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1. 发明申请

US20070172430A1 DRY POWDER COMPOSITIONS FOR RNA INFLUENZA THERAPEUTICS 审中-公开
标题翻译：用于RNA流感病毒治疗的干粉组合物
公开(公告)号：US20070172430A1
公开(公告)日：2007-07-26
申请号：US11623306
申请日：2007-01-15
申请人： Luis Brito , Donghao Chen , Qing Ge , Doug Treco
发明人： Luis Brito , Donghao Chen , Qing Ge , Doug Treco
IPC分类号： A61K48/00 , A61K9/14
CPC分类号： A61K9/0075 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2760/16111
摘要： A dry powder formulation for mucosal, intranasal, inhalation or pulmonary delivery which may include one or more siRNAs or dicer-active precursors thereof targeted to a transcript involved in infection by, or replication or production of an influenza virus.
摘要翻译：用于粘膜，鼻内，吸入或肺部递送的干粉制剂，其可以包含一种或多种siRNA或切片剂活性前体，其靶向涉及感染或复制或产生流感病毒的转录物。

2. 发明申请

US20110077284A1 DRY POWDER COMPOSITIONS FOR RNA INFLUENZA THERAPEUTICS 审中-公开
标题翻译：用于RNA流感病毒治疗的干粉组合物
公开(公告)号：US20110077284A1
公开(公告)日：2011-03-31
申请号：US12903814
申请日：2010-10-13
申请人： Luis Brito , Donghao Chen , Qing Ge , Douglas A. Treco
发明人： Luis Brito , Donghao Chen , Qing Ge , Douglas A. Treco
IPC分类号： A61K31/713 , A61P31/16
CPC分类号： A61K9/0075 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2760/16111
摘要： A dry powder formulation for delivery to a mammal by inhalation, the formulation comprising particles comprising a lipid, a carrier, and one or more double-stranded siRNA molecules or dicer-active precursors targeted to influenza virus A method for treating or preventing influenza in a mammal comprising administering a therapeutically-effective amount of a dry powder formulation.
摘要翻译：一种用于通过吸入递送至哺乳动物的干粉制剂，该制剂包含包含脂质，载体和靶向流感病毒的一种或多种双链siRNA分子或切片剂活性前体的颗粒。用于治疗或预防流感病毒的方法哺乳动物包括施用治疗有效量的干粉制剂。

3. 发明授权

US08471054B2 Resorbable phenolic polymers 有权
公开(公告)号：US08471054B2
公开(公告)日：2013-06-25
申请号：US13414090
申请日：2012-03-07
申请人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
发明人： Arikha Moses , Satish Pulapura , Arthur Schwartz , Qing Ge , Irene Shatova
IPC分类号： C07C69/00 , C08G65/38
CPC分类号： C08G69/48 , C07C235/34 , C07C235/52 , C08G63/6856 , C08G64/12 , C08G73/028
摘要： The invention provides biocompatible resorbable polymers, comprising monomer units having formula (I), formula (II), formula (III) or formula (IV). The polymers degrade over time when implanted in the body, and are useful as components of implantable medical devices.

4. 发明申请

US20120052292A1 NOVEL MEDICAL DEVICE COATINGS 有权
标题翻译：新型医疗器械涂料
公开(公告)号：US20120052292A1
公开(公告)日：2012-03-01
申请号：US13218096
申请日：2011-08-25
申请人： Satish Pulapura , Qing Ge
发明人： Satish Pulapura , Qing Ge
IPC分类号： B32B3/00 , A61K31/65 , A61K31/496 , A61K9/00 , A61K31/155 , A61K33/38 , A61P31/00 , A61P23/00 , A61P29/00 , A61P17/02 , A61P43/00 , A61P9/00 , A61P25/00 , A61P27/02 , A61P7/02 , A61P1/02 , A61P7/04 , A61P35/00 , A61P31/04 , A61L27/34 , A61L15/26 , A61L29/08 , A61L31/10 , B32B15/04 , A61K47/34
CPC分类号： A61L31/10 , A61K31/155 , A61K31/496 , A61K31/65 , A61K33/38 , A61L31/16 , A61L2300/204 , A61L2300/216 , A61L2300/404 , A61L2300/606 , A61L2420/06 , C09D5/14 , C09D171/02 , Y02A50/406 , Y10T428/265 , Y10T428/31678 , C08L71/02 , C08L67/02
摘要： The present invention relates to coatings comprising polyethylene glycol and at least one polyphenolic polymer. In particular, the polyphenolic polymer could be selected from the group consisting of tyrosine-derived polyarylates, linear polyesteramides, dihydroxybenzoate polymers, and resorcinol-derived polymers. The coating of the present invention may also include a drug, such as an antibiotic. The coatings of the present invention are suitable for use as coatings for medical devices, such as orthopedic pins or stents.
摘要翻译：本发明涉及包含聚乙二醇和至少一种多酚聚合物的涂料。特别地，多酚聚合物可以选自酪氨酸衍生的多芳基化合物，线性聚酯酰胺，二羟基苯甲酸酯聚合物和间苯二酚衍生的聚合物。本发明的涂层还可以包括药物，例如抗生素。本发明的涂层适用于医疗装置如矫形针或支架的涂层。

