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1. 发明授权

US08133199B2 Electroactive polymer activation system for a medical device 有权
标题翻译：一种用于医疗器械的电活性聚合物激活系统
公开(公告)号：US08133199B2
公开(公告)日：2012-03-13
申请号：US12199720
申请日：2008-08-27
申请人： Jan Weber , Kent D. Harrison
发明人： Jan Weber , Kent D. Harrison
IPC分类号： A61M29/00 , A61M31/00
CPC分类号： A61M25/1006 , A61B1/00082 , A61B5/0215 , A61B2017/00871 , A61B2017/22001 , A61F2/856 , A61F2/958 , A61M25/005 , A61M25/0054 , A61M25/0067 , A61M25/008 , A61M2025/0058 , A61M2025/0079 , A61M2025/0183 , A61M2025/1015 , A61M2025/1045 , A61M2025/105 , A61M2025/1056 , A61M2025/1093 , A61M2205/0288
摘要： An activation circuit for selectively providing an electrical current to one or more electroactive polymers (EAPs) in a medical device is disclosed. The activation circuit may include a sensor for sensing a measure related to a parameter of an elongated member and/or a balloon of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter.
摘要翻译：公开了一种用于选择性地向医疗装置中的一种或多种电活性聚合物（EAP）提供电流的激活电路。激活电路可以包括用于感测与医疗装置的细长构件和/或气囊的参数有关的措施的传感器。可以根据感测到的细长构件的参数和/或医疗装置的气囊将电流提供给一个或多个EAP。在一些情况下，激活电路可以包括比较器，用于将感测的测量值与阈值进行比较，以确定电流何时被施加到EAP。该参数可以是压力，流体流量，温度和/或其它合适的参数。

2. 发明申请

US20100057174A1 ELECTRICALLY CONDUCTIVE PATHWAYS IN MEDICAL DEVICES 有权
标题翻译：医疗器械中的电导通道
公开(公告)号：US20100057174A1
公开(公告)日：2010-03-04
申请号：US12199563
申请日：2008-08-27
申请人： Kent D. Harrison , Derek C. Sutermeister , Tim Ostroot
发明人： Kent D. Harrison , Derek C. Sutermeister , Tim Ostroot
IPC分类号： A61N1/04
CPC分类号： A61M25/0009 , A61L29/04 , A61L29/14 , A61M25/0029 , A61M25/0045 , A61M25/0051 , A61M2025/0039 , A61N1/05 , B29C47/0016 , B29C47/06 , B29K2065/00 , B29K2081/04 , B29K2995/0005 , B29L2031/7542 , Y10T29/49117
摘要： Apparatuses, systems, and methods for electrically conductive pathways in medical devices. One embodiment of a medical device can include an elongate polymeric body having a proximal end and a distal end. Discrete particles of an electrically conductive material in the elongate polymeric body can form an electrically conductive pathway that extends at least partially between the proximal end and the distal end of the elongate polymeric body.
摘要翻译：用于医疗器械中导电通路的装置，系统和方法。医疗装置的一个实施例可以包括具有近端和远端的细长聚合体。细长聚合物体中的导电材料的分散颗粒可以形成至少部分地延伸到细长聚合物体的近端和远端之间的导电通路。

