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1. 发明申请

US20090075327A1 Methods for improving secondary metabolite production in fungi 审中-公开
公开(公告)号：US20090075327A1
公开(公告)日：2009-03-19
申请号：US09800863
申请日：2001-03-07
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12P37/00 , C12P17/08 , C12N1/18 , C12N1/16
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.

2. 发明申请

US20060263864A1 Methods for improving secondary metabolite production of fungi 审中-公开
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US20060263864A1
公开(公告)日：2006-11-23
申请号：US10309407
申请日：2002-12-03
申请人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
发明人： Robert Busby , Brian Cali , Peter Hecht , Douglas Holtzman , Kevin Madden , Mary Maxon , G. Milne , Thea Norman , John Royer , Jeff Silva , Eric Summers , Lixin Zhang , Maria Mayorga , Toby Feibelman , Reed Doten
IPC分类号： C12P17/06 , C12P7/62 , C12N15/74 , C12N1/16
CPC分类号： C12N15/80 , C12P15/00 , C12P17/04 , C12P17/06 , C12P19/62 , C12P37/00
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.
摘要翻译：包括编码CreA，AreA，GanB，Gna3，FadA，Gna1，Gpa1，RfeH，An09，PacC，Lys14，LovU，Ste7，Pde2，Nc1，Vps34等基因的调控某些参与次级代谢产物的基因的次级代谢产物生成方法及其真菌同系物。

3. 发明授权

US07088263B1 Runway approach lighting system and method 有权
标题翻译：跑道方式照明系统及方法
公开(公告)号：US07088263B1
公开(公告)日：2006-08-08
申请号：US10942067
申请日：2004-09-15
申请人： Kenneth Nicholas Krause , Vincent Robert Busby
发明人： Kenneth Nicholas Krause , Vincent Robert Busby
IPC分类号： G08G5/00
CPC分类号： H05B33/0806 , G08G5/0026 , G08G5/025 , H05B33/0842 , H05B33/0884
摘要： A method and system for visually guiding an aircraft in its landing approach to a runway having an approach area equipped with approach lights operable in off, low, medium, and high intensity states. The lights are communicated with a secondary side of a transformer, which has a primary side with low, medium, and high taps that correspond to the light states. Off, low, medium, and high lighting intensity requests correspond to the low, medium, and high states of the plurality of lights. AC power is switched between the transformer taps in response to a request for an increase in lighting intensity. Power is sequentially applied to the taps by supplying the power to the low tap for a first predetermined time interval before supplying the power to the medium tap.
摘要翻译：一种用于在其着陆方法中将飞机视觉引导到跑道的方法和系统，该跑道具有装备有在关闭，低，中等和高强度状态下操作的接近光的接近区域。灯与变压器的次级侧连通，变压器的次级侧具有对应于光状态的低，中和高抽头的初级侧。关闭，低，中，高照明强度请求对应于多个灯的低，中和高状态。响应于增加照明强度的要求，在变压器抽头之间切换交流电力。在将电力供应到介质抽头之前，通过在第一预定时间间隔内向低抽头提供电力来将功率顺序地施加到抽头。

4. 发明授权

US06949356B1 Methods for improving secondary metabolite production in fungi 有权
标题翻译：改善真菌次生代谢产物的方法
公开(公告)号：US06949356B1
公开(公告)日：2005-09-27
申请号：US09487558
申请日：2000-01-19
申请人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
发明人： Robert Busby , Brian Cali , Peter Hecht , Doug Holtzman , Kevin Madden , Mary Maxon , Todd Milne , Thea Norman , John Royer , Sofie Salama , Amir Sherman , Jeff Silva , Eric Summers
IPC分类号： C12N15/09 , A61K31/351 , A61K38/00 , A61K45/00 , A61P3/06 , A61P31/04 , A61P35/00 , A61P37/06 , C07D309/30 , C07K14/38 , C07K14/395 , C12N1/15 , C12N15/80 , C12P17/06 , C12P35/00 , C12P35/06 , C12P37/00 , C12R1/66 , C12R1/82 , C12P1/00 , C12P1/02
CPC分类号： C12P17/06 , C07K14/38 , C07K14/395 , C12N15/80 , C12P35/06 , C12P37/00
摘要： The invention relates to the production of secondary metabolites by fungi. More particularly, the invention relates to improvement of production of commercially important secondary metabolites by fungi. The invention provides methods for improving secondary metabolite production in a fungus, comprising modulating the expression of a gene involved in regulation of secondary metabolite production.
摘要翻译：本发明涉及由真菌生产次级代谢物。更具体地，本发明涉及通过真菌改善商业上重要的次级代谢物的生产。本发明提供了改善真菌中次生代谢物产生的方法，包括调节参与次级代谢产物调节的基因的表达。

5. 发明申请

US20100310541A1 Compositions and Methods for Reducing the Toxicity of Certain Toxins 审中-公开
标题翻译：减少某些毒素毒性的组合物和方法
公开(公告)号：US20100310541A1
公开(公告)日：2010-12-09
申请号：US12601994
申请日：2008-05-27
申请人： Marco Kessler , Mark G. Currie , Robert Busby
发明人： Marco Kessler , Mark G. Currie , Robert Busby
IPC分类号： A61K38/44 , A61K31/095 , A61K38/06 , A61K33/04 , A61P31/04 , A61P31/00 , A61P29/00
CPC分类号： A61K31/095 , A61K31/198 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/481
摘要： Compositions and methods for reducing the toxic effect of certain peptide toxins by administering an agent that directly or indirectly reduces disulfide bonds that are important for maintaining the toxin in an active conformation. Also described are compositions and methods for reducing the toxic effect of toxins that contain a heavy metal using an agent that destabilizes the binding of a metal ion that is important for toxin activity.
摘要翻译：通过施用直接或间接减少对维持毒素成活性构象重要的二硫键的试剂来降低某些肽毒素的毒性作用的组合物和方法。还描述了使用使对毒素活性重要的金属离子的结合不稳定的试剂降低含有重金属的毒素的毒性作用的组合物和方法。

6. 发明授权

US07068188B1 Runway approach lighting system and method 失效
公开(公告)号：US07068188B1
公开(公告)日：2006-06-27
申请号：US10863421
申请日：2004-06-08
申请人： Kenneth Nicholas Krause , Vincent Robert Busby
发明人： Kenneth Nicholas Krause , Vincent Robert Busby
IPC分类号： B64F1/18
CPC分类号： H05B39/041 , H05B39/044 , Y02B20/146
摘要： A method and system for visually guiding an aircraft in its landing approach to a runway having an approach area equipped with approach lights operable in off, low, medium, and high intensity states. The lights are communicated with a secondary side of a transformer, which has a primary side with low, medium, and high taps that correspond to the light states. Off, low, medium, and high lighting intensity requests correspond to the low, medium, and high states of the plurality of lights. AC power is switched between the transformer taps in response to a request for an increase in lighting intensity. Power is sequentially applied to the taps by supplying the power to the low tap for a first predetermined time interval before supplying the power to the medium tap.

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