. The adsorptive media includes multiple layers of planarly cohesive media and when operated in a shallow bed configuration possesses significant tensile strength along its planar dimensions enabling it to support the hydraulic pressures that will be generated by the fluids being processed through the adsorptive devices.

10. 发明公开

US20240367150A1 MONOLITHIC MICROPOROUS SUBSTRATE FOR CHROMATOGRAPHIC BEDS 审中-公开
公开(公告)号：US20240367150A1
公开(公告)日：2024-11-07
申请号：US18646164
申请日：2024-04-25
申请人： SPF Technologies LLC
发明人： Robert S Zeller , Gaston de los Reyes , Erik O. Blomquist
IPC分类号： B01J20/285 , B01D15/10 , B01J20/28 , B01J20/30
CPC分类号： B01J20/285 , B01D15/10 , B01J20/28004 , B01J20/28023 , B01J20/28042 , B01J20/28085 , B01J20/3007 , B01J20/3035 , B01J20/3078
摘要： Methods and devices are disclosed for a separation device including a sintered polymeric monolith having polymeric microparticulate solids with a pore size from about 0.5 to about 8 microns, a porosity between about 50 percent to about 80 percent and a chromatographic uniformity characterized by an HETP (height equivalent of a theoretical plate) less than about 100 microns.

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