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1. 发明授权

US11925686B2 Materials for phototherapies of ophthalmic diseases 有权
公开(公告)号：US11925686B2
公开(公告)日：2024-03-12
申请号：US15746746
申请日：2016-07-22
申请人： EYEBRIGHT MEDICAL TECHNOLOGY (BEIJING) CO., LTD.
发明人： Xince Sui , Yongji Wei , Jiangbing Xie
IPC分类号： A61K41/00 , A61F9/007 , A61F9/008 , A61K47/58 , A61K47/69 , A61N5/06
CPC分类号： A61K41/0071 , A61F9/0079 , A61F9/008 , A61K41/0057 , A61K41/0076 , A61K47/58 , A61K47/6957 , A61N5/062 , A61N2005/0648
摘要： The present invention relates to a medicinal material for light therapy, comprising a matrix material and a photosensitizer, wherein the photosensitizer is dispersed inside the matrix material by copolymerization, is mixed inside the matrix material, or attached to the surface of the matrix material by surface grafting, modification, coating and the like. The present material can kill diseased tissue cells with a radiation under selected wavelength so as to obtain a phototherapy treatment of ophthalmic diseases. The present invention also provides a process for preparing the material and a use in preparing an ophthalmic medical device.

2. 发明公开

US20230364247A1 NON-LINEAR MULTIBLOCK COPOLYMER-DRUG CONJUGATES FOR THE DELIVERY OF ACTIVE AGENTS 审中-公开
公开(公告)号：US20230364247A1
公开(公告)日：2023-11-16
申请号：US18306872
申请日：2023-04-25
申请人： The Johns Hopkins University
发明人： Jie Fu , Peter A. Campochiaro , Justin Scot Hanes
IPC分类号： A61K47/60 , A61K47/59 , A61K47/69 , A61K47/68
CPC分类号： A61K47/60 , A61K47/59 , A61K47/6927 , A61K47/6957 , A61K47/6827
摘要： Non-linear multiblock copolymer-drug conjugates for the treatment and prevention of diseases and disorders of the eye are provided. The polymer-drug conjugates can form nanoparticles, microparticles, and implants that are capable of effectively delivering therapeutic levels of one or more active agents for an extended period of time. Administration to the eye of an active agent in the form of a non-linear multiblock copolymer-drug conjugate produces decreased side effects when compared to administration of the active agent alone. Also provided are methods of treating intraocular neovascular diseases, such as wet age-related macular degeneration as well as diseases and disorders of the eye associated with inflammation, such as uveitis.

3. 发明申请

US20180117171A1 IMMUNOCONJUGATES FOR PROGRAMMING OR REPROGRAMMING OF CELLS 审中-公开
公开(公告)号：US20180117171A1
公开(公告)日：2018-05-03
申请号：US15563878
申请日：2016-04-01
申请人： President and Fellows of Harvard College
发明人： David J. Mooney , Roger Warren Sands , Joel Stern , Aileen W. Li , Rajiv Desai , Beverly Ying Lu
IPC分类号： A61K47/64 , A61K47/69 , A61L27/54 , A61L27/28 , A61L27/22 , A61P35/00 , A61P31/00 , A61P37/00 , A61P37/06 , A61P37/08 , A61P11/06 , A61P3/08 , A61P1/00 , A61P19/02 , A61P17/06 , A61P17/10 , A61P17/00 , A61P25/00 , A61K45/06 , A61P29/00
CPC分类号： A61K47/646 , A61K39/00 , A61K39/0008 , A61K39/0011 , A61K45/06 , A61K47/543 , A61K47/549 , A61K47/554 , A61K47/64 , A61K47/643 , A61K47/6957 , A61K2039/55522 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , A61K2039/60 , A61K2039/6018 , A61K2039/6025 , A61L27/227 , A61L27/28 , A61L27/54 , A61L2300/416 , A61L2300/426 , A61L2300/43 , A61L2300/432 , A61L2300/45 , A61L2300/606 , A61L2430/02 , A61P1/00 , A61P3/08 , A61P11/06 , A61P17/00 , A61P17/06 , A61P17/10 , A61P19/02 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P37/08 , C07H21/00
摘要： The conjugate compositions and methods are useful to elicit/augment an immune response to a tumor or microbial infection or to reduce the severity of autoimmunity, chronic inflammation, allergy, asthma, periodontal disease, and transplant rejection.

