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1. 发明授权

US06238406B1 Percutaneous myocardial revascularization growth factor mediums and method 有权
标题翻译：经皮心肌血运重建生长因子介质及方法
公开(公告)号：US06238406B1
公开(公告)日：2001-05-29
申请号：US09516531
申请日：2000-03-01
申请人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
发明人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
IPC分类号： A61B1732
CPC分类号： A61B17/32002 , A61B17/320758 , A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61F2/2493 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译：通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并具有流明和侧孔。一种替代方法是利用不可生物降解的钉与流明和侧孔。另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。血管生成物质可以携带在可生物降解的粘合剂中。通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。

2. 发明授权

US6045565A Percutaneous myocardial revascularization growth factor mediums and method 失效
标题翻译：经皮心肌血运重建生长因子介质及方法
公开(公告)号：US6045565A
公开(公告)日：2000-04-04
申请号：US184220
申请日：1998-11-02
申请人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
发明人： Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang , Timothy J. Mickley
IPC分类号： A61B17/32 , A61B17/00 , A61B17/22 , A61B17/34 , A61B19/00 , A61F2/02 , A61M25/00
CPC分类号： A61B17/32002 , A61B17/3468 , A61B17/3478 , A61F2/2493 , A61B17/320758 , A61B2017/00247 , A61B2017/003 , A61B2017/22077 , A61B2017/320084 , A61B2018/00208 , A61B2018/00392 , A61B2018/1425 , A61B2018/1861 , A61B90/39 , A61M2025/0089
摘要： Devices and methods for increasing blood perfusion within the myocardium of the heart by wounding the myocardium and applying growth factors to promote vascularization. One method includes driving spikes into the myocardium from within the heart, with the spikes being formed of biodegradable material, containing releasable growth factors, and having lumens and side holes. An alternative method utilizes non-biodegradable spikes with lumens and side holes. Another method promotes vascularization by injecting angiogenic material into holes bored into the myocardium, leaving a patent hole. Another method includes injecting angiogenic material into the myocardium without boring, leaving no patent hole. The angiogenic material can be carried in a biodegradable adhesive. Revascularization of the myocardium is promoted in one method by externally wounding the heart and applying a patch including growth factors.
摘要翻译：通过伤害心肌并应用生长因子促进血管形成来增加心脏心肌内的血液灌注的装置和方法。一种方法包括从心脏内将尖峰驱动到心肌中，其中尖峰由可生物降解的材料形成，包含可释放的生长因子，并且具有腔和侧孔。一种替代方法是利用不可生物降解的钉与流明和侧孔。另一种方法通过将血管生成材料注入穿入心肌的孔中来促进血管形成，留下专利孔。另一种方法包括将血管生成物质注入到心肌中而无需镗孔，没有留下专利孔。血管生成物质可以携带在可生物降解的粘合剂中。通过外部伤心并施用包括生长因子的贴片在一种方法中促进心肌的血运重建。

3. 发明授权

US06953466B2 Methods for delivering a therapeutic implant to tissue 失效
标题翻译：将治疗性植入物递送至组织的方法
公开(公告)号：US06953466B2
公开(公告)日：2005-10-11
申请号：US10837612
申请日：2004-05-04
申请人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
发明人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
IPC分类号： A61B17/00 , A61B17/32 , A61B17/34 , A61B19/00 , A61F2/02 , A61L29/16 , A61M25/00 , A61M31/00 , A61M37/00
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A method for delivering a therapeutic implant to a tissue is provided. This method includes providing an elongate catheter having a distal end including a lumen, providing a carrier including a therapeutic agent, placing the carrier including the therapeutic agent into the lumen, advancing the distal end of the catheter to the tissue, and depositing the carrier including the therapeutic agent into the tissue.
摘要翻译：提供了将治疗性植入物递送到组织的方法。该方法包括提供细长的导管，其具有包括内腔的远端，提供包括治疗剂的载体，将包括治疗剂的载体放置在内腔中，将导管的远端推进到组织，以及沉积载体，包括治疗剂进入组织。

4. 发明授权

US07854743B2 Catheter for the delivery of therapeutic agents to tissues 有权
标题翻译：用于将治疗剂递送至组织的导管
公开(公告)号：US07854743B2
公开(公告)日：2010-12-21
申请号：US11185801
申请日：2005-07-21
申请人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
发明人： Maria Palasis , James J. Barry , Louis Ellis , Gary L. Hendrickson , Kent D. Harrison , Lixiao Wang
IPC分类号： A61B17/32
CPC分类号： A61B17/3468 , A61B17/3478 , A61B90/39 , A61B2017/00247 , A61B2017/320084 , A61B2018/00392 , A61B2018/1425 , A61F2/2493 , A61L29/16 , A61L2300/258 , A61L2300/414 , A61L2300/64 , A61M25/0084 , A61M37/0069 , A61M2025/0004 , A61M2025/0089
摘要： A catheter for placement of an in situ implant is provided. This catheter may include a first elongate shaft having a proximal end and a distal end, a second elongate shaft having a proximal end and a distal end, a first sharpened distal tip disposed at the distal end of the first shaft and a second sharpened distal tip disposed at the distal end of the second shaft. The first shaft and the second shaft may also be secured to one another at the distal end of the first shaft according to the invention. Still further, according to other teachings, the first sharpened distal tip may extend beyond the second sharpened distal tip in a catheter that practices the invention.
摘要翻译：提供了用于放置原位植入物的导管。该导管可以包括具有近端和远端的第一细长轴，具有近端和远端的第二细长轴，设置在第一轴的远端处的第一尖锐的远侧末端和第二尖锐远端设置在第二轴的远端。根据本发明，第一轴和第二轴也可以在第一轴的远端处彼此固定。此外，根据其他教导，第一锐化的远侧末端可以在实践本发明的导管中延伸超过第二锋利的远侧末端。

