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1. 发明申请

US20120165495A1 RESORBABLE PHENOLIC POLYMERS 有权
标题翻译：可分离的酚醛聚合物
公开(公告)号：US20120165495A1
公开(公告)日：2012-06-28
申请号：US13414090
申请日：2012-03-07
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
IPC分类号： C08G63/193 , C07H15/18 , C07C69/716 , C07C235/52 , C07C237/52
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.
摘要翻译：本发明提供具有式（I），式（II），式（III）或式（IV））的单体单元的生物相容性可再吸收聚合物。当植入体内时，聚合物随时间降解，并且可用作可植入医疗装置的组件。

2. 发明授权

US07976936B2 Endoprostheses 有权
标题翻译：内假体
公开(公告)号：US07976936B2
公开(公告)日：2011-07-12
申请号：US11111509
申请日：2005-04-21
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： B32B3/00
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprostheses are disclosed.
摘要翻译：公布内裤假体。

3. 发明申请

US20100254945A1 Rnai Therapeutic for Respiratory Virus Infection 审中-公开
标题翻译： Rnai治疗呼吸道病毒感染
公开(公告)号：US20100254945A1
公开(公告)日：2010-10-07
申请号：US11910971
申请日：2006-04-07
申请人： Qing Ge , Mukesh Kumar , James Anthony McSwiggen
发明人： Qing Ge , Mukesh Kumar , James Anthony McSwiggen
IPC分类号： A61K48/00 , A61K39/145 , C07H21/02 , C12N15/86
CPC分类号： C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2310/3521
摘要： Disclosed herein is a double stranded siRNA molecule that inhibits production of a respiratory virus, wherein each strand of said siRNA molecule is about 15 to about 50 nucleotides, and wherein one strand of said siRNA molecule comprises a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus, and uses thereof.
摘要翻译：本文公开了抑制呼吸病毒生产的双链siRNA分子，其中所述siRNA分子的每条链约为15至约50个核苷酸，并且其中所述siRNA分子的一条链包含与保守位点相同的核酸序列，或其变体，以及其用途。

4. 发明申请

US20100204297A1 INFLUENZA THERAPEUTIC 审中-公开
标题翻译：流感治疗
公开(公告)号：US20100204297A1
公开(公告)日：2010-08-12
申请号：US11909413
申请日：2006-03-22
申请人： Jianzhu Chen , Qing Ge , Herman N. Eisen
发明人： Jianzhu Chen , Qing Ge , Herman N. Eisen
IPC分类号： A61K31/713 , C07K7/08 , C07K14/00 , A61P31/16 , C12N15/63
CPC分类号： A61K9/5146 , A61K9/5153 , A61K38/00 , C12N15/111 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/321 , C12N2310/53 , C12N2320/11 , C12N2320/32 , C12N2799/021 , C12N2310/3521
摘要： The present invention provides compositions comprising an RNAi-inducing entity targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for inhibiting a biological activity of an influenza virus and/or for treatment or prevention of influenza. The invention provides target portion sequences that are favorably conserved for RNAi across a plurality of influenza virus A strains isolated from human hosts and/or avian hosts and RNAi-inducing entities, e.g., siRNAs and shRNAs, targeted to such favorably conserved target portions. The invention provides a variety of nucleic acids comprising sequences identical or complementary to at least a portion of one or more of these favorably conserved target portion sequences. The invention further provides methods and compositions for delivering RNAi-inducing agents to an organ or tissue of a mammalian subject, e.g., to the lung. Methods of diagnosing influenza and determining the susceptibility of an influenza virus to inhibition by an RNAi-inducing agent are also provided. Transgenic animals that express an RNAi-inducing agent targeted to an influenza gene are another aspect of the invention.
摘要翻译：本发明提供了包含针对流感病毒转录物的RNAi诱导实体和各种递送试剂中的任一种的组合物。本发明还包括使用该组合物抑制流感病毒的生物学活性和/或用于治疗或预防流感的方法。本发明提供了针对分离自人宿主和/或禽类宿主和RNAi诱导实体（例如siRNA和shRNA）的多个流感病毒A菌株的RNAi有利地保守的靶标部分序列，靶向这些有利的保守靶部分。本发明提供了多种核酸，其包含与这些有利保守的靶部分序列中的一种或多种的至少一部分相同或互补的序列。本发明进一步提供了将哺乳动物受试者的器官或组织例如向肺部递送RNAi诱导剂的方法和组合物。还提供了诊断流感和确定流感病毒对RNAi诱导剂抑制的易感性的方法。表达靶向流感基因的RNAi诱导剂的转基因动物是本发明的另一方面。

