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1. 发明申请

US20140154807A1 METHOD FOR HOMOLOGOUS RECOMBINATION 审中-公开
标题翻译：同种异体重建方法
公开(公告)号：US20140154807A1
公开(公告)日：2014-06-05
申请号：US14146858
申请日：2014-01-03
申请人： Hesselien TOUW-RIEL , Marco Alexander BERG VAN DEN
发明人： Hesselien TOUW-RIEL , Marco Alexander BERG VAN DEN
IPC分类号： C12N15/80
CPC分类号： C12N15/80 , C07K14/385 , C12N15/1058 , C12N15/902 , C12N2800/30
摘要： The present invention discloses a method to construct eukaryotic cells having a target sequence in a chromosomal DNA sequence replaced by a replacement sequence of interest comprising: modifying a parent eukaryotic cell with a preference for NHR to provide a eukaryotic cell having an increased HR/NHR ratio as compared to the parent cell, providing two sets of DNA molecules of which the first set comprises DNA molecules each comprising a first non-functional fragment of the replacement sequence of interest flanked at its 5′-side by a DNA sequence substantially homologous to a sequence of the chromosomal DNA flanking the target sequence and the second set comprises DNA molecules each comprising a second non-functional fragment of the DNA replacement sequence of interest overlapping with the first non-functional fragment and flanked at its 3′-side by a DNA sequence substantially homologous to a sequence of the chromosomal DNA flanking the target sequence, wherein the first and second non-functional fragments become functional upon recombination; transforming the modified eukaryotic cells with both sets of DNA molecules; and growing the cells to obtain transformed progeny cells having a DNA molecule from the first set recombined with a DNA molecule from the second set into a DNA molecule comprising a functional replacement sequence and having the target sequence replaced by the functional replacement sequence.
摘要翻译：本发明公开了一种构建真核细胞的方法，所述真核细胞在染色体DNA序列中被替换的目标序列替代，所述染色体DNA序列被替换的目标序列所替代，包括：以优选NHR修饰亲本真核细胞以提供具有增加的HR / NHR比的真核细胞与亲本细胞相比，提供两组DNA分子，其中第一组包含DNA分子，每个DNA分子包含在其5'侧两侧的替换序列的第一个非功能性片段，其基本上与在靶序列侧翼的染色体DNA的序列和第二组包含DNA分子，每个DNA分子包含与第一非功能片段重叠的DNA置换序列的第二个非功能性片段，并在其3'侧通过DNA侧接基本上与靶序列侧翼的染色体DNA的序列同源的序列，其中第一和第二非功能性片段在重组时变得有功能; 用两组DNA分子转化修饰的真核细胞; 并生长细胞以获得具有来自第一组的DNA分子的转化后代细胞与来自第二组的DNA分子重组为包含功能性替换序列的DNA分子并且将靶序列替换为功能性替换序列。

2. 发明申请

US20140115740A1 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same 有权
公开(公告)号：US20140115740A1
公开(公告)日：2014-04-24
申请号：US14105668
申请日：2013-12-13
申请人： Novozymes, Inc. , Novozymes A/S
发明人： Lan Tang , Ye Liu , Junxin Duan , Yu Zhang , Christian Isak Jorgensen , Randall Kramer
IPC分类号： C12N9/42
CPC分类号： C12N9/2437 , C07K14/385 , C12N9/2434 , C12N15/01 , C12N15/1137 , C12N15/8218 , C12N15/8246 , C12N2310/14 , C12N2310/141 , C12P7/14 , C12P19/02 , C12P19/14 , C12P2203/00
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

3. 发明申请

US20140106398A1 VECTOR-HOST SYSTEM 审中-公开
标题翻译：矢量主机系统
公开(公告)号：US20140106398A1
公开(公告)日：2014-04-17
申请号：US14004671
申请日：2012-03-12
申请人： Roelof Ary Lans Bovenberg , Jan Andries Kornelis Willem Kiel , Thibaut José Wenzel , Alrik Pieter Los
发明人： Roelof Ary Lans Bovenberg , Jan Andries Kornelis Willem Kiel , Thibaut José Wenzel , Alrik Pieter Los
IPC分类号： C12N15/80
CPC分类号： C12N15/80 , C07K14/385 , C12N15/65
摘要： The present invention relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell is a filamentous fungal cell. The invention also relates to a host cell deficient in an essential gene, comprising a vector, said vector comprising at least said essential gene and an autonomous replication sequence, wherein the host cell comprises a recombinant polynucleotide construct comprising a polynucleotide encoding a biological compound of interest or a compound involved in the synthesis of a biological compound of interest.
摘要翻译：本发明涉及必需基因缺陷的宿主细胞，其包含载体，所述载体至少包含所述必需基因和自主复制序列，其中所述宿主细胞是丝状真菌细胞。本发明还涉及基本基因缺陷的宿主细胞，其包含载体，所述载体至少包含所述必需基因和自主复制序列，其中所述宿主细胞包含重组多核苷酸构建体，其包含编码感兴趣的生物化合物的多核苷酸或涉及合成感兴趣的生物化合物的化合物。

