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1. 发明授权

US09732132B2 Therapeutic compositions and methods for disorders associated with neuronal degeneration 有权
公开(公告)号：US09732132B2
公开(公告)日：2017-08-15
申请号：US13979451
申请日：2012-01-13
申请人： Tonia S. Rex , Timothy A. Sullivan
发明人： Tonia S. Rex , Timothy A. Sullivan
IPC分类号： C12N5/00 , C12N7/00 , C12N15/09 , C12N15/18 , C07K14/505 , C12N15/00 , C12N15/86 , C12N15/10
CPC分类号： C07K14/505 , C12N5/00 , C12N7/00 , C12N15/00 , C12N15/10 , C12N15/86 , C12N2750/14143
摘要： Disclosed are isolated mutant erythropoietin (EPO) polypeptides, functional fragment thereof, nucleic acid encoding such peptides, vectors including such nucleic acids and compositions including such peptides and nucleic acids. The mutant EPO peptides are unique in that they include a substitution at amino acid position number 76, such as a glutamic acid for arginine substitution at position 76. This substitution inhibits erythropoietic activity while retaining their neuroprotection. Also disclosed are methods of treating or inhibiting neuronal degeneration, reducing or inhibiting one or more symptoms associated with neuronal degeneration and/or glaucoma in a subject. The methods include administering a therapeutically effective amount of a isolated mutant erythropoietin EPO polypeptide, an expression vector encoding such a mutant erythropoietin EPO polypeptide, a viral particle including an expression vector, or a composition, thereby treating or inhibiting neuronal degeneration in the subject.

2. 发明授权

US09631003B2 Host cell lines expressing human recombinant growth and differentiation factor-5 (rhGDF-5) 有权
公开(公告)号：US09631003B2
公开(公告)日：2017-04-25
申请号：US14921225
申请日：2015-10-23
申请人： Warsaw Orthopedic, Inc.
发明人： David S. Scher , Roger E. Harrington
IPC分类号： C12N1/21 , C12N5/10 , C12N15/12 , C12N15/18 , C12N15/19 , C12N15/63 , C12N15/09 , C12N15/70 , C12N15/71 , C07K14/475
CPC分类号： C07K14/475 , C12N15/70
摘要： Expression vector systems are provided for increased production of a recombinant GDF-5 (rhGDF-5) protein. Also provided are transformed host cells that were engineered to produce and express high levels of rhGDF-5 protein. Methods for isolating recombinant GDF-5 protein from an inclusion body of a cell are disclosed herein. The methods as disclosed are cost-effective, time-saving and are of manufacturing quality.

3. 发明授权

US08637646B2 Growth hormone variants 有权
标题翻译：生长激素变体
公开(公告)号：US08637646B2
公开(公告)日：2014-01-28
申请号：US10153207
申请日：2002-05-22
申请人： James A. Wells , Brian C. Cunningham
发明人： James A. Wells , Brian C. Cunningham
IPC分类号： C07K14/475 , C12N15/18 , C12N15/63
CPC分类号： C07K14/575 , C12N15/1058 , Y10S530/806 , Y10S530/808
摘要： The invention provides variants of human growth hormone having an amino acid substitution at amino acid residue R77, numbered from the N-terminus of 191-amino add human growth hormone as well as nucleic acid molecules encoding these variants.
摘要翻译：本发明提供在氨基酸残基R77具有氨基酸取代的人类生长激素的变体，编号为191-氨基加人生长激素的N末端，以及编码这些变体的核酸分子。

4. 发明授权

US08530191B2 Method for preventing formation of trisulfide derivatives of polypeptides 失效
标题翻译：防止多肽三硫化物衍生物形成的方法
公开(公告)号：US08530191B2
公开(公告)日：2013-09-10
申请号：US12714900
申请日：2010-03-01
申请人： Peter Becker , Thorkild Christensen
发明人： Peter Becker , Thorkild Christensen
IPC分类号： C12N15/18 , C07K1/14 , C07K1/34 , A61K38/27 , A61P5/06 , C07K14/61
CPC分类号： C07K1/1136 , C07K14/61
摘要： A method for reducing or substantially preventing formation of a trisulfide derivative of a polypeptide in a liquid medium containing the polypeptide ijn question comprises stripping the liquid medium with a gas, suitably a chemically unreactive gas such as nitrogen or argon.
摘要翻译：减少或基本上阻止在含有多肽问题的液体介质中形成多肽的三硫化物衍生物的方法包括用合适的化学反应性气体如氮气或氩气气体汽提液体介质。