5. 发明申请

US20090106852A1 Influenza Therapeutic 审中-公开
公开(公告)号：US20090106852A1
公开(公告)日：2009-04-23
申请号：US11952056
申请日：2007-12-06
申请人： Jianzhu Chen , Herman N. Eisen , Qing Ge
发明人： Jianzhu Chen , Herman N. Eisen , Qing Ge
IPC分类号： A01K67/027 , C07H21/02 , A61K31/7105 , A61K9/12 , A61P31/16 , C12N15/63 , C12N5/10
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.

6. 发明申请

US20080241212A1 Biodegradable, Polymer Coverings for Breast Implants 有权
标题翻译：可生物降解，乳房植入物的聚合物覆盖物
公开(公告)号：US20080241212A1
公开(公告)日：2008-10-02
申请号：US12058060
申请日：2008-03-28
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Irene Shatova , Archana Rajaram
IPC分类号： A61F2/12 , A61K31/496 , A61K31/65 , A61K31/7036 , A61K38/00 , A61K31/7048 , A61K31/545 , A61K31/47 , A61K31/41 , A61K31/404 , A61K31/381 , A61K31/167 , A61K31/445 , A61P29/00 , A61P17/00
CPC分类号： A61F2/12 , A61K31/167 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/445 , A61K31/47 , A61K31/496 , A61K31/545 , A61K31/65 , A61K31/7036 , A61K31/7048 , A61K38/13 , B29C41/14 , A61K2300/00
摘要： A biodegradable, flexible covering for a breast implant is provided which comprises one or more biodegradable polymer layers dimensioned and shaped to cover at least a portion of the breast implant. The implant can be inserted into an opening of the covering immediately prior to surgery, but alternate configurations and times of insertion are contemplated as well as open or sheet type devices. The coverings can optionally contain one or more drugs for delivery at the surgical site, particularly for treating or preventing infection, pain, inflammation, capsular contracture, scarring or other complications associated with breast augmentation or breast reconstruction.
摘要翻译：提供了一种用于乳房植入物的可生物降解的柔性覆盖物，其包括尺寸和形状以覆盖乳房植入物的至少一部分的一个或多个可生物降解的聚合物层。植入物可以在手术之前立即插入覆盖物的开口中，但可以考虑插入的交替构型和时间以及开式或片式装置。覆盖物可任选地含有一种或多种用于在手术部位递送的药物，特别是用于治疗或预防感染，疼痛，炎症，囊肿挛缩，瘢痕或与隆胸或乳房重建相关的其他并发症。

7. 发明申请

US20070213293A1 RNAI THERAPEUTIC FOR RESPIRATORY VIRUS INFECTION 审中-公开
标题翻译： RNAI治疗呼吸道病毒感染
公开(公告)号：US20070213293A1
公开(公告)日：2007-09-13
申请号：US11687564
申请日：2007-03-16
申请人： James Anthony McSwiggen , Qing Ge
发明人： James Anthony McSwiggen , Qing Ge
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/1131 , C12N2310/14
摘要： Double stranded siRNA molecules for combating a respiratory virus, wherein the strands of an siRNA molecule may be from about 15 to about 60 nucleotides, and uses thereof. One strand of an siRNA molecule can be a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus.
摘要翻译：用于对抗呼吸病毒的双链siRNA分子，其中siRNA分子的链可以是约15至约60个核苷酸，及其用途。 siRNA分子的一条链可以是与呼吸病毒核酸序列中的保守位点或其变体相同的核酸序列。

8. 发明申请

US20070172430A1 DRY POWDER COMPOSITIONS FOR RNA INFLUENZA THERAPEUTICS 审中-公开
标题翻译：用于RNA流感病毒治疗的干粉组合物
公开(公告)号：US20070172430A1
公开(公告)日：2007-07-26
申请号：US11623306
申请日：2007-01-15
申请人： Luis Brito , Donghao Chen , Qing Ge , Doug Treco
发明人： Luis Brito , Donghao Chen , Qing Ge , Doug Treco
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： A61K9/0075 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2760/16111
摘要： A dry powder formulation for mucosal, intranasal, inhalation or pulmonary delivery which may include one or more siRNAs or dicer-active precursors thereof targeted to a transcript involved in infection by, or replication or production of an influenza virus.
摘要翻译：用于粘膜，鼻内，吸入或肺部递送的干粉制剂，其可以包含一种或多种siRNA或切片剂活性前体，其靶向涉及感染或复制或产生流感病毒的转录物。