4. 发明申请

US20130195916A1 System and Method for Identifying Complex Patterns of Amino Acids 审中-公开
标题翻译：识别氨基酸复杂模式的系统和方法
公开(公告)号：US20130195916A1
公开(公告)日：2013-08-01
申请号：US13787450
申请日：2013-03-06
申请人： Samuel Bogoch , Elenore S. Bogoch , Anne-Elenore Bogoch Borsanyi , Samuel Winston Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch , Anne-Elenore Bogoch Borsanyi , Samuel Winston Bogoch
IPC分类号： G06F19/16 , C40B30/02
CPC分类号： G16B15/00 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , G16B30/00 , G16B35/00 , G16C20/60
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译：公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。

5. 发明授权

US08242329B2 Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same 有权
公开(公告)号：US08242329B2
公开(公告)日：2012-08-14
申请号：US13434108
申请日：2012-03-29
申请人： Lan Tang , Ye Liu , Junxin Duan , Yu Zhang , Christian Isak Jorgensen , Randall Kramer
发明人： Lan Tang , Ye Liu , Junxin Duan , Yu Zhang , Christian Isak Jorgensen , Randall Kramer
IPC分类号： A01H9/00 , C12P21/06 , C12N1/20 , C12N5/00
CPC分类号： C12N9/2437 , C07K14/385 , C12N9/2434 , C12N15/01 , C12N15/1137 , C12N15/8218 , C12N15/8246 , C12N2310/14 , C12N2310/141 , C12P7/14 , C12P19/02 , C12P19/14 , C12P2203/00
摘要： The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.

6. 发明申请

US20100278860A1 SYSTEM AND METHOD FOR IDENTIFYING COMPLEX PATTERNS OF AMINO ACIDS 失效
标题翻译：用于鉴定氨基酸复合体的系统和方法
公开(公告)号：US20100278860A1
公开(公告)日：2010-11-04
申请号：US12349955
申请日：2009-01-07
申请人： Samuel BOGOCH , Elenore S. BOGOCH , Anne Elenore BORSANYI , Samuel Winston BOGOCH
发明人： Samuel BOGOCH , Elenore S. BOGOCH , Anne Elenore BORSANYI , Samuel Winston BOGOCH
IPC分类号： A61K39/145 , A61P31/16 , G01N33/68
CPC分类号： G06F19/16 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , C40B30/02 , G06F19/22
摘要： A method and system are disclosed for identifying and/or locating complex patterns in an amino acid sequence stored in a computer file or database. According to an aspect of the present invention, techniques are provided to facilitate queries of protein databases. For protein descriptions received in response to the queries, embodiments of the present invention may scan the received protein descriptions to identify and locate Replikin patterns. A Replikin pattern is defined to be a sequence of 7 to about 50 amino acids that include the following three (3) characteristics, each of which may be recognized by an embodiment of the present invention: (1) the sequence has at least one lysine residue located six to ten amino acid residues from a second lysine residue; (2) the sequence has at least one histidine residue; and (3) at least 6% of the amino acids in the sequence are lysine residues.
摘要翻译：公开了用于识别和/或定位存储在计算机文件或数据库中的氨基酸序列中的复杂模式的方法和系统。根据本发明的一个方面，提供了用于促进蛋白质数据库查询的技术。对于响应于查询而接收到的蛋白质描述，本发明的实施例可以扫描接收到的蛋白质描述以识别和定位Replikin模式。复制素模式被定义为7至约50个氨基酸的序列，其包括以下三（3）个特征，每个特征可以被本发明的实施方案识别：（1）序列具有至少一个赖氨酸残基位于第二赖氨酸残基6至10个氨基酸残基; （2）该序列具有至少一个组氨酸残基; 和（3）序列中至少6％的氨基酸是赖氨酸残基。

7. 发明授权

US07749744B2 Hybrid enzymes 失效
标题翻译：杂交酶
公开(公告)号：US07749744B2
公开(公告)日：2010-07-06
申请号：US11953933
申请日：2007-12-11
申请人： Torben V. Borchert , Steffen Danielsen , Eric J. Allain
发明人： Torben V. Borchert , Steffen Danielsen , Eric J. Allain
IPC分类号： C12N9/34 , C12N9/24 , A61K39/00
CPC分类号： C07K14/32 , C07K14/37 , C07K14/375 , C07K14/38 , C07K14/385 , C07K2319/00 , C12N9/2428 , Y02E50/16 , Y02E50/17
摘要： The present invention relates to a hybrid enzyme comprising at least one carbohydrate-binding module amino acid sequence and at least the catalytic module of a glucoamylase amino acid sequence. The invention also relates to the use of the hybrid enzyme in starch processing and especially ethanol production.
摘要翻译：本发明涉及包含至少一种碳水化合物结合组件氨基酸序列和至少葡糖淀粉酶氨基酸序列的催化组件的杂合酶。本发明还涉及杂交酶在淀粉加工中尤其是乙醇生产中的应用。