5. 发明授权

US08329448B2 Yeast host, transformant and method for producing heterologous proteins 有权
标题翻译：酵母宿主，转化体和产生异源蛋白质的方法
公开(公告)号：US08329448B2
公开(公告)日：2012-12-11
申请号：US12025138
申请日：2008-02-04
申请人： Alimjan Idiris , Hideki Tohda , Yuko Hama
发明人： Alimjan Idiris , Hideki Tohda , Yuko Hama
IPC分类号： C12N1/16 , C12N1/19 , C12N15/09 , C12N15/12 , C12N15/16 , C12N15/18 , C12N15/81
CPC分类号： C12N15/815 , C07K14/61 , C12P21/02
摘要： The efficiency of production of a heterologous protein by a transformant of a yeast host is improved.A method of constructing a host for expression of a foreign gene which comprises deleting or inactivating at least one gene selected from the protease-associated genes (especially, metalloprotease genes and serine protease genes) of Schizosaccharomyces pombe, a host in which the above-mentioned gene is deleted or inactivated, a transformant obtained by introducing a foreign gene into the host and a method of producing a heterologous protein using the transformant.The protease-associated gene is at least one gene selected from the group consisting of psp3 (SPAC1006.01), is sxa2 (SPAC1296.03c), ppp51 (SPAC22G7.01c) and ppp52 (SPBC18A7.01) or at least two genes selected from the group consisting of metalloprotease genes and serine protease genes, especially, three genes psp3 (SPAC1006.01), isp6 (SPAC4A8.04) and ppp53 (SPAP14E8.04). A host in which four genes consisting of the above three genes and ppp16 (SPBC1711.12), or five genes consisting of the above four genes and ppp22 (SPBC14C8.03) are deleted or inactivated is preferred.
摘要翻译：通过酵母宿主的转化体产生异源蛋白质的效率得到改善。构建用于表达外源基因的宿主的方法，其包括删除或失活选自粟酒裂殖酵母的蛋白酶相关基因（特别是金属蛋白酶基因和丝氨酸蛋白酶基因）中的至少一种基因，其中上述基因被缺失或失活，通过将外源基因导入宿主获得的转化体和使用转化体产生异源蛋白质的方法。蛋白酶相关基因是选自psp3（SPAC1006.01），sxa2（SPAC1296.03c），ppp51（SPAC22G7.01c）和ppp52（SPBC18A7.01）中的至少一种基因或选自至少两种基因来自由金属蛋白酶基因和丝氨酸蛋白酶基因组成的组，特别是3个基因psp3（SPAC1006.01），isp6（SPAC4A8.04）和ppp53（SPAP14E8.04）。优选缺失或失活的由以上三种基因组成的四种基因和ppp16（SPBC1711.12）或由上述四种基因组成的五种基因和ppp22（SPBC14C8.03）的宿主。

6. 发明授权

US08188039B2 VEGF-D mutants and their use 有权
标题翻译： VEGF-D突变体及其用途
公开(公告)号：US08188039B2
公开(公告)日：2012-05-29
申请号：US12599294
申请日：2008-06-02
申请人： Pyry Toivanen , Kari Juhani Airenne , Seppo Yla-Herttuala
发明人： Pyry Toivanen , Kari Juhani Airenne , Seppo Yla-Herttuala
IPC分类号： A61K388/18 , C07K14/475 , C12N15/18
CPC分类号： C07K14/52 , A61K38/00
摘要： The present invention is a VEGF-D protein, containing one or more amino acid mutations at the dimer interface, and their use in therapy, particularly in the promotion of angiogenesis.
摘要翻译：本发明是在二聚体界面含有一个或多个氨基酸突变的VEGF-D蛋白，以及它们在治疗中的用途，特别是在促进血管发生中。

7. 发明申请

US20110237509A1 hGH AND METHODS FOR PREPARING hGH 审中-公开
标题翻译： hGH和制备hGH的方法
公开(公告)号：US20110237509A1
公开(公告)日：2011-09-29
申请号：US13029961
申请日：2011-02-17
申请人： Matthew M. Skinner , Ronald Zimmerman
发明人： Matthew M. Skinner , Ronald Zimmerman
IPC分类号： A61K38/27 , C12N15/18 , C07K14/61 , C12N1/21 , C12N15/63 , A61P5/00
CPC分类号： C07K14/61 , C12P21/06
摘要： Preparations of recombinant human growth hormone (hGH) are provided having a purity that comprises 2% or less of a peptide other than native human growth hormone (e.g., essentially free of multimeric forms) are disclosed. Active pharmaceutical ingredient (API) preparations of recombinant hGH suitable for commercial production of formulation grade recombinant hGH are provided. A stable Master Cell Bank of transformed E. coli is also disclosed, as well as methods for creating a transformed E. coli preparation that includes a Met-AsphGH encoding sequence. Improved manufacturing methods are also presented that are suitable for large scale production of highly purified preparations of recombinant human growth hormone.
摘要翻译：提供重组人生长激素（hGH）的制备，所述重组人生长激素（hGH）的纯度包括比天然人生长激素（例如，基本上不含多聚体形式）2％或更少的肽。提供了适用于制剂级重组hGH的商业生产的重组hGH的活性药物成分（API）制剂。还公开了转化的大肠杆菌的稳定的主细胞库，以及用于产生包含Met-AsphGH编码序列的转化的大肠杆菌制剂的方法。还提出了适用于大规模生产重组人生长激素高度纯化制剂的改进的制备方法。