9. 发明授权

US07091297B2 Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segments 有权
标题翻译：基于具有纳米结构硬链段的半结晶热塑性聚氨酯的形状记忆聚合物
公开(公告)号：US07091297B2
公开(公告)日：2006-08-15
申请号：US10683167
申请日：2003-10-10
申请人： Patrick T. Mather , Qing Ge , Changdeng Liu
发明人： Patrick T. Mather , Qing Ge , Changdeng Liu
IPC分类号： C08G18/32 , C08G18/38 , C08G18/64 , C08G18/76 , C08G18/40
CPC分类号： A61F2/88 , A61F2/958 , A61F2002/8483 , A61F2220/0016 , A61F2250/0037 , A61L31/14 , A61M27/008 , C08G18/3893 , C08G18/4833 , C08G18/61 , C08G18/718 , C08G61/08 , C08G65/336 , C08G2230/00 , C08J3/005 , C08L65/00 , C08L71/02 , C08L2205/05 , C08L83/00
摘要： Thermoplastic polyurethanes having an alternating sequence of hard and soft segments in which a nanostructured polyhedral oligomeric silsesquioxane diol is used as a chain extender to form a crystalline hard segment constituting SMPs. The polyurethanes are formed by reacting a polyol, a chain extender dihydroxyl-terminated POSS and a diisocyanate. The polyurethanes have multiple applications including for example, implants for human health care, drug delivery matrices, superabsorbant hydrogels, coatings, adhesives, temperature and moisture sensors, etc.
摘要翻译：具有硬链段和软链段的交替序列的热塑性聚氨酯，其中使用纳米结构多面体低聚倍半硅氧烷二醇作为扩链剂以形成构成SMP的结晶硬链段。聚氨酯通过多元醇，扩链剂二羟基封端的POSS和二异氰酸酯反应形成。聚氨酯具有多种应用，包括例如用于人体保健的植入物，药物递送基质，超吸收水凝胶，涂层，粘合剂，温度和湿度传感器等。

10. 发明申请

US20050245719A1 Shape memory polymers based on semicrystalline thermoplastic polyurethanes bearing nanostructured hard segments 有权
标题翻译：基于具有纳米结构硬链段的半结晶热塑性聚氨酯的形状记忆聚合物
公开(公告)号：US20050245719A1
公开(公告)日：2005-11-03
申请号：US11111388
申请日：2005-04-21
申请人： Patrick Mather , Changdeng Liu , Qing Ge
发明人： Patrick Mather , Changdeng Liu , Qing Ge
IPC分类号： C08G18/38 , C08G18/61 , C08G61/08 , C08L65/00 , C08G18/10
CPC分类号： C08G18/3893 , C08G18/4277 , C08G18/428 , C08G18/4833 , C08G18/61 , C08G61/08 , C08G2230/00 , C08G2280/00 , C08L65/00
摘要： Thermoplastic polyurethanes having an alternating sequence of hard and soft segments in which a nanostructured polyhedral oligosilsesquioxane diol is used as a chain extender to form a crystalline hard segment constituting SMPs. The polyurethanes are formed by reacting a polyol, a chain extender dihydroxyl-terminated polyhedral oligosilsesquioxane and a diisocyanate. The polyurethanes have multiple applications including for example, implants for human health care, drug delivery matrices, superabsorbant hydrogels, coatings, adhesives, temperature and moisture sensors, etc.
摘要翻译：具有硬链段和软链段的交替序列的热塑性聚氨酯，其中使用纳米结构多面体寡聚倍半硅氧烷二醇作为扩链剂以形成构成SMP的结晶硬链段。聚氨酯通过使多元醇，扩链剂二羟基封端的多面体寡聚倍半硅氧烷和二异氰酸酯反应而形成。聚氨酯具有多种应用，包括例如用于人体保健的植入物，药物递送基质，超吸收水凝胶，涂层，粘合剂，温度和湿度传感器等。

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