5. 发明授权

US06764461B2 Catheter system for the delivery of a low volume bolus 有权
标题翻译：用于输送低体积推注的导管系统
公开(公告)号：US06764461B2
公开(公告)日：2004-07-20
申请号：US09138131
申请日：1998-08-21
申请人： Timothy J. Mickley , Thomas R. Hektner , Louis Ellis , Gary L. Hendrickson
发明人： Timothy J. Mickley , Thomas R. Hektner , Louis Ellis , Gary L. Hendrickson
IPC分类号： A61F1320
CPC分类号： A61M25/104 , A61M5/00 , A61M29/02 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093
摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.
摘要翻译：导管系统包括具有近端，远端和在其中延伸的内腔的导管。给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。本发明还包括向处理部位施用液体的方法。导管的远端位于治疗部位附近。导管通过将大量液体放置在内腔中来进行充电。产生正压力以将推注驱动到施用尖端以从导管的远端表达推注。

6. 发明授权

US07695455B2 Delivery of a low volume liquid bolus 失效
标题翻译：输送低体积液体丸剂
公开(公告)号：US07695455B2
公开(公告)日：2010-04-13
申请号：US10882397
申请日：2004-07-02
申请人： Timothy J. Mickley , Thomas R. Hektner , Louis Ellis , Gary L. Hendrickson
发明人： Timothy J. Mickley , Thomas R. Hektner , Louis Ellis , Gary L. Hendrickson
IPC分类号： A61M5/178 , A61M5/24 , A61M5/00
CPC分类号： A61M25/104 , A61M5/00 , A61M29/02 , A61M2025/0057 , A61M2025/1013 , A61M2025/105 , A61M2025/1086 , A61M2025/1093
摘要： A catheter system includes a catheter having a proximal end, a distal end, and a lumen extending therein. An administering portion is disposed at the distal end of the catheter and is configured to administer a bolus of liquid in response to positive pressure in a distal portion of the lumen. The catheter system of the present invention has a dead space of less 0.32 cc and preferably less than 0.15 cc in which residual therapeutic agents remain after delivery. The present invention also includes a method of administering a liquid to a treatment site. The distal end of the catheter is transluminally positioned proximate the treatment site. The catheter is charged by placing a bolus of the liquid in the lumen. A positive pressure is created to drive the bolus to the administering tip to express the bolus from the distal end of the catheter.
摘要翻译：导管系统包括具有近端，远端和在其中延伸的内腔的导管。给药部分设置在导管的远端处，并且构造成响应于内腔的远端部分中的正压而施用大量液体。本发明的导管系统具有小于0.32cc，优选小于0.15cc的死空间，其中残留的治疗剂在分娩后残留。本发明还包括向处理部位施用液体的方法。导管的远端位于治疗部位附近。通过将大量液体放置在管腔中来对导管进行充电。产生正压力以将推注剂驱动到施用尖端以从导管的远端表达推注。

