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1. 发明授权

US5554119A Drug delivery catheter with manifold 失效
标题翻译：药物输送导管与歧管
公开(公告)号：US5554119A
公开(公告)日：1996-09-10
申请号：US187614
申请日：1994-01-27
申请人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
发明人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
IPC分类号： A61M25/00 , A61F2/958 , A61M16/04 , A61M29/02 , A61M5/32
CPC分类号： A61M25/1002 , A61M16/0481 , A61M2025/105 , A61M2025/1052 , A61M2025/1072 , A61M2025/1097
摘要： A drug delivery catheter which may be inserted into a vessel, such as a blood vessel is disclosed. The drug delivery catheter comprises any elongated tubular member which has a proximal end and a distal end. A drug lumen which provides a communication path for fluid is provided in the elongated tubular member for delivering a fluid, such as the drug to be administered. An inflatable balloon assembly is provided at the distal end of the elongated tubular member. The balloon assembly includes apertures which communicate with the drug lumen. The balloon assembly comprises a tubular balloon which is helically wound through the elongated tubular member and a sheath. The sheath is attached to the helically wound tubular balloon such that when the balloon member is uninflated, the first fluid in the vessel flows around the balloon assembly and such that when the balloon member is inflated, sections of the helically wound balloon contact the vessel wall to form a containment pocket between the vessel wall, the contacting sections of the balloon and the sheath. The apertures are provided in the containment pocket. An inflatable lumen is defined through the interior of the helically wound balloon and the sheath to allow perfusion of the first fluid.
摘要翻译：公开了一种可插入容器（如血管）中的药物输送导管。药物递送导管包括具有近端和远端的任何细长管状构件。提供用于流体的连通路径的药物腔室设置在细长管状构件中，用于输送流体，例如待施用的药物。在细长管状构件的远端处设置可充气气囊组件。气囊组件包括与药物腔连通的孔。球囊组件包括通过细长管状构件和护套螺旋缠绕的管状球囊。护套附接到螺旋形缠绕的管状气囊，使得当球囊构件未膨胀时，容器中的第一流体围绕球囊组件流动，使得当球囊构件膨胀时，螺旋形卷绕的球囊的部分接触血管壁以在容器壁，球囊和护套的接触部分之间形成容纳袋。孔口设置在容纳口袋中。通过螺旋缠绕气囊和护套的内部限定可充气腔，以允许第一流体的灌注。

2. 发明申请

US20080171974A1 Commom bond, double-balloon catheter 有权
标题翻译：通气栓，双气囊导管
公开(公告)号：US20080171974A1
公开(公告)日：2008-07-17
申请号：US11541735
申请日：2006-10-02
申请人： Daniel M. Lafontaine , Gary L. Hendrickson
发明人： Daniel M. Lafontaine , Gary L. Hendrickson
IPC分类号： A61M29/00
CPC分类号： A61M25/1011 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61M25/1034 , A61M2025/1013 , A61M2025/1079
摘要： A method of manufacturing a catheter can include assembling an inner balloon within a separate outer balloon. The inner and outer balloons can each be open on opposing longitudinal ends and have a central radially expandable portion, and proximal and distal reduced diameter portions on opposite longitudinal end portions of the balloon. The method can further include bonding a portion of an inner surface of the outer balloon proximal reduced diameter portion to a portion of an outer surface of the inner balloon proximal reduced diameter portion and bonding a distal end portion of an elongate catheter shaft to a proximal portion of the bonded inner and outer balloons.
摘要翻译：制造导管的方法可以包括将内气囊组装在单独的外气囊中。内部和外部气囊可以在相对的纵向端部上敞开，并且具有中心径向可膨胀部分，并且在气囊的相对的纵向端部上具有近端和远端缩径部分。该方法还可以包括将外球囊近端缩小直径部分的内表面的一部分粘合到内球囊近直径部分的外表面的一部分，并将细长导管轴的远端部分接合到近端部分的粘合内外气球。