3. 发明授权

US06253769B1 Method for percutaneous coronary artery bypass 失效
标题翻译：经皮冠状动脉搭桥方法
公开(公告)号：US06253769B1
公开(公告)日：2001-07-03
申请号：US09391112
申请日：1999-09-07
申请人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
发明人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
IPC分类号： A61B1900
CPC分类号： A61F2/82 , A61B17/32053 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2017/306 , A61B2090/3929 , A61B2090/3945 , A61B2090/3958 , A61F2/06 , A61F2/064 , A61F2/90 , A61F2/958 , A61F2250/0098 , Y10S623/902
摘要： A percutaneous system for bypassing a restriction in an artery of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. First and second expandable stents are provided at the first and second ends of the graft, respectively. Apertures are formed in the artery, distal of the restriction, and in the aorta and the graft is inserted between the apertures. At least a portion of the first stent is inserted through the aperture in the artery and the stent is deployed to connect the first end of the graft within the artery. The second stent is positioned such that a first expandable portion is outside the aorta and a second expandable portion is within the aorta. The first and second expandable portions of the second stent are expanded to have outer diameters at least as large as the aperture in the aorta to anchor the first end of the graft in the aorta such that the lumen in the graft communicates with the aorta and the artery.
摘要翻译：用于绕过具有主动脉的哺乳动物的动脉中的限制的经皮系统包括提供具有主体部分的移植物，其具有第一端，第二端和内腔。第一和第二可扩张支架分别设置在移植物的第一和第二端。孔径形成在动脉的远端，在主动脉的远侧，移植物插入孔之间。第一支架的至少一部分插入通过动脉中的孔，并且支架被展开以将移植物的第一端连接在动脉内。第二支架定位成使得第一可膨胀部分在主动脉外侧，第二可膨胀部分在主动脉内。第二支架的第一和第二可膨胀部分被扩张以具有至少与主动脉中的孔相同的外径，以将移植物的第一端锚定在主动脉中，使得移植物中的内腔与主动脉连通，并且动脉。

4. 发明授权

US06213126B1 Percutaneous artery to artery bypass using heart tissue as a portion of a bypass conduit 失效
标题翻译：经皮动脉到动脉旁路，使用心脏组织作为旁路导管的一部分
公开(公告)号：US06213126B1
公开(公告)日：2001-04-10
申请号：US08878933
申请日：1997-06-19
申请人： Daniel M. LaFontaine , Thomas R. Hektner , Kent D. Harrison
发明人： Daniel M. LaFontaine , Thomas R. Hektner , Kent D. Harrison
IPC分类号： A61B1900
CPC分类号： A61F2/064 , A61B17/11 , A61B18/1492 , A61B2017/00243 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2018/00214 , A61F2/2481 , A61F2002/30092 , A61F2210/0014
摘要： A restriction in a restricted vessel lying closely proximate the heart is bypassed. An aperture is formed in a supply vessel suitable for providing a blood supply. An aperture is formed in the restricted vessel distal of the restriction. Heart tissue is removed from the surface of the heart to form a channel in the heart tissue between the aperture in the supply vessel and the aperture in the restricted vessel distal of the restriction. The channel is covered to form a conduit to conduct blood from the supply vessel to the restricted vessel distal of the restriction.
摘要翻译：在靠近心脏的受限制血管中的限制被绕过。在适于提供血液供应的供应容器中形成孔。在限制器的远端的限制容器中形成孔。将心脏组织从心脏表面移除，以在供应容器中的孔和限制器远侧限制性血管的孔之间的心脏组织中形成通道。通道被覆盖以形成导管，以将血液从供应容器运送到限制器远侧的受限容器。

5. 发明授权

US06155264A Percutaneous bypass by tunneling through vessel wall 失效
标题翻译：经皮旁路经隧道穿过血管壁
公开(公告)号：US06155264A
公开(公告)日：2000-12-05
申请号：US812879
申请日：1997-03-06
申请人： Thomas V. Ressemann , Kent D. Harrison
发明人： Thomas V. Ressemann , Kent D. Harrison
IPC分类号： A61B17/00 , A61B17/22 , A61B19/00
CPC分类号： A61B17/320758 , A61B2017/00247 , A61B2017/00252 , A61B2018/00392
摘要： A parent vessel lies adjacent heart tissue, and a restriction in the parent vessel is bypassed. A first region of the parent vessel on a first side of the restriction is accessed and an aperture is formed therein. A lumen is formed through the heart tissue, and the lumen communicates with the parent vessel through the first aperture. A second aperture is formed in a second region of the parent vessel on a second side of the restriction. The lumen through the heart tissue communicates with the parent vessel through the first and second apertures, thus bypassing the restriction.
摘要翻译：父母血管位于心脏组织附近，并绕过母体血管的限制。访问在限制器的第一侧上的母血管的第一区域，并且在其中形成孔。通过心脏组织形成管腔，并且内腔通过第一孔与母体血管连通。第二孔形成在限制的第二侧上的母血管的第二区域中。穿过心脏组织的内腔通过第一和第二孔与母体血管连通，从而绕过限制。

