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1. 发明授权

US09939439B2 Microfluidic system having a magnetic particle bed 有权
公开(公告)号：US09939439B2
公开(公告)日：2018-04-10
申请号：US14426342
申请日：2013-09-06
申请人： Jean-Louis Viovy , Sanae Tabnaoui , Laurent Malaquin , Stéphanie Descroix
发明人： Jean-Louis Viovy , Sanae Tabnaoui , Laurent Malaquin , Stéphanie Descroix
IPC分类号： B03C1/00 , G01N33/569 , B03C1/28 , G01N33/543 , B03C1/01
CPC分类号： G01N33/56966 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/54326 , G01N33/56916 , G01N2333/255 , G01N2333/70596
摘要： The invention concerns a microfluidic system (1) comprising: at least one channel (2) for the flow of fluid having an inlet (4), an outlet (5) and a longitudinal axis (7) extending between the inlet (4) and the outlet (5), said channel (2) comprising a capture zone (3), and the cross section of the channel (2) orthogonal to the longitudinal axis (7) of the channel (2) increasing in size in the capture zone (3), from the inlet (4) towards the outlet (5) of the channel (2); and means (6) for applying a magnetic field having a decreasing intensity in the capture zone (3) of the channel (2), from the inlet (4) towards the outlet (5) of the channel. The invention also concerns a method for treating a sample that can be implemented with this system.

2. 发明申请

US20140342373A1 MICROFLUIDIC SYSTEM 审中-公开
标题翻译：微流体系
公开(公告)号：US20140342373A1
公开(公告)日：2014-11-20
申请号：US14345910
申请日：2012-07-24
申请人： Jean-Louis Viovy , Laurent Malaquin , Stefano Begolo , AnaïS Ali Cherif , Stephanie Descroix
发明人： Jean-Louis Viovy , Laurent Malaquin , Stefano Begolo , AnaïS Ali Cherif , Stephanie Descroix
IPC分类号： B01L3/00 , G01N33/543
CPC分类号： B01L3/502784 , B01L2200/0673 , B01L2300/0654 , B01L2300/0887 , B01L2400/043 , G01N33/54333 , H01F1/447 , H01F21/06 , Y10T436/255
摘要： The present invention concerns a microfluidic system comprising: a microchannel containing several elements of two non-miscible fluids, the microchannel comprising a droplet (30) containing magnetic particles (M), and a device for generating inside the microchannel magnetic field, said device comprising an activable magnetic element, the activable magnetic element comprising a tip (5,6), the microfluidic system being configured to transport the droplet by flow or by pressure difference.
摘要翻译：本发明涉及一种微流体系统，包括：包含两种不可混溶流体的几种元素的微通道，该微通道包括含有磁性颗粒（M）的液滴（30），以及用于在微通道磁场内产生的装置，所述装置包括可激活的磁性元件，所述可激活的磁性元件包括尖端（5,6），所述微流体系统被配置为通过流动或通过压力差来输送液滴。

3. 发明授权

US08545770B2 Method for improving the bonding properties of microstructured substrates, and devices prepared with this method 失效
标题翻译：用于改善微结构基材的粘合性能的方法，以及用该方法制备的装置
公开(公告)号：US08545770B2
公开(公告)日：2013-10-01
申请号：US12448169
申请日：2007-12-11
申请人： Jean-Louis Viovy , Jeremie Weber , Debjani Paul , Laurent Malaquin , Sandrine Miserere
发明人： Jean-Louis Viovy , Jeremie Weber , Debjani Paul , Laurent Malaquin , Sandrine Miserere
IPC分类号： B01L3/00
CPC分类号： C08J7/02 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/16 , B29C65/4895 , B29C66/0242 , B29C66/54 , B29C66/71 , B29C66/73117 , B29C66/73751 , B29C66/73752 , B29C66/73755 , B29C66/73756 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29C66/73941 , B29L2031/756 , Y10T428/24744 , B29K2025/04 , B29K2069/00 , B29K2075/00 , B29K2067/003 , B29K2081/06 , B29K2067/00 , B29K2061/00 , B29K2063/00 , B29K2079/08 , B29K2033/12 , B29K2083/00 , B29K2071/00 , B29K2033/08 , B29K2027/12 , B29K2025/08 , B29K2025/06 , B29K2023/38 , B29K2005/00
摘要： A method for treating the surface of a polymerio substrate, including the following steps: providing a first polymeric substrate; contracting at least one part of one face of the first substrate with some liquid solvent system, the liquid solvent system containing at least a first volatile compound and at least a second compound having a low molecular weight and able to swell and/or soften the polymeric material forming the face; letting at least the volatile compound to evaporate from the face of the first substrate and; contracting the so-treated face of first substrate with a third material.
摘要翻译：一种处理聚合物基材表面的方法，包括以下步骤：提供第一聚合物基材; 用一些液体溶剂系统收缩第一底物的一个面的至少一部分，液体溶剂体系含有至少第一挥发性化合物和至少第二化合物，其具有低分子量并能够使聚合物溶胀和/或软化材料成型面; 使至少挥发性化合物从第一基板的表面蒸发; 用第三种材料收缩第一基底的经处理的面。