8. 发明申请

US20110195911A1 SYNTHETIC ANALOGS OF THE JUXTAMEMBRANE DOMAIN OF IGF1R AND USES THEREOF 审中-公开
标题翻译： IGF1R的JUXTAMEMBRARE域的合成模拟及其用途
公开(公告)号：US20110195911A1
公开(公告)日：2011-08-11
申请号：US12934911
申请日：2009-03-27
申请人： Nadya I. Tarasova , Sergey G. Tarasov
发明人： Nadya I. Tarasova , Sergey G. Tarasov
IPC分类号： A61K38/16 , C07K7/06 , C07K7/08 , C07K14/00 , C12N15/18 , C07K16/22 , A61K31/7052 , A61K38/10 , A61K38/08 , C12N5/00 , A61P35/00
CPC分类号： C07K14/72
摘要： A peptide or peptidomimetic comprising the amino acid sequence RXGNGV (SEQ ID NO: 1) or the inverse thereof, or comprising at least six contiguous amino acids of the juxtamembrane domain of IGF1R (SEQ ID NO: 43) or inverse thereof, wherein the peptide or peptidomimetic comprises a total of about 50 or fewer amino acids and inhibits IFG-R1 activity, as well as a method of inhibiting a IGF1R in a cell, a method of treating or preventing IGF1R-mediated disease, and related compounds, compositions, and methods.
摘要翻译：包含氨基酸序列RXGNGV（SEQ ID NO：1）或其逆向或包含IGF1R（SEQ ID NO：43）的并置结构域的至少六个相邻氨基酸或其逆转的肽或肽模拟物，其中所述肽或肽模拟物包含总共约50个或更少的氨基酸并且抑制IFG-R1活性，以及抑制细胞中IGF1R的方法，治疗或预防IGF1R介导的疾病的方法，以及相关化合物，组合物和方法。

9. 发明授权

US07846718B2 Methods and means for producing efficient silencing construct using recombinational cloning 有权
标题翻译：使用重组克隆产生高效沉默构建体的方法和手段
公开(公告)号：US07846718B2
公开(公告)日：2010-12-07
申请号：US11033553
申请日：2005-01-12
申请人： Christopher A. Helliwell , Susan V. Wesley , Peter M. Waterhouse
发明人： Christopher A. Helliwell , Susan V. Wesley , Peter M. Waterhouse
IPC分类号： C12N15/00 , C12N15/18 , C07H21/04
CPC分类号： C12N15/825 , C12N15/10 , C12N15/63 , C12N15/8218 , C12N15/8249 , C12N15/827
摘要： Methods and vectors and kits are provided for producing chimeric nucleic acid constructs capable of producing dsRNA for silencing target nucleic acid sequences of interest using recombinational cloning.
摘要翻译：提供了方法和载体和试剂盒，用于生产能够使用重组克隆沉默靶核酸序列的dsRNA的嵌合核酸构建体。

10. 发明授权

US07671180B2 Fibroblast growth factor-like polypeptides and variants thereof 失效
标题翻译：成纤维细胞生长因子样多肽及其变体
公开(公告)号：US07671180B2
公开(公告)日：2010-03-02
申请号：US11733769
申请日：2007-04-11
申请人： Arlen Thomason , Benxian Liu
发明人： Arlen Thomason , Benxian Liu
IPC分类号： C07K14/475 , C07K14/50 , C12N1/21 , C12N15/18 , C12N15/62 , C12N15/63
CPC分类号： C07K14/50 , A61K38/00 , C07K2319/30 , C12N2310/111 , G01N2333/50
摘要： The present invention provides novel Fibroblast Growth Factor-like (FGF-like) fusion polypedtides.
摘要翻译：本发明提供新型成纤维细胞生长因子样（FGF样）融合多肽。

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