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1. 发明授权

US07604628B2 Multi-cap reservoir devices for controlled release or exposure of reservoir contents 有权
标题翻译：用于控制释放或暴露储层内容物的多盖储存装置
公开(公告)号：US07604628B2
公开(公告)日：2009-10-20
申请号：US11217799
申请日：2005-09-01
申请人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
IPC分类号： A61K9/22
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Reservoir-based devices are provided in which an individual reservoir has at least two openings with a support structure therebetween and closed by reservoir caps covering the openings to control release or exposure of reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor. The device includes a substrate; at least one reservoir disposed in the substrate, the reservoir having two or more openings; reservoir contents located in the reservoir; two or more discrete reservoir caps, each reservoir cap sealingly covering at least one of the reservoir openings; and control means for selectively disintegrating or permeabilizing the reservoir caps.
摘要翻译：提供了一种储存器装置，其中单个储存器具有至少两个开口，其间具有支撑结构，并且通过覆盖开口的储存器盖封闭以控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。该装置包括基板; 设置在基板中的至少一个储存器，储存器具有两个或更多个开口; 水库内容位于水库; 两个或更多个分立的储存器盖，每个储存器盖密封地覆盖至少一个储存器开口; 以及用于选择性地使贮存器盖分解或渗透的控制装置。

2. 发明授权

US08403915B2 Multi-opening reservoir devices for controlled release or exposure of reservoir contents 有权
标题翻译：用于控制释放或暴露储存器内容物的多开式储存装置
公开(公告)号：US08403915B2
公开(公告)日：2013-03-26
申请号：US12581558
申请日：2009-10-19
申请人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
发明人： John T. Santini, Jr. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, Jr.
IPC分类号： A61K9/22 , A61M5/14
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
摘要翻译：提供了诸如医疗装置的装置，其包括具有至少一个具有两个或更多个开口的储存器的主体部分，所述两个或多个开口部分地由储存器盖支撑件限定; 设置在储存器内部的储存器内容物，例如药物制剂或传感器; 以及封闭两个或更多储存器开口的储存器盖。可能破裂的储存盖控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。

3. 发明申请

US20100042075A1 MULTI-OPENING RESERVOIR DEVICES FOR CONTROLLED RELEASE OR EXPOSURE OF RESERVOIR CONTENTS 有权
标题翻译：用于控制释放或储存内容物暴露的多开式储存装置
公开(公告)号：US20100042075A1
公开(公告)日：2010-02-18
申请号：US12581558
申请日：2009-10-19
申请人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
发明人： John T. Santini, JR. , Zouhair Sbiaa , Jonathan R. Coppeta , Scott A. Uhland , Norman F. Sheppard, JR.
IPC分类号： A61M37/00
CPC分类号： B01L3/50853 , A61K9/0009 , A61K9/0024 , A61K9/0097 , A61M5/14 , A61M5/14276 , A61N1/05 , B01L2300/0627 , B01L2300/0819 , B01L2400/0677 , Y10T436/25
摘要： Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.
摘要翻译：提供了诸如医疗装置的装置，其包括具有至少一个具有两个或更多个开口的储存器的主体部分，所述两个或多个开口部分地由储存器盖支撑件限定; 设置在储存器内部的储存器内容物，例如药物制剂或传感器; 以及封闭两个或更多储存器开口的储存器盖。可能破裂的储存盖控制储存器内容物的释放或暴露。在一个实施例中，该装置是可植入医疗装置，并且提供药物的受控释放或传感器的暴露。