4. 发明申请

US20100104480A1 METHOD FOR IMPROVING THE BONDING PROPERTIES OF MICROSTRUCTURED SUBSTRATES, AND DEVICES PREPARED WITH THIS METHOD 失效
标题翻译：用于改善微结构衬底的结合性能的方法以及用该方法制备的器件
公开(公告)号：US20100104480A1
公开(公告)日：2010-04-29
申请号：US12448169
申请日：2007-12-11
申请人： Jean-Louis Viovy , Jeremie Weber , Dejbani Paul , Laurent Malaquin , Sandrine Miserere
发明人： Jean-Louis Viovy , Jeremie Weber , Dejbani Paul , Laurent Malaquin , Sandrine Miserere
IPC分类号： B81B7/00 , B32B37/14 , B01L3/00 , B81C1/00 , B32B3/30
CPC分类号： C08J7/02 , B01L3/502707 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/123 , B01L2300/16 , B29C65/4895 , B29C66/0242 , B29C66/54 , B29C66/71 , B29C66/73117 , B29C66/73751 , B29C66/73752 , B29C66/73755 , B29C66/73756 , B29C66/7392 , B29C66/73921 , B29C66/7394 , B29C66/73941 , B29L2031/756 , Y10T428/24744 , B29K2025/04 , B29K2069/00 , B29K2075/00 , B29K2067/003 , B29K2081/06 , B29K2067/00 , B29K2061/00 , B29K2063/00 , B29K2079/08 , B29K2033/12 , B29K2083/00 , B29K2071/00 , B29K2033/08 , B29K2027/12 , B29K2025/08 , B29K2025/06 , B29K2023/38 , B29K2005/00
摘要： A method for treating the surface of a polymerio substrate, including the following steps: providing a first polymeric substrate; contracting at least one part of one face of the first substrate with some liquid solvent system, the liquid solvent system containing at least a first volatile compound and at least a second compound having a low molecular weight and able to swell and/or soften the polymeric material forming the face; letting at least the volatile compound to evaporate from the face of the first substrate and; contracting the so-treated face of first substrate with a third material.
摘要翻译：一种处理聚合物基材表面的方法，包括以下步骤：提供第一聚合物基材; 用一些液体溶剂系统收缩第一底物的一个面的至少一部分，液体溶剂体系含有至少第一挥发性化合物和至少第二化合物，其具有低分子量并能够使聚合物溶胀和/或软化材料成型面; 使至少挥发性化合物从第一基板的表面蒸发; 用第三种材料收缩第一基底的经处理的面。

5. 发明授权

US10704074B2 Method for detecting organisms in a diluted sample 有权
公开(公告)号：US10704074B2
公开(公告)日：2020-07-07
申请号：US15520922
申请日：2015-10-23
申请人： Jean-Louis Viovy , Stephanie Descroix , Laurent Malaquin , Iago Pereiro , Lucile Alexandre
发明人： Jean-Louis Viovy , Stephanie Descroix , Laurent Malaquin , Iago Pereiro , Lucile Alexandre
IPC分类号： C12Q1/04 , G01N33/543 , G01N33/569 , C12M1/34 , C12M1/00 , G01N33/487 , B05D1/00 , C12M1/12
摘要： The invention relates to a method for detecting organisms in a liquid sample, comprising the provision of a capture area including particles in a liquid medium and subjected to a hydrodynamic flow, wherein the organisms to be detected are capable of binding to these particles, the method comprising the steps of: (a) circulating the sample through the capture area; (b) circulating a growth medium through the capture area; and (c) determining the presence, nature or concentration of organisms in the capture area; said particles being retained in the capture area as a fluidized bed for at least one part of these steps. The invention also relates to a system for implementing this method.

