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1. 发明授权

US07235366B1 Methods of identifying agonists and antagonists of opioid receptors 失效
标题翻译：鉴定阿片受体激动剂和拮抗剂的方法
公开(公告)号：US07235366B1
公开(公告)日：2007-06-26
申请号：US08455683
申请日：1995-05-31
申请人： Graeme I. Bell , Terry Reisine , Kazuki Yasuda
发明人： Graeme I. Bell , Terry Reisine , Kazuki Yasuda
IPC分类号： G01N33/53 , G01N33/567 , C12P21/06
CPC分类号： G01N33/9486 , A61K38/00 , C07K14/705 , C07K2319/00 , G01N33/566 , G01N2500/00
摘要： The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得阿片受体多肽的组合物和方法。本发明还涉及编码阿片受体多肽的多核苷酸，携带这些序列的重组载体，包含序列或载体的重组宿主细胞以及重组阿片受体多肽。举例来说，本发明公开了至少三种不同阿片受体多肽的克隆和功能表达。本发明还包括在测定中使用分离的重组受体多肽的方法，其设计用于选择和改进能够与用于诊断，药物设计和治疗应用的与阿片受体多肽相互作用的物质。

2. 发明授权

US5405942A Prepro insulin-like growth factors I and II 失效
标题翻译： Prepro胰岛素样生长因子I和II
公开(公告)号：US5405942A
公开(公告)日：1995-04-11
申请号：US65673
申请日：1987-06-16
申请人： Graeme I. Bell , Leslie B. Rall , James P. Merryweather
发明人： Graeme I. Bell , Leslie B. Rall , James P. Merryweather
IPC分类号： C12N15/00 , A61K38/00 , C07H21/04 , C07K14/65 , C12N15/09 , C12N15/17 , C12P21/00 , C12Q1/68 , C12N15/12
CPC分类号： C07K14/65
摘要： Polynucleotide sequences which encode for human prepro insulin-like growth factors are provided. Such sequences are obtained from the human genome, typically by screening a cDNA library obtained from human liver cells. The polynucleotide sequences may be used for cloning and expression of insulin-like growth factors in suitable hosts, as well as for the production of DNA and RNA which may be used as hybridization probes.E. coli strains HB101(phigf1) and HB101(phigf2) were deposited at the ATCC on Jun. 8, 1984, and granted accession nos. 39729 and 39730, respectively.
摘要翻译：提供编码人前胰岛素样生长因子的多核苷酸序列。通常通过筛选从人肝细胞获得的cDNA文库，从人类基因组获得这样的序列。多核苷酸序列可用于在合适的宿主中克隆和表达胰岛素样生长因子，以及用于产生可用作杂交探针的DNA和RNA。大肠杆菌菌株HB101（phigf1）和HB101（phigf2）于1984年6月8日保藏在ATCC，并授予登录号。 39729和39730。

3. 发明授权

US06319686B1 Nucleic acids encoding kappa opioid receptors 失效
标题翻译：编码κ阿片受体的核酸
公开(公告)号：US06319686B1
公开(公告)日：2001-11-20
申请号：US08292694
申请日：1994-08-19
申请人： Graeme I. Bell , Terry Reisine , Kazuki Yasuda
发明人： Graeme I. Bell , Terry Reisine , Kazuki Yasuda
IPC分类号： C12P2106
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00 , C07K2319/033 , C07K2319/32
摘要： The invention relates generally to compositions of and methods for obtaining opioid receptor polypeptides. The invention relates as well to polynucleotides encoding opioid receptor polypeptides. More specifically, the invention relates to polynucleotides encoding kappa opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant opioid receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different opioid receptor polypeptides. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with opioid receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及获得阿片受体多肽的组合物和方法。本发明还涉及编码阿片受体多肽的多核苷酸。更具体地，本发明涉及编码κ阿片受体多肽的多核苷酸，携带这些序列的重组载体，包含序列或载体的重组宿主细胞和重组阿片受体多肽。举例来说，本发明公开了至少三种不同阿片受体多肽的克隆和功能表达。本发明还包括在测定中使用分离的重组受体多肽的方法，其设计用于选择和改进能够与用于诊断，药物设计和治疗应用的与阿片受体多肽相互作用的物质。

