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    • 51. 发明授权
    • Reaction plate sealing means
    • 反应板密封装置
    • US06475774B1
    • 2002-11-05
    • US09956592
    • 2001-09-18
    • Hemant Gupta
    • Hemant Gupta
    • C12M134
    • B01L3/50853B01J2219/00788B01J2219/00804B01J2219/00869B01L3/50851B01L2300/042B01L2300/044
    • The invention comprises a wide range of pierceable and memory-recloseable septa cover for multi-well plates for PCR or other small sample well processes, where such seals are joined into an easily applied or removed sheet or otherwise joined means. A reaction chamber well comprises a liquid level portion at the bottom that contains the various levels of reaction liquid, a super-liquid portion comprising the gas volumes above the reaction liquid. In one form of the invention embodiments, the cover comprises a gas tight seal between the cover and the side of the well substantially above the liquid level, thereby forming the super-liquid space. The disturbance, pressure change and/or gas exchange in this small gas space results in a rather dramatic potential change in reaction or mixing results. The invention cover reduces each of these to a minimum not attainable in the prior art.
    • 本发明包括用于PCR或其它小样品井工艺的多孔板的可广泛范围的可刺穿和记忆可再封闭的隔膜盖,其中这种密封件被连接到易于涂覆或去除的片材或以其他方式连接的装置中。 反应室井底部包含含有各种水平的反应液体的液面部分,包含反应液体上方的气体体积的超液体部分。 在本发明实施例的一种形式中,盖子包括在盖子和井的侧面之间的气密密封,基本上在液面上方,从而形成超液体空间。 在这种小气体空间中的扰动,压力变化和/或气体交换导致反应或混合结果相当戏剧性的潜在变化。 本发明的覆盖将这些中的每一个减少到现有技术中不可能达到的最低限度。
    • 56. 发明申请
    • METHOD TO ALIGN COVERS ON STRUCTURED LAYERS AND RESULTING DEVICES
    • 将结构化层和结构设备对齐的方法
    • US20140318706A1
    • 2014-10-30
    • US14361383
    • 2012-11-28
    • Corning Incorporated
    • Stephane Poissy
    • B32B37/18
    • B32B37/18B01J19/0093B01J2219/00783B01J2219/00804B01J2219/00824B01J2219/00831B01L3/502707B01L3/569B01L2200/0689B01L2300/0816B01L2300/0887B01L2300/12B32B3/30B81C1/00119C03B23/245C03C27/06C04B37/00C04B37/001C04B37/042C04B2237/32C04B2237/62
    • A method for forming a fluidic module for a continuous flow reactor includes providing at least one planar glass or ceramic sheet having one or more through-holes, forming at least one patterned glass or ceramic layer having at least one patterned surface such that the patterned surface comprises channels defined between walls having an upper surface at a common height, stacking the at least one glass or ceramic sheet and the at least one patterned glass or ceramic layer together, the sheet contacting the walls at the common height, such that the channels are enclosed between the sheet and the patterned layer, the sheet being aligned with the patterned layer such that the one or more through-holes each align with respective spaces between walls of the patterned layer to provide fluid access to said respective spaces, and joining the sheet and the patterned layer together by pressing the sheet and the patterned layer together while heating the sheet and the patterned layer; wherein the patterned glass or ceramic layer further comprises one or more raised structures extending above the common height, and wherein the step of stacking comprises stacking the sheet on the upper surface of the walls at the common height, in a position such that the one or more raised structures confine the sheet to a desired position or alignment on the patterned layer.
    • 用于形成连续流动反应器的流体模块的方法包括提供具有一个或多个通孔的至少一个平面玻璃或陶瓷片,形成至少一个图案化的玻璃或陶瓷层,其具有至少一个图案化表面,使得图案化表面 包括限定在具有共同高度的上表面的壁之间的通道,将所述至少一个玻璃或陶瓷片和所述至少一个图案化的玻璃或陶瓷层堆叠在一起,所述片在共同的高度处接触所述壁,使得所述通道是 封闭在片材和图案化层之间,片材与图案化层对准,使得一个或多个通孔各自与图案化层的壁之间的相应空间对准,以提供对所述相应空间的流体通路,并且将片材 并且通过在加热片材和图案化层的同时将片材和图案层压在一起而将图案化层一起; 其中所述图案化玻璃或陶瓷层还包括在公共高度上延伸的一个或多个凸起结构,并且其中所述堆叠步骤包括在所述共同高度的所述壁的上表面上堆叠所述片材,使得所述一个或多个 更多的凸起结构将片材限制在图案化层上的期望位置或对准。