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1. 发明授权

US08585689B2 Cryotreatment devices and methods of forming conduction blocks 有权
公开(公告)号：US08585689B2
公开(公告)日：2013-11-19
申请号：US13252817
申请日：2011-10-04
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B18/0218 , A61B2018/0212 , A61B2018/0262 , A61B2018/0293
摘要： Cryotreatment devices and methods of ablating tissue within the body are disclosed. A cryotreatment device in accordance with an exemplary embodiment of the present invention includes an elongated member having one or more needle-like ablation tips configured to induce necrosis at a target site within the heart. A cooling fluid such as a cryogen may be injected through a lumen extending into the distal portion of the device. The ablation tips can be configured to pierce and ablate surrounding tissue, blocking electrical stimuli that can cause fibrillations or other arrhythmias of the heart. The device may also include means for controlling the transmural depth at which the ablation tips are inserted into the cardiac tissue. Methods of forming a contiguous line of conduction block in accordance with the present invention are also disclosed.

2. 发明授权

US08398677B2 Closure device with textured surface 有权
标题翻译：带纹理表面的封闭装置
公开(公告)号：US08398677B2
公开(公告)日：2013-03-19
申请号：US12790554
申请日：2010-05-28
申请人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
发明人： Daniel M. Lafontaine , Mark T. Ungs , William J. Drasler , Sheng-Ping (Samuel) Zhong
IPC分类号： A61B17/08
CPC分类号： A61B17/0057 , A61B2017/00004 , A61B2017/00349 , A61B2017/00637 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61B2017/12004
摘要： A closure device closes an opening in a body cavity. The closure device includes a plurality of fibrous tissue engaging members coupled to a proximally extending elongate member, a closure sheath sized to receive the elongate member and slidable over the elongate member to move the fibrous tissue engaging members from an expanded position to a collapsed position, a delivery sheath sized to receive the closure sheath and having a distal end sized to engage the fibrous tissue engaging members in the expanded position, and a closure member having an aperture sized to receive the closure sheath.
摘要翻译：闭合装置关闭体腔中的开口。闭合装置包括多个与近端延伸的细长构件联接的纤维组织接合构件，封闭护套，其尺寸适于容纳细长构件，并可在细长构件上方滑动，以将纤维组织接合构件从扩张位置移动到收缩位置，传送护套的尺寸被设计成容纳封闭护套并且具有尺寸适于接合处于展开位置的纤维组织接合构件的远端，以及封闭构件，该封闭构件具有尺寸适于容纳闭合护套的孔。

3. 发明授权

US08123741B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US08123741B2
公开(公告)日：2012-02-28
申请号：US12428719
申请日：2009-04-23
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

4. 发明申请

US20110282272A1 CRYOTREATMENT DEVICE AND METHOD 有权
标题翻译： CRYOTREATMENT设备和方法
公开(公告)号：US20110282272A1
公开(公告)日：2011-11-17
申请号：US13195717
申请日：2011-08-01
申请人： DANIEL M. LAFONTAINE
发明人： DANIEL M. LAFONTAINE
IPC分类号： A61M25/10 , A61M39/22 , A61N7/00
CPC分类号： A61F7/10 , A61B18/02 , A61B2017/00243 , A61B2017/00867 , A61B2017/22002 , A61B2017/22051 , A61B2017/22067 , A61B2018/00041 , A61B2018/00196 , A61B2018/0022 , A61B2018/0212 , A61B2018/0275 , A61B2018/0287 , A61B2018/1861 , A61B2090/0463 , A61B2090/064 , A61B2090/3782 , A61F7/123 , A61F2007/0001 , A61F2007/0063
摘要： Devices and methods for cooling vessel walls to inhibit restenosis in conjunction with medical procedures such as coronary artery angioplasty. Stenosed vessel walls can be cooled prior to angioplasty, after angioplasty, or both. The invention is believed to inhibit restenosis through cooling to a temperature near freezing, preferably without causing substantial vessel wall cell death. One catheter device includes a distal tube region having coolant delivery holes radially and longitudinally distributed along the distal region. In some devices, holes spray coolant directly onto the vessel walls, with the coolant absorbed into the blood stream. In other embodiments, a balloon or envelope is interposed between the coolant and the vessel walls and the coolant returned out of the catheter through a coolant return lumen. Some direct spray devices include an occlusion device to restrict blood flow past the region being cooled. Pressure, temperature, and ultrasonic probes are included in some cooling catheters. Pressure control valves are included in some devices to regulate balloon interior pressure within acceptable limits. In applications using liquid carbon dioxide as coolant, the balloon interior pressure can be maintained above the triple point of carbon dioxide to inhibit dry ice formation. Some cooling catheters are coiled perfusion catheters supporting longer cooling periods by allowing perfusing blood flow simultaneously with vessel wall cooling. One coiled catheter is biased to assume a coiled shape when unconstrained and can be introduced into the body in a relatively straight shape, having a stiffening wire inserted through the coil strands.
摘要翻译：用于冷却血管壁的装置和方法，以与医疗程序如冠状动脉血管成形术结合来抑制再狭窄。狭窄的血管壁可以在血管成形术，血管成形术或两者之后冷却。据信本发明通过冷却至几乎冻结的温度来抑制再狭窄，优选不引起实质的血管壁细胞死亡。一个导管装置包括远端管区域，其具有沿远端区域径向和纵向分布的冷却剂输送孔。在一些装置中，孔将冷却剂直接喷射到容器壁上，同时将冷却剂吸收到血流中。在其它实施例中，气囊或外壳插入在冷却剂和容器壁之间，并且冷却剂通过冷却剂返回内腔从导管返回。一些直接喷射装置包括阻塞装置以限制血液流过被冷却的区域。压力，温度和超声波探头包括在一些冷却导管中。压力控制阀包括在一些装置中，以将球囊内部压力调节在可接受的限度内。在使用液态二氧化碳作为冷却剂的应用中，气囊内部压力可以保持在二氧化碳三重点以上以抑制干冰的形成。一些冷却导管是通过允许血管流动与血管壁冷却同时支持更长的冷却时间的盘绕灌注导管。当不受约束时，一个盘绕的导管被偏压成呈螺旋状，并且可以相对直的形状引入到本体中，该导线具有穿过线圈股线的加强丝。