4. 发明授权

US09724428B2 Medical devices for collecting pathogenic cells 有权
公开(公告)号：US09724428B2
公开(公告)日：2017-08-08
申请号：US14458651
申请日：2014-08-13
申请人： Cook Medical Technologies LLC
发明人： Julia E. Leslie , Andrew K. Hoffa , Tyler J. Bunch , Sean Chambers , Colleen Gemborys
IPC分类号： A61K39/395 , A61F2/00 , A61K47/48 , A61L29/08 , A61L29/16 , A61L31/04 , A61L31/08 , A61L31/16 , A61K9/00 , A61F2/01 , A61K39/00
CPC分类号： A61K47/6849 , A61F2/01 , A61F2002/016 , A61F2250/0067 , A61K9/0024 , A61K39/39558 , A61K47/6957 , A61K2039/505 , A61L29/08 , A61L29/16 , A61L31/047 , A61L31/08 , A61L31/16 , A61L2300/252 , A61L2300/404 , A61L2300/606
摘要： Disclosed is a medical device constructed and arranged for contact with a flow of blood or other bodily fluid of a patient and including an attached binding agent or a roughened surface that binds to pathogenic cells targeted for elimination from the blood or other bodily fluid. Also disclosed are methods for making and using the device.

5. 发明授权

US09636401B2 Flexible and/or elastic brachytherapy seed or strand 有权
公开(公告)号：US09636401B2
公开(公告)日：2017-05-02
申请号：US14473159
申请日：2014-08-29
申请人： Microspherix LLC
发明人： Edward J. Kaplan
IPC分类号： A61K49/04 , A61K41/00 , A61K47/48 , A61K51/12 , A61N5/10 , A61K49/00 , A61B5/06 , A61L31/14 , A61L31/10 , A61L31/16 , A61L31/18 , A61B90/00
CPC分类号： A61L31/16 , A61B5/064 , A61B90/39 , A61B2090/3966 , A61K41/0038 , A61K47/6957 , A61K49/00 , A61K49/0409 , A61K51/1282 , A61L31/02 , A61L31/04 , A61L31/10 , A61L31/146 , A61L31/148 , A61L31/18 , A61L2300/44 , A61L2300/45 , A61N5/1007 , A61N5/1027 , A61N2005/1023 , A61N2005/1024
摘要： A flexible or elastic brachytherapy strand that includes an imaging marker and/or a therapeutic, diagnostic or prophylactic agent such as a drug in a biocompatible carrier that can be delivered to a subject upon implantation into the subject through the bore of a brachytherapy implantation needle has been developed. Strands can be formed as chains or continuous arrays of seeds up to 50 centimeters or more, with or without spacer material, flaccid, rigid, or flexible.

6. 发明申请

US20160376305A1 COMPOSITIONS CONTAINING HC-HA/PTX3 COMPLEXES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20160376305A1
公开(公告)日：2016-12-29
申请号：US15214706
申请日：2016-07-20
申请人： TissueTech, Inc.
发明人： Scheffer TSENG , Hua HE , Sean TIGHE , Suzhen ZHANG , Ying-Tieng ZHU
IPC分类号： C07K1/36 , C07K19/00 , C07K14/47
CPC分类号： C07K1/36 , A61K38/00 , A61K38/191 , A61K47/55 , A61K47/69 , A61K47/6957 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/236 , A61L2300/252 , A61L2300/41 , A61L2300/412 , A61L2300/426 , C07K14/47 , C07K14/525 , C07K14/81 , C07K19/00
摘要： Provided herein are methods for the production of native and reconstituted hyaluronan (HA) complexes containing pentraxin-3 (PTX3) and heavy chain 1 (HC1) of inter alpha inhibitor (IαI). Compositions containing the complexes and therapeutic methods using the complexes are provided. Combinations and kits for use in practicing the methods also are provided.

