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1. 发明公开

US20240382869A1 SPIN COLUMN 审中-公开
公开(公告)号：US20240382869A1
公开(公告)日：2024-11-21
申请号：US18661828
申请日：2024-05-13
申请人： LABTURBO BIOTECH CORPORATION
发明人： Chi-Sheng TAI , Shih Jeng DAI , Shih Tsung HUANG
IPC分类号： B01D15/22
CPC分类号： B01D15/22
摘要： The spin column of the present invention is used for filtering and extracting biological molecules, such as nucleic acids and proteins. When the spin column is used, it is placed inside a collection tube, which is then placed in a centrifuge slot and the centrifuge is activated. The internal volume of the spin column of the present invention is larger than that of a conventional spin column, allowing it to accommodate a larger amount of specimens. Additionally, the filter membrane positioned inside the spin column of the present invention is smaller than that of conventional spin columns. The amount of washing solution required to wash the biological molecules from the filter membrane is proportional to the size of the filter membrane. Therefore, less washing solution is required in the present invention. Since the spin column of the present invention can accommodate a larger amount of specimen, the number of biomolecules contained in the specimen is also larger. Since less washing solution is required to dissolve and recover the biomolecules from the filter membrane, the concentration of collected biological molecules in the washing solution is higher.

2. 发明授权

US12145082B2 Sample size chromatography device 有权
公开(公告)号：US12145082B2
公开(公告)日：2024-11-19
申请号：US17420338
申请日：2020-01-08
申请人： Solventum Intellectual Properties Company
发明人： Kannan Dasharathi , Jon P. Kragness
IPC分类号： B01D15/22 , B01D15/36 , G01N30/06
CPC分类号： B01D15/22 , B01D15/363 , G01N30/06
摘要： A chromatography device having a housing formed from an upper housing ultrasonically welded to a lower housing. A compression extension and a boss located inside of the housing with the media disposed between the compression extension and the boss such that a perimeter of the media is compressed between the compression extension and the boss forming a liquid impermeable seal along the perimeter after the upper housing is ultrasonically welded to the lower housing.

3. 发明公开

US20240359161A1 PARTICLES FOR AFFINITY CHROMATOGRAPHY AND METHODS OF PRODUCTION THEREOF 审中-公开
公开(公告)号：US20240359161A1
公开(公告)日：2024-10-31
申请号：US18647811
申请日：2024-04-26
申请人： Waters Technologies Corporation
发明人： Kevin Wyndham , Beatrice Muriithi , Oksana Tchoul , Yeliz Tunc Sarisozen , MingCheng Xu , Matthew Lauber
IPC分类号： B01J20/289 , B01D15/22 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/32
CPC分类号： B01J20/289 , B01D15/22 , B01D15/3809 , B01J20/261 , B01J20/28004 , B01J20/28016 , B01J20/321 , B01J20/3219 , B01J20/3274
摘要： The present disclosure is directed to nonporous polymer particles having an average particle size of 1 to 10 micrometers and being functionalized with streptavidin. The streptavidin functionalized particles of the present disclosure can be bound to biotinylated antibodies, biotinylated antigen-binding fragments thereof, or biotinylated oligonucleotides to create customizable affinity chromatography columns. That is, the functionalized nonporous polymer particles can be packed in a stainless steel, titanium, or other metal or metal alloy column for affinity high pressure liquid chromatography (HPLC).

4. 发明授权

US12129935B2 High-flow fluid valve block 有权
公开(公告)号：US12129935B2
公开(公告)日：2024-10-29
申请号：US18196321
申请日：2023-05-11
申请人： Tosoh Bioscience LLC
发明人： Brian A. Harbrecht , Robert Charles Mierendorf , Scott G. Manke
IPC分类号： F16K7/17 , B01D15/18 , B01D15/22 , F16K11/22 , F16K25/00 , F16K27/00 , F16K27/02 , F16K31/126
CPC分类号： F16K7/17 , B01D15/1842 , B01D15/22 , F16K11/22 , F16K25/005 , F16K27/003 , F16K27/0236 , F16K27/0263 , F16K31/1266
摘要： A valve block includes a fluid-transfer plate with multiple inlet bores connecting to a common inlet channel, and multiple outlet bores connecting to a common outlet channel. The inlet bores and the outlet bores are arranged in a curved shape. The valve block also includes a pressure plate and diaphragm aligned and connected to the fluid-transfer plate in a way that allows pressurized material in the pressure plate to control the state of the channels formed by the inlet and outlet bores.

5. 发明公开

US20240279797A1 METAL COMPONENTS WITH INERT VAPOR PHASE COATING ON INTERNAL SURFACES 审中-公开
公开(公告)号：US20240279797A1
公开(公告)日：2024-08-22
申请号：US18649231
申请日：2024-04-29
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
IPC分类号： C23C16/24 , B01D15/22 , C23C16/04 , C23C16/32 , C23C16/40 , C23C16/44 , C23C16/455
CPC分类号： C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
摘要： The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.

6. 发明公开

US20240279795A1 METAL COMPONENTS WITH INERT VAPOR PHASE COATING ON INTERNAL SURFACES 审中-公开
公开(公告)号：US20240279795A1
公开(公告)日：2024-08-22
申请号：US18649171
申请日：2024-04-29
申请人： AGILENT TECHNOLOGIES, INC.
发明人： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
IPC分类号： C23C16/24 , B01D15/22 , C23C16/04 , C23C16/32 , C23C16/40 , C23C16/44 , C23C16/455
CPC分类号： C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
摘要： The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.