4. 发明授权

US06235481B1 Polynucleotides encoding calpain 10 有权
标题翻译：编码钙蛋白酶的多核苷酸10
公开(公告)号：US06235481B1
公开(公告)日：2001-05-22
申请号：US09422869
申请日：1999-10-21
申请人： Yukio Horikawa , Naohisa Oda , Craig L. Hanis , Graeme I. Bell , Nancy J. Cox
发明人： Yukio Horikawa , Naohisa Oda , Craig L. Hanis , Graeme I. Bell , Nancy J. Cox
IPC分类号： C07H168
CPC分类号： C12N9/6472 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172
摘要： The present invention relates generally to the field of diabetes. More particularly, it concerns the identification of genes responsible for NIDDM1 for use in diagnostic and therapeutic applications. The present invention demonstrates that the NIDDM1 locus is, in fact, the calpain 10 gene. The invention further relates to the discovery that analysis of mutations in calpain genes and gene products can be diagnostic for type 2 diabetes. The invention also contemplates methods of treating diabetes in view of the fact that calpain mutations can cause diabetes. Further, the invention relates to novel polynucleotides of the NIDDM1 locus and polypeptides encoded by such polynucleotides.
摘要翻译：本发明一般涉及糖尿病领域。更具体地，涉及鉴定负责NIDDM1用于诊断和治疗应用的基因。本发明证明NIDDM1基因座实际上是钙蛋白酶10基因。本发明还涉及对钙蛋白酶基因和基因产物的突变的分析可以诊断为2型糖尿病的发现。考虑到钙蛋白酶突变可引起糖尿病的事实，本发明还考虑了治疗糖尿病的方法。此外，本发明涉及NIDDM1基因座的新型多核苷酸和由该多核苷酸编码的多肽。

5. 发明授权

US5723299A Somatostatin receptors 失效
标题翻译：生长抑素受体
公开(公告)号：US5723299A
公开(公告)日：1998-03-03
申请号：US417103
申请日：1995-04-05
申请人： Graeme I. Bell , Yuichiro Yamada , Susumu Seino
发明人： Graeme I. Bell , Yuichiro Yamada , Susumu Seino
IPC分类号： G01N33/53 , A61K39/395 , C07K14/575 , C07K14/655 , C07K14/705 , C07K14/72 , C07K16/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/566
CPC分类号： C07K14/723
摘要： The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及用于获得生长抑素受体的组合物和方法。本发明还涉及编码生长抑素受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞和重组生长抑素受体多肽。举例来说，本发明公开了来自两种不同哺乳动物来源的至少三种不同生长抑素受体SSTR1，SSTR2和SSTR3的克隆和功能表达。本发明还包括在测定中使用分离的重组受体多肽的方法，其设计用于选择和改善能够与生长抑素受体多肽相互作用的物质，用于诊断，药物设计和治疗应用。

6. 发明授权

US5605816A Recombinant DNA encoding PDGF A-chain polypeptides 失效
标题翻译：编码PDGF A链多肽的重组DNA
公开(公告)号：US5605816A
公开(公告)日：1997-02-25
申请号：US454425
申请日：1995-05-30
申请人： Carl-Henrik Heldin , Christer Betsholtz , Bengt Westermark , Timothy J. Knott , James Scott , Graeme I. Bell
发明人： Carl-Henrik Heldin , Christer Betsholtz , Bengt Westermark , Timothy J. Knott , James Scott , Graeme I. Bell
IPC分类号： C07K14/49 , C12N9/02 , C12N15/18 , C12N15/62 , C12N15/81 , C12N15/85 , C12N15/19
CPC分类号： C12N9/0089 , C07K14/49 , C12N15/62 , C12N15/81 , C12N15/85 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/36 , C12N2830/55 , C12N2830/702
摘要： DNA encoding two forms of PDGF A-chain polypeptide, the construction of expression vectors for expressing such DNA in yeast and mammalian cells, and the expression of such DNA in yeast and mammalian cells to produce active PDGF A-chain homodimer and active PDGF A-chain/B-chain heterodimer are disclosed.
摘要翻译：编码两种形式的PDGF A链多肽的DNA，构建用于在酵母和哺乳动物细胞中表达这种DNA的表达载体，以及在酵母和哺乳动物细胞中表达这种DNA以产生活性PDGF A链同源二聚体和活性PDGFA- 链/ B链异源二聚体。