8. 发明申请

US20090162897A1 Promoter Sequences 审中-公开
标题翻译：启动子序列
公开(公告)号：US20090162897A1
公开(公告)日：2009-06-25
申请号：US12097799
申请日：2006-12-20
申请人： Heiko Eichhorn , Thomas Specht , Ivo Zadra
发明人： Heiko Eichhorn , Thomas Specht , Ivo Zadra
IPC分类号： C12P21/00 , C12N15/11 , C12N15/80 , C12N1/15 , C07H21/02 , C12P19/34 , C12P1/02
CPC分类号： C07K14/385 , C12N15/80
摘要： The present invention relates to methods for producing polypeptides or nucleic acids, in particular antisense RNA and hairpin RNA in filamentous fungi. The present invention also relates to isolated Penicillium promoter sequences and to nucleic acid constructs, vectors, and host cells comprising the promoter sequences operably linked to nucleic acid sequences encoding polypeptides or nucleic acids, in particular antisense RNA and hairpin RNA. Furthermore, the present invention relates to fermentative production of small organic compounds by use of the Penicillium promoter sequences.
摘要翻译：本发明涉及生产丝状真菌中多肽或核酸，特别是反义RNA和发夹RNA的方法。本发明还涉及分离的青霉属启动子序列和核酸构建体，载体和宿主细胞，其包含与编码多肽或核酸，特别是反义RNA和发夹RNA的核酸序列可操作地连接的启动子序列。此外，本发明涉及通过使用青霉属启动子序列发酵生产小有机化合物。

9. 发明授权

US07452963B2 Replikin peptides and antibodies therefore 失效
标题翻译：因此，复制素肽和抗体
公开(公告)号：US07452963B2
公开(公告)日：2008-11-18
申请号：US10189437
申请日：2002-07-08
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： A61K38/03 , A61K38/16
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16022 , C12N2760/16122 , Y02A50/412
摘要： The present invention provides a new class of peptides related to rapid replication and their use in diagnosing, preventing and treating disease.
摘要翻译：本发明提供了与快速复制相关的新一类肽及其在诊断，预防和治疗疾病中的用途。

10. 发明授权

US07176275B2 Anthrax and small pox replikins and methods of use 有权
标题翻译：炭疽和小痘复制品及使用方法
公开(公告)号：US07176275B2
公开(公告)日：2007-02-13
申请号：US09984056
申请日：2001-10-26
申请人： Samuel Bogoch , Elenore S. Bogoch
发明人： Samuel Bogoch , Elenore S. Bogoch
IPC分类号： C07K4/00 , C07K11/00 , C07K14/195
CPC分类号： C07K16/44 , A61K38/00 , A61K39/00 , A61K2039/505 , C07K14/005 , C07K14/195 , C07K14/205 , C07K14/21 , C07K14/22 , C07K14/24 , C07K14/245 , C07K14/255 , C07K14/26 , C07K14/27 , C07K14/28 , C07K14/285 , C07K14/30 , C07K14/305 , C07K14/31 , C07K14/315 , C07K14/32 , C07K14/33 , C07K14/335 , C07K14/34 , C07K14/345 , C07K14/35 , C07K14/355 , C07K14/36 , C07K14/37 , C07K14/38 , C07K14/385 , C07K14/39 , C07K14/40 , C07K14/405 , C07K14/415 , C07K14/44 , C07K14/445 , C07K14/47 , C12N2710/24122 , C12N2760/16122
摘要： Isolated peptides of the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01–107, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Bacillus anthracis Anthrax Toxin Lethal factor Protein pX01–107 are disclosed. Also disclosed are isolated peptides of the Small Pox Virus Surface Antigen S Precursor Protein, antibodies specific for the peptides and methods of stimulating the immune response of a subject to produce antibodies to the Small Pox Virus Surface Antigen S Precursor Protein.
摘要翻译：炭疽芽孢杆菌炭疽毒素致死致死因子蛋白质pX01-107的分离肽，肽特异性抗体和刺激受试者的免疫应答的方法以产生针对炭疽芽孢杆菌炭疽杆菌毒素致死因子蛋白质pX01-107的抗体。还公开了小型痘病毒表面抗原S前体蛋白质的分离肽，对肽有特异性的抗体以及刺激受试者的免疫应答以产生针对小痘病毒表面抗原S前体蛋白的抗体的方法。

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