6. 发明申请

US20170335364A1 METHOD FOR DETECTING ORGANISMS IN A DILUTED SAMPLE 审中-公开
公开(公告)号：US20170335364A1
公开(公告)日：2017-11-23
申请号：US15520922
申请日：2015-10-23
申请人： Jean-Louis Viovy , Stephanie Descroix , Laurent Malaquin , Iago Pereiro , Lucile Alexandre
发明人： Jean-Louis Viovy , Stephanie Descroix , Laurent Malaquin , Iago Pereiro , Lucile Alexandre
IPC分类号： C12Q1/04 , C12M1/00 , G01N33/487 , C12M1/34 , C12M1/12 , B05D1/00
摘要： The invention relates to a method for detecting organisms in a liquid sample, comprising the provision of a capture area including particles in a liquid medium and subjected to a hydrodynamic flow, wherein the organisms to be detected are capable of binding to these particles, the method comprising the steps of: (a) circulating the sample through the capture area; (b) circulating a growth medium through the capture area; and (c) determining the presence, nature or concentration of organisms in the capture area; said particles being retained in the capture area as a fluidized bed for at least one part of these steps. The invention also relates to a system for implementing this method.

7. 发明申请

US20120070911A1 Method of Detecting and Quantifying Analytes of Interest in a Liquid and Implementation Device 审中-公开
标题翻译：检测和定量液体和实施装置中感兴趣的分析物的方法
公开(公告)号：US20120070911A1
公开(公告)日：2012-03-22
申请号：US13258580
申请日：2010-03-29
申请人： Jean-Pierre Peyrade , David Peyrade , Christophe Vieu , Laurent Malaquin
发明人： Jean-Pierre Peyrade , David Peyrade , Christophe Vieu , Laurent Malaquin
IPC分类号： G01N33/53 , G01N21/78 , G01N21/64 , B82Y15/00
CPC分类号： G01N33/54366 , B01L3/502761 , B01L2200/0678 , B01L2300/1861 , B01L2400/0466 , G01N35/00029 , G01N2001/4027 , G01N2035/00158
摘要： The invention provides a method of detecting and quantifying analytes present in a solution, which is portable, rapid, inexpensive, selective and ultra-sensitive. For this purpose, the subject of the invention is a method of detecting and quantifying analytes of interest (2) in a specimen (1) of liquid obtained from a mother liquor, the liquid being able to evaporate in an atmosphere (Atm) under defined evaporation conditions, the method comprising the following steps: b) the specimen (1) is deposited on a substrate (10) having a microstructured or nanostructured surface (20) defining analyte capture probes, in order for the liquid specimen to at least partially cover the structured surface of the substrate; c) the specimen undergoes controlled evaporation (5) in the vicinity (VT) of a liquid/substrate/atmosphere triple line (T), in such a way that this triple line moves, at a controlled rate, over the structured surface of the substrate as the liquid evaporates into the atmosphere, and so that the target analytes are captured, by convective assembly and directed capillary action, by the probes; and d) the structured surface of the substrate obtained after step c) is analysed.
摘要翻译：本发明提供了一种检测和定量解决方案中存在的分析物的方法，其是便携式的，快速的，廉价的，选择性的和超灵敏的。为此目的，本发明的主题是检测和定量从母液获得的液体样品（1）中感兴趣的分析物（2）的方法，该液体可在规定的气氛（Atm）中蒸发蒸发条件，该方法包括以下步骤：b）将样品（1）沉积在具有限定分析物捕获探针的微结构或纳米结构化表面（20）的基底（10）上，以使液体样品至少部分覆盖基板的结构化表面; c）样品在液体/衬底/气氛三线（T）的附近（VT）处经受受控蒸发（5），使得该三线以受控的速率移动超过结构化表面底物作为液体蒸发到大气中，并且通过探针通过对流装配和定向毛细管作用捕获目标分析物; 和d）分析在步骤c）之后获得的基材的结构化表面。

8. 发明授权

US10130949B2 Microfluidic system 有权
公开(公告)号：US10130949B2
公开(公告)日：2018-11-20
申请号：US14345910
申请日：2012-07-24
申请人： Jean-Louis Viovy , Laurent Malaquin , Stefano Begolo , Anaïs Ali Cherif , Stephanie Descroix
发明人： Jean-Louis Viovy , Laurent Malaquin , Stefano Begolo , Anaïs Ali Cherif , Stephanie Descroix
IPC分类号： B01L3/00 , G01N33/543 , H01F21/06 , H01F1/44
摘要： The present invention concerns a microfluidic system comprising: a microchannel containing several elements of two non-miscible fluids, the microchannel comprising a droplet (30) containing magnetic particles (M), and a device for generating inside the microchannel magnetic field, said device comprising an activable magnetic element, the activable magnetic element comprising a tip (5,6), the microfluidic system being configured to transport the droplet by flow or by pressure difference.