6. 发明授权

US5554119A Drug delivery catheter with manifold 失效
标题翻译：药物输送导管与歧管
公开(公告)号：US5554119A
公开(公告)日：1996-09-10
申请号：US187614
申请日：1994-01-27
申请人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
发明人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
IPC分类号： A61M25/00 , A61F2/958 , A61M16/04 , A61M29/02 , A61M5/32
CPC分类号： A61M25/1002 , A61M16/0481 , A61M2025/105 , A61M2025/1052 , A61M2025/1072 , A61M2025/1097
摘要： A drug delivery catheter which may be inserted into a vessel, such as a blood vessel is disclosed. The drug delivery catheter comprises any elongated tubular member which has a proximal end and a distal end. A drug lumen which provides a communication path for fluid is provided in the elongated tubular member for delivering a fluid, such as the drug to be administered. An inflatable balloon assembly is provided at the distal end of the elongated tubular member. The balloon assembly includes apertures which communicate with the drug lumen. The balloon assembly comprises a tubular balloon which is helically wound through the elongated tubular member and a sheath. The sheath is attached to the helically wound tubular balloon such that when the balloon member is uninflated, the first fluid in the vessel flows around the balloon assembly and such that when the balloon member is inflated, sections of the helically wound balloon contact the vessel wall to form a containment pocket between the vessel wall, the contacting sections of the balloon and the sheath. The apertures are provided in the containment pocket. An inflatable lumen is defined through the interior of the helically wound balloon and the sheath to allow perfusion of the first fluid.
摘要翻译：公开了一种可插入容器（如血管）中的药物输送导管。药物递送导管包括具有近端和远端的任何细长管状构件。提供用于流体的连通路径的药物腔室设置在细长管状构件中，用于输送流体，例如待施用的药物。在细长管状构件的远端处设置可充气气囊组件。气囊组件包括与药物腔连通的孔。球囊组件包括通过细长管状构件和护套螺旋缠绕的管状球囊。护套附接到螺旋形缠绕的管状气囊，使得当球囊构件未膨胀时，容器中的第一流体围绕球囊组件流动，使得当球囊构件膨胀时，螺旋形卷绕的球囊的部分接触血管壁以在容器壁，球囊和护套的接触部分之间形成容纳袋。孔口设置在容纳口袋中。通过螺旋缠绕气囊和护套的内部限定可充气腔，以允许第一流体的灌注。

7. 发明申请

US20100056985A1 ELECTROACTIVE POLYMER ACTIVATION SYSTEM FOR A MEDICAL DEVICE 有权
标题翻译：用于医疗设备的电动聚合物激活系统
公开(公告)号：US20100056985A1
公开(公告)日：2010-03-04
申请号：US12199720
申请日：2008-08-27
申请人： JAN WEBER , KENT D. HARRISON
发明人： JAN WEBER , KENT D. HARRISON
IPC分类号： A61N1/30
CPC分类号： A61M25/1006 , A61B1/00082 , A61B5/0215 , A61B2017/00871 , A61B2017/22001 , A61F2/856 , A61F2/958 , A61M25/005 , A61M25/0054 , A61M25/0067 , A61M25/008 , A61M2025/0058 , A61M2025/0079 , A61M2025/0183 , A61M2025/1015 , A61M2025/1045 , A61M2025/105 , A61M2025/1056 , A61M2025/1093 , A61M2205/0288
摘要： An activation circuit for selectively providing an electrical current to one or more electroactive polymers (EAPs) in a medical device is disclosed. The activation circuit may include a sensor for sensing a measure related to a parameter of an elongated member and/or a balloon of the medical device. The electrical current may be provided to the one or more EAPs according to the sensed parameter of the elongated member and/or the balloon of the medical device. In some cases, the activation circuit may include a comparator for comparing the sensed measure to a threshold to determine when the electrical current is applied to the EAPs. The parameter may be a pressure, a fluid flow, a temperature, and/or other suitable parameter.
摘要翻译：公开了一种用于选择性地向医疗装置中的一种或多种电活性聚合物（EAP）提供电流的激活电路。激活电路可以包括用于感测与医疗装置的细长构件和/或气囊的参数有关的措施的传感器。可以根据感测到的细长构件的参数和/或医疗装置的气囊将电流提供给一个或多个EAP。在一些情况下，激活电路可以包括比较器，用于将感测的测量值与阈值进行比较，以确定电流何时被施加到EAP。该参数可以是压力，流体流量，温度和/或其它合适的参数。

