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1. 发明申请

US20090075327A1 Methods for improving secondary metabolite production in fungi 审中-公开
公开(公告)号：US20090075327A1
公开(公告)日：2009-03-19
申请号：US09800863
申请日：2001-03-07
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12P37/00 , C12P17/08 , C12N1/18 , C12N1/16
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

2. 发明申请

US20050095633A1 Novel regulators of fungal gene expression 审中-公开
标题翻译：真菌基因表达的新型调节剂
公开(公告)号：US20050095633A1
公开(公告)日：2005-05-05
申请号：US10952045
申请日：2004-09-28
申请人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
发明人： Brian Cali , Douglas Holtzman , Jeffrey Silva , Joshua Trueheart , Lixin Zhang , Kevin Madden , G. Milne , Amir Sherman
IPC分类号： C12N15/09 , C07K14/37 , C07K14/38 , C07K14/385 , C12N15/31 , C12Q1/68 , C07H21/04 , C12N1/18 , C12N9/22 , C12N15/74
CPC分类号： C07K14/385 , C07K14/38
摘要： The invention relates to regulators of fungal gene expression and their use in commercial and medical applications. More particularly, the invention relates to regulators of fungal genes involved in production of enzymes, secondary metabolites and other useful products, as well as to regulators of genes involved in fungal invasion. The invention provides novel regulators of fungal gene expression, and methods for using regulator genes in commercial and medical applications.
摘要翻译：本发明涉及真菌基因表达的调节剂及其在商业和医学应用中的应用。更具体地，本发明涉及涉及酶，次生代谢物和其它有用产物的生产的真菌基因调节剂，以及参与真菌侵袭的基因的调节剂。本发明提供了真菌基因表达的新型调节剂，以及在商业和医学应用中使用调节基因的方法。

3. 发明申请

US20100102992A1 SYSTEMS AND METHODS FOR REMOTE MONITORING OF WEATHER 审中-公开
标题翻译：远程监测天气的系统和方法
公开(公告)号：US20100102992A1
公开(公告)日：2010-04-29
申请号：US12259875
申请日：2008-10-28
申请人： Alan Cornett , Craig Kevin Madden , David W. Meyers , Robert Charles Becker , David Todd Spoor
发明人： Alan Cornett , Craig Kevin Madden , David W. Meyers , Robert Charles Becker , David Todd Spoor
IPC分类号： G01C23/00
CPC分类号： G01S7/06 , G01S13/86 , G01S13/953 , G01W1/08 , Y02A90/18
摘要： Systems and methods are operable to capture images of weather along a portion of a flight path of an aircraft, and are operable to wirelessly communicate information corresponding to the captured images to the aircraft. An exemplary embodiment has at least one camera pointed in a direction corresponding to a portion of the flight path of the aircraft and configured to capture images of weather in proximity to the portion of the flight path, and has a transceiver configured to wirelessly communicate images captured by the at least one camera.
摘要翻译：系统和方法可操作地捕获沿着飞行器的飞行路径的一部分的天气的图像，并且可操作以将对应于所捕获的图像的信息无线地传送到飞行器。示例性实施例具有指向与飞行器的飞行路径的一部分相对应的方向的至少一个摄像机，并且被配置为捕获靠近飞行路径的该部分的天气的图像，并且具有收发器，被配置为无线地传送捕获的图像由至少一个相机。

4. 发明申请

US20060263864A1 Methods for improving secondary metabolite production of fungi 审中-公开
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US20060263864A1
公开(公告)日：2006-11-23
申请号：US10309407
申请日：2002-12-03
申请人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
发明人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
IPC分类号： C12P17/06 , C12P7/62 , C12N15/74 , C12N1/16
CPC分类号： C12N15/80 , C12P15/00 , C12P17/04 , C12P17/06 , C12P19/62 , C12P37/00
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
摘要翻译：包括编码CreA，AreA，GanB，Gna3，FadA，Gna1，Gpa1，RfeH，An09，PacC，Lys14，LovU，Ste7，Pde2，Nc1，Vps34等基因的调控某些参与次级代谢产物的基因的次级代谢产物生成方法及其真菌同系物。

5. 发明授权

US06949356B1 Methods for improving secondary metabolite production in fungi 有权
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US06949356B1
公开(公告)日：2005-09-27
申请号：US09487558
申请日：2000-01-19
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12N15/09 , A61K31/351 , A61K38/00 , A61K45/00 , A61P3/06 , A61P31/04 , A61P35/00 , A61P37/06 , C07D309/30 , C07K14/38 , C07K14/395 , C12N1/15 , C12N15/80 , C12P17/06 , C12P35/00 , C12P35/06 , C12P37/00 , C12R1/66 , C12R1/82 , C12P1/00 , C12P1/02
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
摘要翻译：本发明涉及由真菌生产次级代谢物。更具体地，本发明涉及通过真菌改善商业上重要的次级代谢物的生产。本发明提供了改善真菌中次生代谢物产生的方法，包括调节参与次级代谢产物调节的基因的表达。

