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71. 发明申请

US20120241100A1 METHODS AND DEVICES FOR CRYSTALLIZATION BY CONTROLLED EVAPORATION 有权
标题翻译：通过控制蒸发进行结晶的方法和装置
公开(公告)号：US20120241100A1
公开(公告)日：2012-09-27
申请号：US13480747
申请日：2012-05-25
申请人： Jack Barger , James Sinclair , Michael P. Emery
发明人： Jack Barger , James Sinclair , Michael P. Emery
IPC分类号： B01D1/14
CPC分类号： B01D3/346 , B01D1/14 , B01L3/06 , B01L3/50853 , B01L2200/0678 , B01L2300/048 , B01L2300/049 , B01L2300/0829 , G01N2001/4027
摘要： Methods and devices for controlled evaporation of solvent from a solution are provided. In one embodiment, a method for controlled evaporation of solvent from at least one solution includes filling a selected first set of wells in a multi-well plate with a first solution comprising at least one first solvent. The method also includes attaching an inlet manifold to the plate, the inlet manifold comprising an inlet port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method further includes attaching an exhaust manifold to the plate, the exhaust manifold comprising an exhaust port connected to and in fluid communication only with each of the wells in the selected first set of wells. The method also includes introducing a gas into the inlet port and removing solvent vapor from the selected first set of wells.
摘要翻译：提供了从溶液中控制溶剂蒸发的方法和装置。在一个实施方案中，用于从至少一种溶液控制蒸发溶剂的方法包括用包含至少一种第一溶剂的第一溶液填充多孔板中选定的第一组孔。该方法还包括将入口歧管连接到板上，入口歧管包括连接到所选择的第一组井中的每个井中并仅与其中的每个井连通并且仅在其中流体连通的入口歧管。所述方法还包括将排气歧管连接到所述板上，所述排气歧管包括与所选择的第一组井中的每个孔连接并且仅与所述第一组井中的每个井相连通的排气口。该方法还包括将气体引入入口并从所选择的第一组孔中除去溶剂蒸气。

72. 发明授权

US08252139B2 Method of making a fluid separator collection card 有权
标题翻译：制造流体分离器收集卡的方法
公开(公告)号：US08252139B2
公开(公告)日：2012-08-28
申请号：US13273048
申请日：2011-10-13
申请人： Mark Lee Pankow
发明人： Mark Lee Pankow
IPC分类号： B29C65/00 , B32B37/00 , G01N21/75 , G01N31/22 , G01N33/52 , G01N1/00
CPC分类号： B01L3/5023 , B01L2200/026 , B01L2200/0678 , B01L2300/028 , G01N33/491 , Y10T436/2525
摘要： A method of making a fluid sample collection card includes providing a support layer, forming an upper layer with a card stock, the upper layer including a sample window and a viewing window, supporting an absorbent layer with the support layer, and positioning the upper layer on the absorbent layer, wherein the upper layer is configured such that as a fluid is being absorbed by the first absorbent layer portion, presence of a portion of the fluid within the second absorbent layer portion indicates that a first volume of the fluid absorbed by the absorbent layer is a minimum necessary volume of the fluid sufficient to perform at least one test on at least one component in the fluid.
摘要翻译：制备流体样品采集卡的方法包括提供支撑层，用卡片材料形成上层，上层包括样品窗和观察窗，用支撑层支撑吸收层，并将上层在所述吸收层上，其中所述上层被构造成使得当流体被所述第一吸收层部分吸收时，所述第二吸收层部分内的所述流体的一部分的存在表示所述第一吸收层吸收层是足以对流体中的至少一种组分进行至少一次测试的流体的最小必需体积。

73. 发明申请

US20120111506A1 METHOD FOR THE CONTROLLED EVAPORATION OF A LIQUID DROP IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：用于微流控器件中液滴的控制方法
公开(公告)号：US20120111506A1
公开(公告)日：2012-05-10
申请号：US13292627
申请日：2011-11-09
申请人： Arnaud RIVAL
发明人： Arnaud RIVAL
IPC分类号： B01D1/00 , B81B1/00
CPC分类号： B01L3/502784 , B01L2200/0678 , B01L2300/089 , B01L2400/0427 , G01N1/4022 , G01N2001/4027
摘要： The invention relates to a method for the controlled evaporation of a liquid drop (2) in a closed or confined type microfluidic device (1), enabling the concentration of analytes possibly present in the drop (2) to be increased.According to the invention, a drop (2) and/or a bubble (4) are brought into contact with each other, said contact enabling the drop (2) to evaporate in the bubble (4).
摘要翻译：本发明涉及一种用于在封闭或密闭型微流体装置（1）中液滴（2）的受控蒸发的方法，使得能够增加可能存在于液滴（2）中的分析物的浓度。根据本发明，液滴（2）和/或气泡（4）彼此接触，所述接触使得液滴（2）在气泡（4）中蒸发。