9. 发明申请

US20150219650A1 MICROFLUIDIC SYSTEM HAVING A MAGNETIC PARTICLE BED 审中-公开
标题翻译：具有磁性颗粒床的微流体系统
公开(公告)号：US20150219650A1
公开(公告)日：2015-08-06
申请号：US14426342
申请日：2013-09-06
申请人： Jean-Louis Viovy , Sanae Tabnaoui , Laurent Malaquin , Stéphanie Descroix
发明人： Jean-Louis Viovy , Sanae Tabnaoui , Laurent Malaquin , Stéphanie Descroix
IPC分类号： G01N33/569
CPC分类号： G01N33/56966 , B03C1/01 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N33/54326 , G01N33/56916 , G01N2333/255 , G01N2333/70596
摘要： The invention concerns a microfluidic system (1) comprising: at least one channel (2) for the flow of fluid having an inlet (4), an outlet (5) and a longitudinal axis (7) extending between the inlet (4) and the outlet (5), said channel (2) comprising a capture zone (3), and the cross section of the channel (2) orthogonal to the longitudinal axis (7) of the channel (2) increasing in size in the capture zone (3), from the inlet (4) towards the outlet (5) of the channel (2); and means (6) for applying a magnetic field having a decreasing intensity in the capture zone (3) of the channel (2), from the inlet (4) towards the outlet (5) of the channel. The invention also concerns a method for treating a sample that can be implemented with this system.
摘要翻译：本发明涉及一种微流体系统（1），包括：流体流动的至少一个通道（2），其具有入口（4），出口（5）和纵向轴线（7），所述纵向轴线（7）在入口（4）和出口（5），所述通道（2）包括捕获区（3），并且与通道（2）的纵向轴线（7）正交的通道（2）的横截面在捕获区域中尺寸增加（3），从所述通道（2）的入口（4）朝向所述出口（5）; 以及用于在通道（2）的捕获区域（3）中从通道的入口（4）朝向通道的出口（5）施加具有降低的强度的磁场的装置（6）。本发明还涉及一种用于处理可以用该系统实现的样品的方法。

10. 发明申请

US20050161728A1 Molecular memory and method for making same 有权
标题翻译：分子记忆及其制备方法
公开(公告)号：US20050161728A1
公开(公告)日：2005-07-28
申请号：US10487796
申请日：2002-08-29
申请人： Azzedine Bousseksou , Christophe Vieu , Jean-Francois Letard , Philippe Demont , Jean-Pierre Tuchagues , Laurent Malaquin , Jerome Menegotto , Lionel Salmon
发明人： Azzedine Bousseksou , Christophe Vieu , Jean-Francois Letard , Philippe Demont , Jean-Pierre Tuchagues , Laurent Malaquin , Jerome Menegotto , Lionel Salmon
IPC分类号： H01L27/10 , G11C5/00 , G11C13/02 , H01L21/00 , H01L21/02 , H01L27/28 , H01L29/76 , H01L31/119 , H01L51/05 , H01L51/30 , H01L27/108
CPC分类号： H01L51/0595 , B82Y10/00 , G11C13/0014 , G11C13/0016 , G11C13/02 , H01L28/40 , H01L51/0077 , Y10S977/933
摘要： A molecular memory including a substrate made of silicon; a set of condensers, each condenser including two conductive layers constituting armatures of the condensers and between which is placed a dielectric layer; and a connector to provide electric contacts with external circuits, wherein the dielectric layer comprises at least partially a polymer containing triazole derivatives, a spin transition phenomenon support material or a spin transition molecular complex; and a method for manufacturing a molecular memory including covering a substrate with a conductive layer; coating a dielectric material on the conductive layer; covering the dielectric material with the conductive layer; impregnating by immersion a buffer in an inking solution of hexadecanethiol; drying and washing the impregnated buffer; creating a protective monolayer on the conductive layer by application of the impregnated, dried and washed buffer; and creating a chemical etching on the sample.
摘要翻译：包括由硅制成的衬底的分子存储器; 一组冷凝器，每个冷凝器包括构成冷凝器电枢的两个导电层，并在其间放置介电层; 以及连接器以提供与外部电路的电接触，其中所述电介质层至少部分包含含有三唑衍生物，自旋转移现象支持材料或自旋转移分子复合物的聚合物; 以及用于制造分子存储器的方法，包括用导电层覆盖衬底; 在导电层上涂覆介电材料; 用导电层覆盖电介质材料; 将缓冲液浸渍在十六烷硫醇的上墨液中浸渍; 干燥和洗涤浸渍的缓冲液; 通过施加浸渍的干燥和洗涤的缓冲液在导电层上形成保护性单层; 并在样品上形成化学蚀刻。

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