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1. 发明授权

US08649840B2 Electrochemical biosensors and arrays 有权
标题翻译：电化学生物传感器和阵列
公开(公告)号：US08649840B2
公开(公告)日：2014-02-11
申请号：US12134966
申请日：2008-06-06
申请人： Norman F. Sheppard, Jr. , John T. Santini, Jr.
发明人： Norman F. Sheppard, Jr. , John T. Santini, Jr.
IPC分类号： A61B5/05
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/004 , G01N27/3272
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
摘要翻译：以各种电流，电位和电导率的传感器装置配置提供电化学传感器装置。电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储存器内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

2. 发明授权

US08604810B2 Multi-channel potentiostat for biosensor arrays 有权
标题翻译：用于生物传感器阵列的多通道恒电位仪
公开(公告)号：US08604810B2
公开(公告)日：2013-12-10
申请号：US12905710
申请日：2010-10-15
申请人： Norman F. Sheppard, Jr.
发明人： Norman F. Sheppard, Jr.
IPC分类号： G01R27/08
CPC分类号： G01N27/3273
摘要： Arrays of biosensors are provided along with methods for operating the arrays of biosensors. The array of biosensors may include a first reference electrode that is connected to an input of a first control amplifier; a first working electrode and a second working electrode in proximity with the first reference electrode; and a counter electrode that is connected to at least an output of the first control amplifier, where the first control amplifier is operative with the counter electrode to maintain a first specified voltage between the first working electrode and the first reference electrode, and between the second working electrode and the first reference electrode. The array of biosensors optionally may further include a second reference electrode that is connected to an input of a second control amplifier, where the second control amplifier is operative with the counter electrode to maintain a second specified voltage between the first working electrode and the second reference electrode, and between the second working electrode and the second reference electrode.
摘要翻译：提供生物传感器的阵列以及用于操作生物传感器阵列的方法。生物传感器阵列可以包括连接到第一控制放大器的输入的第一参考电极; 第一工作电极和靠近第一参考电极的第二工作电极; 以及对电极，其连接到所述第一控制放大器的至少一个输出端，其中所述第一控制放大器与所述对电极一起操作以维持所述第一工作电极和所述第一参考电极之间的第一规定电压，工作电极和第一参考电极。生物传感器的阵列可选地还可以包括连接到第二控制放大器的输入的第二参考电极，其中第二控制放大器与对电极一起操作以在第一工作电极和第二参考电极之间保持第二规定电压电极，以及第二工作电极和第二参考电极之间。

3. 发明授权

US08442611B2 Medical device with reservoir-based sensors 有权
标题翻译：带有储液传感器的医疗设备
公开(公告)号：US08442611B2
公开(公告)日：2013-05-14
申请号：US12688508
申请日：2010-01-15
申请人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Chung Chang Young , Robert S. Langer
发明人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Chung Chang Young , Robert S. Langer
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： A medical device is provided which may include a reservoir which has an opening and contains a sensor; a reservoir cap closing off the opening to isolate the sensor from an environmental component outside the reservoirs, the reservoir cap being impermeable to the environmental component and adapted to selectively undergo a phase change to disintegrate the reservoir cap and thereby expose the sensor to the environmental component. A method of use may include (i) selectively disintegrating a reservoir cap to expose a sensor which is disposed inside a reservoir of a device implanted in a patient, the disintegrating comprising inducing a phase change in the reservoir cap; and (ii) using the sensor to generate an output signal, wherein the output signal is recorded and stored in a writeable computer memory chips, directed to a microprocessor for immediate analysis and processing, or sent to a remote location away from the device.
摘要翻译：提供一种医疗装置，其可以包括具有开口并包含传感器的储存器; 储存器盖封闭开口以将传感器与储存器外部的环境部件隔离，储存器盖不可渗透到环境部件并且适于选择性地进行相变以分解储存器盖，从而将传感器暴露于环境部件。使用的方法可以包括（i）选择性地分解储存器盖以暴露设置在植入患者体内的装置的储存器内部的传感器，所述分解包括引起储存器盖中的相变; 以及（ii）使用所述传感器来产生输出信号，其中所述输出信号被记录并存储在可写入计算机存储器芯片中，指向微处理器以进行即时分析和处理，或者发送到远离所述设备的远程位置。