3. 发明授权

US5964782A Closure device and method 失效
标题翻译：封闭装置和方法
公开(公告)号：US5964782A
公开(公告)日：1999-10-12
申请号：US932990
申请日：1997-09-18
申请人： Daniel M. Lafontaine , Kent D. Harrison
发明人： Daniel M. Lafontaine , Kent D. Harrison
IPC分类号： A61B17/04 , A61B17/00 , A61B17/10 , A61B18/04 , A61B18/14
CPC分类号： A61B18/148 , A61B17/0057 , A61B2017/00637 , A61B2017/00663 , A61B2017/00668 , A61B2017/00672 , A61B2018/00196 , A61B2018/0022 , A61B2018/00273 , A61B2018/00279
摘要： An apparatus is provided for closing a perforation in a wall of a patient's blood vessel or other organs, and a method of introducing the apparatus and causing the closure are described. The apparatus includes an elongated support member having a distal end supporting one or more tissue engaging hooks configured to engage fibrous vessel tissue when moved in a first direction and to disengage the tissue when moved in a second direction, and a proximal end for applying rotational torque to the support member to cause the hooks to engage collagen fibrous tissue in the adventitia of the blood vessel or fibrous tissue in other body organs. The hooks engaging the collagen fiber causes the blood vessel tissue surrounding the perforation to be drawn into close proximity such that the perforation can be closed. The apparatus can be removed by applying reverse rotation of the support member, whereby the hooks are disengaged. The apparatus is deployed in an outer sheath with the hooks encased until a selected engaging location has been achieved. When positioned in the aperture to be closed, the hooks are exposed to allow interaction with the adventitia. Puncture closure can be accomplished by various techniques, including stasis, cauterizing, or by clamping. Various embodiments of the apparatus are described.
摘要翻译：提供了用于封闭患者血管或其他器官的壁中的穿孔的装置，并且描述了引入该装置并引起闭合件的方法。该装置包括细长的支撑构件，其具有支撑一个或多个组织接合钩的远端，所述组织接合钩构造成当沿第一方向移动时接合纤维血管组织，并且在沿第二方向移动时使组织脱离，以及用于施加旋转扭矩的近端到支撑构件以引起钩将胶原纤维组织接合在血管的外膜或其他身体器官中的纤维组织中。接合胶原纤维的钩使得穿孔周围的血管组织被拉近，使得穿孔可以闭合。可以通过施加支撑构件的反向旋转来移除该装置，由此钩脱开。该装置部署在外护套中，钩被包住，直到达到选定的接合位置。当定位在要关闭的孔中时，钩暴露以允许与外膜相互作用。穿刺闭合可以通过各种技术来实现，包括瘀斑，烧灼或夹紧。描述该装置的各种实施例。

4. 发明授权

US06660003B1 Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device 失效
标题翻译：经皮心肌血运重建篮输送系统及射频治疗仪
公开(公告)号：US06660003B1
公开(公告)日：2003-12-09
申请号：US09544348
申请日：2000-04-06
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B1814
CPC分类号： A61F2/2493 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.
摘要翻译：血管内装置和在心室壁中同时形成多个经皮心肌血运重建（PMR）孔的方法。一个装置包括由其长度上承载切割探针的柔性臂形成的篮。筐臂向外弯曲偏置，以便在无约束时呈现向外弯曲的弓形形状。该装置包括一个远离固定在篮子的近端部分并可滑动地设置在外轴内的内轴。内轴和塌缩的筐可以缩回到外轴内，血管内递送到左心室，并且向远侧前进，迫使篮筐呈现弓形。提供给电切割探头的射频电流将孔插入心室壁和心肌。一个实施例具有高压流体射流切割装置。另一个实施例使用篮子作为锚定器来定位可操纵的切割探针。另一个实施例包括由多个弓形的向外张开的电极形成的电刷，其可以一旦从约束外轴向远侧远端接触心室壁。

5. 发明授权

US6063082A Percutaneous myocardial revascularization basket delivery system and radiofrequency therapeutic device 失效
公开(公告)号：US6063082A
公开(公告)日：2000-05-16
申请号：US35738
申请日：1998-03-05
申请人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
发明人： Lauri DeVore , Louis Ellis , Gary L. Hendrickson , Daniel M. Lafontaine , Zihong Guo , Ryan Kaveckis
IPC分类号： A61B17/00 , A61B17/22 , A61B17/32 , A61B17/34 , A61B18/14 , A61B19/00 , A61F2/02 , A61M25/00
CPC分类号： A61F2/2493 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B18/1492 , A61B17/32037 , A61B17/32056 , A61B17/3207 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00077 , A61B2018/00083 , A61B2018/00136 , A61B2018/00148 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00279 , A61B2018/00351 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1407 , A61B2018/1425 , A61B2018/143 , A61B2018/1432 , A61B2018/1435 , A61B2018/1467 , A61B2090/3966 , A61B2218/002 , A61B90/39 , A61M2025/009
摘要： An intravascular device and methods for forming multiple percutaneous myocardial revascularization (PMR) holes in a heart chamber wall simultaneously. One device includes a basket formed of flexible arms carrying cutting probes over their length. The basket arms are outwardly arcuately biased so as to assume an outwardly bowed, arcuate shape when unconstrained. The device includes an inner shaft distally secured to a proximal portion of the basket and slidably disposed within an outer shaft. The inner shaft and collapsed basket can be retracted within the outer shaft, delivered intravascularly to the left ventricle, and distally advanced, forcing the basket to assume the bowed shape. Radio frequency current supplied to the electrical cutting probes burn holes into the ventricle wall and myocardium. One embodiment has high pressure fluid jet cutting means. Another embodiment uses a basket as an anchor to position a steerable cutting probe. Yet another embodiment includes a brush formed of multiple, arcuate, outwardly splayed electrodes that can contact heart chamber walls once advanced distally from a constraining outer shaft.