74. 发明申请

US20120070911A1 Method of Detecting and Quantifying Analytes of Interest in a Liquid and Implementation Device 审中-公开
标题翻译：检测和定量液体和实施装置中感兴趣的分析物的方法
公开(公告)号：US20120070911A1
公开(公告)日：2012-03-22
申请号：US13258580
申请日：2010-03-29
申请人： Jean-Pierre Peyrade , David Peyrade , Christophe Vieu , Laurent Malaquin
发明人： Jean-Pierre Peyrade , David Peyrade , Christophe Vieu , Laurent Malaquin
IPC分类号： G01N33/53 , G01N21/78 , G01N21/64 , B82Y15/00
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0678 , B01L2300/1861 , B01L2400/0466 , G01N35/00029 , G01N2001/4027 , G01N2035/00158
摘要： The invention provides a method of detecting and quantifying analytes present in a solution, which is portable, rapid, inexpensive, selective and ultra-sensitive. For this purpose, the subject of the invention is a method of detecting and quantifying analytes of interest (2) in a specimen (1) of liquid obtained from a mother liquor, the liquid being able to evaporate in an atmosphere (Atm) under defined evaporation conditions, the method comprising the following steps: b) the specimen (1) is deposited on a substrate (10) having a microstructured or nanostructured surface (20) defining analyte capture probes, in order for the liquid specimen to at least partially cover the structured surface of the substrate; c) the specimen undergoes controlled evaporation (5) in the vicinity (VT) of a liquid/substrate/atmosphere triple line (T), in such a way that this triple line moves, at a controlled rate, over the structured surface of the substrate as the liquid evaporates into the atmosphere, and so that the target analytes are captured, by convective assembly and directed capillary action, by the probes; and d) the structured surface of the substrate obtained after step c) is analysed.
摘要翻译：本发明提供了一种检测和定量解决方案中存在的分析物的方法，其是便携式的，快速的，廉价的，选择性的和超灵敏的。为此目的，本发明的主题是检测和定量从母液获得的液体样品（1）中感兴趣的分析物（2）的方法，该液体可在规定的气氛（Atm）中蒸发蒸发条件，该方法包括以下步骤：b）将样品（1）沉积在具有限定分析物捕获探针的微结构或纳米结构化表面（20）的基底（10）上，以使液体样品至少部分覆盖基板的结构化表面; c）样品在液体/衬底/气氛三线（T）的附近（VT）处经受受控蒸发（5），使得该三线以受控的速率移动超过结构化表面底物作为液体蒸发到大气中，并且通过探针通过对流装配和定向毛细管作用捕获目标分析物; 和d）分析在步骤c）之后获得的基材的结构化表面。

75. 发明申请

US20120011945A1 Method and Sample Holding Assembly for Use in Sample Preparation 有权
标题翻译：用于样品制备的方法和样品保持组件
公开(公告)号：US20120011945A1
公开(公告)日：2012-01-19
申请号：US13254465
申请日：2010-03-29
申请人： Roger Lee-Smith
发明人： Roger Lee-Smith
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L2200/026 , B01L2200/04 , B01L2200/0678 , G01N2001/4027
摘要： A method and sample holding assembly are described for use in the preparation of samples for analysis. In known techniques, following concentration of a sample using an evaporator, the concentrated solution is manually transferred to a smaller vial compatible with analysis apparatus using a pipette. This leads to loss of the sample and risks cross-contamination. Using the present method, a sample is concentrated directly into the vial. The method comprises the steps of collecting a sample in a concentration tube which is open at one end and closed at the other, the closed end being selectively openable. A vial is coupled to the open end, the tube is inverted, the closed end is opened, and then solvent is evaporated from the sample via the opened end until the concentrated sample is confined to the vial. A sample holding assembly for use in the present method is also described. It comprises a concentration tube, and an adaptor arrangement for coupling a vial to the open end of the tube and defining a fluid path between the tube and the vial.
摘要翻译：描述了用于制备用于分析的样品的方法和样品保持组件。在已知的技术中，使用蒸发器浓缩样品后，将浓缩的溶液用移液管手动转移到与分析装置相容的较小的小瓶中。这导致样品的损失，并有交叉污染的风险。使用本方法，将样品直接浓缩到小瓶中。该方法包括以下步骤：在一端开放并在另一端闭合的浓缩管中收集样品，封闭端可选择性地打开。将小瓶联接到开口端，将管倒置，封闭端打开，然后通过开口端从样品中蒸发溶剂，直到浓缩的样品被限制在小瓶中。还描述了用于本方法的样品保持组件。它包括浓缩管和用于将小瓶连接到管的开口端并在管和小瓶之间限定流体路径的适配器装置。