5. 发明申请

US20110172753A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20110172753A1
公开(公告)日：2011-07-14
申请号：US13053461
申请日：2011-03-22
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： A61F2/82
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprosthesis are disclosed.
摘要翻译：公开内置假体。

6. 发明申请

US20110112169A1 RNAi-BASED THERAPEUTICS FOR ALLERGIC RHINITIS AND ASTHMA 审中-公开
标题翻译：用于过敏性RHINITIS和ASTHMA的基于RNAi的治疗方法
公开(公告)号：US20110112169A1
公开(公告)日：2011-05-12
申请号：US12891626
申请日：2010-09-27
申请人： Jianzhu Chen , Herman N. Eisen , Qing Ge
发明人： Jianzhu Chen , Herman N. Eisen , Qing Ge
IPC分类号： A61K31/713 , C07H21/02 , A61K31/7105 , A61P11/00 , A61P11/06 , C12N15/63
CPC分类号： C12N15/113 , C12N15/111 , C12N15/1137 , C12N15/1138 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32
摘要： The present invention provides compositions comprising one or more RNAi agents (e.g., siRNAs, shRNAs, or RNAi vectors) for the treatment of conditions and diseases mediated by (e.g., featuring IgE-mediated hypersensitivity), as well as systems for identifying RNAi agents effective for this purpose. The compositions are suitable for the treatment of allergic rhinitis and/or asthma. In certain embodiments of the invention the RNAi agent is targeted to a transcript that encodes a protein selected from the group consisting of the FCεRIα chain, the FCεRIβ chain, c-Kit, Lyn, Syk, ICOS, OX40L, CD40, CD80, CD86, Re1A, Re1B, 4-1BB ligand, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, CD83, SLAM, common γ chain, and COX-2. In addition, the invention provides RNAi agent/delivery agent compositions and methods of use. In certain embodiments of the invention compositions comprising an RNAi agent are delivered by the respiratory route.
摘要翻译：本发明提供包含用于治疗由（例如，特征为IgE介导的超敏反应）介导的病症和疾病的一种或多种RNAi剂（例如siRNA，shRNA或RNAi载体）的组合物，以及用于鉴定有效的RNAi剂的系统以此目的。该组合物适用于治疗过敏性鼻炎和/或哮喘。在本发明的某些实施方案中，所述RNAi试剂靶向编码选自下组的蛋白质的转录物：FC＆amp;RIα链，FC＆amp; RI＆bgr; 链，c-Kit，Lyn，Syk，ICOS，OX40L，CD40，CD80，CD86，Re1A，Re1B，4-1BB配体，TLR1，TLR2，TLR3，TLR4，TLR5，TLR6，TLR7，TLR8，TLR9，CD83，SLAM ，普通γ链和COX-2。此外，本发明提供RNAi剂/递送剂组合物和使用方法。在本发明的某些实施方案中，包含RNAi试剂的组合物通过呼吸途径递送。

7. 发明申请

US20100129417A1 Dihydroxybenzoate Polymers and Uses Thereof 有权
标题翻译：二羟基苯甲酸酯聚合物及其用途
公开(公告)号：US20100129417A1
公开(公告)日：2010-05-27
申请号：US12598559
申请日：2008-05-02
申请人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
发明人： Arikha Moses , Satish Pulapura , Qing Ge , Sarita Nethula , Archana Rajaram
IPC分类号： A61K31/65 , A61F2/00 , A61K31/496 , C08L67/02 , C08G63/133 , A61P27/02 , A61P9/00 , A61P25/00
CPC分类号： A23L3/3481 , A61K31/765 , A61K45/06 , A61K2300/00
摘要： The present invention is directed to polyphenolic polymers formed from dihydroxybenzoic acid (DHB) derivatives or from resorcinol derivatives, monomers which form such polymers, blends of the polymers with drugs and/or additional polymers, as well as medical devices formed from, coated with, impregnated by or coverings made with any of the foregoing polymers (with or without drugs) or blends (with or without drugs).
摘要翻译：本发明涉及由二羟基苯甲酸（DHB）衍生物或间苯二酚衍生物形成的多酚聚合物，形成这种聚合物的单体，聚合物与药物和/或另外的聚合物的共混物，以及由涂覆，用任何前述聚合物（含或不含药物）或共混物（含或不含药物）制成的浸渍或覆盖物。

