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    • 3. 发明授权
    • Compensating for a measured variation in length of a flight tube of a mass spectrometer
    • 补偿质谱仪飞行管长度的测量变化
    • US07183543B1
    • 2007-02-27
    • US11333744
    • 2006-01-17
    • Gregor OverneyJean-Luc Truche
    • Gregor OverneyJean-Luc Truche
    • H01J49/00
    • H01J49/40
    • A mass spectrometer system comprises a flight tube having an operational length, a measurement device for measuring a variation in the longitudinal length of the flight tube, means for compensating for the measured variation in the longitudinal flight tube length, and a detector positioned near a downstream end of the flight tube. The measurement device comprises an optical interferometer, and may specifically comprise a Michelson interferometer. In a first embodiment, the mass spectrometer system includes an actuator coupled to the measurement device and the detector for moving the detector in a longitudinal direction to compensate for the measured variation in the operational flight tube length. In a second embodiment, the mass spectrometer system includes a processor coupled to the measurement device configured to calculate analyte ion mass to charge ratio. The processor is configured to modify a calculation of analyte ion mass to charge ratio using the measured variation in operational flight tube length.
    • 质谱仪系统包括具有操作长度的飞行管,用于测量飞行管的纵向长度变化的测量装置,用于补偿所测量的纵向飞行管长度的变化的装置,以及位于下游 飞行管的末端。 测量装置包括光学干涉仪,并且可以具体地包括迈克尔逊干涉仪。 在第一实施例中,质谱仪系统包括联接到测量装置的致动器和用于沿纵向方向移动检测器的检测器,以补偿测量的操作飞行管长度的变化。 在第二实施例中,质谱仪系统包括耦合到被配置为计算分析物离子质量与电荷比的测量装置的处理器。 处理器被配置为使用测量的操作飞行管长度的变化来修改分析物离子质量与电荷比的计算。
    • 4. 发明授权
    • Apparatus for combined laser focusing and spot imaging for MALDI
    • MALDI组合激光聚焦和点成像装置
    • US07423260B2
    • 2008-09-09
    • US11266950
    • 2005-11-04
    • Gregor OverneyJean-Luc Truche
    • Gregor OverneyJean-Luc Truche
    • H01J49/04
    • H01J49/164H01J49/0004
    • A MALDI ion source includes a sample plate for receiving a sample, a laser for producing laser radiation to ionize the sample, a first optical element arranged so as to direct the laser radiation along a first optical path toward the target area, and a second optical element arranged along the first optical path to focus the laser radiation onto the target area. The first and second optical elements are arranged that light that is reflected from the target area travels along the first optical path through the first and second optical elements, the first optical element reflecting the laser radiation along a first direction and transmitting the light reflected from the target area that has traversed the first optical path in a second direction. An imaging device for viewing the plate surface may be arranged to receive the light that has been reflected from the target area and has traversed the first optical path through the first and second optical elements.
    • MALDI离子源包括用于接收样品的样品板,用于产生激光辐射以使样品电离的激光器,布置成将激光辐射沿着第一光路引导到目标区域的第一光学元件,以及第二光学 元件沿着第一光路布置以将激光辐射聚焦到目标区域上。 第一和第二光学元件布置成从目标区域反射的光通过第一和第二光学元件沿着第一光学路径行进,第一光学元件沿着第一方向反射激光辐射,并且透射从 目标区域沿第二方向穿过第一光路。 用于观察板表面的成像装置可以被布置成接收已经从目标区域反射并已穿过第一光路的光经过第一和第二光学元件。
    • 5. 发明授权
    • Method and apparatus for surface desorption ionization by charged particles
    • 带电粒子表面解吸电离的方法和装置
    • US07723678B2
    • 2010-05-25
    • US11398305
    • 2006-04-04
    • Jean-Luc TruchePaul C. GoodleyGregor Overney
    • Jean-Luc TruchePaul C. GoodleyGregor Overney
    • H01J49/14
    • H01J49/142
    • An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
    • 一种用于从样品中产生分析物离子的装置和方法。 提供一种离子产生装置,其具有具有出口的腔室和具有材料的表面,以及用于将高速气流经由腔室朝向出口施加的装置,使得通过高速气体和材料之间的物理相互作用产生带电粒子 。 带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。 主要离子从离子产生装置的出口朝向样品承载表面发射,分析物离子通过主离子冲击表面上的分析物样品而产生。
    • 8. 发明申请
    • Apparatus for combined laser focusing and spot imaging for MALDI
    • MALDI组合激光聚焦和点成像装置
    • US20070102632A1
    • 2007-05-10
    • US11266950
    • 2005-11-04
    • Gregor OverneyJean-Luc Truche
    • Gregor OverneyJean-Luc Truche
    • H01J49/16
    • H01J49/164H01J49/0004
    • A MALDI ion source includes a sample plate for receiving a sample, a laser for producing laser radiation to ionize the sample, a first optical element arranged so as to direct the laser radiation along a first optical path toward the target area, and a second optical element arranged along the first optical path to focus the laser radiation onto the target area. The first and second optical elements are arranged that light that is reflected from the target area travels along the first optical path through the first and second optical elements, the first optical element reflecting the laser radiation along a first direction and transmitting the light reflected from the target area that has traversed the first optical path in a second direction. An imaging device for viewing the plate surface may be arranged to receive the light that has been reflected from the target area and has traversed the first optical path through the first and second optical elements.
    • MALDI离子源包括用于接收样品的样品板,用于产生激光辐射以使样品电离的激光器,布置成将激光辐射沿着第一光路引导到目标区域的第一光学元件,以及第二光学 元件沿着第一光路布置以将激光辐射聚焦到目标区域上。 第一和第二光学元件布置成从目标区域反射的光通过第一和第二光学元件沿着第一光学路径行进,第一光学元件沿着第一方向反射激光辐射,并且透射从 目标区域沿第二方向穿过第一光路。 用于观察板表面的成像装置可以被布置成接收已经从目标区域反射并已穿过第一光路的光经过第一和第二光学元件。
    • 10. 发明授权
    • Method and apparatus for surface desorption ionization by charged particles
    • 带电粒子表面解吸电离的方法和装置
    • US08129677B2
    • 2012-03-06
    • US12753786
    • 2010-04-02
    • Jean-Luc TruchePaul C. GoodleyGregor Overney
    • Jean-Luc TruchePaul C. GoodleyGregor Overney
    • H01J49/26
    • H01J49/142
    • An apparatus and method for generating analyte ions from a sample. An ion generating device is provided having a chamber with an outlet and a surface having a material and means for applying a high velocity gas flow through the chamber toward the outlet such that charged particles are produced by physical interaction between the high velocity gas and the material. The charged particles then induce the generation of primary ions by interaction with molecules of the high velocity gas. The primary ions are emitted from the outlet of the ion generating device toward a sample-bearing surface and analyte ions are generated by impact of the primary ions on the analyte sample on the surface.
    • 一种用于从样品中产生分析物离子的装置和方法。 提供一种离子产生装置,其具有具有出口的腔室和具有材料的表面,以及用于将高速气流经由腔室朝向出口施加的装置,使得通过高速气体和材料之间的物理相互作用产生带电粒子 。 带电粒子然后通过与高速气体分子的相互作用诱导产生初级离子。 主要离子从离子产生装置的出口朝向样品承载表面发射,分析物离子通过主离子冲击表面上的分析物样品而产生。