76. 发明申请

US20110287976A1 MICROFLUIDIC SOLUTION FOR HIGH-THROUGHPUT, DROPLET-BASED SINGLE MOLECULE ANALYSIS WITH LOW REAGENT CONSUMPTION 有权
标题翻译：微量流动解决方案，用于高渗透，基于滴定的单分子分析，低试剂消耗
公开(公告)号：US20110287976A1
公开(公告)日：2011-11-24
申请号：US13147742
申请日：2010-03-02
申请人： Jeff Tza-Huei Wang , Kelvin J. Liu , Christopher M. Puleo , Tushar D. Rane
发明人： Jeff Tza-Huei Wang , Kelvin J. Liu , Christopher M. Puleo , Tushar D. Rane
IPC分类号： C40B30/10 , C40B60/12
CPC分类号： C12Q1/6825 , B01L3/502753 , B01L3/502769 , B01L7/52 , B01L2200/0678 , B01L2200/10 , B01L2300/088 , B01L2400/0481 , B01L2400/0655 , G01N1/38 , G01N15/1484 , G01N21/6458 , G01N2001/4027 , G01N2015/0038 , G01N2015/1493 , G01N2021/6419 , G01N2021/6421 , Y10T436/143333
摘要： A microfluidic device for a confocal fluorescence detection system has an input channel defined by a body of the microfluidic device, a sample concentration section defined by the body of the microfluidic device and in fluid connection with the input channel, a mixing section defined by the body of the microfluidic device and in fluid connection with the concentration section, and a detection region that is at least partially transparent to illumination light of the confocal fluorescence detection system and at least partially transparent to fluorescent light when emitted from a sample under observation as the sample flows through the detection region.
摘要翻译：用于共焦荧光检测系统的微流体装置具有由微流体装置的主体限定的输入通道，由微流体装置的主体限定并与输入通道流体连接的样品浓度部分，由身体限定的混合部分的微流体装置，并且与浓缩部分流体连接;以及检测区域，其对于共聚焦荧光检测系统的照明光至少部分透明，并且当从作为样品的观察样品发射时对荧光至少部分透明流过检测区域。

77. 发明申请

US20110188037A1 CONCENTRATOR AND LOCATOR DEVICE OF A SOLUTE AND METHOD FOR CONCENTRATING AND LOCATING A SOLUTE 失效
标题翻译：解决方案的集中器和定位装置和用于集中和定位解决方案的方法
公开(公告)号：US20110188037A1
公开(公告)日：2011-08-04
申请号：US13061457
申请日：2009-08-28
申请人： Enzo Mario Di Fabrizio , Giovanni Cuda , Federico Mecarini , Francesco De Angelis , Francesco Gentile
发明人： Enzo Mario Di Fabrizio , Giovanni Cuda , Federico Mecarini , Francesco De Angelis , Francesco Gentile
IPC分类号： G01J3/28 , B05D1/36 , B01L3/00 , B01D1/00 , G03F7/20
CPC分类号： B01L3/502746 , B01L3/502707 , B01L3/5088 , B01L2200/0678 , B01L2300/089 , B01L2300/0896 , B01L2300/166 , B01L2400/086 , B82Y30/00 , G01N21/554
摘要： Concentrator and locator device (1) of a solute comprising a substrate (2) and a plurality of prismatic lithographic micro-structures (4) orthogonally emerging from the substrate (2). The microstructures (4) are spaced from one another in a periodical manner so as to make such a substrate (2) super-hydrophobic.
摘要翻译：包括基板（2）和从基板（2）正交地出射的多个棱镜光刻微结构（4）的溶质的集中器和定位装置（1）。微结构（4）以周期性方式彼此间隔开，以使这种基底（2）超疏水。

78. 发明申请

US20090084679A1 APPARATUS AND METHOD FOR TRAPPING BEAD BASED REAGENTS WITHIN MICROFLUIDIC ANALYSIS SYSTEMS 审中-公开
标题翻译：在微流感分析系统中捕获基于珠粒的试剂的装置和方法
公开(公告)号：US20090084679A1
公开(公告)日：2009-04-02
申请号：US12257337
申请日：2008-10-23
申请人： D. Jed HARRISON , Abebaw Belay Jemere
发明人： D. Jed HARRISON , Abebaw Belay Jemere
IPC分类号： G01N27/453
CPC分类号： G01N30/56 , B01L2200/0678 , B01L2300/041 , B01L2400/0415 , G01N30/6095 , G01N2030/285 , G01N2030/565
摘要： The present invention provides an on-chip packed reactor bed design that allows for an effective exchange of packing materials such as beads at a miniaturized level. The present invention extends the function of microfluidic analysis systems to new applications including on-chip solid phase extraction (SPE) and on-chip capillary electrochromatography (CEC). The design can be further extended to include integrated packed bed immuno- or enzyme reactors.
摘要翻译：本发明提供一种片上填充反应器床设计，其允许以小型化水平有效地交换诸如珠粒的包装材料。本发明将微流控分析系统的功能扩展到包括片上固相萃取（SPE）和片上毛细管电色谱（CEC）的新应用。该设计可以进一步扩展到包括集成的填充床免疫或酶反应器。