8. 发明申请

US20160296677A1 ENDOPROSTHESES 审中-公开
公开(公告)号：US20160296677A1
公开(公告)日：2016-10-13
申请号：US15185851
申请日：2016-06-17
申请人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
发明人： Ronald A. Sahatjian , Francisca Tan , Patrick T. Mather , Changdeng Liu , Qing Ge
IPC分类号： A61L31/10 , A61L31/02 , A61L31/04 , A61L31/16
CPC分类号： A61L31/10 , A61F2250/0067 , A61L31/022 , A61L31/04 , A61L31/16 , A61L2300/402 , Y10T428/24926 , C08L75/04 , C08L83/04
摘要： Endoprostheses are disclosed.
摘要翻译：公布内裤假体。

9. 发明申请

US20100144843A1 RNAI THERAPEUTIC FOR RESPIRATORY VIRUS INFECTION 审中-公开
标题翻译： RNAI治疗呼吸道病毒感染
公开(公告)号：US20100144843A1
公开(公告)日：2010-06-10
申请号：US12705463
申请日：2010-02-12
申请人： James Anthony McSwiggen , Qing Ge
发明人： James Anthony McSwiggen , Qing Ge
IPC分类号： A61K31/713 , C07H21/04
CPC分类号： C12N15/1131 , C12N2310/14
摘要： Double stranded siRNA molecules for combatting a respiratory virus, wherein the strands of an siRNA molecule may be from about 15 to about 60 nucleotides, and uses thereof. One strand of an siRNA molecule can be a nucleic acid sequence identical to a conserved site, or a variant thereof, within the nucleic acid sequence of the respiratory virus.
摘要翻译：用于对抗呼吸道病毒的双链siRNA分子，其中siRNA分子的链可以是约15至约60个核苷酸，及其用途。 siRNA分子的一条链可以是与呼吸病毒核酸序列中的保守位点或其变体相同的核酸序列。

10. 发明申请

US20090124567A1 Influenza Therapeutic 审中-公开
标题翻译：流感治疗
公开(公告)号：US20090124567A1
公开(公告)日：2009-05-14
申请号：US12167593
申请日：2008-07-03
申请人： Jianzhu Chen , Herman N. Eisen , Qing Ge
发明人： Jianzhu Chen , Herman N. Eisen , Qing Ge
IPC分类号： A61K31/7052 , C07H21/00 , C12N5/00 , A61P31/16 , C12N15/63 , A01K67/033
CPC分类号： C12N15/1131 , A61K38/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/32 , C12N2799/021
摘要： The present invention provides methods and compositions for inhibiting influenza infection and/or replication based on the phenomenon of RNA interference (RNAi) well as systems for identifying effective siRNAs and shRNAs for inhibiting influenza virus and systems for studying influenza virus infective mechanisms. The invention also provides methods and compositions for inhibiting infection, pathogenicity and/or replication of other infectious agents, particularly those that infect cells that are directly accessible from outside the body, e.g., skin cells or mucosal cells. In addition, the invention provides compositions comprising an RNAi-inducing entity, e.g., an siRNA, shRNA, or RNAi-inducing vector targeted to an influenza virus transcript and any of a variety of delivery agents. The invention further includes methods of use of the compositions for treatment of influenza.
摘要翻译：本发明提供了用于基于RNA干扰（RNAi）现象抑制流感感染和/或复制的方法和组合物以及用于鉴定用于抑制流感病毒的有效siRNA和shRNA以及用于研究流感病毒感染机制的系统的系统。本发明还提供用于抑制感染，致病性和/或其他感染因子的复制的方法和组合物，特别是感染可以从身体外部直接接近的细胞的感染，例如皮肤细胞或粘膜细胞的方法和组合物。此外，本发明提供了包含RNAi诱导实体的组合物，例如靶向流感病毒转录物的siRNA，shRNA或RNAi诱导载体以及各种递送试剂中的任何一种。本发明还包括使用该组合物治疗流感的方法。

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