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1. 发明申请

US20060263864A1 Methods for improving secondary metabolite production of fungi 审中-公开
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US20060263864A1
公开(公告)日：2006-11-23
申请号：US10309407
申请日：2002-12-03
申请人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
发明人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
IPC分类号： C12P17/06 , C12P7/62 , C12N15/74 , C12N1/16
CPC分类号： C12N15/80 , C12P15/00 , C12P17/04 , C12P17/06 , C12P19/62 , C12P37/00
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
摘要翻译：包括编码CreA，AreA，GanB，Gna3，FadA，Gna1，Gpa1，RfeH，An09，PacC，Lys14，LovU，Ste7，Pde2，Nc1，Vps34等基因的调控某些参与次级代谢产物的基因的次级代谢产物生成方法及其真菌同系物。

2. 发明授权

US06949356B1 Methods for improving secondary metabolite production in fungi 有权
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US06949356B1
公开(公告)日：2005-09-27
申请号：US09487558
申请日：2000-01-19
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12N15/09 , A61K31/351 , A61K38/00 , A61K45/00 , A61P3/06 , A61P31/04 , A61P35/00 , A61P37/06 , C07D309/30 , C07K14/38 , C07K14/395 , C12N1/15 , C12N15/80 , C12P17/06 , C12P35/00 , C12P35/06 , C12P37/00 , C12R1/66 , C12R1/82 , C12P1/00 , C12P1/02
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
摘要翻译：本发明涉及由真菌生产次级代谢物。更具体地，本发明涉及通过真菌改善商业上重要的次级代谢物的生产。本发明提供了改善真菌中次生代谢物产生的方法，包括调节参与次级代谢产物调节的基因的表达。

3. 发明申请

US20090075327A1 Methods for improving secondary metabolite production in fungi 审中-公开
公开(公告)号：US20090075327A1
公开(公告)日：2009-03-19
申请号：US09800863
申请日：2001-03-07
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12P37/00 , C12P17/08 , C12N1/18 , C12N1/16
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

4. 发明申请

US20060258593A1 Methods and compositions for the treatment of gastrointestinal disorders 有权
公开(公告)号：US20060258593A1
公开(公告)日：2006-11-16
申请号：US10899806
申请日：2004-07-27
申请人： Mark Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Sun , Thea Norman , G. Milne
发明人： Mark Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Sun , Thea Norman , G. Milne
IPC分类号： A61K38/10 , C07K7/08 , C12P21/06 , C07H21/04
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.

5. 发明申请

US20110288279A1 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 有权
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的用途
公开(公告)号：US20110288279A1
公开(公告)日：2011-11-24
申请号：US13178189
申请日：2011-07-07
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C07K16/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed Herein are Non-Natural Amino Acids and Polypeptides that Include at Least One non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及用于制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

6. 发明申请

US20110124583A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20110124583A1
公开(公告)日：2011-05-26
申请号：US12754138
申请日：2010-04-05
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Thea Norman , G. Todd Milne
IPC分类号： A61K38/10 , C07K7/00 , A61P1/00
CPC分类号： C07K7/08 , A61K38/00 , C07K14/245
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation, and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘和便秘相关与使用活化鸟苷酸环化酶C（GC-C）受体的肽和其他试剂的神经性疾病以及其它病症和病症。

7. 发明授权

US07928163B2 Compositions containing, methods involving, and uses of non-natural amino acids and polypeptides 有权
标题翻译：含有，涉及非天然氨基酸和多肽的方法和使用的组合物
公开(公告)号：US07928163B2
公开(公告)日：2011-04-19
申请号：US11873347
申请日：2007-10-16
申请人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
发明人： Zhenwei Miao , Junjie Liu , Thea Norman , Russell Driver
IPC分类号： C08G65/02 , C08F26/06 , C08F16/00 , C08F16/06
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , A61K47/60 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02A50/473 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛的可能的官能团，但典型的具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

8. 发明申请

US20100159586A1 Hybrid Suppressor tRNA for Vertebrate Cells 有权
标题翻译：用于脊椎动物细胞的杂种抑制子tRNA
公开(公告)号：US20100159586A1
公开(公告)日：2010-06-24
申请号：US12440015
申请日：2007-09-07
申请人： Feng Tian , Thea Norman , Stephanie Chu
发明人： Feng Tian , Thea Norman , Stephanie Chu
IPC分类号： C12N5/071 , C07H21/02
CPC分类号： C12P21/02 , C12N9/93 , C12N15/11
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O-tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。本发明提供具有翻译成分的脊椎动物细胞，例如正交氨基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA）及其各自成分的对，其用于脊椎动物蛋白质生物合成机制以掺入非天然氨基在生长的多肽链中，在脊椎动物细胞中。

9. 发明申请

US20100159585A1 Suppressor tRNA Transcription in Vertebrate Cells 有权
标题翻译：抑制子tRNA转录在脊椎动物细胞
公开(公告)号：US20100159585A1
公开(公告)日：2010-06-24
申请号：US12440013
申请日：2007-09-07
申请人： Feng Tian , Thea Norman , Stephanie Chu
发明人： Feng Tian , Thea Norman , Stephanie Chu
IPC分类号： C12N5/071 , C12N15/74 , C12N5/10
CPC分类号： C12N15/85 , C12N9/93 , C12N15/11 , C12P21/02
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。

10. 发明申请

US20090191611A1 Methods and Compositions for the Treatment of Gastrointestinal Disorders 有权
标题翻译：用于治疗胃肠道疾病的方法和组合
公开(公告)号：US20090191611A1
公开(公告)日：2009-07-30
申请号：US12120023
申请日：2008-05-13
申请人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
发明人： Mark G. Currie , Shalina Mahajan-Miklos , Angelika Fretzen , Li Jing Sun , Thea Norman , G. Todd Milne
IPC分类号： C12N1/21 , C12N15/11 , C12N15/00
CPC分类号： C07K5/1016 , A61K36/17 , A61K36/38 , A61K38/00 , C07K7/06 , C07K7/08 , C07K14/00 , A61K2300/00
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠道疾病和病症（例如胃肠蠕动障碍，功能性胃肠道疾病，胃食管反流病（GERD），十二指肠胃反流，克罗恩病，溃疡性结肠炎，炎性肠病，功能性胃灼热的组合物和相关方法，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的疾病和病症，例如与使用阿片类止痛药相关的便秘，手术后便秘（术后肠梗阻）和与神经性疾病相关的便秘以及使用活化鸟苷酸环化酶C（GC-C）受体的肽和其它试剂的其它病症和障碍。

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