7. 发明授权

US5436155A Isolated DNA encoding a somatostatin receptor 失效
标题翻译：编码生长抑素受体的分离DNA
公开(公告)号：US5436155A
公开(公告)日：1995-07-25
申请号：US816283
申请日：1991-12-31
申请人： Graeme I. Bell , Yuichiro Yamada , Susumu Seino
发明人： Graeme I. Bell , Yuichiro Yamada , Susumu Seino
IPC分类号： G01N33/53 , A61K39/395 , C07K14/575 , C07K14/655 , C07K14/705 , C07K14/72 , C07K16/00 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/12 , C12P21/02 , C12P21/08 , C12R1/91 , G01N33/566 , C07K14/71
CPC分类号： C07K14/723
摘要： The invention relates generally to compositions of and methods for obtaining somatostatin receptors. The invention relates as well to the DNA sequences encoding somatostatin receptors, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors, and recombinant somatostatin receptor polypeptides. By way of example, the invention discloses the cloning and functional expression of at least three different somatostatin receptors, SSTR1, SSTR2 and SSTR3 from two different mammalian sources. The invention includes as well, methods for using the isolated, recombinant receptor polypeptides in assays designed to select and improve substances capable of interacting with somatostatin receptor polypeptides for use in diagnostic, drug design and therapeutic applications.
摘要翻译：本发明一般涉及用于获得生长抑素受体的组合物和方法。本发明还涉及编码生长抑素受体的DNA序列，携带这些序列的重组载体，包含序列或载体的重组宿主细胞和重组生长抑素受体多肽。举例来说，本发明公开了来自两种不同哺乳动物来源的至少三种不同生长抑素受体SSTR1，SSTR2和SSTR3的克隆和功能表达。本发明还包括在测定中使用分离的重组受体多肽的方法，其设计用于选择和改善能够与生长抑素受体多肽相互作用的物质，用于诊断，药物设计和治疗应用。

8. 发明授权

US5541060A Detection of glucokinase-linked early-onset non-insulin-dependent diabetes mellitus 失效
标题翻译：葡萄糖激酶联合早发非胰岛素依赖型糖尿病的检测
公开(公告)号：US5541060A
公开(公告)日：1996-07-30
申请号：US872678
申请日：1992-04-22
申请人： Graeme I. Bell , Markus Stoffel , Jun Takeda , Nathalie Vionnet , Kazuki Yasuda , Simon J. Pilkis , Habib Zouali , Gilberto Velho , Daniel Cohen , Philippe Froguel
发明人： Graeme I. Bell , Markus Stoffel , Jun Takeda , Nathalie Vionnet , Kazuki Yasuda , Simon J. Pilkis , Habib Zouali , Gilberto Velho , Daniel Cohen , Philippe Froguel
IPC分类号： C12N9/12 , C12Q1/68 , C12P19/34
CPC分类号： C12N9/12 , C12Q1/6883 , C12Q2600/156
摘要： The invention relates to the observed tight linkage between DNA polymorphisms in the glucokinase gene (GCK) on the short arm of chromosome 7, and NIDDM in a cohort of sixteen French families having MODY. It further relates to identification of mutations in GCK and their linkage with diabetes in particular families are disclosed. This invention provides the first evidence implicating specific mutations in a gene involved in glucose metabolism in the pathogenesis of NIDDM. The invention further discloses the isolation and characterization of human pancreatic .beta.-cell GCK and a method for searching for mutations that cause early-onset NIDDM. To assess the effect of these mutations on glucokinase activity, a method is disclosed for generating an .alpha.-carbon backbone model for human glucokinase based on the crystal structure of the structurally-related yeast hexokinase B. Thus, in its most general sense, the invention relates to a method for detecting a propensity to develop early-onset, non-insulin-dependent diabetes mellitus.
摘要翻译：本发明涉及在染色体7的短臂上的葡萄糖激酶基因（GCK）中的DNA多态性与具有MODY的16个法国家族的NIDDM中观察到的紧密连锁。其进一步涉及GCK突变的鉴定及其与特定家族中糖尿病的联系。本发明提供了涉及NIDDM发病机理中涉及葡萄糖代谢的基因中的特定突变的第一个证据。本发明进一步公开了人胰腺β细胞GCK的分离和表征，以及用于搜索引起早发型NIDDM的突变的方法。为了评估这些突变对葡糖激酶活性的影响，公开了一种基于结构相关的酵母己糖激酶B的晶体结构产生人类葡萄糖激酶的α-碳骨架模型的方法。因此，在其最普遍的意义上，本发明涉及用于检测发展早发型非胰岛素依赖性糖尿病倾向的方法。