4. 发明授权

US08403907B2 Method for wirelessly monitoring implanted medical device 有权
标题翻译：无线监测植入式医疗器械的方法
公开(公告)号：US08403907B2
公开(公告)日：2013-03-26
申请号：US11926458
申请日：2007-10-29
申请人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello
发明人： Norman F. Sheppard, Jr. , John T. Santini, Jr. , Michael J. Cima , Robert S. Langer , Dennis Ausiello
IPC分类号： A61M31/00
CPC分类号： A61B1/041 , A61B5/0402 , A61B5/0476 , A61B5/14539 , A61K9/0009 , A61K9/0051 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61M2205/0244 , A61M2205/3523 , A61M2210/0612 , A61M2210/1042 , G06F19/00
摘要： A method is provided for monitoring the status of a medical device implanted in a patient. The method includes the steps of implanting in a patient a medical device which comprises (i) a substrate in which two or more reservoirs are located, with each covered by a reservoir cap, (ii) a drug or sensor located in the reservoir, (iii) a power source and actuation electronics for disintegrating or permeabilizing the reservoir cap, and (iv) a telemetry system; and then using said telemetry system to wirelessly transmit to a remote controller data about the condition of the power source and/or data about which reservoirs have been or have yet to be activated to release the drug therefrom or to expose the sensor therein.
摘要翻译：提供了一种用于监测植入患者体内的医疗装置的状态的方法。该方法包括以下步骤：在医疗装置中植入医疗装置，该医疗装置包括（i）两个或多个储存器所在的基底，每个储存器被储存器盖覆盖，（ii）位于储存器中的药物或传感器 iii）用于使储存器盖分解或渗透的电源和致动电子设备，以及（iv）遥测系统; 然后使用所述遥测系统无线地向遥控器发送关于电源的状况的数据和/或关于哪些储存器已经或尚未被启动以从其释放药物或者将传感器暴露于其中的数据。

5. 发明申请

US20120241216A1 COMPRESSION AND COLD WELD SEALING METHODS AND DEVICES 有权
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：US20120241216A1
公开(公告)日：2012-09-27
申请号：US13488355
申请日：2012-06-04
申请人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
发明人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
IPC分类号： F16B11/00 , B23K20/00 , H01R4/02
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , H01L2924/16315 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：提供压缩冷焊方法，接头结构和密封的密封装置。该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。

6. 发明授权

US07985386B2 Implantable medical device for diagnostic sensing 有权
标题翻译：用于诊断感测的植入式医疗设备
公开(公告)号：US07985386B2
公开(公告)日：2011-07-26
申请号：US12240728
申请日：2008-09-29
申请人： John T. Santini, Jr. , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Norman F. Sheppard, Jr.
IPC分类号： B01D21/00
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： An implantable medical device is provided for use with an external detector to detect an analyte in vivo. In one embodiment, the device consisting essentially of a substrate; a plurality of discrete reservoirs located in the substrate, each reservoir having at least one opening; a reacting component contained in each reservoir; and at least one non-degradable barrier layer covering each reservoir opening, the barrier layer being permeable to an analyte to be detected, wherein the reacting component remains inside the reservoirs and can react with the analyte to be detected, and wherein the device is adapted for implantation into the body of a patient.
摘要翻译：提供可植入的医疗装置，用于与外部检测器一起检测体内分析物。在一个实施例中，该装置基本上由基底组成; 多个分立储存器，位于基板中，每个储存器具有至少一个开口; 每个储存器中包含的反应组分; 以及覆盖每个储存器开口的至少一个不可降解的阻挡层，所述阻挡层对待检测的分析物是可渗透的，其中所述反应成分保留在所述储存器的内部并且可以与待检测的分析物反应，并且其中所述装置适应用于植入患者的身体。

7. 发明申请

US20110172587A1 METHOD AND SYSTEM FOR DRUG DELIVERY TO THE EYE 失效
标题翻译：药物递送到眼睛的方法和系统
公开(公告)号：US20110172587A1
公开(公告)日：2011-07-14
申请号：US13012426
申请日：2011-01-24
申请人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
发明人： John T. Santini, JR. , Michael J. Cima , Robert S. Langer , Dennis Ausiello , Norman F. Sheppard, JR. , Stephen J. Herman
IPC分类号： A61F9/00
CPC分类号： A61K9/0051 , A61F9/0017 , A61K9/0009 , A61K9/0048 , A61K9/0097 , H01L24/96 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01011 , H01L2924/01013 , H01L2924/01015 , H01L2924/0102 , H01L2924/01027 , H01L2924/01033 , H01L2924/01074 , H01L2924/01075 , H01L2924/01079 , H01L2924/014 , H01L2924/12041 , H01L2924/12042 , H01L2924/12043 , H01L2924/14 , H01L2924/1461 , H01L2924/19041 , H01L2924/19043 , H01L2924/00
摘要： Methods and systems are provided for delivering drug to the eye. The method and system may include implanting into the eye a device which comprises two or more discrete reservoirs, each reservoir containing a drug; and directing focused light to the implanted device to open a first one of the reservoirs and thereby permit the drug to diffuse from the first reservoir to the patient's eye.
摘要翻译：提供了将药物输送到眼睛的方法和系统。该方法和系统可以包括将包括两个或更多个离散储器的装置植入眼中，每个储存器包含药物; 以及将聚焦光引导到所述植入装置以打开所述储存器中的第一个，从而允许所述药物从所述第一储存器扩散到所述患者的眼睛。