4. 发明授权

US07114312B2 Low temperature methods for hermetically sealing reservoir devices 有权
标题翻译：用于气密封装置的低温方法
公开(公告)号：US07114312B2
公开(公告)日：2006-10-03
申请号：US10894265
申请日：2004-07-19
申请人： Jonathan R. Coppeta , Scott A. Uhland , Benjamin F. Polito , Norman F. Sheppard, Jr. , Christina M. Feakes , Douglas B. Snell , John T. Santini, Jr.
发明人： Jonathan R. Coppeta , Scott A. Uhland , Benjamin F. Polito , Norman F. Sheppard, Jr. , Christina M. Feakes , Douglas B. Snell , John T. Santini, Jr.
IPC分类号： B65B7/28
CPC分类号： B01L3/5085 , A61K9/0009 , A61K9/0097 , B01L3/5027 , B01L2400/0677 , B81B2201/058 , B81C1/00269 , B81C2203/0145 , H01L21/50
摘要： Methods are provided for hermetically sealing an opening in a reservoir of a containment device. The method comprises applying a polymeric material to an opening in a reservoir of a containment device, the reservoir comprising reservoir contents (such as a drug or a sensor) to be hermetically isolated within the reservoir, the applied polymeric material closing off the opening and forming a temporary seal; and adhering a hermetic sealing material onto the polymeric material to hermetically seal the opening. The reservoir can be a micro-reservoir. The containment device can comprises an array of two or more of reservoirs, and the method comprises hermetically sealing each of the two or more reservoirs.
摘要翻译：提供了用于气密地密封容纳装置的储存器中的开口的方法。该方法包括将聚合物材料施加到容纳装置的储存器中的开口中，所述储存器包括要在储存器内气密隔离的储存器内容物（例如药物或传感器），所施加的聚合物材料封闭开口并形成临时印章并将气密密封材料粘附到聚合物材料上以气密地密封开口。储层可以是微储层。容纳装置可以包括两个或更多个储存器的阵列，并且该方法包括气密地密封两个或更多储存器中的每一个。

5. 发明授权

US07534241B2 Micro-reservoir osmotic release systems and microtube array device 有权
标题翻译：微储层渗透释放系统和微管阵列装置
公开(公告)号：US07534241B2
公开(公告)日：2009-05-19
申请号：US10668573
申请日：2003-09-23
申请人： Jonathan R. Coppeta , John T. Santini, Jr. , Scott A. Uhland
发明人： Jonathan R. Coppeta , John T. Santini, Jr. , Scott A. Uhland
IPC分类号： A61K9/22
CPC分类号： A61M31/002 , A61K9/0004 , A61K9/0024 , A61K9/0097 , A61M5/141 , A61M5/14276 , A61M5/14526 , A61M31/00 , A61M37/00 , A61M37/0015 , A61M2005/14513 , A61M2037/0023 , A61M2205/0244 , A61M2205/0266
摘要： Devices and methods are provided for controlled release of chemical molecules, such as drugs. One device comprises a plurality of reservoirs; a rupturable covering, such as a thin metal film, enclosing a first end of each reservoir; a release formulation in each reservoir comprising chemical molecules for release; an expanding material layer in each reservoir; and a semi-permeable membrane enclosing a second end of each reservoir distal the release formulation, the semi-permeable membrane being operable to permit selected molecules (e.g., water) from outside the reservoir to diffuse to the expanding material layer to expand the expanding material layer and displace the release formulation in an amount effective rupture the rupturable membrane and discharge the release formulation. The device may further comprises a reservoir cap covering semi-permeable membrane and means for selectively disintegrating the reservoir cap to initiate diffusion of fluid molecules from outside the reservoir and through the semi-permeable membrane.
摘要翻译：提供了用于控制释放化学分子（例如药物）的装置和方法。一个装置包括多个储存器; 诸如薄金属膜的破裂覆盖物，其包围每个储存器的第一端; 每个储存器中的释放制剂包含用于释放的化学分子; 每个储存器中的膨胀材料层; 以及半透膜，其围绕所述释放制剂封闭每个储存器的第二端，所述半透膜可操作以允许从所述储存器外部的选定分子（例如水）扩散到所述膨胀材料层以膨胀所述膨胀材料并将释放制剂置于有效破裂可破裂膜并排出释放制剂的量。装置还可以包括覆盖半透膜的储存器盖和用于选择性地分解储存器盖以启动流体分子从储存器外部并通过半透膜的装置的装置。