7. 发明申请

US20150297281A1 MEDICAL DEVICES FOR THERAPEUTIC HEAT TREATMENTS 审中-公开
标题翻译：用于治疗热治疗的医疗设备
公开(公告)号：US20150297281A1
公开(公告)日：2015-10-22
申请号：US14689455
申请日：2015-04-17
申请人： Boston Scientific Scimed, Inc.
发明人： DEREK C. SUTERMEISTER , JOSEPH ALAN KRONSTEDT , TIMOTHY A. OSTROOT , PATRICK A. HAVERKOST , JAN WEBER , JAMES M. ANDERSON , CASS ALEXANDER HANSON , MARTIN R. WILLARD
IPC分类号： A61B18/08 , A61B18/14
CPC分类号： A61B18/082 , A61B17/320725 , A61B18/04 , A61B18/14 , A61B18/1492 , A61B2017/00088 , A61B2017/22061 , A61B2018/00011 , A61B2018/00125 , A61B2018/00136 , A61B2018/00148 , A61B2018/00154 , A61B2018/0016 , A61B2018/00178 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00404 , A61B2018/00434 , A61B2018/00511 , A61B2018/00577 , A61B2018/00595 , A61B2018/00601 , A61B2018/00642 , A61B2018/00714 , A61B2018/00815 , A61B2018/087 , A61B2018/1465 , A61K41/0052 , A61K47/6957 , A61M25/0043 , A61M25/0082 , A61M37/00 , A61M2025/0042 , A61M2025/105 , A61M2025/1081 , A61M2025/1086 , A61N1/406
摘要： An expandable balloon catheter having an elongate shaft having a distal end region and an expandable balloon coupled to the distal end region of the elongate shaft is disclosed. One or more cutting members are attached to the expandable balloon, wherein at least a portion of each of the one or more cutting members comprises a Curie material having a Curie temperature between 60° and 400° Celsius.
摘要翻译：公开了一种具有细长轴的可扩张气囊导管，其具有远端区域和与细长轴的远端区域联接的可膨胀气囊。一个或多个切割构件附接到可膨胀气囊，其中一个或多个切割构件中的每一个的至少一部分包括居里温度在60°至400℃之间的居里材料。

8. 发明授权

US09150646B2 Surface-oriented antibody coating for the reduction of post-stent restenosis 有权
标题翻译：表面取向抗体涂层用于减少支架内再狭窄
公开(公告)号：US09150646B2
公开(公告)日：2015-10-06
申请号：US13230036
申请日：2011-09-12
申请人： Michael Thompson , Pasquale Benvenuto , Christophe Blaszykowski
发明人： Michael Thompson , Pasquale Benvenuto , Christophe Blaszykowski
IPC分类号： G01N33/543 , C07K16/28 , A61K47/48 , A61L31/10 , A61L31/16 , C07K17/14 , B05D1/18 , B05D7/14
CPC分类号： C07K16/28 , A61K47/6957 , A61L31/10 , A61L31/16 , A61L2300/256 , A61L2300/416 , B05D1/185 , B05D7/14 , C07K17/14 , C07K2317/55
摘要： A coating for a surface of a surgical implant, the coating including a binding protein for capturing cells to the surface via a bi-functional linker molecule. The linker can have a first functional group (such as a trichlorosilyl group) for covalently linking to the surface, and a second functional group (such as a benzothiosulfonate group) for covalently linking to the binding protein. One exemplary linker molecule is S-(11-trichlorosilyl-undecenyl)benzenethiosulfonate. The coating may be a self-assembled monolayer and may also include a spacer molecule, which can be unreactive with the binding protein. The target cells may be endothelial stem cells (such as endothelial progenitor cells). The binding protein may be an antibody, antibody fragment or non-antibody derived antigen binding molecule. The binding protein may bind a cell surface marker specific to target cell type. Coated surgical implants, and methods of forming such a coating are also contemplated.
摘要翻译：用于外科植入物表面的涂层，该涂层包括用于通过双功能连接分子将细胞捕获到表面的结合蛋白。连接体可以具有用于共价连接到表面的第一官能团（例如三氯甲硅烷基）和与结合蛋白共价连接的第二官能团（例如苯并硫代磺酸酯基团）。一个示例性的连接分子是S-（11-三氯甲硅烷基 - 十一碳烯基）苯硫代磺酸酯。涂层可以是自组装单层，并且还可以包括间隔分子，其可以与结合蛋白不反应。靶细胞可以是内皮干细胞（例如内皮祖细胞）。结合蛋白可以是抗体，抗体片段或非抗体衍生的抗原结合分子。结合蛋白可以结合靶细胞类型特异性的细胞表面标志物。涂敷的外科手术植入物，以及形成这种涂层的方法也被考虑。

