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1. 发明授权

US09631244B2 Reagent storage on a droplet actuator 有权
公开(公告)号：US09631244B2
公开(公告)日：2017-04-25
申请号：US14131061
申请日：2012-06-26
申请人： Jennifer Foley , Stefan Burde , Vamsee K. Pamula , Michael G. Pollack
发明人： Jennifer Foley , Stefan Burde , Vamsee K. Pamula , Michael G. Pollack
IPC分类号： A61K39/00 , A61K9/14 , A61K38/20 , A61K38/21 , A61K39/39 , C12Q1/70 , B01L3/00 , B01L7/00 , C12Q1/68
CPC分类号： C12Q1/703 , B01L3/502784 , B01L3/502792 , B01L7/525 , B01L2200/0678 , B01L2200/16 , B01L2300/0816 , B01L2400/0427 , C12Q1/6806 , C12Q2523/308 , C12Q2527/125 , C12Q2531/113 , C12Q2563/159 , C12Q2565/607
摘要： A method of providing a droplet comprising one or more reagents, the method comprising, depositing a first aqueous droplet comprising the one or more reagents on a surface; drying the droplet to yield a dried composition on the surface comprising the one or more reagents; covering the dried composition with oil; and causing a second aqueous droplet in the oil to contact the dried composition and thereby resuspend one or more reagents.

2. 发明申请

US20160349090A1 Arrangement for Providing Information on Fluid Flow Rate 有权
标题翻译：提供流体流量信息的安排
公开(公告)号：US20160349090A1
公开(公告)日：2016-12-01
申请号：US15159221
申请日：2016-05-19
申请人： Stichting IMEC Nederland
发明人： Marcel Arie Günther Zevenbergen , Rajesh Mandamparambil , Chuan Nie , Arnoldus Joannes Hubertus Frijns , Jacob Marinus Jan Den Toonder
IPC分类号： G01F1/56 , G01F1/34
CPC分类号： G01F1/00 , B01L3/5027 , B01L3/502723 , B01L2200/0605 , B01L2200/0621 , B01L2200/0678 , B01L2300/048 , B01L2300/069 , B01L2300/0816 , B01L2300/0864 , B01L2300/0883 , B01L2300/0887 , B01L2400/0487 , G01F1/68
摘要： The present disclosure relates to an arrangement for providing information about a flow rate of a fluid, comprising: a fluid inlet opening, at least one flow channel, and at least one porous zone located above the at least one flow channel, wherein the surface size and position of the at least one porous zone relative to the fluid inlet opening defines the evaporation rate of a fluid, arranged such that when a fluid is injected through the fluid inlet opening the fluid flows via hydraulic pressure through the at least one flow channel and then through the respective at least one porous zone.
摘要翻译：本发明涉及一种用于提供关于流体流速的信息的装置100，包括：流体入口开口111，至少一个流动通道112和位于流动通道上方的至少一个多孔区域114，其中表面至少一个多孔区域114相对于流体入口开口111的尺寸和位置限定了流体的蒸发速率，其布置成使得当流体通过流体入口开口111注入时，流体经由液压通过至少一个流动通道112，然后通过相应的至少一个多孔区域114

3. 发明授权

US09138742B2 Receiver plate with multiple cross-sections 有权
公开(公告)号：US09138742B2
公开(公告)日：2015-09-22
申请号：US14514853
申请日：2014-10-15
申请人： EMD Millipore Corporation
发明人： Christopher A. Scott , Brian Foley
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/5085 , B01L2200/025 , B01L2200/0678 , B01L2200/0684 , B01L2200/141 , B01L2300/0681 , B01L2300/0829 , B01L2300/0858
摘要： A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.