79. 发明授权

US07429354B2 Structural units that define fluidic functions 失效
标题翻译：定义流体功能的结构单元
公开(公告)号：US07429354B2
公开(公告)日：2008-09-30
申请号：US10472255
申请日：2002-03-19
申请人： Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
发明人： Per Andersson , Gunnar Ekstrand , Ulrike Selditz , Sussanne Wallenborg , Helene Derand , Gunnar Thorsen , Ebru Togan-Tekin
IPC分类号： G01N21/00
CPC分类号： G01N33/54366 , B01J19/0093 , B01L3/5025 , B01L3/502723 , B01L3/50273 , B01L3/502746 , B01L2200/0605 , B01L2200/0678 , B01L2200/0684 , B01L2300/0806 , B01L2300/0864 , B01L2300/0867 , B01L2300/087 , B01L2400/0406 , B01L2400/0409 , B01L2400/0688 , B01L2400/086 , G01N35/00069
摘要： A microfluidic device that comprises several microchannel structures in which there are an inlet port, an outlet port and therebetween a substructure comprising a fluidic function. The device has an axis of symmetry around which the microchannel structures are arranged as two or more concentric annular zones. for an inlet port and an outlet port of the same microchannel structure the inlet port is typically closer to the axis of symmetry than the outlet port. Each microchannel structure comprises a substructure that can retain liquid while the disc is spun around the axis and/or the inlet ports are positioned separate from the paths waste liquid leaving open waste outlet ports will follow across the surface of the disc when it is spun. For the microchannel structures of an annular zones the corresponding substructures are at essentially at the same radial distance while corresponding substructures in microchannel structures of different annular zones are at different radial distances. The invention also refers to several other substructures. The substructure are primarily adapted for transporting liquid aliquots that have a surface tnsion >5 mN/m with centrifugal force.
摘要翻译：一种微流体装置，其包括几个微通道结构，其中存在入口端口，出口以及其间具有流体功能的子结构。该装置具有对称轴，微通道结构围绕该轴布置为两个或更多个同心的环形区域。对于相同微通道结构的入口和出口，入口通常比出口更接近对称轴。每个微通道结构包括一个子结构，其可以在圆盘围绕轴线旋转时保持液体，和/或入口端口与路径分离，离开开放废料出口的废液在旋转时将跟随盘的表面。对于环形区域的微通道结构，相应的子结构基本上处于相同的径向距离，而不同环形区域的微通道结构中的相应子结构处于不同的径向距离。本发明还涉及几个其他子结构。子结构主要适用于输送具有离心力的表面尺寸> 5mN / m的液体等分试样。

80. 发明申请

US20040228772A1 Method and apparatus for processing biological and chemical samples 审中-公开
标题翻译：用于处理生物和化学样品的方法和装置
公开(公告)号：US20040228772A1
公开(公告)日：2004-11-18
申请号：US10844774
申请日：2004-05-13
申请人： Becton, Dickinson and Company
发明人： Xiaoxi Chen , Michael Shanler
IPC分类号： B01L003/00
CPC分类号： H01J49/0418 , B01L3/50255 , B01L3/5085 , B01L2200/0678 , B01L2200/0689 , B01L2300/0822 , B01L2300/0829 , B01L2300/0851 , G01N1/34 , G01N1/40 , G01N2001/4027 , G01N2035/00158
摘要： The subject invention provides a target support plate and an assembly of a target support plate and a target device for processing biological and chemical samples The target support plate includes spaced-apart top and bottom surfaces, and a plurality of columns extending between, and through, the top and bottom surfaces. The target support plate may be releaseably secured to the target device by an elastomeric seal with the target support plate being at least partially formed of an elastomeric material; an adhesive; an elastomeric gasket; and/or, a mechanical fixation. The target device may be a device for collecting samples, including a multi-well plate, a mass spectrometric plate, or a secondary target support plate.
摘要翻译：本发明提供了一种目标支撑板和用于处理生物和化学样品的目标支撑板和目标装置的组件。目标支撑板包括间隔开的顶部和底部表面，以及多个柱，顶面和底面。目标支撑板可以通过弹性体密封件可释放地固定到目标装置，目标支撑板至少部分地由弹性体材料形成; 粘合剂弹性垫片; 和/或机械固定。目标装置可以是用于收集样品的装置，包括多孔板，质谱板或辅助靶支撑板。

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