8. 发明授权

US06443158B1 Percutaneous coronary artery bypass through a venous vessel 失效
标题翻译：经皮冠状动脉旁路穿过静脉血管
公开(公告)号：US06443158B1
公开(公告)日：2002-09-03
申请号：US09088496
申请日：1998-06-01
申请人： Daniel M. LaFontaine , Kent D. Harrison , Chad J. Kugler , John M. K. Daniel
发明人： Daniel M. LaFontaine , Kent D. Harrison , Chad J. Kugler , John M. K. Daniel
IPC分类号： A61B1900
CPC分类号： A61B17/11 , A61B18/1492 , A61B2017/00243 , A61B2017/00252 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139 , A61B2017/22067 , A61B2018/00023 , A61B2018/00261 , A61B2018/00386
摘要： A bypass system for bypassing a restriction in a parent vessel of a mammal to provide blood flow past the restriction. The bypass system couples a restricted artery to a venous vessel distal of a restriction to provide blood flow through the artery distal of the restriction. Blood flow is provided to a distal portion of the artery through an adjacent venous vessel so that blood can be provided to distal portions of the restricted artery.
摘要翻译：用于绕过哺乳动物的母体血管中的限制以提供血液流过限制的旁路系统。旁路系统将限制性动脉连接到限制器远端的静脉血管，以提供通过限制远端的动脉的血液流动。通过相邻的静脉血管将动脉血流提供到动脉的远端部分，以便可以将血液提供到受限动脉的远端部分。

9. 发明授权

US06238406B1 Percutaneous myocardial revascularization growth factor mediums and method 有权
标题翻译：经皮心肌血运重建生长因子介质及方法
公开(公告)号：US06238406B1
公开(公告)日：2001-05-29
申请号：US09516531
申请日：2000-03-01
申请人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
发明人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
IPC分类号： A61B1732
CPC分类号： A61B17/32002 , A61B17/320758 , A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61F2/2493 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译：通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。一种替代方法是利用不可生物降解的钉与流明和侧孔。另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。血管生成物质可以携带在可生物降解的粘合剂中。通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。

10. 发明授权

US06026814A System and method for percutaneous coronary artery bypass 失效
公开(公告)号：US06026814A
公开(公告)日：2000-02-22
申请号：US813038
申请日：1997-03-06
申请人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
发明人： Daniel M. LaFontaine , Kent D. Harrison , Charles L. Euteneuer , Roger N. Hastings , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/11 , A61B17/30 , A61B17/32 , A61B19/00 , A61F2/00 , A61F2/06 , A61F2/82 , A61F2/90
CPC分类号： A61F2/82 , A61F2/06 , A61F2/064 , A61B17/32053 , A61B2017/00243 , A61B2017/00252 , A61B2017/1135 , A61B2017/306 , A61B2090/3929 , A61B2090/3945 , A61B2090/3958 , A61F2/90 , A61F2/958 , A61F2250/0098 , Y10S623/902
摘要： A percutaneous system for bypassing a restriction in a native vessel of a mammal having an aorta includes providing a graft having a body portion with a first end, a second end and a lumen therebetween. An aperture is formed in the aorta. The graft is inserted into the aorta and the first end of the graft is connected to the aorta about the aperture in the aorta. An aperture is then formed in the native vessel distal of the restriction. The second end of the graft is connected to the native vessel about the aperture therein such that the lumen in the graft communicates with the aorta and the native vessel.

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