4. 发明申请

US20150194288A1 SPECIMEN PREPARATION FOR TRANSMISSION ELECTRON MICROSCOPY 有权
标题翻译：用于传输电子显微镜的样品制备
公开(公告)号：US20150194288A1
公开(公告)日：2015-07-09
申请号：US14412653
申请日：2013-07-08
申请人： NATIONAL HEALTH RESEARCH INSTITUTES , MATERIALS ANALYSIS TECHNOLOGY (US) CORP
发明人： Yong-fen Hsieh , Chih-hsun Chu , Pradeep Sharma , Yu-feng Ko , Chung-shi Yang , Lin-ai Tai , Yu-ching Chen , Hsiao-chun Ting
IPC分类号： H01J37/26 , H01J37/16 , G01N1/28 , H01J37/22
CPC分类号： H01J37/261 , B01L3/508 , B01L2200/0678 , B01L2300/0822 , G01N1/28 , G01N1/4022 , G01N23/02 , G01N2001/4027 , H01J37/16 , H01J37/20 , H01J37/222 , H01J37/3178 , H01J2237/2007 , H01J2237/2602 , H01J2237/2802
摘要： A TEM specimen kit is disclosed, which comprises: (a) a top substrate and a bottom substrate, the top and the bottom substrates being transparent and substantially parallel to each other; (b) a first spacer and a second spacer, located beneath the top substrate and sitting on the bottom substrate, the second spacer being opposite to and spaced apart from the first spacer at a distance of d; and (c) a chamber formed between the top and bottom substrate and between the first and second spacer, the chamber having two ends open to the atmosphere and characterized by having a height defined by the thickness h of the spacer, wherein the height being smaller than the diameter of a red blood cell. Also enclosed are methods for preparing a dry specimen for TEM nanoparticle characterization, and methods for analyzing TEM images of nanoparticles in a liquid sample.
摘要翻译：公开了TEM样本试剂盒，其包括：（a）顶部基底和底部基底，所述顶部和底部基底是透明的并且基本上彼此平行; （b）第一间隔件和第二间隔件，位于顶部基板下方并且位于底部基板上，第二间隔件与第一间隔件相对并间隔开距离d; 和（c）在顶部和底部基底之间以及在第一和第二间隔物之间形成的腔室，该腔室具有通向大气的两个端部，其特征在于具有由间隔物的厚度h限定的高度，其中高度较小比红细胞的直径。还包括用于制备用于TEM纳米颗粒表征的干试样的方法，以及用于分析液体样品中纳米颗粒的TEM图像的方法。

5. 发明授权

US08968679B2 Receiver plate with multiple cross-sections 有权
标题翻译：接收板有多个横截面
公开(公告)号：US08968679B2
公开(公告)日：2015-03-03
申请号：US11132996
申请日：2005-05-19
申请人： Christopher A. Scott , Brian Foley
发明人： Christopher A. Scott , Brian Foley
IPC分类号： B01L3/00
CPC分类号： B01L3/50255 , B01L3/5085 , B01L2200/025 , B01L2200/0678 , B01L2200/0684 , B01L2200/141 , B01L2300/0681 , B01L2300/0829 , B01L2300/0858
摘要： A multi-well assembly including a filter plate and receiver plate. Each plate includes a plurality of wells, which, when the filter plate is placed in nesting relationship with the receiver plate, each filter plate well has a corresponding receiver plate well into which it extends. The receiver plate wells are of a non-uniform cross-section in order to increase the gap between the outer walls of the filter plate wells and the inner walls of a corresponding receiver plate well when the receiver plate and filter plate are in nesting relationship. The increased gap size reduces wicking and cross-contamination. A multi-section well of maximum cross-section in an upper region and a minimized cross-section in a lower region, with a gradual transition between the regions, is thus provided. The multi-well assembly of the present invention also improves the repeatability of positioning the filter plate and receiver plate in proper nesting relationship and provides stability during handling, mixing and shaking operations.
摘要翻译：包括过滤板和接收板的多孔组件。每个板包括多个孔，当过滤板与接收板放置成嵌套关系时，每个过滤板井具有相应的容纳板，井中延伸。接收器板孔具有不均匀的横截面，以便当接收板和过滤板处于嵌套关系时，增加过滤板孔的外壁和对应的接收器板的内壁之间的间隙。增加的间隙大小减少芯吸和交叉污染。因此，提供了在上部区域中的最大横截面的多部分井和在下部区域中具有逐渐过渡的区域中的最小化横截面。本发明的多孔组件还提高了将过滤板和接收板定位成适当的嵌套关系的重复性，并且在处理，混合和摇动操作期间提供了稳定性。