9. 发明授权

US09011918B2 Biocompatible and biodegradable elastomeric polymers 有权
标题翻译：生物相容性和可生物降解的弹性体聚合物
公开(公告)号：US09011918B2
公开(公告)日：2015-04-21
申请号：US13566392
申请日：2012-08-03
申请人： Asima Pattanaik
发明人： Asima Pattanaik
IPC分类号： A61K38/08 , A61K47/42 , C07K7/06 , A61K47/48 , A61L27/18 , A61L27/22 , A61L27/58 , A61L31/10 , A61K9/00 , A61K9/16 , A61K47/34
CPC分类号： A61K47/48192 , A61K9/0024 , A61K9/1641 , A61K47/34 , A61K47/42 , A61K47/59 , A61K47/593 , A61K47/64 , A61K47/6957 , A61L27/18 , A61L27/227 , A61L27/58 , A61L31/10 , C07K7/06
摘要： Disclosed herein are biocompatible and biodegradable polymers which are useful in tissue engineering, wound healing, coatings, and drug delivery, the polymers comprising one or more ECM-mimetic peptides and one or more biodegradable moieties, wherein the moieties do not comprise an amino acid or residue thereof. Further disclosed herein are methods for making and using the disclosed biocompatible polymers.
摘要翻译：本文公开了可用于组织工程，伤口愈合，涂层和药物递送的生物相容性和可生物降解的聚合物，所述聚合物包含一种或多种ECM-模拟肽和一种或多种可生物降解的部分，其中所述部分不包含氨基酸或残留物。本文进一步公开的是制备和使用所公开的生物相容性聚合物的方法。

10. 发明授权

US08936811B2 Device coated with glycogen particles comprising nucleic acid complexes 有权
标题翻译：涂覆有包含核酸复合物的糖原颗粒的装置
公开(公告)号：US08936811B2
公开(公告)日：2015-01-20
申请号：US12437287
申请日：2009-05-07
申请人： Joram Slager , Joseph Schmidt McGonigle
发明人： Joram Slager , Joseph Schmidt McGonigle
IPC分类号： A61K9/14 , A61K31/7052 , A61P43/00
CPC分类号： A61K9/1641 , A61K9/0024 , A61K9/1623 , A61K9/1652 , A61K9/1658 , A61K47/543 , A61K47/58 , A61K47/59 , A61K47/593 , A61K47/60 , A61K47/61 , A61K47/6921 , A61K47/6923 , A61K47/6957 , A61K48/00 , C12N15/87
摘要： Embodiments of the invention include particles with nucleic acid complexes, medical devices including the same and related methods. In an embodiment, the invention can include a method of making a medical device. The method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, adsorbing the nucleic acid complexes to porous particles to form nucleic acid complex containing particles, mixing the nucleic acid complex containing particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the method can include contacting nucleic acids with cationic carrier agents to form nucleic acid complexes, combining the nucleic acid complexes with a material to form nucleic acid complex containing particles in situ, mixing the nucleic acid complex particles with a polymer solution to form a coating mixture, and applying the coating mixture to a substrate. In an embodiment, the invention can include an implantable medical device including a substrate, an elution control matrix disposed on the substrate; a plurality of particles disposed within the elution control matrix, and a plurality of nucleic acid complexes disposed within the particles, the nucleic acid complexes comprising a nucleic acid and a cationic carrier agent. Other embodiments are included herein.
摘要翻译：本发明的实施方案包括具有核酸复合物的颗粒，包括相同方法的医疗装置。在一个实施例中，本发明可以包括制造医疗装置的方法。该方法可以包括使核酸与阳离子载体接触以形成核酸复合物，将核酸复合物吸附到多孔颗粒上以形成含有核酸复合物的颗粒，将含有核酸复合物的颗粒与聚合物溶液混合以形成涂层混合物，并将涂覆混合物施加到基底上。在一个实施方案中，该方法可以包括使核酸与阳离子载体试剂接触以形成核酸复合物，将核酸复合物与材料组合以形成原位含有颗粒的核酸复合物，将核酸复合物颗粒与聚合物溶液混合形成涂料混合物，并将涂料混合物施加到基材上。在一个实施例中，本发明可以包括可植入医疗装置，其包括基底，设置在基底上的洗脱控制矩阵; 布置在洗脱控制基质内的多个颗粒，以及设置在颗粒内的多个核酸复合物，所述核酸复合物包含核酸和阳离子载体试剂。本文还包括其它实施例。

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