7. 发明授权

US5554119A Drug delivery catheter with manifold 失效
标题翻译：药物输送导管与歧管
公开(公告)号：US5554119A
公开(公告)日：1996-09-10
申请号：US187614
申请日：1994-01-27
申请人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
发明人： Kent D. Harrison , Gary L. Hendrickson , Thomas J. Holman , Daniel M. Lafontaine , Matthew J. Miller , David B. Robinson
IPC分类号： A61M25/00 , A61F2/958 , A61M16/04 , A61M29/02 , A61M5/32
CPC分类号： A61M25/1002 , A61M16/0481 , A61M2025/105 , A61M2025/1052 , A61M2025/1072 , A61M2025/1097
摘要： A drug delivery catheter which may be inserted into a vessel, such as a blood vessel is disclosed. The drug delivery catheter comprises any elongated tubular member which has a proximal end and a distal end. A drug lumen which provides a communication path for fluid is provided in the elongated tubular member for delivering a fluid, such as the drug to be administered. An inflatable balloon assembly is provided at the distal end of the elongated tubular member. The balloon assembly includes apertures which communicate with the drug lumen. The balloon assembly comprises a tubular balloon which is helically wound through the elongated tubular member and a sheath. The sheath is attached to the helically wound tubular balloon such that when the balloon member is uninflated, the first fluid in the vessel flows around the balloon assembly and such that when the balloon member is inflated, sections of the helically wound balloon contact the vessel wall to form a containment pocket between the vessel wall, the contacting sections of the balloon and the sheath. The apertures are provided in the containment pocket. An inflatable lumen is defined through the interior of the helically wound balloon and the sheath to allow perfusion of the first fluid.
摘要翻译：公开了一种可插入容器（如血管）中的药物输送导管。药物递送导管包括具有近端和远端的任何细长管状构件。提供用于流体的连通路径的药物腔室设置在细长管状构件中，用于输送流体，例如待施用的药物。在细长管状构件的远端处设置可充气气囊组件。气囊组件包括与药物腔连通的孔。球囊组件包括通过细长管状构件和护套螺旋缠绕的管状球囊。护套附接到螺旋形缠绕的管状气囊，使得当球囊构件未膨胀时，容器中的第一流体围绕球囊组件流动，使得当球囊构件膨胀时，螺旋形卷绕的球囊的部分接触血管壁以在容器壁，球囊和护套的接触部分之间形成容纳袋。孔口设置在容纳口袋中。通过螺旋缠绕气囊和护套的内部限定可充气腔，以允许第一流体的灌注。

8. 发明授权

US5447497A Balloon catheter having nonlinear compliance curve and method of using 失效
标题翻译：气球导管具有非线性顺应性曲线和使用方法
公开(公告)号：US5447497A
公开(公告)日：1995-09-05
申请号：US243473
申请日：1994-05-16
申请人： David J. Sogard , Gary L. Hendrickson , Lixiao Wang , Pete T. Keith
发明人： David J. Sogard , Gary L. Hendrickson , Lixiao Wang , Pete T. Keith
IPC分类号： A61F2/958 , A61M29/02
CPC分类号： A61M25/1011 , A61M2025/1013 , A61M2025/1084
摘要： A balloon catheter, having a non-linear compliance curve, made up of a dual layered balloon, one balloon being a Compliant balloon and the other balloon being a Non-Compliant balloon.
摘要翻译：具有非线性顺应性曲线的球囊导管由双层气球构成，一个气囊为柔性球囊，另一个球囊为不合格球囊。

9. 发明授权

US5316016A Imaging balloon catheter and methods for use and manufacture 失效
标题翻译：成像气囊导管及使用和制造方法
公开(公告)号：US5316016A
公开(公告)日：1994-05-31
申请号：US909772
申请日：1992-07-07
申请人： Daniel O. Adams , Lixiao Wang , David J. Sogard , Gary L. Hendrickson
发明人： Daniel O. Adams , Lixiao Wang , David J. Sogard , Gary L. Hendrickson
IPC分类号： A61B5/107 , A61B19/00 , A61M25/00 , A61B5/103
CPC分类号： A61M25/1029 , A61B5/1078 , A61B90/39 , A61M2025/0098
摘要： The present invention includes an imaging catheter for providing a three-dimensional representation of a body vessel wall. The imaging catheter includes an expandable deformable balloon which is inserted into a lumen of the body vessel at a position of interest on the vessel wall. After the balloon has been inflated, the balloon is then deflated and withdrawn from the body vessel to provide a three-dimensional image of the position of interest on the vessel wall.
摘要翻译：本发明包括用于提供身体血管壁的三维表示的成像导管。成像导管包括可膨胀的可变形气囊，其在感兴趣的位置在血管壁上插入身体血管的内腔。气囊膨胀后，气球然后放气并从体内容器中取出，以便在血管壁上提供感兴趣位置的三维图像。

10. 发明授权

US06416490B1 PMR device and method 失效
公开(公告)号：US06416490B1
公开(公告)日：2002-07-09
申请号：US09035736
申请日：1998-03-05
申请人： Louis Ellis , Gary L. Hendrickson , Lauri DeVore
发明人： Louis Ellis , Gary L. Hendrickson , Lauri DeVore
IPC分类号： A61B1720
CPC分类号： A61B18/1492 , A61B17/3468 , A61B17/3478 , A61B18/1477 , A61B90/39 , A61B2017/00247 , A61B2017/00296 , A61B2017/00867 , A61B2017/320084 , A61B2018/00148 , A61B2018/0016 , A61B2018/00279 , A61B2018/00392 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/162 , A61B2218/002 , A61F2/2493 , A61M2025/0089
摘要： A catheter having an elongate shaft including a proximal and a distal end. The shaft includes a conductor. An electrode is disposed at the distal end of the shaft and is connected to the conductor. The electrode has a generally annular, cross-sectional shape. The annular shape defines an opening within the electrode. An insulator surrounds the conductor. In accordance with the method of the present invention, a crater wound can be formed through the endocardium and into the myocardium of a patient's heart. Collateral damage to the myocardium can be made by infusing pressurized fluid into the crater wound.

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