6. 发明申请

US20130023885A1 Unidirectional Plunger Device For Syringe 审中-公开
标题翻译：注射器单向柱塞装置
公开(公告)号：US20130023885A1
公开(公告)日：2013-01-24
申请号：US13187978
申请日：2011-07-21
申请人： Kevin Madden , John Henry , Andreas Legner
发明人： Kevin Madden , John Henry , Andreas Legner
IPC分类号： A61B17/58 , B23P17/04
CPC分类号： A61M5/31505 , A61M5/19 , A61M5/3137 , A61M5/315 , Y10T29/49826
摘要： A unidirectional plunger device for a syringe includes a base member and a ratchet mechanism. The base member is configured to attach to the proximal end of the syringe body such that the ratchet mechanism engages the plunger of the syringe. The ratchet mechanism may include a pawl configured to engage teeth on a plunger rod of the plunger. The ratchet mechanism is desirably configured to permit distal movement of the plunger while resisting proximal movement of the plunger. The unidirectional plunger device may be a retrofit that can be attached to (e.g., clipped onto) an existing syringe design. The device may be used in conjunction with a two-barrel syringe for dispensing a two-part curable composition, such as calcium phosphate bone cement or epoxy resin.
摘要翻译：用于注射器的单向柱塞装置包括基部构件和棘轮机构。基部构件被构造成附接到注射器主体的近端，使得棘轮机构接合注射器的柱塞。棘轮机构可以包括构造成接合柱塞的柱塞杆上的齿的棘爪。棘轮机构理想地构造成允许柱塞的远端运动同时抵抗柱塞的近端运动。单向柱塞装置可以是可以附接到（例如，夹在）现有注射器设计上的改装。该装置可以与双筒注射器结合使用，用于分配两部分可固化组合物，例如磷酸钙骨水泥或环氧树脂。

7. 发明申请

US20050255568A1 Methods and compositions for amino acid production 审中-公开
标题翻译：用于氨基酸生产的方法和组成
公开(公告)号：US20050255568A1
公开(公告)日：2005-11-17
申请号：US10858730
申请日：2004-06-01
申请人： Richard Bailey , Paul Blomquist , Reed Doten , Edward Driggers , Kevin Madden , Jessica O'Leary , George O'Toole , Joshua Trueheart , Michael Walbridge , Peter Yorgey
发明人： Richard Bailey , Paul Blomquist , Reed Doten , Edward Driggers , Kevin Madden , Jessica O'Leary , George O'Toole , Joshua Trueheart , Michael Walbridge , Peter Yorgey
IPC分类号： C12N1/21 , C12N9/02 , C12N9/04 , C12N9/06 , C12N9/10 , C12N9/12 , C12N9/88 , C12P13/04 , C12P13/08 , C12P13/12
CPC分类号： C12N9/0008 , C12N9/0006 , C12N9/1007 , C12N9/1029 , C12N9/1085 , C12N9/1217 , C12N9/88 , C12P13/04 , C12P13/08 , C12P13/12
摘要： Methods and compositions for amino acid production using genetically modified bacteria are disclosed.
摘要翻译：公开了使用转基因细菌进行氨基酸生产的方法和组合物。

8. 发明申请

US20070026505A1 Amino acid and metabolite biosynthesis 审中-公开
标题翻译：氨基酸和代谢物生物合成
公开(公告)号：US20070026505A1
公开(公告)日：2007-02-01
申请号：US11455390
申请日：2006-06-19
申请人： Kevin Madden , Michael Walbridge , Peter Yorgey , Reed Doten
发明人： Kevin Madden , Michael Walbridge , Peter Yorgey , Reed Doten
IPC分类号： C12P13/04 , C12N1/21 , C12N15/74
CPC分类号： C12N1/20 , C07K14/24 , C07K14/34 , C12N9/00 , C12N15/52 , C12P13/08 , C12P13/12
摘要： Bacterial strains that are engineered to increase the production of amino acids, including aspartate-derived amino acids (e.g., methionine, lysine, threonine, isoleucine, and S-adenosylmethionine (S-AM)) and cysteine, and related metabolites are described. The strains can be genetically engineered to harbor one or more nucleic acid molecules (e.g., recombinant nucleic acid molecules) encoding a polypeptide (e.g., a polypeptide that is heterologous or homologous to the host cell) and/or they may be engineered to increase or decrease expression and/or activity of polypeptides (e.g., by mutation of endogenous nucleic acid sequences).
摘要翻译：描述了旨在增加氨基酸生产的细菌菌株，包括天冬氨酸衍生的氨基酸（例如甲硫氨酸，赖氨酸，苏氨酸，异亮氨酸和S-腺苷甲硫氨酸（S-AM））和半胱氨酸以及相关的代谢产物。菌株可以被遗传工程化以携带编码多肽（例如，与宿主细胞异源或同源的多肽）的一个或多个核酸分子（例如，重组核酸分子）和/或它们可被工程化以增加或降低多肽的表达和/或活性（例如，通过内源核酸序列的突变）。

9. 发明申请

US20070015237A1 Production of carotenoids in oleaginous yeast and fungi 有权
标题翻译：在含油酵母和真菌中生产类胡萝卜素
公开(公告)号：US20070015237A1
公开(公告)日：2007-01-18
申请号：US11385580
申请日：2006-03-20
申请人： Richard Bailey , Kevin Madden , Joshua Trueheart
发明人： Richard Bailey , Kevin Madden , Joshua Trueheart
IPC分类号： C12P23/00 , C12N15/74 , C12N1/18
CPC分类号： C12N15/80 , A23L31/00 , A23L31/10 , C12P23/00
摘要： The present invention provides systems for producing engineered oleaginous yeast or fungi that express carotenoids
摘要翻译：本发明提供用于生产表达类胡萝卜素的工程化含油酵母或真菌的系统

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