6. 发明申请

US20140053988A1 GAS-BLOWING VAPORIZING AND DRYING DEVICE 审中-公开
标题翻译：气体蒸发和干燥装置
公开(公告)号：US20140053988A1
公开(公告)日：2014-02-27
申请号：US13972036
申请日：2013-08-21
申请人： Tomoyuki Yamazaki
发明人： Tomoyuki Yamazaki
IPC分类号： B01D1/18
CPC分类号： B01D1/18 , B01L3/50825 , B01L2200/0678 , B01L2300/044 , B01L2300/048 , G01N2001/4027
摘要： Provided is a gas-blowing vaporizing and drying device, which includes: a sample tube in the form of a double tube including an inner tube for a solution and an outer tube for a gas, the inner tube protruding from one end of the outer tube by length L; and a collection container including a container body and a lid provided with a protrusion sleeve tube, the protrusion sleeve tube including a coupling portion at an end to be located outside the container body and a sleeve portion of a length equal to or longer than L having an open end to be located inside the container body, the coupling portion being designed to be coupled to the aforementioned one end of the outer tube in an air-tight manner.
摘要翻译：本发明提供一种气体蒸发干燥装置，其特征在于，包括：具有溶液内管和双重管的形式的样品管，所述内管从所述外管的一端突出，长度L; 以及收容容器，包括容器主体和设置有突出套筒管的盖，所述突出套管包括位于容器主体外侧的端部处的联接部分和长度等于或大于L的套筒部分，其长度等于或大于L，位于容器主体内部的开口端，联接部分被设计成以气密方式联接到外管的上述一端。

7. 发明申请

US20130334154A1 Modular pegs for drying rack 审中-公开
标题翻译：干燥架的模块化钉
公开(公告)号：US20130334154A1
公开(公告)日：2013-12-19
申请号：US13507270
申请日：2012-06-18
申请人： Robert DeLuca , William Mabanta
发明人： Robert DeLuca , William Mabanta
IPC分类号： A47G29/00 , F16M13/02
CPC分类号： A47L19/04 , A47F5/0823 , B01L9/00 , B01L13/02 , B01L2200/0678 , F16B21/09
摘要： A drying rack used primarily for air-drying wet glassware, which utilizes modular pegs that are installed on drying racks of differing materials of construction.
摘要翻译：干燥架主要用于风湿湿玻璃器皿，其使用安装在不同材料结构的干燥架上的模块化钉。

8. 发明申请

US20130309679A1 FLUIDIC DEVICES AND SYSTEMS FOR SAMPLE PREPARATION OR AUTONOMOUS ANALYSIS 有权
标题翻译：用于样品制备或自动分析的流体装置和系统
公开(公告)号：US20130309679A1
公开(公告)日：2013-11-21
申请号：US13868028
申请日：2013-04-22
申请人： SlipChip, LLC , California Institute of Technology
发明人： Rustem F. Ismagilov , Feng Shen , Liang Li , Yu-Hsiang Hsu , Stefano Begolo , Mikhail Karymov , David Selck , Stephanie McCalla , Philip James Homewood
IPC分类号： C12N15/10
CPC分类号： C12N15/1003 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L3/502784 , B01L3/52 , B01L7/52 , B01L2200/027 , B01L2200/0605 , B01L2200/0673 , B01L2200/0678 , B01L2300/045 , B01L2300/0681 , B01L2300/0803 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0874 , B01L2400/0406 , B01L2400/0487 , B01L2400/0644 , B01L2400/065 , G01N33/525
摘要： The present invention relates to fluidic devices for preparing, processing, storing, preserving, and/or analyzing samples. In particular, the devices and related systems and methods allow for preparing and/or analyzing samples (e.g., biospecimen samples) by using one or more of capture regions and/or automated analysis.
摘要翻译：本发明涉及用于制备，加工，储存，保存和/或分析样品的流体装置。特别地，装置和相关系统和方法允许通过使用一个或多个捕获区域和/或自动化分析来制备和/或分析样品（例如生物样本样品）。