8. 发明授权

US07648677B2 Method for operating a reservoir-based sensor device 有权
标题翻译：用于操作基于储液器的传感器装置的方法
公开(公告)号：US07648677B2
公开(公告)日：2010-01-19
申请号：US11927092
申请日：2007-10-29
申请人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Robert S. Langer , Chung Chang Young
发明人： John T. Santini, Jr. , Norman F. Sheppard, Jr. , Robert S. Langer , Chung Chang Young
IPC分类号： C12Q1/68
CPC分类号： B01L3/50853 , A61B5/00 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61K9/0004 , A61K9/0009 , A61K9/0097 , A61K47/6957 , A61K49/0002 , B01J19/0093 , B01J2219/00317 , B01J2219/00351 , B01J2219/00783 , B01J2219/00819 , B01J2219/00822 , B01J2219/00824 , B01J2219/00828 , B01J2219/00831 , B01J2219/00833 , B01J2219/00835 , B01J2219/00844 , B01J2219/00853 , B01J2219/00873 , B01J2219/00889 , B01J2219/00907 , B01J2219/00925 , B01J2219/00952 , B01J2219/00957 , B01J2219/00966 , B01J2219/0097 , B01J2219/00984 , B01J2219/00986 , B01L2200/12 , B01L2300/023 , B01L2300/049 , B01L2300/0627 , B01L2300/0654 , B01L2300/0819 , B01L2400/0677 , C40B60/14 , G01N2035/00158 , G01N2035/00247 , Y10T29/49007 , Y10T29/49117 , Y10T436/25
摘要： Methods for operating a sensor device are provided, which may include (a) providing at a site (e.g., implanting in a patient) a device which comprises at least first and second reservoirs, a first sensor and corresponding first reference sensor located within the first reservoir, a second sensor and corresponding second reference sensor located within the second reservoir, a first reservoir cap closing an opening in the first reservoir and a second reservoir cap closing an opening in the second reservoir, and a power source, control circuitry, and electrodes for selectively disintegrating each reservoir cap; (b) disintegrating the first reservoir cap and operating the first sensor and reference sensor; and (c) using the first reference sensor to determine whether the first sensor is operating properly. If not operating properly, then the control circuitry initiates disintegration of the second reservoir cap and operation of the second sensor and reference sensor.
摘要翻译：提供了用于操作传感器装置的方法，其可以包括（a）在现场（例如，植入患者体内）提供包括至少第一和第二储存器的装置，第一传感器和位于第一储存器，第二传感器和位于第二储存器内的对应的第二参考传感器，封闭第一储存器中的开口的第一储存器盖和封闭第二储存器中的开口的第二储存器盖，以及电源，控制电路和电极用于选择性地分解每个储存器盖; （b）分解第一储存器盖并操作第一传感器和参考传感器; 和（c）使用第一参考传感器来确定第一传感器是否正常工作。如果操作不正常，则控制电路启动第二储存器盖的分解和第二传感器和参考传感器的操作。

9. 发明授权

US07604628B2 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 有权
标题翻译：用于控制释放或暴露储层内容物的多盖储存装置
公开(公告)号：US07604628B2
公开(公告)日：2009-10-20
申请号：US11217799
申请日：2005-09-01
申请人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.
摘要翻译：提供了一种储存器装置，其中单个储存器具有至少两个开口，其间具有支撑结构，并且通过覆盖开口的储存器盖封闭以控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。该装置包括基板; 设置在基板中的至少一个储存器，储存器具有两个或更多个开口; 水库内容位于水库; 两个或更多个分立的储存器盖，每个储存器盖密封地覆盖至少一个储存器开口; 以及用于选择性地使贮存器盖分解或渗透的控制装置。

10. 发明申请

US20080302659A1 ELECTROCHEMICAL BIOSENSORS AND ARRAYS 有权
标题翻译：电化学传感器和阵列
公开(公告)号：US20080302659A1
公开(公告)日：2008-12-11
申请号：US12134966
申请日：2008-06-06
申请人： Norman F. Sheppard, JR. , John T. Santini, JR.
发明人： Norman F. Sheppard, JR. , John T. Santini, JR.
IPC分类号： G01N33/487 , A61M25/00
CPC分类号： A61B5/14865 , A61B5/14532 , C12Q1/004 , G01N27/3272
摘要： Electrochemical sensor devices are provided, in various amperometric, potentiometric, and conductometric sensor device configurations. An amperometric sensor device may include a structural body which has at least one reservoir that has at least one opening; a working electrode located within the reservoir; analyte sensor chemistry located within the reservoir and deposited on at least the working electrode; an auxiliary electrode located outside of the reservoir; a reference electrode; at least one reservoir cap closing the opening to isolate the working electrode and analyte sensor chemistry within the reservoir and to prevent an analyte outside of the reservoir from contacting the analyte sensor chemistry; and means for rupturing or displacing the reservoir cap to permit the analyte from outside of the reservoir to contact the analyte sensor chemistry.
摘要翻译：以各种电流，电位和电导率的传感器装置配置提供电化学传感器装置。电流传感器装置可以包括具有至少一个具有至少一个开口的储存器的结构体; 位于储存器内的工作电极; 分析物传感器化学位于储存器内并沉积在至少工作电极上; 位于储存器外部的辅助电极; 参考电极; 至少一个储存器盖封闭所述开口以将所述工作电极和所述分析物传感器化学物质隔离在所述储存器内并防止所述储存器外的分析物接触所述分析物传感器化学物质; 以及用于破裂或移动储存器盖以允许来自储存器外部的分析物接触分析物传感器化学物质的装置。

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