7. 发明公开

US20240279794A1 METAL COMPONENTS WITH INERT VAPOR PHASE COATING ON INTERNAL SURFACES 审中-公开
公开(公告)号：US20240279794A1
公开(公告)日：2024-08-22
申请号：US18649035
申请日：2024-04-29
申请人： Agilent Technologies, Inc.
发明人： Elizabeth Carr , Karen L. Seaward , Kevin P. Killeen
IPC分类号： C23C16/24 , B01D15/22 , C23C16/04 , C23C16/32 , C23C16/40 , C23C16/44 , C23C16/455
CPC分类号： C23C16/24 , B01D15/22 , C23C16/045 , C23C16/325 , C23C16/401 , C23C16/403 , C23C16/405 , C23C16/44 , C23C16/45555 , Y10T428/13
摘要： The invention provides metal liquid chromatography components with uniformly coated internal surfaces and methods for achieving the same. The invention addresses the problem of corrosion or interference of metal components in the flow path for LC analyses in which the sample interacts with metal ions or surfaces. The invention also alleviates the difficulties in coating very long metal tubes and very small metal channels with an inert, continuous coating that adheres well to metal surfaces. The metal flow path is rendered inert by the coating, and thus compatible with bioanalytical separations, for example, by using a vapor phase deposition process to coat the inner surfaces with a coating that continuously covers all metal surfaces in the flow path.

8. 发明公开

US20240278212A1 CHROMATOGRAPHIC COLUMN 审中-公开
公开(公告)号：US20240278212A1
公开(公告)日：2024-08-22
申请号：US18112806
申请日：2023-02-22
申请人： KING SAUD UNIVERSITY
发明人： Ahmed Yacine Badjah Hadj AHMED , Mohamed Ali OULADSMANE , Taieb AOUAK , Zeid Abdullah ALOTHMAN
IPC分类号： B01J20/286 , B01D15/22 , B01J20/26 , B01J20/28 , B01J20/30 , B01J20/32
CPC分类号： B01J20/286 , B01D15/22 , B01J20/267 , B01J20/28042 , B01J20/3092 , B01J20/3219 , B01J2220/58 , B01J2220/82 , B01J2220/84 , B01J2220/86
摘要： The chromatographic column is a stainless steel column having a stationary phase of porous monolithic polymer chemically bonded to the interior wall of the stainless steel column so that the stationary phase is fixed and immobile and does not require frits or other seals to retain particulate matter or a slurry in the column. The inner wall of the column is oxidized and then vinylized with a difunctional linker to chemically bond the polymer to the column. The difunctional linker may be 3-(trimethoxysilyl) propyl methacrylate, vinyl trimethoxysilane, 3-mercaptopropyl trimethoxysilane, or glycidoxypropyltrimethoxysilane. The monolithic polymer is prepared in situ in the column by radical polymerization of a monovinyl monomer with a crosslinking divinyl monomer. The column may be a conventional stainless steel column (¼″ inner diameter), capillary micro-LC ( 1/16″), or nan-LC (( 1/32″).

9. 发明公开

US20240261704A1 INTERCHANGEABLE CHROMATOGRAPHY CARTRIDGE ADAPTER SYSTEM 审中-公开
公开(公告)号：US20240261704A1
公开(公告)日：2024-08-08
申请号：US18623582
申请日：2024-04-01
申请人： SUPERCRITICAL FLUID TECHNOLOGIES, INC.
发明人： Kenneth Richard Krewson , Andrew Cloud , Kenneth Joseph James , Curtis EBERSOLD , Kim FERRARA
IPC分类号： B01D15/22 , B01D15/20 , B01D53/02
CPC分类号： B01D15/22 , B01D15/20 , B01D53/025 , B01D2256/22
摘要： A chromatography system has a cartridge adapter that is detachably attachable to enable a chromatography cartridge to be quickly interchanged. Chromatography cartridges are configured with threads for coupling to a corresponding interchangeable coupling component having matching threads. The interchangeable coupling component may be secured to the chromatography system by a coupling retainer. A coupling retainer may have a keyway that is configured for quick interchanging of the interchangeable coupling components. The interchangeable coupling component may have a pair of parallel sides that align with a slot of the keyway to secure the interchangeable coupling components to the coupling retainer. An inlet nipple of the chromatography cartridge may extend through an opening in the coupling components and couple to an inlet conduit for sample gas. Analyte gas may flow back to the chromatography system for detection and collection.

10. 发明授权

US11911711B2 Parallel assembly of chromatography column modules 有权
公开(公告)号：US11911711B2
公开(公告)日：2024-02-27
申请号：US17938653
申请日：2022-10-06
申请人： Cytiva BioProcess R&D AB
发明人： Klaus Gebauer
IPC分类号： B01D15/14 , B01D15/18 , B01D15/22 , G01N30/46 , G01N30/60 , G01N30/88
CPC分类号： B01D15/14 , B01D15/1864 , B01D15/1885 , B01D15/22 , G01N30/466 , G01N30/6043 , G01N30/6091 , G01N30/6039 , G01N2030/8881 , Y10T29/49826
摘要： A parallel assembly of chromatography column modules, the assembly having one common assembly inlet and one common assembly outlet, each column module comprising a bed space filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space of the column module with the assembly inlet and the assembly outlet, wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.

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