9. 发明授权

US08281500B2 Device and method for increasing evaporation rates of blow-down apparatus 失效
标题翻译：提高排放装置蒸发率的装置和方法
公开(公告)号：US08281500B2
公开(公告)日：2012-10-09
申请号：US12605655
申请日：2009-10-26
申请人： Herbert J. Hedberg , Brian A. Kangas , Michael A. Burns
发明人： Herbert J. Hedberg , Brian A. Kangas , Michael A. Burns
IPC分类号： B01D1/14 , B01D3/00
CPC分类号： G01N1/40 , B01D1/14 , B01D1/30 , B01L3/5082 , B01L2200/0678 , B01L2300/0609 , G01N2001/4027
摘要： A drying container insert that manages the evaporation rate of liquid solutions when subjected to blow-down gas flows. Certain gas flow separator baffles or framed inserts with vanes may be especially effective to enhance evaporation when combined with aggressive blow-down flow rates and centrifugal force. The centrifugal force applied to the evaporating liquid protects sample integrity by preventing the solution(s) from splashing out of the drying container. Such splashing, when high blow-down gas flow rates are directed into the sample containers, affects yield and purity.
摘要翻译：一种干燥容器插入物，用于在经受吹扫气体流动时管理液体溶液的蒸发速率。当与积极的排污流量和离心力相结合时，某些气流分离器挡板或具有叶片的框架插入件可能特别有效地增强蒸发。施加到蒸发液体上的离心力通过防止溶液溅出干燥容器来保护样品的完整性。当高的吹扫气体流量被引导到样品容器中时，这种飞溅会影响产量和纯度。

10. 发明申请

US20120103113A1 SYSTEM AND METHOD FOR MICROPLATE PRESSURIZATION 审中-公开
标题翻译：微波加压的系统和方法
公开(公告)号：US20120103113A1
公开(公告)日：2012-05-03
申请号：US13282904
申请日：2011-10-27
申请人： Edmund Y. Ting , Alexander Lazarev
发明人： Edmund Y. Ting , Alexander Lazarev
IPC分类号： G01N1/28 , B01L3/00
CPC分类号： B01L3/50853 , B01L3/50851 , B01L9/50 , B01L2200/021 , B01L2200/0631 , B01L2200/0678 , B01L2200/0689 , B01L2200/141 , B01L2300/042 , B01L2300/048 , B01L2300/123 , B01L2300/14 , B01L2400/0487 , G01N1/28
摘要： A pressurizable sample system includes a microplate having a planar plate surface and several sample wells. Each sample well has a flange positioned circumferentially around an outer surface of the sample well and against the planar plate surface. The sample system further includes a capping plate with a planar cap surface and several caps projecting from the planar cap surface. Each cap has a geometrical configuration in complementary correspondence with the configuration of the sample well.
摘要翻译：可加压的样品系统包括具有平板表面和几个样品孔的微孔板。每个样品阱具有围绕样品阱的外表面周围定位并且抵靠平板表面的凸缘。样品系统还包括具有平面盖表面的盖板和从平面盖表面突出的多个盖。每个盖具有与样品阱的构造互补对应的几何构型。

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