6. 发明授权

US08617149B2 Common bond, double-balloon catheter 有权
标题翻译：普通粘结，双气囊导管
公开(公告)号：US08617149B2
公开(公告)日：2013-12-31
申请号：US11541735
申请日：2006-10-02
申请人： Daniel M. Lafontaine , Gary L. Hendrickson
发明人： Daniel M. Lafontaine , Gary L. Hendrickson
IPC分类号： A61B18/18 , A61M29/00
CPC分类号： A61M25/1011 , A61B2018/0022 , A61B2018/00577 , A61B2018/0212 , A61B2018/0262 , A61M25/1034 , A61M2025/1013 , A61M2025/1079
摘要： A method of manufacturing a catheter can include assembling an inner balloon within a separate outer balloon. The inner and outer balloons can each be open on opposing longitudinal ends and have a central radially expandable portion, and proximal and distal reduced diameter portions on opposite longitudinal end portions of the balloon. The method can further include bonding a portion of an inner surface of the outer balloon proximal reduced diameter portion to a portion of an outer surface of the inner balloon proximal reduced diameter portion and bonding a distal end portion of an elongate catheter shaft to a proximal portion of the bonded inner and outer balloons.
摘要翻译：制造导管的方法可以包括将内气囊组装在单独的外气囊中。内部和外部气囊可以在相对的纵向端部上敞开，并且具有中心径向可膨胀部分，并且在气囊的相对的纵向端部上具有近端和远端缩径部分。该方法还可以包括将外球囊近端缩小直径部分的内表面的一部分粘合到内球囊近直径部分的外表面的一部分，并将细长导管轴的远端部分接合到近端部分的粘合内外气球。

7. 发明授权

US08585689B2 Cryotreatment devices and methods of forming conduction blocks 有权
公开(公告)号：US08585689B2
公开(公告)日：2013-11-19
申请号：US13252817
申请日：2011-10-04
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293
摘要： Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.

8. 发明授权

US08398677B2 Closure device with textured surface 有权
标题翻译：带纹理表面的封闭装置
公开(公告)号：US08398677B2
公开(公告)日：2013-03-19
申请号：US12790554
申请日：2010-05-28
申请人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
发明人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00349 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/12004
摘要： A closure device closes an opening in a body cavity. The closure device includes a plurality of fibrous tissue engaging members coupled to a proximally extending elongate member, a closure sheath sized to receive the elongate member and slidable over the elongate member to move the fibrous tissue engaging members from an expanded position to a collapsed position, a delivery sheath sized to receive the closure sheath and having a distal end sized to engage the fibrous tissue engaging members in the expanded position, and a closure member having an aperture sized to receive the closure sheath.
摘要翻译：闭合装置关闭体腔中的开口。闭合装置包括多个与近端延伸的细长构件联接的纤维组织接合构件，封闭护套，其尺寸适于容纳细长构件，并可在细长构件上方滑动，以将纤维组织接合构件从扩张位置移动到收缩位置，传送护套的尺寸被设计成容纳封闭护套并且具有尺寸适于接合处于展开位置的纤维组织接合构件的远端，以及封闭构件，该封闭构件具有尺寸适于容纳闭合护套的孔。

9. 发明授权

US08123741B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US08123741B2
公开(公告)日：2012-02-28
申请号：US12428719
申请日：2009-04-23
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

10. 发明申请

US20100100173A1 VALVE APPARATUS, SYSTEM AND METHOD 有权
标题翻译：阀门装置，系统和方法
公开(公告)号：US20100100173A1
公开(公告)日：2010-04-22
申请号：US12648221
申请日：2009-12-28
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61M25/1011
摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.
摘要翻译：一种心脏瓣膜，其具有第一锚架和第一锚架上的盖子，用于单向流动液体通过该阀。

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