6. 发明申请

US20120035528A1 LOW-PERMEABILITY, LASER-ACTIVATED DRUG DELIVERY DEVICE 有权
标题翻译：低渗透性，激光激活药物递送装置
公开(公告)号：US20120035528A1
公开(公告)日：2012-02-09
申请号：US13023370
申请日：2011-02-08
申请人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
发明人： Jonathan R. Coppeta , Kenneth N. Horne , John T. Santini, JR. , John A. Scholl , Gregory J.R. Spooner , Cynthia L. Stevenson , Naveed Shams , Andrew Poutiatine
IPC分类号： A61M37/00 , B65B1/04
CPC分类号： A61F9/0017 , A61F9/008 , A61K9/0009 , A61K9/0051
摘要： An implantable drug delivery device that uses multiple reservoir elements to contain and release doses of active pharmaceutical ingredients. The device includes a first shell element, which has a first enclosed cavity volume and forms a low-permeability barrier. The first shell element is configured to absorb light irradiation from a laser source, the laser irradiation causing a breach in the first shell element. A first active pharmaceutical ingredient is contained in the first enclosed cavity volume and is released when the first shell element is breached. The device also includes a second shell element, which has a second enclosed cavity volume and also forms a low-permeability barrier. A second active pharmaceutical ingredient is contained in the second enclosed cavity volume. The device also includes an envelope element containing the first and second shell elements.
摘要翻译：一种可植入药物递送装置，其使用多个储存元件来容纳和释放剂量的活性药物成分。该装置包括第一壳单元，其具有第一封闭空腔体积并形成低渗透屏障。第一壳元件被配置为吸收来自激光源的光照射，激光照射引起第一壳元件中的破裂。第一活性药物成分包含在第一封闭空腔体积中，并且当第一壳元件被破坏时被释放。该装置还包括第二壳单元，其具有第二封闭空腔体积并且还形成低渗透屏障。第二活性药物成分包含在第二封闭空腔体积中。该装置还包括包含第一和第二壳单元的包络元件。

7. 发明申请

US20120241216A1 COMPRESSION AND COLD WELD SEALING METHODS AND DEVICES 有权
标题翻译：压缩和冷焊密封方法和装置
公开(公告)号：US20120241216A1
公开(公告)日：2012-09-27
申请号：US13488355
申请日：2012-06-04
申请人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
发明人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, JR. , Douglas Snell , Catherine M.B. Santini
IPC分类号： F16B11/00 , B23K20/00 , H01R4/02
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , H01L2924/16315 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：提供压缩冷焊方法，接头结构和密封的密封装置。该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。

8. 发明授权

US09796583B2 Compression and cold weld sealing method for an electrical via connection 有权
公开(公告)号：US09796583B2
公开(公告)日：2017-10-24
申请号：US13488355
申请日：2012-06-04
申请人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, Jr. , Douglas Snell , Catherine M. B. Santini
发明人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, Jr. , Douglas Snell , Catherine M. B. Santini
IPC分类号： B81C1/00 , A61K9/00 , B23K20/02 , F16B4/00 , F16B5/08 , F16B11/00 , H01L23/10 , H01L23/31 , B33Y80/00 , A61M5/142
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , H01L2924/16315 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.