9. 发明授权

US5219759A Recombinant DNA encoding PDGF A-chain polypeptide and expression vectors 失效
标题翻译：编码PDGF A链多肽和表达载体的重组DNA
公开(公告)号：US5219759A
公开(公告)日：1993-06-15
申请号：US574540
申请日：1990-08-27
申请人： Carl-Henrik Heldin , Christer Betsholtz , Bengt Westermark , Timothy J. Knott , James Scott , Graeme I. Bell
发明人： Carl-Henrik Heldin , Christer Betsholtz , Bengt Westermark , Timothy J. Knott , James Scott , Graeme I. Bell
IPC分类号： C07K14/49 , C12N9/02 , C12N15/18 , C12N15/62 , C12N15/81 , C12N15/85
CPC分类号： C12N9/0089 , C07K14/49 , C12N15/62 , C12N15/81 , C12N15/85 , C07K2319/00 , C07K2319/02 , C07K2319/50 , C07K2319/75 , C12N2800/108 , C12N2830/002 , C12N2830/005 , C12N2830/15 , C12N2830/36 , C12N2830/55 , C12N2830/702
摘要： DNA encoding two forms of PDGF A-chain polypeptide, the construction of expression vectors for expressing such DNA in yeast and mammalian cells, and the expression of such DNA in yeast and mammalian cells to produce active PDGF A-chain homodimer and active PDGF A-chain/B-chain heterodimer are disclosed.
摘要翻译：编码两种形式的PDGF A链多肽的DNA，构建用于在酵母和哺乳动物细胞中表达这种DNA的表达载体，以及在酵母和哺乳动物细胞中表达这种DNA以产生活性PDGF A链同源二聚体和活性PDGFA- 链/ B链异源二聚体。

10. 发明授权

US4510245A Adenovirus promoter system 失效
标题翻译：腺病毒启动子系统
公开(公告)号：US4510245A
公开(公告)日：1985-04-09
申请号：US442687
申请日：1982-11-18
申请人： Lawrence S. Cousens , Graeme I. Bell , Pablo D. T. Valenzuela
发明人： Lawrence S. Cousens , Graeme I. Bell , Pablo D. T. Valenzuela
IPC分类号： C07K14/02 , C12N15/81 , C12N15/85 , C12N15/00 , C07H21/04 , C12N1/00 , C12N1/16 , C12N1/18 , C12N1/20 , C12P19/34 , C12P21/00 , C12P21/02
CPC分类号： C07K14/005 , C12N15/81 , C12N15/85 , C12N2730/10122
摘要： The adenovirus major late promoter is employed as a promoter for expression in a yeast host. Constructions are provided for expression in yeast with the adenovirus major late promoter and a coding segment.
摘要翻译：腺病毒主要晚期启动子用作在酵母宿主中表达的启动子。提供了用于在具有腺病毒主要晚期启动子和编码区段的酵母中表达的构建体。

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