5. 发明申请

US20100100173A1 VALVE APPARATUS, SYSTEM AND METHOD 有权
标题翻译：阀门装置，系统和方法
公开(公告)号：US20100100173A1
公开(公告)日：2010-04-22
申请号：US12648221
申请日：2009-12-28
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2418 , A61F2/2433 , A61F2/2436 , A61F2/2439 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61M25/1011
摘要： A cardiac valve with a first anchor frame and a cover on the first anchor frame for unidirectional flow of a liquid through the valve.
摘要翻译：一种心脏瓣膜，其具有第一锚架和第一锚架上的盖子，用于单向流动液体通过该阀。

6. 发明授权

US07674256B2 Treating internal body tissue 有权
标题翻译：治疗内部身体组织
公开(公告)号：US07674256B2
公开(公告)日：2010-03-09
申请号：US11082677
申请日：2005-03-17
申请人： Nassir Marrouche , Daniel M. Lafontaine
发明人： Nassir Marrouche , Daniel M. Lafontaine
IPC分类号： A61B18/02 , A61B18/04
CPC分类号： A61B18/02 , A61B18/04 , A61B2017/00243 , A61B2017/22069 , A61B2018/0022 , A61B2018/0212
摘要： Some embodiments of the invention relate to a system for treating tissue internal to a body, such as heart tissue. For example, the system may be used to ablate tissue as a treatment for atrial fibrillation. In certain embodiments, the system is capable of causing scar tissue to form in ostial areas of the atrium rather than inside the pulmonary vein. In such embodiments, the system may include a tissue treatment member that is operable to form an annular area of ablated tissue along the outer portion of the ostium in an area known as the antrum.
摘要翻译：本发明的一些实施方案涉及用于治疗身体内部的组织例如心脏组织的系统。例如，该系统可用于消融组织作为心房颤动的治疗。在某些实施方案中，该系统能够在心房的口部区域中形成瘢痕组织，而不是在肺静脉内部。在这样的实施例中，系统可以包括组织处理构件，其可操作以沿着称为窦的区域沿着口的外部部分形成消融组织的环形区域。

7. 发明授权

US07566343B2 Cardiac valve, system, and method 有权
标题翻译：心脏瓣膜，系统和方法
公开(公告)号：US07566343B2
公开(公告)日：2009-07-28
申请号：US10933088
申请日：2004-09-02
申请人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
发明人： Mark L. Jenson , William J. Drasler , Daniel M. Lafontaine
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2412 , A61F2230/008
摘要： A cardiac valve with a support frame having a first end member and a second end member opposing the first end member in a substantially fixed distance relationship, and a cover extending over the support frame to allow for unidirectional flow of a liquid through the valve.
摘要翻译：具有支撑框架的心脏瓣膜具有第一端构件和与所述第一端构件基本上固定的距离关系相对的第二端构件，以及在所述支撑框架上延伸以允许液体通过所述瓣膜的单向流动的盖。

8. 发明授权

US07022120B2 Cryoplasty device and method 失效
公开(公告)号：US07022120B2
公开(公告)日：2006-04-04
申请号：US10659116
申请日：2003-09-10
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B18/18
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

9. 发明授权

US06656199B1 Magnetic clamp assembly for an elongated flexible medical device 失效
标题翻译：用于细长柔性医疗设备的磁性夹具组件
公开(公告)号：US06656199B1
公开(公告)日：2003-12-02
申请号：US09645222
申请日：2000-08-24
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B500
CPC分类号： A61M25/0127
摘要： A magnetic clamp assembly for an elongated flexible medical device. The clamp assembly includes magnetic clamp members operably coupled to clamp a portion of the flexible medical device to secure the medical device during treatment.
摘要翻译：一种用于细长柔性医疗装置的磁夹组件。夹具组件包括可操作地联接以夹紧柔性医疗装置的一部分以在治疗期间固定医疗装置的磁性夹具构件。

10. 发明授权

US06648878B2 Cryoplasty device and method 有权
公开(公告)号：US06648878B2
公开(公告)日：2003-11-18
申请号：US09916147
申请日：2001-07-25
申请人： Daniel M. Lafontaine
发明人： Daniel M. Lafontaine
IPC分类号： A61B1818
CPC分类号： A61B18/02 , A61B2017/00088 , A61B2017/00292 , A61B2017/00557 , A61B2017/22002 , A61B2018/00101 , A61B2018/0022 , A61B2018/0212 , A61M25/104 , C21B13/0033 , C22B5/14 , C22B23/021
摘要： A cryoplasty catheter and method for preventing or slowing reclosure of a lesion following angioplasty. The cryoplasty catheter includes a shaft having proximal and distal ends and a dilatation balloon disposed at the distal end. An intake lumen and exhaust lumen are defined by the shaft to deliver coolant to the balloon and to exhaust or drain coolant from the balloon. The method in accordance with the present invention includes cooling a lesion to aid in remodeling the lesion through dilatation and/or freezing a portion of the lesion adjacent the dilatation balloon to kill cells within the lesion to prevent or retard restenosis.

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