9. 发明申请

US20130211219A1 Implantable Biosensor Device and Methods of Use Thereof 审中-公开
标题翻译：植入式生物传感器装置及其使用方法
公开(公告)号：US20130211219A1
公开(公告)日：2013-08-15
申请号：US13818545
申请日：2011-08-12
申请人： Jonathan R. Coppeta , Robert Farra , Kenneth L. Hilts , Norman F. Sheppard, JR.
发明人： Jonathan R. Coppeta , Robert Farra , Kenneth L. Hilts , Norman F. Sheppard, JR.
IPC分类号： A61B5/145 , A61B5/1486
CPC分类号： A61B5/14532 , A61B5/14865 , A61B2562/046 , A61B2562/066
摘要： Sensor devices and methods are provided for detecting the presence or concentration of an analyte in fluid. The device has a reservoir; a working electrode located within the reservoir, a catalyst covering at least part of the working electrode; an oxygen-generating auxiliary electrode in the reservoir; and a reservoir cap to isolate the working and auxiliary electrodes within the reservoir. The device further includes means for selectively rupturing the cap to permit analyte from outside the reservoir to contact the catalyst. The methods may include in vivo glucose monitoring and may include implanting the device in a patient; disintegrating a reservoir cap to permit glucose to enter the reservoir; generating oxygen using the oxygen-generating auxiliary electrode; and using a working electrode to oxidize hydrogen peroxide produced by the reaction of the oxygen with glucose in the presence of glucose oxidase, and thereby detecting endogenous glucose in the patient.
摘要翻译：提供了传感器装置和方法，用于检测流体中分析物的存在或浓度。设备有一个水库; 位于储存器内的工作电极，覆盖工作电极的至少一部分的催化剂; 储存器中的产氧辅助电极; 以及用于隔离储存器内的工作和辅助电极的储存器盖。该装置还包括用于选择性地破裂盖以允许来自储存器外部的分析物与催化剂接触的装置。所述方法可以包括体内葡萄糖监测，并且可以包括将装置植入患者体内; 分解储存器盖以允许葡萄糖进入储存器; 使用产生氧的辅助电极产生氧气; 并且在葡萄糖氧化酶的存在下使用工作电极氧化由氧与葡萄糖的反应产生的过氧化氢，从而检测患者的内源性葡萄糖。

10. 发明授权

US08191756B2 Hermetically sealing using a cold welded tongue and groove structure 有权
标题翻译：密封采用冷焊舌榫结构
公开(公告)号：US08191756B2
公开(公告)日：2012-06-05
申请号：US11267541
申请日：2005-11-04
申请人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, Jr. , Douglas Snell , Catherine M. B. Santini
发明人： Jonathan R. Coppeta , Kurt Shelton , Norman F. Sheppard, Jr. , Douglas Snell , Catherine M. B. Santini
IPC分类号： B23K20/12 , B23K31/00
CPC分类号： B81C1/00269 , A61K9/0097 , A61M5/14276 , A61M2205/0244 , A61M2207/00 , B23K20/02 , B33Y80/00 , B81B2201/06 , B81C1/00047 , B81C1/00095 , B81C2203/0109 , B81C2203/019 , B81C2203/038 , F16B4/004 , F16B5/08 , F16B11/004 , H01L23/10 , H01L23/3142 , H01L2224/05001 , H01L2224/05023 , H01L2224/051 , H01L2224/05568 , H01L2224/056 , H01L2224/16237 , H01L2224/81193 , H01L2924/01322 , H01L2924/10253 , H01L2924/1461 , H01L2924/16315 , Y10T403/477 , H01L2924/00 , H01L2924/00014
摘要： Compression cold welding methods, joint structures, and hermetically sealed containment devices are provided. The method includes providing a first substrate having at least one first joint structure which comprises a first joining surface, which surface comprises a first metal; providing a second substrate having at least one second joint structure which comprises a second joining surface, which surface comprises a second metal; and compressing together the at least one first joint structure and the at least one second joint structure to locally deform and shear the joining surfaces at one or more interfaces in an amount effective to form a metal-to-metal bond between the first metal and second metal of the joining surfaces. Overlaps at the joining surfaces are effective to displace surface contaminants and facilitate intimate contact between the joining surfaces without heat input. Hermetically sealed devices can contain drug formulations, biosensors, or MEMS devices.
摘要翻译：提供压缩冷焊方法，接头结构和密封的密封装置。该方法包括提供具有至少一个第一接头结构的第一基底，该第一接合结构包括第一接合表面，该表面包括第一金属; 提供具有至少一个第二接头结构的第二基底，所述第二接头结构包括第二接合表面，所述表面包括第二金属; 以及将所述至少一个第一接合结构和所述至少一个第二接头结构压在一起，以在一个或多个界面上局部变形和剪切所述接合表面，所述接合面有效地在所述第一金属和所述第二接头结构之间形成金属与金属之间的接合金属的接合面。在接合表面上的重叠有效地移动表面污染物并促进接合表面之间的紧密接触而不需要热量输入。密封装置可以包含药物制剂，生物传感器或MEMS装置。

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